You’ve heard about the potential benefits of tesamorelin.
We take it you’re now looking for a comprehensive tesamorelin review — including benefits, dosage, side effects and more?
Well, you’ve come to the right place.
In this full tesamorelin review, we’ll give you an overview of this peptide and explain exactly what it is and how it works. We’ll also share our top recommendation for researchers looking for a reliable, cost-effective tesamorelin vendor.
Buy Tesamorelin from the #1 online Peptides vendor in the world: Peptides Sciences
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What is Tesamorelin?
Tesamorelin acetate, also known by its trade name “Egrifta” or simply as “tesamorelin”, is a synthetic analogue of human growth hormone-releasing hormone (GHRH). It’s used to stimulate the manufacture (synthesis) and release of growth hormone (GH) in the human body .
As an analogue, tesamorelin has similar physical properties to GHRH (also known as growth hormone-releasing factor) but is actually a peptide. Peptides are chains of amino acids — the substances that make up proteins. They’re basically small proteins that do not have the 3D shape that proteins have. Tesamorelin is made up of a chain of 44 amino acids as well as a trans-3-hexenoic acid group . The extra trans-3-hexenoic acid group helps make tesamorelin more stable and longer-lasting than natural GHRH.
Tesamorelin was developed by a Canadian company called Theratechnologies to treat a condition called lipodystrophy that’s common in patients with HIV who receive long-term antiretroviral therapy (ART) . Lipodystrophy sufferers experience an increase in the amount of abdominal fat — a condition that tesamorelin helps improve.
Why does growth hormone (GH) matter?
Growth hormone is a powerful anabolic hormone and is one of the most important chemical signals for your body to build and repair tissue. It’s involved in many processes, from creating new muscle to repairing torn tissue and even breaking down fat. Serum levels of GH in the body are variable and are dependent on such factors as age, level of fitness, gender and body composition.
Because of its role in creating new tissue, GH is plentiful in the body during childhood and adolescence, but decreases with age. This can affect athletic performance, mobility and the length of time it takes to recover from an injury. Tesamorelin and other GHRH anaolgues stimulate the pituitary gland and encourage the synthesis and release of endogenous GH in the body .
While there is no scientific evidence that injecting biosynthetic forms of GH (tesamorelin included) increases athletic performance, all synthetic GHRH analogues and peptides are banned from sports, indicating that they are beneficial to that end. Anecdotal reports suggest that athletes and bodybuilders do undertake growth hormone treatment .
Does Tesamorelin Actually Work?
Yes, tesamorelin has been evaluated by the United States Food & Drug Administration (FDA) and is an approved treatment for HIV-related lipodystrophy . Numerous scientific studies have shown that tesamorelin is a safe and effective treatment for adults with HIV.
Tesamorelin’s research-backed benefits include its ability to increase lean muscle area and decrease muscle fat in adults with HIV , and its ability to lower levels of visceral adipose tissue (VAT) in patients with HIV-related lipodystrophy . Studies have shown that tesamorelin is able to trigger lipolysis (fat burning) in lipohypertrophy patients .
Tesamorelin’s effectiveness in treating non-HIV patients has not been evaluated. There is no scientific evidence documenting an improvement in athletic performance following tesamorelin supplementation. However, it has been shown to decrease levels of an osmolyte linked to Alzheimer disease — MI (myo-inositol) — in healthy adults, while raising levels of GABA (Gamma aminobutyric acid) .
Is Tesamorelin Legal?
Based on the data we have on this peptide, you may be asking yourself: is tesamorelin legal?
In short, yes.
Tesamorelin is available as a prescription medication for patients with HIV-related lipodystrophy and is available from registered pharmacies across the U.S. and worldwide .
While tesamorelin is not approved to be taken as a dietary supplement or for cosmetic use, researchers are free to buy tesamorelin as a “reference material” online from sources like Peptide Sciences.
We repeat: For research purposes, tesamorelin is an unregulated compound that is widely available.
Tesamorelin Before and After
What is the effect of tesamorelin before and after?
According to results from two well designed, 26-week clinical trials in patients with HIV-associated central fat accumulation, tesamorelin therapy was associated with “significant improvements in body composition measures such as waist circumference and trunk fat” .
In a separate study into the effects of tesamorelin on people living with HIV, researchers found that tesamorelin was “associated with significantly greater increases in density of four truncal muscle groups,” “in total area” and “in the lean muscle area,” compared to a placebo .
Although World Anti-Doping Agency (WADA) regulations prohibit the use of growth hormone-releasing hormones (GHRHs) such as tesamorelin in sports, we simply do not have the evidence that tesamorelin can build muscle, burn fat or enhance athletic performance in healthy individuals . Anecdotal reports, however, suggest that tesamorelin is commonly used in bodybuilding circles and by athletes .
Tesamorelin Benefits and Uses
As tesamorelin has been approved by the FDA, there’s been lots of research on this peptide and we know quite a lot about it. Here’s what the research says about how tesamorelin might benefit subjects and how it can be used.
Increasing growth hormone
Tesamorelin has been found to be very effective at increasing the rate at which growth hormone is synthesized and released in the body . Studies have shown that it can increase lean muscle tissue in HIV-positive adults .
One of the primary uses of tesamorelin is to treat HIV-afflicted individuals that suffer from lipodystrophy, a condition that causes the accumulation of fat in the upper back and around the stomach . This increase in body fat can cause body image issues as well as increase the risk of heart attack and other cardiovascular diseases.
While its exact mechanism of action is unclear, tesamorelin has been shown to trigger lipolysis (fat loss) in individuals with this condition. In HIV-infected patients with lipodystrophy and excess body fat around the abdomen, tesamorelin was found to significantly decrease subcutaneous adipose tissue (body fat) by 15 percent . In contrast, the control group participants had a 5 percent increase in body fat. Tesamorelin was also found to improve insulin resistance and cholesterol.
More importantly, patients’ scores on body image improved significantly in the tesamorelin group, with subjects perceiving their bodies as more attractive following treatment .
These results are not isolated; they’ve been confirmed by a review of 4 randomized controlled trials . The research suggests that tesamorelin is actually 4 times more effective in reducing adipose tissue (body fat) than all other treatments combined .
Injury, surgery and even diabetes can cause peripheral nerve damage and result in the loss of motor and sensory function in various parts of the body. Typically, there is very little that can be done about this; nerve cells are very difficult to regenerate.
Some research has shown, though, that tesamorelin and other GHRH secretagogues may actually be able to improve the extent to which nerves can regenerate themselves. Tesamorelin is currently being tested for this and is one of the more promising treatment options .
Improved cognitive function
There is also some promising research about the role that GHRH analogues, including tesamorelin, may play in improving cognitive function for individuals. A large control trial out of Washington state found evidence that tesamorelin may increase levels of some neurotransmitters in the brain that are associated with better cognitive function . More research is needed to confirm these findings.
Tesamorelin Side Effects
Adverse side effects are rare with tesamorelin in adults with HIV, but as with most peptides, there is a possibility of side effects. The risk of tesamorelin side effects appears to increase in line with dosage.
Some of the more commonly reported side effects include:
- Swelling and itching at or around the injection site
- Muscular aches and pain
Less common but more serious side effects include:
- Diarrhea with fever and dehydration
- Congestive heart failure
- Shortness of breath
- Muscle or joint pain
- Numbness, tingling, swelling in arms or legs
One side effect of tesamorelin is that it may cause glucose intolerance and increase the risk of type 2 diabetes mellitus. The drug is contraindicated during pregnancy .
There is a possibility of allergic reactions to all medications. Patients or research subjects who experience any persisting or serious side effects after taking tesamorelin should contact their primary care physician immediately.
Tesamorelin Dosage Guide
Tesamorelin, like all drugs, should be used under the guidance of a qualified health professional such as a doctor or a medical researcher. Patients who are prescribed tesamorelin should follow the directions of their doctor to administer tesamorelin properly and at the right dose.
For the treatment for HIV-related lipodystrophy, patients typically dose tesamorelin as follows:
- One subcutaneous injection, daily
- At least 90 minutes after eating
- Preferably at night, before sleep.
- Each injection dosed at 2 mg
- Five days per week
While there’s a lack of scientific data definitively supporting the idea that growth hormone supplementation improves athletic performance, lean muscle gain or fat loss in healthy individuals, anecdotal reports suggest that many athletes and bodybuilders do use tesamorelin . According to J G Macintyre, “anecdotal reports have been equivocal, with some individuals reporting spectacular results while others report no change.”
Based on anecdotal reports, a common tesamorelin dosage for bodybuilding is 1 mg per dose, five days per week, administered late at night, at least 90 minutes after eating.
Where to Buy Tesamorelin Online? | 2021 Guide
Tesamorelin is legally available for researchers to buy online.
Now the main challenge facing researchers is finding a reliable vendor that sells high-quality tesamorelin at reasonable prices. Our recommended vendor is Peptide Sciences. They publish independent, third-party test results for all of these products, which offers clarity and transparency about the purity of their peptides.
In addition to that, Peptide Sciences also:
- Manufactures their product in the US;
- Offers convenient shipping. Orders within the US are received within 2 to 3 days. International orders can take up to 10 days;
- Accepts a range of secure, convenient payment methods. If you like credit cards, they’ll accept all the main ones. If you are into cryptocurrency, Peptide Sciences also accepts Bitcoin, Ethereum and some others;
- Offers great customer service. If you have any problems with your order or just want to ask a question, you can get in touch with them by phone or email.
Buy Tesamorelin from our #1 recommended vendor...
How to Order Tesamorelin in Your Country
Patients with a prescription for tesamorelin can buy this drug from any pharmacy. Researchers can pay significantly less for tesamorelin by ordering online through Peptide Sciences. The beauty of Peptide Science is that they deliver internationally. No matter where you’re located, if you are accessible by courier, you can order tesamorelin online from Peptide Sciences.
The process of ordering tesamorelin online is simple. All you need is a valid email address and shipping address, and an accepted method of payment such as a debit or credit card. Adding your personal data and payment information to Peptide Sciences’ secure website takes just a few moments and orders are generally dispatched within 24 hours.
While there are other vendors that offer tesamorelin, we’ve found that Peptide Science offers the best value for money and reliable, cost-effective delivery times. When ordering tesamorelin online, be careful that you can trust the vendor and that you’re going to get an authentic product without fillers or additives.
Tesamorelin Review | Verdict
Researchers are very excited about tesamorelin.
Tesamorelin is an FDA-approved lipodystrophy treatment that has been proven to help HIV patients reduce stubborn belly fat. Several high-quality, randomized, placebo-controlled studies have reported that subjects lose significant amounts of fat when they take this peptide.
While studies into tesamorelin effect in healthy individuals are lacking, this drug’s clear impact on lipid metabolism makes it an ideal candidate for further research. Researchers can easily buy tesamorelin online from Peptide Sciences.