Have you heard that 5-amino-1MQ capsules may hold the key to treating weight loss?
If so, then you’re not alone!
We have examined the research on this potent molecule to create a thorough guide to 5-amino-1MQ capsules.
In this article, our research team addresses questions like:
- What is 5-amino-1MQ?
- What are the potential benefits of 5-amino-1MQ?
- Is 5-amino-1MQ safe?
- How should 5-amino-1MQ be dosed and stored?
In addition, we provide our top recommendation of a 5-amino-1MQ capsules supplier.
Read on to explore the current evidence on 5-amino-1MQ benefits and discover whether you should include this powerful NNMT blocker in your research.
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What is 5-amino-1MQ?
Researchers at the University of Texas first characterized 5-amino-1MQ (5-amino-1-methyl quinolinium) in 2017 while searching for ways to inhibit nicotinamide-N-methyltransferase (NNMT) .
NNMT is an enzyme that is highly active in fat tissue and key to cellular metabolism and energy homeostasis. Notably, the enzyme has been linked to obesity and type 2 diabetes (T2D). The researchers thus hypothesized that blocking NNMT could open a novel path to treating obesity and its metabolic complications [1, 2].
5-amino-1MQ is a small, membrane-permeable molecule with a chemical formula of C10H11N2+. By inhibiting NNMT, 5-amino-1MQ improves glucose clearance from the blood and enables cells to more rapidly use available energy, reducing glycogen and fat deposition [1, 3].
The NNMT-blocking mechanism of 5-amino-1MQ has been shown to increase levels of the cofactor NAD+, whose replenishment in organisms promotes muscular, cognitive, and immune function, as well as increased lifespan [4, 5].
In a 2021 study in obese mice, 5-amino-1MQ administration caused significant body mass reductions in the rodents, who achieved body composition and liver adiposity parameters that were comparable to the lean mice in the control group. The study authors reinforced the idea that NNMT inhibition could potentially treat obesity and related metabolic comorbidities .
5-amino-1MQ has yet to enter clinical trials and accordingly is yet to be approved for human use by the United States Food and Drug Administration (“USFDA”).
At this time, 5-amino-1MQ is available to qualified researchers for in vitro testing and laboratory experimentation only.
Benefits of 5-Amino-1MQ
While there are encouraging test tube and animal studies into the effects of 5-amino-1MQ, it is important to note that we still lack quality data in humans. Future research is expected to shed more light into the potential benefits and uses of this NNMT inhibitor.
For now, 5-amino-1MQ appears to be a promising candidate for treating obesity and diabetes, as well as improving muscle function.
5-Amino-1MQ for Weight Loss
By blocking NNMT, 5-amino-1MQ increases availability of NAD+ and influences metabolic processes that rely on this cofactor. This allows the body to burn more calories and suppress storing additional glycogen and fat deposits.
Research shows that increased NNMT is strongly associated with obesity, so targeting this enzyme could be beneficial for weight loss .
High activity of NNMT is also correlated with lower levels of glucose transporter 4 (GLUT4), which is vital for glucose uptake from the bloodstream into fat and muscle cells. When glucose transport is impaired, the body stores glycogen and fat because it cannot use all the energy, resulting in weight gain .
Subjects with high levels of GLUT4 have a “faster metabolism,” and their bodies burn more calories. The production of this transporter can be increased through exercise . However, this remains challenging for many obese individuals.
5-amino-1MQ not only works to reduce NNMT but increases GLUT4 transporter expression. This result is improved glucose clearance from the blood, which supports energy metabolism and reduces fat storage .
In a seminal study in diet-induced obese mice, 5-amino-1MQ administration led to a 35% reduction in mass and size, a 30% decrease in adipocyte size, and a 40% decrease in adipocyte volume in the rodents. In addition, the treated mice showed cholesterol levels that were comparable to those of healthy mice. These findings were not attributed to variations in food intake, which implies that the observed results were mediated by alterations in metabolic processes .
5-Amino-1MQ for Diabetes and Metabolic Disorders
NNMT is a potential biomarker for reduced insulin sensitivity, since higher activity of this enzyme has been linked to insulin resistance and type 2 diabetes .
Inhibition of NNMT may thus improve glucose tolerance and insulin sensitivity. One study investigating these effects in obese mice discovered that administration of an NNMT blocker reduced insulin serum levels by 50-60% in the subjects. In addition, the mice experienced significant fat loss, reduced adipocyte size and volume, and decreased triglycerides and free fatty acids .
These findings highlight the potential of 5-amino-1MQ peptide therapy as a blood sugar management tool in diabetic and prediabetic individuals.
5-Amino-1MQ for Muscle Repair
Since 5-amino-1MQ inhibits NNMT in skeletal muscle and enhances the activity of GLUT4, the molecule may represent a promising intervention to improve workout capacity and physical performance.
Scientists are investigating how 5-amino-1MQ can affect stem cells and muscle repair. In a study in old mice, NNMT inhibition was shown to promote stem cell activation following injury. The 5-amino-1MQ-treated mice experienced a two-fold increase in myofiber size and cross-sectional area distribution. In addition, the 5-amino-1MQ group had 70% stronger contractile force in healed muscle compared to the control .
Higher NNMT levels have also been observed in patients with some forms of muscular dystrophy . Scientists believe that inflammation linked to these conditions is what drives the increase of NNMT. An NNMT inhibitor like 5-amino-1MQ could help by stimulating the synthesis of NAD+, a vital cofactor in the electron transport chain. In addition, it appears that NAD+ protects muscles from metabolic and structural degeneration .
5-Amino-1MQ Side Effects
5-amino-1MQ has the potential to support weight loss by increasing energy metabolism and reducing fat storage. However, it is important to be aware of the molecule’s safety profile and potential side effects before administering it to test subjects.
While there is no data to establish the safety of 5-amino-1MQ in humans, rodent studies have found no significant adverse effects [1, 6, 11]. Considering that most current pharmacological treatments of obesity are linked to major side effects, the preclinical research into 5-amino-1MQ looks promising.
Independent researchers have reported that taking 5-amino-1MQ too late in the day may result in difficulty with falling asleep. It has also been reported that 5-amino-1MQ treatment requires an acclimation period, with some subjects reporting decreased exercise tolerance with cardiovascular exercise.
Given the limited safety information available on 5-amino-1MQ, researchers must consider excluding certain groups from their trials until we have more pre-clinical and clinical data.
This would include pregnant and breastfeeding subjects, those with chronic conditions, and those taking medications that can interact with 5-amino-1MQ.
5-Amino-1MQ Dosage Guide
Given its status as a research peptide, there are no official dosing guidelines and safety protocols in place for 5-amino-1MQ.
Researchers looking to investigate the effects of 5-amino-1MQ capsules are advised to consider all data available.
Here are some pointers to keep in mind when designing a 5-amino-1MQ dosing protocol.
- The optimal administration schedule and dosage vary depending on the desired therapeutic outcome.
- Dosages used in rodent studies range from 10mg/kg/day to 150mg/kg/day [1, 6, 11]. These doses, of course, do not scale to human subjects.
- Independent researchers typically administer a daily 5-amino-1MQ dose of 50-150mg of 5-amino-1MQ to human subjects.
- Quality, long-term data on 5-amino-1MQ is lacking. Researchers are accordingly advised to refrain from administering 5-amino-1MQ indefinitely. Independent researchers report study durations of four to eight weeks.
Sample 5-Amino-1MQ Dosing Protocol
Researchers using 50mg 5-amino-1MQ capsules for weight loss may refer to the following dosing protocol:
- 5-amino-1MQ Dosage: 50mg-150mg per day. Since one capsule contains 50mg of 5-amino-1MQ, subjects require one to three capsules daily. The full dose may be taken once in the morning on an empty stomach, or split into two to three daily doses throughout the day, each on an empty stomach.
- Course Duration: 1-2 months.
- Notes: A 60-capsule container represents a 20-day supply at the 150mg/daily dose, a 40-day supply at the 100mg/daily dose, and a 60-day supply at the 50mg/daily dose.
We encourage researchers to stay up-to-date on the latest research regarding 5-amino-1MQ and NNMT blockers.
5-Amino-1MQ Capsules | What Researchers Need to Know
In this section, we take a deeper look into 5-amino-1MQ capsule characteristics, best practices for storage and administration, and how to select a reliable vendor of research capsules.
5-Amino-1MQ Structure and Bioavailability
The chemical formula of 5-amino-1MQ is C10H11N2+. It consists of a quinoline ring, which is a bicyclic aromatic system of a benzene and pyridine ring. The quinoline ring contains an amino group at position 5 and a methyl group at position 1 .
5-amino-1MQ is effective in capsule form as it is chemically stable and does not degrade during processing, transportation, and storage. In addition, 5-amino-1MQ is selective membrane-permeable, allowing our bodies to digest it so it can enter the bloodstream and cells. Animal research has confirmed the high oral bioavailability of 5-amino-1MQ, making it suitable for administration in capsule form .
5-Amino-1MQ Capsule Administration and Storage
Researchers should follow manufacturer’s instructions for the safe storage and administration of 5-amino-1MQ. While the molecule is stable at room temperature under normal conditions, different factors can affect the purity of this compound and cause degradation.
It is important to keep 5-amino-1MQ capsules in their original container, which is designed to protect the capsules from light, moisture, high temperatures, and other factors that can degrade the quality of the compound. To ensure shelf life, researchers should store the container in a cool, dry place, away from direct sunlight, heat, and moisture.
There is currently no established protocol for administering 5-amino-1MQ capsules. Some independent researchers recommend taking the full daily dose on an empty stomach, first thing in the morning. Others spread the daily dose into 2-3 doses, taken in the morning and prior to physical exercise, in both cases on an empty stomach.
Selecting a Reliable Vendor of Research Peptides
Researchers should always source 5-amino-1MQ capsules from a reputable vendor with transparent sourcing practices, ethical and compliant marketing, and laboratory test results available online. Not all research chemical vendors adhere to these practices, which is why you should perform due diligence when selecting the right vendor
Using peptides from questionable vendors may compromise the safety and effectiveness of your experiment. In addition, products from such vendors may contain impurities or harmful chemicals, increasing the risk of adverse effects.
When selecting a vendor of 5-amino-1MQ capsules, you will need to verify:
- The vendor’s track record and customer reviews
- Availability of third-party laboratory results
- Shipping options and policies
- Available payment options
- Customer service quality
In addition, steer clear of online vendors who make unsupported claims regarding their products. Although 5-amino-1MQ displays high potential for clinical applications, quality data is still needed to establish its safety and efficacy.
Where to Buy 5-Amino-1MQ Capsules Online?
5-amino-1MQ shows great potential in the treatment of obesity and related metabolic disorders. However, it is vital to purchase 5-amino-1MQ capsules from a legitimate vendor.
After comparing online peptide vendors, Peptides.org is proud to recommend the best 5-amino-1MQ capsules you can find online.
We recommend Peptide Sciences' 5-amino-1MQ capsules, and here is why:
- Lab-Tested Peptides: Third-party lab testing is a must when ordering peptides from an online vendor. Peptide Sciences submits each product batch for independent lab testing and displays the results online. This reflects the vendor’s commitments to both transparency and product quality.
- Domestic Production: All compounds sold by Peptide Sciences are sourced in the United States. This vendor partners only with WHO/GMP and ISO 9001:2008-approved manufacturers to ensure the quality of their research chemicals.
- Convenient payment options: Peptide Sciences offers individual and wholesale pricing, allowing you to get a better deal if you need to purchase in bulk. They accept major credit cards, e-checks, and a host of other convenient payment methods.
- Fast and reliable shipping: Peptide Sciences reliably ships their products within the U.S. and to select international destinations. U.S.-based researchers can expect their purchases to be delivered in 2-3 business days, while international shipments take 7-10 business days. Shipping is affordable, and they waive shipping on U.S. orders over $200.
- Friendly customer service: Peptide Sciences has a responsive and friendly customer service team ready to answer any questions via email. In our experience, they respond to inquiries within 48 hours and provide helpful information about their products.
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5-Amino-1MQ Capsules | Verdict
5-amino-1MQ capsules represent a potentially novel treatment of obesity, type 2 diabetes, and muscle wasting conditions. It works by inhibiting NNMT, an enzyme that regulates cellular energy metabolism and is mostly found in fat tissue.
By blocking this enzyme, 5-amino-1MQ has been shown to increase fat burning, improve glucose clearance, and prevent new fatty tissue deposits. The small molecule has also been shown to help lower blood cholesterol levels and stimulate muscle repair in animal studies, paving the way for a host of research applications.
Since this NNMT blocker has yet to enter clinical trials, its sale online is limited to qualified researchers and laboratory professionals.
To source research-grade 5-amino-1MQ capsules, turn to Peptide Sciences, an established leader within the research chemicals industry.