PT-141 Dosage Calculator and Chart | A-Z Guide

Researchers interested in exploring peptides for sexual function will inevitably have questions about PT-141 dosage. 

PT-141 (bremelanotide) is used clinically as a libido treatment in premenopausal women. Researchers have also uncovered other potential benefits of this alpha-MSH analog, including: 

• Increased sexual desire in men 
• Stronger and longer-lasting erections 
• Improved mood and energy 

In this educational guide, we include a PT-141 dosage calculator and provide basic guidance on administering this sexual health peptide. 

Qualified researchers looking to experiment with PT-141 can also find full details of where to buy PT-141 online.

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PT-141 Dosage Chart | Quick Breakdown

PT-141 Formulation	PT-141 Dosage for Research	PT-141 Nasal Spray Dosage for Research
Single Dosage	1.25-1.75mg	7-20mg
Maximum Daily Applications	1	1
Maximum Monthly Applications	8	8

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What is PT-141?

PT-141 is the chemical name for bremelanotide, a melanocortin receptor agonist that was initially developed by Palatin Technologies and released under the brand name “Vyleesi”. Its manufacture was subsequently out-licensed to AMAG Pharmaceuticals Inc. [2].

In 2019, PT-141 was approved by the US Food and Drug Administration for the treatment of premenopausal women with hypoactive sexual desire disorder (HSDD) [1]. In the US, bremelanotide is available as a prescription medicine to patients who have received an HSDD diagnosis. It can be self-administered subcutaneously on demand by patients in their homes [3].

PT-141 can be purchased by researchers as a reference material for the purpose of conducting experiments. Below, the top benefits and uses of this research chemical will be summarized.

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PT-141 Benefits and Uses

In the US, PT-141 is an FDA-approved medicine that is used to treat premenopausal women who have been diagnosed with HSDD.

Clinical trials involving premenopausal women have shown that PT-141 can:

• Increase sexual desire [2]
• Stimulate the release of dopamine [4]
• Increase the frequency of “satisfying sexual events” [5]
• Lower intercourse-related distress [6]

It should be noted that these benefits apply solely to premenopausal women with HSDD and do not apply to postmenopausal women (with or without HSDD) or men. Furthermore, PT-141 is not indicated to enhance sexual performance [7].

While PT-141 has not received FDA approval as a treatment for erectile dysfunction (ED), there is some evidence that it may be beneficial for men suffering from this condition.

A 2004 study found that PT-141 prompted a “statistically significant erectile response” when administered to male test subjects who had reported an insufficient response to 100 mg of sildenafil (Viagra) [8].

A later study found that PT-141 produced a “positive clinical result” in 33.5% of men who took it intranasally prior to intercourse [9].

These findings suggest that PT-141 may offer potential as a complementary ED therapy alongside other established treatment options such as Viagra.

Having reviewed the main benefits offered by PT-141, we’ll now briefly consider its known side effects.

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PT-141 Side Effects

PT-141 has been extensively researched and found to be safe and well-tolerated. The most common adverse reactions (incidence > 4%) are [7]:

• Nausea
• Flushing
• Injection site reactions
• Headaches
• Vomiting

Phase 2 and 3 clinical trials involving bremelanotide (Vyleesi) found that adverse events occurred at the following rates [2,10]:

• Headaches (11-12%)
• Facial flushing (20.4-20.6%)
• Nausea (39.9-40.4%)

Serious adverse reactions were reported in 1.1% of PT-141-treated patients and 0.5% of placebo-treated patients, and 18% of the patients who experienced a serious adverse reaction decided to discontinue the study. The most common reasons for discontinuation were [7]:

• Nausea (8%)
• Headache (2%)
• Vomiting (1%)
• Flushing (1%)
• Injection site reactions (1%)
• Flu-like symptoms (<1%)
• Increased blood pressure (<1%)

Researchers concluded that PT-141 was safe when administered at 1.75 mg per day, up to a maximum of 8 times per month [11]. However, in very rare cases, PT-141 may cause elevated serum enzyme levels, or liver injury [12].

“Vyleesi” (bremelanotide injections) should not be used by patients with uncontrolled hypertension or known cardiovascular disease and comes with a number of warnings and precautions. Vyleesi may cause [7].

• A transient increase in blood pressure and decrease in heart rate (up to 12 hours)
• Focal hyperpigmentation (<1% of patients)
• Nausea (40% of patients who received up to 8 monthly doses)
• Slowed gastric emptying and impact absorption of concomitantly administered oral medications
• Decreased systemic exposure of orally administered naltrexone

Furthermore, PT-141 should not be used by patients where pregnancy is suspected.

In studies involving male patients, the small sample sizes and short duration of the experiments make it difficult to draw any meaningful conclusions about PT-141’s long-term safety in men. While researchers have noted that PT-141 was “safe” [8, 9], this chemical needs to be tested in a well-designed long-term clinical trial before drawing any conclusions regarding its safety [13].

Having reviewed PT-141’s main side effects, it’s time to focus on the main topic in this guide; how PT-141 has been administered to test subjects in past studies and clinical trials.

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PT-141 Dosage Guide

Researchers curious about how PT-141 has been dosed in past studies and trials may consult the following literature for reference.

What is the Recommended Dosage of PT-141?

When sold as a reference material, PT-141 has no safe or recommended dosage. However, when purchased as bremelanotide (Vyleesi), the recommended dosage for premenopausal patients with HSDD is “1.75 mg administered subcutaneously in the abdomen or thigh, as needed, at least 45 minutes before any anticipated sexual activity” [7]. Vyleesi injections typically comprise 1.75 mg bremelanotide and 0.3 mL solution.

Further research suggests that doses of 1.25mg and 1.75mg per injection have been observed to have the highest effectiveness for improving sexual function in women [14]. PT-141 has also been reported as effective in increasing erections in men, when administered subcutaneously in doses from 1–2mg [8].

Researchers must note that the peptide should not be administered more often than once per 24 hours and eight times per month in men or women, to prevent undesired effects such as darkening of the skin [7, 14].

Based on the available data, here is a sample dosing protocol for subcutaneous PT-141:

• Daily Dose: 1.25mg, administered subcutaneously
• Frequency: No more than once per day and eight times per 30 days
• Study Duration: Phase-3 trials have lasted up to 24 weeks.
• Notes: Administer 45 minutes prior to anticipated sexual activity. A 10mg vial of PT-141 will be sufficient for 8 doses and should be administered within 30 days.

How is PT-141 Administered?

Bremelanotide (Vyleesi) is self-administered by patients via a prefilled autoinjector pen. This lets the patients visually inspect the drug for any discoloration or particulate matter prior to administration. Patients are advised to discard the drug if discoloration, a cloudy appearance, or visible particles are noticed.

In addition, PT-141 may also be administered intranasally as a spray. PT-141 spray is available only for research and is not approved for human use.

According to the available data, PT-141 spray is effective for increasing erectile function in men when administered at a dose of 7mg [15]. Once again, the peptide should not be administered more often than once daily and eight times per month.

When Should PT-141 Be Administered?

If purchased as a research chemical, Vyleesi should not be administered. Bremelanotide (Vyleesi) is typically self-administered by patients “at least 45 minutes before anticipated sexual activity”. The optimal window for bremelanotide “has not yet been fully characterized” [7]. Therefore patients may decide the optimal time based on their experience and whether they experience any adverse reactions such as nausea. The duration of efficacy after each dose is currently unknown.

How Often Can PT-141 Be Administered?

When administered to treat HSDD, bremelanotide (Vyleesi) should be administered no more than once within 24 hours, and no more than 8 times per month, as this “increases the risk for focal hyperpigmentation and the length of time per month when blood pressure is increased” [7].

Now that we’ve explored how PT-141 may be dosed, we can look at how this research chemical may be microdosed.

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Microdosing PT-141

Data from phase 2 and 3 clinical trials does indicate the efficacy of PT-141 (bremelanotide) when administered in smaller, or “micro” doses.

In the aforementioned 2016 trial, female patients were randomized to receive either a placebo or a dose of bremelanotide in one of three doses:

• 0.75 mg
• 1.25 mg
• 1.75 mg

Data from this study showed that 0.75 mg doses produced a statistically insignificant response in participants’ Female Sexual Function Index-desire domain score, while both doses over 1 mg—1.25 mg and 1.75 mg—produced a statistically significant increase in sexual satisfaction, by +0.7 and +3.6 respectively [5].

While bremelanotide is not indicated to treat postmenopausal women or men, studies involving male patients have investigated PT-141 at a number of different microdoses. The aforementioned 2004 study administered PT-141 at doses ranging from “0.3 to 10 gm” and found that “statistically significant” erectile responses occurred only “at doses greater than 1.0 mg” [8].

Having looked at the efficacy of microdosing PT-141, we can turn our attention to the best online sources serving peptide researchers.

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Where To Buy PT-141 Online? | 2024 Edition

While PT-141 is readily available online as a research chemical, buyers may struggle to find a reliable vendor that can supply research-grade PT-141. With so many vendors to choose from, deciding where to place an order is far from easy.

To assist qualified researchers, our team has made a series of test orders from the top online vendors and ranked them according to the quality of their PT-141, prices, customer service, and timeliness of shipping.

The top two vendors?

Core Peptides

Core Peptides outshone the competition in all areas and is our top pick for a reliable, trustworthy PT-141 vendor.

Here are a few specific reasons why we endorse this peptide supplier for researchers looking for top-quality PT-141:

• Independent Testing: Our team was highly impressed by Core Peptides’ dedication to supplying 99% pure, research-grade PT-141. They have every batch of PT-141 tested by an independent lab and post the results on their website.
• Generous Discounts: Core Peptides price their PT-141 at just $41 for a 10mg vial, which in itself is highly reasonable. They also offer a further 10% discount to researchers who place a bulk order of more than 9 vials.
• Friendly Customer Support: After placing a test order, our team received high-quality support from Core Peptides’ customer support team. They kept us informed about the progress of our order and helped us track our shipment until it reached us.

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Limitless Life

Limitless Life is another trusted vendor that offers high-quality peptides at reasonable prices. Here’s where they stand out:

• Third-Party Verified PT-141: Before placing an order for PT-141 on Limitless Life, researchers can view test certifications provided by an esteemed third-party laboratory. This vendor’s PT-141 is truly research-grade and will give accurate results when used in experiments.
• Informative, Secure Website: The Limitless Life website is packed full of top-quality information and is highly secure. It features the latest SSL encryption and protects all customers’ data. Researchers can order in confidence when they shop here.
• Responsive Support Staff: Our team had a fantastic experience when ordering from Limitless Life. Their trained customer service representatives were highly responsive to our questions and inquiries and provided quick responses via phone and email.

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How To Reconstitute PT-141

When it comes to working with research peptides like PT-141, researchers must adhere to the proper methods of reconstitution, storage, and injection.

To do so, certain supplies are indispensable. Bacteriostatic water, insulin syringes, and sterile vials are just some of the items that qualified researchers need to have on hand for proper PT-141 reconstitution.

Access to supplies can be a challenge and research deterrent, requiring hours of searching for products from around the web. However, it is required.

Usually, the researcher will need lab supplies and materials like:

• Bacteriostatic Water
• Insulin Syringes
• Alcohol Prep Pads
• Sterile Empty Glass Vials
• Large Needles + Syringes

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PT-141 Dosage | The Verdict?

Researchers interested in PT-141 dosage will be pleased to know that this well-researched peptide has been dosed at various amounts in past studies with a low incidence of side effects or adverse effects.

While doses of 1.75 mg are common for premenopausal women with HSDD, data from clinical trials show that PT-141 is well-tolerated at larger doses with little risk of causing serious adverse events.

Researchers planning to experiment with PT-141 in the near future are advised to consider Core Peptides as a reliable, world-class vendor who has the capacity to meet their needs.

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