Buy Hexarelin Online | A Comprehensive Guide
Hexarelin is a synthetic growth hormone-releasing peptide (GHRP) consisting of six amino acids. It exhibits powerful effects on pulsatile GH release with minimal side effects and dose-dependent, reversible desensitization of GH response. The peptide’s effect on GH promotes visceral fat reduction, lean tissue growth, and better sleep and recovery. Hexarelin is also researched for potential cardioprotective, neuroprotective, and healing benefits.
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What is Hexarelin?
The growth hormone release resulting from hexarelin treatment can improve the body’s ability to produce collagen, repair ligaments and tendons, grow muscle fibers, reduce visceral body fat, and increase bone density [2, 3].
While hexarelin is a ghrelin analog, studies have found that hexarelin is a superior alternative to ghrelin therapy because of its potency and stability, particularly as a cardioprotective agent .
The administration of hexarelin has also been shown to provide neuroprotective benefits such as promoting the growth of new brain cells, protecting healthy brain cells, and reducing inflammation in the brain .
Below we will explore some of the common reasons researchers are interested in further studies on hexarelin.
Hexarelin Benefits and Uses
Hexarelin is frequently sought out for its marked effects on fat loss and muscle-building. Its ability to affect insulin sensitivity, energy production, and lean muscle growth makes it an attractive compound for researchers wishing to enhance the body composition of their subjects.
Hexarelin for Fat Reduction
Hexarelin is known to activate the CD36 receptor, which is responsible for fatty acid uptake, conversion, and distribution . Studies have shown that the action of hexarelin on CD36 improves the conversion of fat to energy within adipocytes while also increasing the production of cellular mitochondria . This enables subjects to release excess visceral fat and utilize it for energy.
Another way hexarelin aids in fat reduction is by improving insulin sensitivity, which is correlated with successful weight loss and maintenance . Again because of its affinity at the CD36 receptor, hexarelin has been shown to improve the body’s response to circulating insulin, allowing blood glucose to be disposed of or used for energy efficiently .
It is worth noting that even lean individuals can experience abnormal fat distribution, suboptimal fat metabolism, and unfavorable blood lipid profiles. These subjects can still benefit from hexarelin therapy as the peptide may improve all aforesaid markers independent of its effect on fat loss .
Hexarelin for Muscle Gain
Hexarelin-induced pulsatile growth hormone release encourages the body to achieve a desirable lean mass ratio . Growth hormone is vital for lean tissue growth, and there is a compounding effect on lean mass gain and retention over time when GH therapy is combined with consistent resistance training .
Similar to its mitochondrial production within adipocytes, hexarelin has been shown to increase mitochondria in rat skeletal muscle cells along with promoting healthy cell turnover. This effect was maximized by providing stimulus to the muscle through weight training . With more exercise, more lean mass, and less body fat, the body produces more GH in response to hexarelin treatment and is more sensitive to that GH release .
Hexarelin for Heart Health
There are numerous cardiovascular applications of hexarelin. One of these may be aiding cardiac function during bypass surgery.
In one study, 24 male patients with coronary artery disease underwent bypass surgery. During surgery, the patients received one of four intravenous treatments: placebo, GH-releasing hormone, recombinant human GH, or hexarelin. Certain cardiac performance biomarkers were monitored to assess the benefits of each treatment.
Only the subjects treated with hexarelin showed favorable changes in wedge pressure, (Left ventricular ejection fraction) LVEF, cardiac index, and cardiac output. Additionally, hexarelin left heart rate and systemic vascular resistance index unchanged, and elicited a minimal elevation in levels of GH. The researchers concluded that hexarelin could benefit patients undergoing bypass surgery because of its selective activation of GHS-Rs within the cardiovascular system .
Hexarelin Side Effects and Safety
Hexarelin appears to be relatively safe due to its ability to stimulate favorable growth hormone release without overly affecting other hormones. However, there are a few side effects and facts to be aware of.
For one, since the research on hexarelin has been limited mostly to in vitro studies, the United States Food and Drug Administration (FDA) has yet to approve the peptide for use by humans .
As of 2022, hexarelin is listed as a prohibited substance by the World Anti-Doping Agency and similar regulatory bodies. Competitive athletes are thus advised to refrain from participating in hexarelin research .
In terms of side effects, growth hormone release triggered by hexarelin injections may cause fatigue or lethargy .
Because hexarelin is most commonly administered as a subcutaneous injection, it comes with the following risks :
- Redness, swelling, bruising, or pain at the injection site
- Risk of infection
- Accidental injection into a blood vessel
If chronically used in larger-than-necessary doses, hexarelin can cause spikes in growth hormone that may result in downstream adverse effects such as joint pain, insulin resistance, and hypertension [19, 20].
Long-term use of hexarelin can cause partial desensitization of the body’s response to treatment, which is reversible once administration ceases .
Following a science-backed hexarelin dosing cycle and paying careful attention to hygiene during administration can help researchers minimize or avoid side effects
Hexarelin Dosing and Administration
Hexarelin for injection is usually sold as a freeze-dried powder contained within a sterile vial.
Researchers are encouraged to use bacteriostatic water to reconstitute the hexarelin powder for injection. This process is best done as follows:
- Clean the tops of the bacteriostatic water and hexarelin vials with alcohol prep pads.
- Use a sterile 3cc syringe with needle to extract the requisite amount of bacteriostatic water for reconstitution.
- Insert the needle into the hexarelin vial at an angle and slowly depress the syringe to release the bacteriostatic water down the inside of the vial, drop by drop, until it has all been expelled.
- Allow the hexarelin vial to sit undisturbed until the solution is fully dissolved and clear.
- Use an insulin syringe to draw up the desired amount of solution for administration.
- Properly dispose of all needles.
- Store reconstituted hexarelin in a refrigerator for up to 28 days. Do not allow the solution to freeze.
Reference Hexarelin Dosing Protocol
Based on the limited number of hexarelin clinical studies available, the recommended dosing schedule for hexarelin for improving body composition is a 100mcg injection delivered three times daily for a total dose of 300mcg per day [19, 22].
For reference purposes, here is the dosing protocol outlined in greater detail:
- Hexarelin Dose: 300mcg, split into three daily doses of 100mcg each.
- Frequency: Administer hexarelin as three subcutaneous injections spaced evenly throughout the day (e.g., first 100mcg injection at 8:00am, second 100mcg injection at 12:00pm, third subcutaneous injection at 4:00pm).
- Study Duration: 16 weeks (12 weeks of injections, 4 weeks of no injections).
- Repeat Cycle: as needed to achieve desired effects.
- Notes: Subjects should refrain from ingesting food at least 60 minutes before and after each injection.
This dosage can be administered for a period of 12 weeks before taking a 4-week break. Studies have shown that desensitization to hexarelin occurs between 4 and 16 weeks of administration, but that this effect is reversible after four weeks of no treatment .
Where to Buy Hexarelin Online
Finding a trusted source for buying research chemicals can be a challenge. Our team at Peptides.org continues to find that Peptide Sciences is our go-to supplier for injectable hexarelin and many other compounds for the following reasons:
- Purity: Peptide Sciences provides researchers with a full third-party laboratory report that includes a certificate of analysis with high-performance liquid chromatography and mass spectrometry (HPLC-MS) test results. Researchers can rest assured that their hexarelin is pure and potent.
- USA-Based Manufacturing: Peptide Sciences uses only WHO/GMP-approved and ISO 9001:2008-certified manufacturers to produce their peptides. These rigorous standards ensure that this vendor’s products are made in trustworthy facilities by qualified producers.
- Affordability: Peptide Sciences keeps the costs of its products to a minimum, guaranteeing a $15 flat-rate shipping within the U.S. with free shipping on orders over $200.
- Support: When researchers have questions about their purchases, shipping, or any other aspect of their interaction, they may reach out to Peptide Sciences’ dedicated customer service team by phone or email. The support crew tends to resolve all inquiries within one to two business days.
With a reputation for providing the peptide research community with pure, safe, and fairly priced compounds, Peptide Sciences is a great choice for those looking to buy hexarelin online.
Keep in mind that hexarelin is not FDA-approved for human use. Therefore, any hexarelin purchased through Peptide Sciences is intended for use as a research chemical strictly for in vitro or laboratory studies.
How Much Does Hexarelin Cost?
Based on a data-supported dosing regimen, our team has compiled a cost estimate for a researcher to administer 300mcg hexarelin/daily, divided into 3 x 100mcg doses, for 12 weeks:
Six 5mg vials of hexarelin from Peptide Sciences = $258
- Peptide Sciences currently offers a discount for purchasing multiple vials of hexarelin. Because this order would cost over $200, the shipping fee would be waived for U.S. customers.
A research supply kit with the following supplies = $129 (including U.S. shipping)
- Bacteriostatic water for reconstitution
- 3cc sterile syringes with needles for reconstitution
- Insulin syringes for injection
- Alcohol prep pads
- Sterile mixing vial
*We included this kit for convenience and cost-effectiveness. These supplies could be purchased separately if needed.
Additional insulin syringes and alcohol prep pads (if needed) = ~$20
- Use a new syringe for each injection to avoid the risk of contamination or infection . It is good practice to have additional syringes on hand in case any become damaged or compromised during the peptide preparation process.
Please note that shipping costs were calculated for U.S. customers. These may vary for international buyers.
For a total cost of just over $400, a researcher can obtain all the supplies needed to safely administer hexarelin injections to a subject three times per day for 12 weeks.
Ideally, researchers would reconstitute one 5mg vial of hexarelin with 1ml of bacteriostatic water. Then this solution would be stored under the proper conditions until all of it has been administered, which would take about two weeks. Refer to our dosing calculator for guidance on how to draw up the proper 100mcg dose of hexarelin after it has been reconstituted.
Once the first vial of hexarelin has been depleted, the researcher can prepare a second vial. Following this procedure ensures that the solution retains its potency and freshness, as it will degrade significantly after 28 days . This allows researchers to avoid wasting products and to extract the maximum benefit from their investment.
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Is hexarelin a steroid?
No, hexarelin is not a steroid. Anabolic steroids increase testosterone production and carry a high risk of adverse effects . Hexarelin is a growth hormone-secreting peptide that enhances the body’s natural GH production and does not affect other hormones when administered in the proper doses.
Will hexarelin cause weight gain?
There is a possibility that researchers will notice an increase in subjects’ lean body mass, which could lead to weight gain. Hexarelin does not cause an increase in appetite but does improve fat metabolism, so any weight gain is unlikely to be from fat.
Is hexarelin legal?
Hexarelin is not approved for use in humans, but it is legal to purchase and use hexarelin for laboratory research purposes.
Bacteriostatic Water For Injection
Bacteriostatic water is superior to sterile water when reconstituting peptides for injection. Because bacteriostatic water contains the preservative benzyl alcohol, it prolongs the shelf life of solutions by preventing bacterial contamination .
We trust BacteriostaticWater.org when procuring bacteriostatic water and comprehensive reconstitution kits for use with injectable peptides like hexarelin. These all-inclusive kits are a convenient option for researchers as they include all the materials needed to reconstitute and administer hexarelin, eliminating the need to search around for individual components from different suppliers.
The retailer’s premium research kit contains enough supplies to cover almost 12 weeks of hexarelin research. Researchers may need to purchase additional insulin syringes and alcohol prep pads to have extras of these items.
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Hexarelin For Sale | Overall
Hexarelin is a GHRP with activity in the pituitary and endocrine pathways. Its properties interest peptide researchers and clinicians for its abilities to improve body composition in addition to its cardioprotective potential.
This peptide may also have implications for use in the treatment of diabetes, improving the lives of chemotherapy patients, and reversing hypertension, just to name a few possibilities.
While clinical trials are sparse, research on hexarelin to date has demonstrated that it carries few side effects. Most adverse effects are dose-dependent and reversible.
Licensed researchers may buy hexarelin online for inclusion into their studies. Our team fully endorses Peptide Sciences for its responsibly made, thoroughly tested, and highly potent hexarelin and other research chemicals.
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- Pepino, M. Y., Kuda, O., Samovski, D., & Abumrad, N. A. (2014). Structure-Function of CD36 and Importance of Fatty Acid Signal Transduction in Fat Metabolism. Annual Review of Nutrition, 34, 281–303. https://doi.org/10.1146/annurev-nutr-071812-161220
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- Clamp, L. D., Hume, D. J., Lambert, E. V., & Kroff, J. (2017). Enhanced Insulin Sensitivity in Successful, Long-Term Weight Loss Maintainers Compared With Matched Controls With No Weight Loss History. Nutrition & Diabetes, 7(6), e282. https://doi.org/10.1038/nutd.2017.31
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- Kraemer, W. J., Ratamess, N. A., Hymer, W. C., Nindl, B. C., & Fragala, M. S. (2020). Growth Hormone(s), Testosterone, Insulin-Like Growth Factors, and Cortisol: Roles and Integration for Cellular Development and Growth With Exercise. Frontiers in Endocrinology, 11, 33. https://doi.org/10.3389/fendo.2020.00033
- Sirago, G., Conte, E., Fracasso, F., Cormio, A., Fehrentz, J. A., Martinez, J., Musicco, C., Camerino, G. M., Fonzino, A., Rizzi, L., Torsello, A., Lezza, A. M. S., Liantonio, A., Cantatore, P., & Pesce, V. (2017). Growth Hormone Secretagogues Hexarelin and JMV2894 Protect Skeletal Muscle from Mitochondrial Damages in a Rat Model of Cisplatin-Induced Cachexia. Scientific Reports, 7(1), 13017. https://doi.org/10.1038/s41598-017-13504-y
- Rahim, A., O'Neill, P., & Shalet, S. M. (1998). The Effect of Body Composition on Hexarelin-Induced Growth Hormone Release in Normal Elderly Subjects. Clinical Endocrinology, 49(5), 659–664. https://doi.org/10.1046/j.1365-2265.1998.00586.x
- Broglio, F., Guarracino, F., Benso, A., Gottero, C., Prodam, F., Granata, R., Avogadri, E., Muccioli, G., Deghenghi, R., & Ghigo, E. (2002). Effects of acute hexarelin administration on cardiac performance in patients with coronary artery disease during by-pass surgery. European journal of pharmacology, 448(2-3), 193–200. https://doi.org/10.1016/s0014-2999(02)01934-9
- Sigalos, J. T., & Pastuszak, A. W. (2018). The Safety and Efficacy of Growth Hormone Secretagogues. Sexual Medicine Reviews, 6(1), 45–53. https://doi.org/10.1016/j.sxmr.2017.02.004
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