Titus Thorne

Last Updated April 1, 2022

Titus Thorne

 April 1, 2022

Researchers interested in learning how to calculate the correct CJC-1295 dosage for their next experiment should find the answers they need in this CJC-1295 dosage calculator and guide.  

Calculating the correct CJC-1295 dosage is far from straightforward. This peptide is currently classified as a research chemical and hasn’t yet been evaluated by the FDA. This begs the question: Is CJC-1295 safe — and if so, at what dosage should it be administered to test subjects?

This guide will seek to answer those all-important questions and help researchers calculate the right CJC-1295 dosage in future studies. Below, researchers will find a complete overview of CJC-1295’s benefits, side effects, and how it has been administered in past trials. 

Those looking to work with CJC-1295 will find full details of our preferred peptide vendor at the end of this guide. 

Let’s begin!

Buy CJC-1295 from the #1 online Peptides vendor in the world...

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What Is CJC-1295?

CJC-1295 is a peptide that stimulates the pituitary gland to release more Human Growth Hormone (HGH). It’s essentially a modified version (or “analogue”) of growth hormone-releasing hormone (GHRH) that helps increase the amount of GH in the body. Its most well-known iteration, CJC-1295 DAC, was developed by the Canadian biotech company ConjuChem Technologies in the mid-2000s [1].

CJC-1295 DAC was developed to address the main limitation of injectable GH; namely, its short half-life of around seven minutes. DAC, which stands for “Drug Affinity Complex”, is an acetate that helps the CJC-1925 peptide last longer in the body. Studies have shown that CJC-1295 DAC has a half-life of between five and eight days [2].

The other common iteration of CJC-1295 is actually a peptide blend called CJC-1295 ipamorelin. Ipamorelin is a substance known as a “secretagogue,” which means that it increases the specificity of CJC-1295. Researchers are actively investigating whether CJC-1295 ipamorelin has a stronger impact on the secretion of GH and a lower impact on cortisol and prolactin than CJC-1295 DAC and whether it has a stronger effect on fat loss. 

Next, let’s look at the main effects of CJC-1295 observed in past studies.


CJC-1295

 


CJC-1295 Benefits and Uses

Researchers interested in the benefits and uses of CJC-1295 will note that CJC-1295 iterations are currently only available as research materials, meaning that their only permitted uses are in vitro testing and laboratory experimentation.

Given CJC-1295’s status as a research chemical, any claims about this peptide's purported benefits have not been confirmed by human clinical trials and any statements you may read online have not been evaluated by the FDA.

In fact, many of CJC-1295’s purported benefits are based on animal studies. For example, an oft-cited study that attributed a “4-fold increase” in GH levels to CJC-1295 was conducted on rats [3]. This indicates that CJC-1295 research is still in its infancy and further investigation is warranted. 

So, what are the research-backed benefits of CJC-1295?

Increases levels of Growth Hormone (GH) and Insulin-Like Growth Factor 1 (IGF-1)

Past studies have shown that CJC-1295 stimulates the pituitary gland to release both GH and IGF-1. A 2006 double-blind placebo-controlled study found that a single injection of CJC-1295 DAC can  [2]:

  • Increase plasma growth hormone concentration 2-10 fold for six days
  • Increase plasma IGF-1 concentration 1.5-4 fold for 9-12 days

Based on this evidence, CJC-1295 clearly has a significant impact on GH and IGF-1 levels when administered to test subjects.

Long half-Life than GH

The second proven benefit of CJC-1295 is that it has a much longer half-life than GH and other analogues of GH. The aforementioned 2006 study estimated that CJC-1295 DAC has a half-life of 5.8-8.1 days [2]. As this study was based on data from two separate randomized, double-blind, placebo-controlled trials, it provides researchers with a clear picture of CJC-1295’s duration in the human body.

Enhanced athletic performance

There is strong research interest in the application of CJC-1295 for improved athletic performance [4]. This is because GH is an anabolic hormone that plays an important role in muscle growth, and CJC-1295 has a proven ability to increase levels of GH in test subjects. 

CJC-1295 is banned by WADA [5], which strongly indicates that CJC-1295 may enhance athletic performance. To date, there are no scientific studies that support this claim suggesting that further research in this area may be warranted. 

Now that we’ve looked at the main research-backed benefits of CJC-1925, let’s look at some of its documented side effects.


CJC-1295 Side Effects

The 2006 study by Teichman et al found that CJC-1295 DAC was generally well-tolerated and produced only mild, temporary side effects when administered to test subjects [2].

At doses of up to 30 micrograms per kilogram (μg/kg), researchers noted that CJC-1295 DAC caused the following side effects:

  • Mild injection site reactions,
  • Itching,
  • Headaches,
  • Pain,
  • Diarrhea,
  • Hypertension, and
  • Induration.

The study’s authors noted that around 70 percent of the test subjects who received CJC-1295 DAC experienced one or more of these side effects and that the severity of the reactions increased with doses over 30 μg/kg.


CJC-1295

 


CJC-1295 Dosage Calculator and Guide

As CJC-1295 is a research chemical, there is currently no clinical trial data to support dosing guidelines. While many researchers are interested in exploring how CJC-1295 may stimulate the pituitary gland to secrete more endogenous growth hormone, to date there has been no research into its use for these ends [6]. 

By examining published research on CJC-1295, researchers may note how CJC-1295 has been dosed in past studies and trials.

How do researchers administer CJC-1295?

CJC-1295 peptide comes as a liquid suspension and is administered via subcutaneous injection. Common side effects like pain and injection site reactions can be minimized by following the correct injection procedure [7].

What dose of CJC-1295 should researchers administer?

As CJC-1295 has yet to undergo human clinical trials, there is limited published research into dosing protocol. The 2006 study by Teichman et al involved administering CJC-1295 DAC to test subjects in weekly or biweekly dosages of between 30 μg/kg and 60 μg/kg [2]. For an 80 kg test subject, this would give a weekly dosage range of between 2,400-4,800 μg (2.4 – 4.8 mg).

The study’s authors noted that increases in GH and IGF-I levels produced by CJC-1295 DAC were “dose-dependent,” meaning that in the context of that particular study, higher doses of CJC-1295 produced greater rises in GH and IGF-1 levels than lower doses.

These findings suggest that doses of CJC-1295 DAC and CJC-1295 Ipamorelin should be limited to 2,000 μg per week, regardless of an individual test subject’s body weight. The 2,000 μg may be divided into twice-daily 200 μg injections, or once-daily 400 μg injections, five days per week, with two days off to aid the recovery of the anterior pituitary receptors.

When should CJC-1295 be administered?

The study by Teichman et al. involved the nighttime administration of CJC-1295 at least two hours after dinner [2]. The likely rationale for this decision is that animal studies have found dietary glucose (the sugar in food and drinks) can suppress GH levels in rats [8], and GH levels in humans are known to peak in the late evening, just before bedtime.

When an evening dosing schedule isn’t possible, test subjects may take CJC-1295 early in the morning on an empty stomach. This is thought to prevent dietary glucose from interfering with GH levels [2].

How often should CJC-1295 be administered?

In terms of published research, we know that CJC-1295 can be taken weekly or biweekly and still increase levels of GH and IGF-1 [2]. However, according to statements from functional medicine experts Lindgren [9], test subjects are commonly advised to take CJC-1295 Ipamorelin five nights per week. 

For test subjects on a 2,000 μg/week dosing schedule, this would equate to five 400 μg injections per week or twice-daily 200 μg doses.  

How long should CJC-1295 be administered?

According to Lindgren, it takes 3-6 months to see an upregulation, or increase, in the overall amount of GH isolates being produced by the pituitary gland. At this point, test subjects can either be administered lower doses of the CJC-1295 peptide, or the research can be discontinued. This is supported by Teichman et al’s findings that after multiple CJC-1295 DAC doses, “mean IGF-I levels remained above baseline for up to 28 days” [2].


Where To Buy CJC-1295 Online? | 2022 Guide

Researchers interested in buying CJC-1295 DAC, CJC-1295 no DAC and CJC-1295 blends online should find a number of vendors claiming to offer these peptides. However, because CJC-1295 is not a regulated product, researchers may find significant differences in terms of quality, prices, and delivery times between various vendors. 

To assist researchers, our team has evaluated the leading peptide vendors and our recommended vendor is PeptideSciences

Some of the reasons why we rate them so highly are:

  • U.S.-based: US-based PeptideSciences is the most reliable peptide manufacturer we’ve ever tested. They work in partnership with a range of WHO/GMP and ISO 9001:2008-approved manufacturers to create — in our opinion — the highest-quality CJC-1295 peptide on the market.
  • Third-party tested peptides: PeptideSciences tests every batch of CJC-1295 at an independent lab before listing it for sale [10]. Researchers can check the lab report for each batch before placing an order. This ensures that researchers will receive only the very best quality CJC-1295.
  • Low prices: This vendor offers some of the best discounts in the industry, including a six percent discount for researchers who order five peptides and a nine percent discount on orders of ten or more. Overall, PeptideSciences’ prices are incredibly reasonable.
  • Secure ordering: All order information is kept safe and secure with SSL technology, offering researchers the ultimate convenience.
  • Fast worldwide shipping: PeptideSciences charges a $15 flat shipping rate for fast worldwide shipping. This is waived for US-based researchers who order over $100.

Peptide Sciences is the best vendor we’ve come across by far and we highly recommend them!

Buy CJC-1295 from our #1 recommended vendor...


CJC-1295 Dosage | The Verdict?

So what does the evidence say about CJC-1295 dosage?

Well, as CJC-1295 remains a research chemical, there is limited data from human clinical research to tell much about the appropriate dosage. Researchers interested in experimenting with CJC-1295 can consult the published trial data when deciding how to dose this peptide in future studies. 

Hopefully, this guide has given researchers a useful starting point for calculating CJC-1295 in future studies. Those interested in pursuing CJC-1295 research may consider contacting our preferred vendor, Peptide Sciences, for further information.


CJC-1295


References

  1. Albumin_Bioconjugates_Activate_the_GRF_Receptor_on_the_Anterior_Pituitary_in_
    Rats_Identification_of_CJC-1295_as_a_Long_Lasting_GRF_Analog. (2021). Retrieved 26 February 2021, from https://www.researchgate.net/publication/228484039_hGRF1-29-.
  2. Sam L. Teichman, Ann Neale, Betty Lawrence, Catherine Gagnon, Jean-Paul Castaigne, Lawrence A. Frohman, Prolonged Stimulation of Growth Hormone (GH) and Insulin-Like Growth Factor I Secretion by CJC-1295, a Long-Acting Analog of GH-Releasing Hormone, in Healthy Adults, The Journal of Clinical Endocrinology & Metabolism, Volume 91, Issue 3, 1 March 2006, Pages 799–805, https://doi.org/10.1210/jc.2005-1536
  3. Lucie Jetté, Roger Léger, Karen Thibaudeau, Corinne Benquet, Martin Robitaille, Isabelle Pellerin, Véronique Paradis, Pieter van Wyk, Khan Pham, Dominique P. Bridon, Human Growth Hormone-Releasing Factor (hGRF)1–29-Albumin Bioconjugates Activate the GRF Receptor on the Anterior Pituitary in Rats: Identification of CJC-1295 as a Long-Lasting GRF Analog, Endocrinology, Volume 146, Issue 7, 1 July 2005, Pages 3052–3058, https://doi.org/10.1210/en.2004-1286
  4. Henninge J, Pepaj M, Hullstein I, Hemmersbach P. Identification of CJC-1295, a growth-hormone-releasing peptide, in an unknown pharmaceutical preparation. Drug Test Anal. 2010 Nov-Dec;2(11-12):647-50. doi: 10.1002/dta.233. Epub 2010 Dec 10. PMID: 21204297.
  5. What is Prohibited. World Anti-Doping Agency. (2021). Retrieved 26 February 2021, from https://www.wada-ama.org/en/content/what-is-prohibited/prohibited-at-all-times/peptide-hormones-growth-factors-related-substances-and-mimetics.
  6. Macintyre JG. Growth hormone and athletes. Sports Med. 1987 Mar-Apr;4(2):129-42. doi: 10.2165/00007256-198704020-00004. PMID: 3299611.
  7. Usach I, Martinez R, Festini T, Peris JE. Subcutaneous Injection of Drugs: Literature Review of Factors Influencing Pain Sensation at the Injection Site. Adv Ther. 2019 Nov;36(11):2986-2996. doi: 10.1007/s12325-019-01101-6. Epub 2019 Oct 5. PMID: 31587143; PMCID: PMC6822791.
  8. Hage M, Kamenický P, Chanson P. Growth Hormone Response to Oral Glucose Load: From Normal to Pathological Conditions. Neuroendocrinology. 2019;108(3):244-255. doi: 10.1159/000497214. Epub 2019 Jan 25. PMID: 30685760.
  9. Regenerative Medicine Promotes Cellular Level Healing. Lindgren.Health. (2021). Retrieved 28 February 2021, from https://lindgren.health/regenerative-medicine.
  10. CJC-1295 DAC 5mg. PeptideSciences.com. (2021). Retrieved 28 February 2021, from https://www.peptidesciences.com/cjc-1295-dac-5mg.

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