Researchers interested in learning how to calculate the correct CJC-1295 dosage for their next experiment have come to the right place.
Calculating CJC-1295 dosage is far from straightforward, particularly since the peptide is sold in various versions, including:
- CJC-1295 No DAC
- CJC-1295 DAC
- CJC-1295/Ipamorelin blend
As such, this guide is extensive. Below, we answer questions like:
- What are the potential benefits of CJC-1295?
- How is CJC-1295 DAC dosed differently from CJC no DAC?
- What are some potential safety concerns linked to CJC-1295?
Our expert team also includes a CJC-1295 dosage calculator and provides a recommendation on where researchers can buy high-purity CJC-1295 online.
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CJC-1295 DAC Dosage Chart
|Weight (lb)||Weekly Dosage (μg)||Daily Dosage (5 days/week) (μg)||Twice Daily Dosage (5 days/week) (μg)|
|100-150||1360-2040||272 – 408||136 – 204|
|151-200||2040-2720||408 – 544||204 – 272|
|201-250||2720-3400||544 – 680||272 – 340|
What is CJC-1295?
CJC-1295 is a peptide that stimulates the pituitary gland to release more Human Growth Hormone (HGH). It’s essentially a modified version (or “analogue”) of growth hormone-releasing hormone (GHRH) that helps increase the amount of GH in the body. Its most well-known iteration, CJC-1295 DAC, was developed by the Canadian biotech company ConjuChem Technologies in the mid-2000s .
CJC-1295 DAC was developed to address the main limitation of injectable GH; namely, its short half-life of around seven minutes. DAC, which stands for “Drug Affinity Complex”, is an acetate that helps the CJC-1295 peptide last longer in the body. Studies have shown that CJC-1295 DAC has a half-life of between five and eight days .
The other common iteration of CJC-1295 is actually a peptide blend called CJC-1295 ipamorelin. Ipamorelin is a substance known as a “secretagogue,” which means that it increases the specificity of CJC-1295. Researchers are actively investigating whether CJC-1295 ipamorelin has a stronger impact on the secretion of GH and a lower impact on cortisol and prolactin than CJC-1295 DAC and whether it has a stronger effect on fat loss.
Next, let’s look at the main effects of CJC-1295 observed in past studies.
CJC-1295 Benefits and Uses
Researchers interested in the benefits and uses of CJC-1295 will note that CJC-1295 iterations are currently only available as research materials, meaning that their only permitted uses are in vitro testing and laboratory experimentation.
Given CJC-1295’s status as a research chemical, any claims about this peptide's purported benefits have not been confirmed by human clinical trials and any statements online have not been evaluated by the FDA.
In fact, many of CJC-1295’s purported benefits are based on animal studies. For example, an oft-cited study that attributed a “4-fold increase” in GH levels to CJC-1295 was conducted on rats . This indicates that CJC-1295 research is still in its infancy and further investigation is warranted.
So, what are the research-backed benefits of CJC-1295?
Increases levels of Growth Hormone (GH) and Insulin-Like Growth Factor 1 (IGF-1)
Past studies have shown that CJC-1295 stimulates the pituitary gland to release both GH and IGF-1. A 2006 double-blind placebo-controlled study found that a single injection of CJC-1295 DAC can :
- Increase plasma growth hormone concentration 2-10 fold for six days
- Increase plasma IGF-1 concentration 1.5-4 fold for 9-12 days
Based on this evidence, CJC-1295 clearly has a significant impact on GH and IGF-1 levels when administered to test subjects.
Long half-Life than GH
The second proven benefit of CJC-1295 is that it has a much longer half-life than GH and other analogues of GH. The aforementioned 2006 study estimated that CJC-1295 DAC has a half-life of 5.8-8.1 days . As this study was based on data from two separate randomized, double-blind, placebo-controlled trials, it provides researchers with a clear picture of CJC-1295’s duration in the human body.
Enhanced athletic performance
There is strong research interest in the application of CJC-1295 for improved athletic performance . This is because GH is an anabolic hormone that plays an important role in muscle growth, and CJC-1295 has a proven ability to increase levels of GH in test subjects.
CJC-1295 is banned by WADA , which strongly indicates that CJC-1295 may enhance athletic performance. To date, there are no scientific studies that support this claim suggesting that further research in this area may be warranted.
Now that we’ve looked at the main research-backed benefits of CJC-1295, let’s look at some of its documented side effects.
CJC-1295 Side Effects
The 2006 study by Teichman et al found that CJC-1295 DAC was generally well-tolerated and produced only mild, temporary side effects when administered to test subjects .
At doses of up to 30 micrograms per kilogram (μg/kg), researchers noted that CJC-1295 DAC caused the following side effects:
- Mild injection site reactions
The study’s authors noted that around 70 percent of the test subjects who received CJC-1295 DAC experienced one or more of these side effects and that the severity of the reactions increased with doses over 30 μg/kg.
CJC-1295 Dosage Calculator | DAC, No DAC, and Ipamorelin Blend
As CJC-1295 is a research chemical, there is currently no clinical trial data to support dosing guidelines. While many researchers are interested in exploring how CJC-1295 may stimulate the pituitary gland to secrete more endogenous growth hormone, to date there has been no research into its use for these ends .
By examining published research on CJC-1295, researchers may note how CJC-1295 has been dosed in past studies and trials.
How do researchers administer CJC-1295?
CJC-1295 peptide comes as a liquid suspension and is administered via subcutaneous injection. Common side effects like pain and injection site reactions can be minimized by following the correct injection procedure .
What dose of CJC-1295 should researchers administer?
As CJC-1295 has yet to undergo human clinical trials, there is limited published research into dosing protocol. The 2006 study by Teichman et al involved administering CJC-1295 DAC to test subjects in weekly or biweekly dosages of between 30 μg/kg and 60 μg/kg . For an 80 kg test subject, this would give a weekly dosage range of between 2,400-4,800 μg (2.4 – 4.8 mg).
The study’s authors noted that increases in GH and IGF-I levels produced by CJC-1295 DAC were “dose-dependent,” meaning that in the context of that particular study, higher doses of CJC-1295 produced greater rises in GH and IGF-1 levels than lower doses.
These findings suggest that doses of CJC-1295 DAC and CJC-1295 Ipamorelin should be limited to 2,000 μg per week, regardless of an individual test subject’s body weight. The 2,000 μg may be divided into twice-daily 200 μg injections, or once-daily 400 μg injections, five days per week, with two days off to aid the recovery of the anterior pituitary receptors.
When should CJC-1295 be administered?
The study by Teichman et al. involved the nighttime administration of CJC-1295 at least two hours after dinner . The likely rationale for this decision is that animal studies have found dietary glucose (the sugar in food and drinks) can suppress GH levels in rats , and GH levels in humans are known to peak in the late evening, just before bedtime.
When an evening dosing schedule isn’t possible, test subjects may take CJC-1295 early in the morning on an empty stomach. This is thought to prevent dietary glucose from interfering with GH levels .
How often should CJC-1295 be administered?
In terms of published research, we know that CJC-1295 can be taken weekly or biweekly and still increase levels of GH and IGF-1 . However, according to statements from functional medicine experts Lindgren , test subjects are commonly advised to take CJC-1295 Ipamorelin five nights per week.
For test subjects on a 2,000 μg/week dosing schedule, this would equate to five 400 μg injections per week or twice-daily 200 μg doses.
How long should CJC-1295 be administered?
According to Lindgren, it takes 3-6 months to see an upregulation, or increase, in the overall amount of GH isolates being produced by the pituitary gland. At this point, test subjects can either be administered lower doses of the CJC-1295 peptide, or the research can be discontinued. This is supported by Teichman et al’s findings that after multiple CJC-1295 DAC doses, “mean IGF-I levels remained above baseline for up to 28 days” .
CJC-1295 No DAC Dosage Calculator
Similar to its counterpart, CJC-1295 without the drug affinity complex (CJC-1295 no DAC) is a research chemical available only as a reference material. There are no clinical trials or publications related to dosing CJC-1295 no DAC in humans.
Note that CJC-1295 no DAC is essentially the tetrasubstituted version of the smallest GHRH-analog – GRF (1-29), aka sermorelin. This is why CJC-1295 no DAC is also known as tetrasubstituted GRF (1-29), modified GRF (1-29) or simply mod GRF (1-29) .
Since CJC-1295 no DAC is a modified version of sermorelin, and despite the tetra substitution having similar molecular weight, researchers may consider the data on dosage of sermorelin and other modified versions of GRF (1-29) as a reference.
How do researchers administer CJC-1295 No DAC?
CJC-1295 no DAC peptide is available as a lyophilized powder that must be reconstituted and the solution can be administered via subcutaneous injection. Researchers should follow safety recommendations to minimize injection site reactions .
What dose of CJC-1295 No DAC should researchers administer?
As mentioned, CJC-1295 no DAC has not been researched in humans and there is no information on potential dosing.
However, researchers may consider the dosing used in trials with sermorelin due to the similarities with CJC-1295 no DAC. The modifications in the latter work primarily to increase the half-life of the peptide from 5-10 mins for sermorelin, to around 30 mins [13, 14].
The majority of research conducted in adults with sermorelin and other modified versions of GRF (1-29) report dosages from 500μg to 2000μg (0.5-2mg) daily and report favorable safety profiles [15, 16, 17].
One of the trials involving a modified version of GRF(1-29) that has similar modifications to CJC-1295 reported a dose of 10 μg/kg. For a 175lb (80kg) test subject, this would give a daily dosage of 800μg (0.8mg) .
When should CJC-1295 No DAC be administered?
The majority of studies on sermorelin and its modified versions report administering the peptide in the evening to prevent the potential suppression of food on the circadian GH secretion . Therefore, CJC-1295 no DAC may be best administered right before bed.
How often should CJC-1295 No DAC be administered?
Due to the short half-life of CJC-1295 no DAC, it may also be administered twice or thrice daily. The daytime administration should be early in the morning on an empty stomach to prevent the suppressive effects of food intake and insulin release on GH secretion.
How long should CJC-1295 No DAC be administered?
Due to the lack of human studies with CJC-1295 no DAC, it is difficult to estimate how long the peptide should be administered or cycled.
The available research on other modified versions of GRF(1-29) report that the analog led to an increase in GH levels within 2 hours of administration, and the effects were consistent after daily administration for 16 weeks .
Researchers should note that none of these analogs, including sermorelin, has been tested for longer than 16 weeks.
CJC-1295 No DAC Dosage Chart
The dosage breakdown below is based on the 10μg/kg used by Khoram et al. for up to 16 weeks .
|Weight (lb)||Daily Dosage (μg)||Twice Daily Dosage (μg)||Three Times Daily Dosage (mcg)|
CJC-1295/Ipamorelin Dosage Calculator
Researchers are yet to study the potential combined effect of CJC-1295 no DAC and the ghrelin-mimetic ipamorelin. As a result, there are no clinical trials to suggest a potential dosing regime for CJC-1295/ipamorelin in humans.
Researchers will have to refer to the available data from studies that have tested either ipamorelin or GHRH-analogs similar to CJC-1295 no DAC independently.
How do researchers administer CJC-1295/Ipamorelin?
Both CJC-1295 no DAC and ipamorelin are peptides available as lyophilized powders that must be reconstituted before use.
Further, both peptides are typically administered subcutaneously, and they can be mixed and administered simultaneously as there is no risk of chemical reactions between the two.
This is why CJC-1295/ipamorelin is also available as a blend for research purposes.
What dose of CJC-1295/Ipamorelin should researchers administer?
As mentioned, CJC-1295 no DAC has not been researched in humans, so researchers may refer to the dosage of other GRF(1-29) analogs with similar modifications.
According to those trials, CJC-1295 no DAC can be dosed daily at doses of 10μg/kg .
On the other hand, ipamorelin has been tested in a short-term clinical trial (one week) at doses of 30μg/kg split into two daily intakes . The study reported that tolerance at this dose was similar to placebo.
However, researchers who plan on dosing the peptide for longer periods may consider lower doses, such as 10μg/kg, because currently the peptide has not been studied clinically for more than 7 days.
Ultimately, researchers may want to consider administering a CJC-1295/ipamorelin blend with a 1:1 ratio in a total dose of 20μg/kg.
When should CJC-1295/Ipamorelin be administered?
As previously mentioned, the most appropriate dosing of CJC-1295 no DAC is on an empty stomach, such as right before bed or early in the morning.
Similarly, food may also interfere with the effects of ipamorelin on GH synthesis. Therefore, CJC-1295/ipamorelin is best dosed on an empty stomach, right before bed or early in the morning.
How often should CJC-1295/Ipamorelin be administered?
As mentioned CJC-1295 no DAC can be dosed once to three times a day. On the other hand, the research on ipamorelin reports only twice-daily dosing . Therefore, the CJC-1295/ipamorelin may be best dosed twice a day.
How long should CJC-1295/Ipamorelin be administered?
The lack of clinical trials on CJC-1295 no DAC and ipamorelin means that there is no officially approved dosage or time frame for administering CJC-1295/ipamorelin.
Therefore, researchers should pay special attention when dosing the blend in research settings and remain vigilant for potential side effects.
Nevertheless, studies report that administering GRF(1-29) with similar modification to CJC-1295 no DAC may be safe and well tolerated for periods of 16 weeks . Researchers are yet to conduct long-term trials with ipamorelin.
CJC-1295/Ipamorelin Dosage Chart
The dosage breakdown below is based on a 20μg/kg for a 1:1 blend of CJC-1295/ipamorelin.
|Weight (lb)||Daily Dosage (μg)||Twice Daily Dosage (μg)||Three Times Daily Dosage (mcg)|
|100-150||908 – 1360||454 – 680||303-378|
|151-200||1362 – 1816||680 – 908||454 – 606|
|201-250||1818 – 2268||908 – 1134||606 – 756|
Where to Buy CJC-1295 Online? | 2024 Edition
Researchers interested in buying CJC-1295 DAC, CJC-1295 no DAC, and CJC-1295 blends online may order from a number of vendors claiming to offer these peptides.
However, because CJC-1295 is not a tightly regulated product, researchers may find significant differences in terms of quality, prices, and delivery times between various vendors.
To assist researchers, our team has evaluated the leading peptide vendors, and we endorse the two following companies.
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- Low Prices: This vendor offers some of the best pricing and price breaks in the industry, including a 10% discount for researchers who order 9 peptide vials or more.
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Bacteriostatic Water and CJC-1295
Before handling CJC-1295 and other research peptides, researchers need to be equipped with the tools to correctly prepare and store them.
Required items like sterile vials, bacteriostatic water, and more are key to safe and effective peptide research.
The task of securing all the necessary materials can be a challenge, involving searching for products from multiple retailers. However, it is required.
CJC-1295 Dosage | Verdict
So, what does the data say about CJC-1295 dosage?
Well, as CJC-1295 remains a research chemical, there is limited data from human clinical research to tell much about the appropriate dosage. Researchers interested in experimenting with CJC-1295 can consult the published trial data when deciding how to dose this peptide in future studies.
Hopefully, this guide has given researchers a useful starting point for calculating CJC-1295 in future studies.
Those interested in pursuing CJC-1295 research may consider contacting our preferred vendor.