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CJC-1295 is a synthetic, modified version of the first 29 amino acids of growth hormone-releasing hormone (GHRH), with DAC referring to the added chemical compound that prolongs the plasma half-life of CJC-1295. The peptide binds to receptors in the pituitary gland to promote the release of growth hormone (GH) and insulin-like growth factor 1 (IGF-1).

 

Higher levels of both GH and IGF-1 have been linked to increased lean muscle mass and reduced fat, hence why CJC-1295 has been investigated to treat lipodystrophy and growth hormone deficiency. Researchers are also studying CJC-1295 for its potential anti-aging and sleep promoting effects.

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    What Is CJC-1295?

    CJC-1295 is a peptide, often known by other names like CJC-1295 DAC, or DAC:GRF (which stands for drug affinity complex: growth hormone-releasing factor). It’s a synthetic peptide that helps regulate growth hormone levels [1].

    So what does it do?

    CJC-1295 is a chemical analog to one of the body’s natural hormones called growth hormone-releasing hormone (GHRH) [2]. Because the two have a similar chemical structure, CJC-1295 does the same thing as GHRH: It stimulates the body to produce and release more growth hormone (GH) [3].

    That means it increases the amount of GH that makes it into the bloodstream and to the cells. GH is essential for stimulating cell growth, cell reproduction, and regeneration [4]. Since growth hormone is used in so many bodily processes, CJC-1295 purportedly makes those processes more efficient.

    CJC-1295 is just one of several GHRH analogs like Sermorelin and Tesamorelin.

    One of the differences between CJC-1295 and other GH secretagogues is that CJC preserves the normal physiological release of GH. That means that while it does increase GH in the bloodstream, it follows the normal circadian rhythm of peaks and valleys in concentration, which helps reduce side effects [5].

    It also lasts longer. While natural growth hormone-releasing hormone has a half-life of about seven minutes [6], CJC-1295 DAC has a half-life of 6 to 8 days in humans and so its effects can persist for weeks [3]. In other words, it’s powerful.

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    Benefits of CJC-1295

    The CJC-1295 peptide’s primary benefit is that it upregulates the body’s natural growth hormone. That, in turn, may entail several benefits for research subjects.

    The purported benefits of CJC-1295 include:

    • Increased bone density: Bones tend to get brittle and lose density as we age. increased GH may help restore that bone density [7].
    • Increased muscle mass: GH makes it easier to build muscle after exercise and prepares the body to repair muscle tissue [8, 9]. That’s one reason why CJC-1295 bodybuilding has become a popular research subject.
    • Better sleep: CJC-1295 may improve the quality of sleep (and the frequency of vivid dreams) [10].
    • The ability to burn fat: GH has helped research subjects get the most out of workouts and burn through stubborn body fat [8]. It’s not magic, but with exercise, they usually see results [11].
    • Better recovery from injuries: GH increases the body's ability to repair itself when tissue is damaged [12].
    • Smoother, younger-looking skin: GH helps improve the quality of the skin because it helps repair the collagen that is responsible for skin elasticity and fullness [13, 14].

    Considering all these potential benefits of CJC-1295, the difference between CJC-1295 before and after in test subjects can be incredible.

    CJC-1295 Side Effects

    The few scientific studies involving CJC-1295 that have been conducted to date have found that it causes no serious adverse reactions among test subjects [3, 5]. Peptides in general tend to have few side effects because they are so close to the body’s own signals — they aren’t adding a new chemical compound to the body.

    Still, it’s possible that some research subjects could experience side effects. These may include [5]:

    • redness and tenderness at injection site
    • increased heart rate
    • headache
    • nausea
    • dizziness
    • flushing
    • hives
    • hyperactivity
    • difficulty swallowing
    • flu-like symptoms

    Side effects of CJC-1295 appear to be dose-dependent, which means that they become more likely the higher the dose that one is administered. Since a normal dose appears to be twice a week at 100 mcg, taking more than that puts test subjects at a greater risk of experiencing side effects.

    Where To Buy CJC-1295 Online?

    In our experience, the absolute best place to buy CJC-1295 is Peptide Sciences. Here are all the reasons why.

    Pure Product

    The most important factor for researchers choosing a peptide vendor is the quality of the peptide on offer.

    Globally, there’s a general lack of regulation on the production and sale of peptides that are still undergoing research. That means that there aren't many rules for the manufacturers of peptides to follow or any quality standards to which they need to adhere.

    Peptide researchers interested in experimenting with CJC-1295 DAC should aim to source their peptides from a vendor who can guarantee research-grade material.

    Peptide Sciences guarantees its products are over 99% pure. To this end, they use both automated and manual peptide synthesizers as well as solution and solid-phase peptide synthetic technology.

    And as evidence that their products are pure, Science Bio posts independent lab analysis certificates on its website. This proves that the ingredients used in the manufacturing process are of the highest quality.

    Quality of Manufacturing

    Peptide Sciences is based in the U.S. which means they follow very high standards for production. Peptides made elsewhere aren’t always manufactured to the same high standards.

    One of the consequences is that even if the actual peptides are high in purity, the process used to make the peptides may be inferior. Even if 99% of a peptide is CJC-1295, it’s what’s in that last 1% that may interfere with research findings.

    For example, water is used in the manufacturing process to synthesize peptides. Some laboratories use tap water — and in some places, the tap water is far from what could be called “clean.” Peptide Sciences uses laboratory-grade purified water and high-quality filtration systems to make sure there aren’t any contaminants in their peptides.

    Obtaining a contaminant-free product can make a huge difference to the quality of the research data gathered. With Peptide Sciences, researchers will not receive contaminated CJC-1295. Peptide Sciences sells a clean product.

    Fast International Shipping

    Peptide Sciences ships quickly.

    All orders are shipped within 24 hours of the order being processed. U.S.-based researchers should receive their shipment within 2 to 3 business days.

    Peptide Sciences also ship internationally. It takes a little longer — 7 to 10 business days, although it’s often faster than that depending on the country. For example, deliveries to Canada or Mexico are faster than countries further afield.

    There’s a flat rate of $15 for all international shipments, but shipping fees are waived on U.S. orders over US$100 and international orders over US$300. Check their site for details.

    Great Prices

    Peptide Science is among the most affordable options for peptide researchers. For the quality of product that they offer, their prices are very competitive.

    The current cost of 5mg of CJC-1295 peptide is $53. Since a typical dosing schedule for a research subject is 100 mcg twice a week, that works out to 50 doses, or about 25 weeks (6 months) per test subject.

    Researchers can save an additional 9 percent and buy each 5 mg bottle for just $48.50 by ordering ten or more at a time.

    Privacy and Security

    Peptide Sciences cares about its customers’ privacy and follows all U.S. federal and state laws to ensure all personal information remains confidential. They don’t release personal order information to anyone, and it doesn’t get used for anything except filling orders.

    They keep data safe using only the most recent 256 Bit SSL (Secure Socket Layer) technology for encrypting payment information on their secure server.

    Convenient and Secure Payment Options

    This is one of the most important considerations for us. We never like giving out our payment information to companies on the Internet as  we never know whether the information will be sold or passed on.

    Peptide Sciences are the real deal in this regard. They are a legitimate business and ensure that all payment information is kept safe using secure payment technologies.

    They also accept a wide range of payment options including:

    • All major credit cards (Visa, MasterCard, American Express)
    • Other electronic payment options like Venmo, Apple Pay and Google Pay
    • Several types of cryptocurrencies, including Ethereum, Bitcoin and Litecoin

    Great Customer Service

    Peptide Sciences’ customer service team responds to all emails and will answer any question within 48 hours. They’re happy to answer any questions that researchers may have about their products, shipments, or orders that were improperly filled.

    Return and Replacement Policy

    Because of the nature of peptides, Research Peptides obviously will not take back a half-used vial of CJC-1295. That’s not how this game works.

    But Peptide Sciences does aim to guarantee customer satisfaction and is reasonable about refunds and reshipments. In the unlikely event that an order is incorrect, researchers can contact Research Peptides and they’ll make it right.

    We’ve never had an issue.

    Product Blends

    Peptide Sciences is also unique in that they offer several blends of peptides. For example, since research subjects may experience a synergistic effect from taking GHRHs together with GHRPs, Peptide Sciences offer several of these blends, including a CJC-1295 Ipamorelin blend.

    Legal For Researchers

    Many people wonder: “Is CJC-1295 legal?”

    Yes, it’s not a controlled substance and is absolutely legal to use for research purposes. Researchers may buy CJC-1295 online completely legally for their research and use it on research subjects.

    Buy CJC-1295 from our #1 recommended vendor...

    Verdict

    CJC-1295 is a powerful peptide that may be of interest to peptide researchers. Test subjects have experienced dramatic changes in their body composition (more muscle, less fat), general appearance, and well-being from this peptide.

    There are some possible side effects, but to date, these have typically been rare and minor. Following correct dosing guidelines will help research subjects avoid these.

    The only real issue is where to buy CJC-1295. To help resolve this issue, our team has tested multiple peptide vendors and identified a clear winner: Peptide Sciences.

    Here are a few reasons why we rate them so highly:

    • Real, high-quality peptides that work.
    • Fast, accurate shipping with no delays.
    • Reasonable prices on all products.
    • Friendly, responsive customer service.

    Researchers interested in working with CJC-1295 are advised to contact Peptide Sciences for more information.

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    References

    1. Jetté, L., Léger, R., Thibaudeau, K., Benquet, C., Robitaille, M., Pellerin, I., ... & Bridon, D. P. (2005). hGRF1-29-Albumin Bioconjugates Activate the GRF Receptor on the Anterior Pituitary in Rats: Identification of CJC-1295 as a Long Lasting GRF Analog. Endocrinology, 146(7), 3052–3058.
    2. Alba, M., Fintini, D., Sagazio, A., Lawrence, B., Castaigne, J. P., Frohman, L. A., & Salvatori, R. (2006). Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse. American Journal of Physiology-Endocrinology and Metabolism, 291(6), E1290-E1294.
    3. Teichman, S. L., Neale, A., Lawrence, B., Gagnon, C., Castaigne, J. P., & Frohman, L. A. (2006). Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults. The Journal of Clinical Endocrinology & Metabolism, 91(3), 799-805.
    4. Florini, J. R. (1987). Hormonal control of muscle growth. Muscle & Nerve: Official Journal of the American Association of Electrodiagnostic Medicine, 10(7), 577-598.
    5. Ionescu, M., & Frohman, L. A. (2006). Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog. The Journal of Clinical Endocrinology & Metabolism, 91(12), 4792-4797.
    6. Van Hout, M. C., & Hearne, E. (2016). Netnography of female use of the synthetic growth hormone CJC-1295: pulses and potions. Substance Use & Misuse, 51(1), 73-84.
    7. Landin‐Wilhelmsen, K., Nilsson, A., Bosaeus, I., & Bengtsson, B. Å. (2003). Growth hormone increases bone mineral content in postmenopausal osteoporosis: a randomized placebo‐controlled trial. Journal of Bone and Mineral Research, 18(3), 393-405.
    8. Thompson, J. L., Butterfield, G. E., Gylfadottir, U. K., Yesavage, J., Marcus, R., Hintz, R. L., ... & Hoffman, A. R. (1998). Effects of human growth hormone, insulin-like growth factor I, and diet and exercise on body composition of obese postmenopausal women. The Journal of Clinical Endocrinology & Metabolism, 83(5), 1477-1484.
    9. Welle, S., Thornton, C., Statt, M., & McHenry, B. (1996). Growth hormone increases muscle mass and strength but does not rejuvenate myofibrillar protein synthesis in healthy subjects over 60 years old. The Journal of Clinical Endocrinology & Metabolism, 81(9), 3239-3243.
    10. Ghigo, E., Arvat, E., Giordano, R., Broglio, F., Gianotti, L., Maccario, M., ... & Camanni, F. (2001). Biologic activities of growth hormone secretagogues in humans. Endocrine, 14(1), 87-93.
    11. Taaffe, D. R., Pruitt, L., Reim, J., Hintz, R. L., Butterfield, G., Hoffman, A. R., & Marcus, R. (1994). Effect of recombinant human growth hormone on the muscle strength response to resistance exercise in elderly men. The Journal of Clinical Endocrinology & Metabolism, 79(5), 1361-1366.
    12. Erotokritou-Mulligan, I., Holt, R. I., & Sönksen, P. H. (2011). Growth hormone doping: a review. Open Access Journal of Sports Medicine, 2, 99.
    13. Ganceviciene, R., Liakou, A. I., Theodoridis, A., Makrantonaki, E., & Zouboulis, C. C. (2012). Skin anti-aging strategies. Dermato-endocrinology, 4(3), 308-319.
    14. Bartke, A. (2019). Growth hormone and aging: updated review. The World Journal of Men's Health, 37(1), 19-24.