Titus Thorne

Last Updated May 11, 2022

Titus Thorne

 May 11, 2022

Despite strong research interest in BPC-157 many researchers are curious about how to calculate the right BPC-157 dosage for their next experiment. This A-Z guide offers a complete overview of BPC-157 including what it is, the kinds of effects it produces in test subjects, and how it has been dosed in past studies. 

Several animal studies have shown that BPC-157 offers potentially regenerative properties and may help accelerate healing. But little is known about the benefits, side effects, and overall safety profile of this profile in human test subjects. Below, researchers will find full details of all relevant literature and how BPC-157 may be dosed in future experiments. 

Researchers interested in starting research with BPC-157 right away can find full details of our preferred peptide vendor at the end of this guide. 

Let’s begin!

Buy BPC-157 from the #1 online Peptides vendor in the world...

Disclaimer: Peptides.org contains information about products that are intended for laboratory and research use only, unless otherwise explicitly stated. This information, including any referenced scientific or clinical research, is made available for educational purposes only. Peptides.org makes every effort to ensure that any information it shares complies with national and international standards for clinical trial information and is committed to the timely disclosure of the design and results of all interventional clinical studies for innovative treatments publicly available or that may be made available. However, research is not considered conclusive. Peptides.org makes no claims that any products referenced can cure, treat or prevent any conditions, including any conditions referenced on its website or in print materials.


What Is BPC-157?

BPC stands for “Body Protection Compound”. It is a synthetic pentadecapeptide, which means it is a peptide consisting of 15 amino acids.

BPC-157 is derived from naturally occurring BPC and the sequence of amino acids which are most active in the body.

This peptide was first discovered in human gastric juice in 1991 and was later isolated by researchers intent on examining its therapeutic properties.

BPC-157 was initially used to prevent stomach ulcers, but researchers noticed several other potential uses for the compound.

Namely, BPC-157 may help improve healing in test subjects [1]:

Indicatively, BPC 157 improves the healing of the skin wounds, muscle, tendons, ligament, and bone injuries.

Furthermore, considerable recovery of the skin wound and muscle, tendon, ligament, and bone, were observed after severe injury that could not be spontaneously healed.

These healing processes may suggest that BPC 157 may distinctively affect tissue healing.

How exactly does BPC-157 work in test subjects’ bodies?

It is believed that there are multiple mechanisms through which BPC-157 is able to promote healing effects when administered to test subjects.

One of the main mechanisms is through the formation of blood vessels, a process known as angiogenesis.

BPC-157 does this by upregulating vascular endothelial growth factor (VEGF), a protein in the body responsible for stimulating the growth of new blood vessels [2].

It also increases blood flow in the body by increasing the production and release of nitric oxide (NO) [3]. In other words, BPC-157 appears to be a performance-enhancing peptide, but not in the way that researchers might think.

Animal studies have shown that BPC-157 can accelerate the rate of recovery from a wide variety of injuries.

Currently, BPC-157 is not considered an illegal substance and is not banned by international sports organizations, but this may change in the very near future.

As there are very few legitimate human studies available on the effects and safety of BPC-157, it currently remains a research chemical. 

What does the science say regarding the health benefits of BPC-157? Let’s take a look. 


bpc-157


Benefits of BPC-157

To be clear, the benefits of BPC-157 are only extrapolations.

The majority of the studies conducted with this compound involved cell cultures and animals. To date, BPC-157 has yet to pass any clinical trial and is sold exclusively to researchers as a “reference material”. 

Here’s a brief guide to past research findings from BPC-157 studies. 

BPC-157 may be neuroprotective

A comprehensive review of BPC-157 completed in 2016 examined the connection between gut health and cognitive disorders in rats.

Specifically, researchers found that BPC-157 affected the rats’ brain function in the following ways [4]:

  • Lowered depression in rats facing chronic and unpredictable stress
  • Inhibited symptoms of alcohol withdrawal and alcohol intoxication
  • Repaired damaged nerve branches within the brain

Most interestingly, BPC-157’s appears to remain stable in human gastric juice, which is one reason why research interest in this peptide is so high. 

BPC-157 may help treat traumatic brain injury (TBI)

In one animal study, researchers were able to successfully use BPC-157 in mice with traumatic brain injury (TBI).

The 2010 study involved the administration of BPC-157 to mice with head injuries [5].

The group of mice that received the strongest dose of BPC-157 (10 mcg/kg) had a higher survival rate compared with mice in the placebo group.

Furthermore, the post-injury damage done to the rats 24 hours after administering BPC-157 was significantly less than what was observed in the placebo group. 

BPC-157 may improve gastrointestinal health

BPC-157 has been found to impact gastrointestinal health in several ways.

It can counteract complications brought about by inflammatory bowel disease (IBD), lower both acute and chronic inflammation within the gut, and reverse short-bowel syndrome following resection of the intestine [6].

Additionally, BPC-157 can counteract colon damage and inhibit the formation of ulcers.

BPC-157 helps reverse the damage done by drug-induced toxicity

An unusual benefit of BPC-157 is that it appears to treat the damage and adverse side effects brought about by commonly used drugs.

For instance, nonsteroidal anti-inflammatory drugs (NSAIDs) can be toxic when taken in high doses. The toxic effects often include seizures, respiratory depression, and hypotension.

In 2013, scientists found that BPC-157 helps counteract the toxic side effects brought about by NSAIDs [7]. There were no reported toxicity events when extremely high doses of BPC-157 were used.

A similar observation was observed in a rat study where BPC-157 was able to reduce the degree and severity of the damage done by methamphetamine-induced neurotoxicity [8].

BPC-157 has anti-inflammatory properties

A 2009 experiment involving rats with periodontitis (a condition where the gums are infected and heavily inflamed) found that rats administered BPC-157 did not have their blood circulation negatively affected.

Most importantly, BPC-157 exhibited anti-inflammatory effects while also healing and preserving the gum tissues [9]. 

It must be stressed that the results from the above-cited animal studies cannot be extrapolated to humans. However, researchers may consult these findings when designing future BPC-157 experiments. 

Buy TB-500 from our #1 recommended vendor...


BPC-157 Dosage Guide | What Researchers MUST Know

Researchers looking for a BPC-157 dosage calculator will note that this peptide has no recommended dosage in human test subjects. Studies on BPC-157 in human subjects are lacking and this merits further research. 

So, how might BPC-157 be dosed in future experiments? 

While dosages used in animal studies cannot be transposed to clinical studies, some researchers have estimated that the BPC-157 doses administered to rats – 10 mcg/kg – would translate to 1.6mcg/kg for humans. This suggests that a 144 mcg dose of BPC-157 could be administered to a 90 kg test subject [10].

Aside from this estimate, there are no official or published figures to indicate the dosage at which BPC-157 should be administered to research subjects. According to some sources, BPC-157 may be administered twice daily at doses up to 250 mcg but these claims have yet to be evaluated in a rigorous, placebo-controlled clinical study [11]. 

Given that there is strong interest in the application of BPC-157 in test subjects, we can summarize the main research findings below. 


BPC-157 For Beginners

Researchers new to BPC-157 experimentation should be aware that data from animal studies indicate the most effective way to administer this peptide is intramuscularly (in the muscle). While BPC-157 can be injected subcutaneously, animal studies suggest that intramuscular administration is more effective. 

There is no convincing evidence to show whether BPC-157 acts systemically or locally, but data from a rat study indicated that it acts locally [9]. This suggests that BPC-157 should be administered close to the site of injury for best results, but further research is warranted.  

In terms of safety, researchers should abide by established protocols when administering BPC-157. This includes using sterile needles, having high-quality bacteriostatic water to reconstitute the peptide, and storing the solution in the refrigerator when it is not being used.

Researchers are advised to avoid oral solutions and transdermal patches, as they are not as effective as injections.


bpc-157


BPC-157 For Healing

Researchers interested in experimenting with BPC-157 for healing should have a full understanding of the three phases of the healing process [12]:

  • PHASE I: The Inflammatory Phase (Days 1-5) Platelets aggregate and trigger the release of pro-inflammatory mediators. A clot is formed around the site of injury to stop further bleeding from occurring, which is later broken down by cellular compounds known as macrophages.
  • PHASE II: The Proliferative Phase (Days 5-14) Healthy cells are attracted to the site of injury, and the body stimulates angiogenesis to ensure that a sufficient amount of oxygen and nutrients are transported to the site.
  • PHASE III: The Remodeling Phase (Days 14+) The cells that were used to heal the wound are no longer needed. Through a form of cellular death called apoptosis, they are removed and a scar with properties resembling the original tissue is formed.

With this understanding in mind, let’s examine the types of injuries in animal test subjects that BPC-157 has been shown to treat:

  • BPC-157 cream was used to heal burn wounds in injured mice [13]
  • In rats, BPC-147 was successfully used to heal skeletal muscle injuries and restore full functionality to the muscles being healed [14]
  • BPC-157 was used to heal spinal cord injury in rats; consistent clinical improvements were observed spinal function was restored [15]
  • BPC-157 was used to accelerate the speed at which injured tendons were healed in rats [16]

These findings indicate that BPC-157 may offer benefits in test subjects and may merits further research.


BPC-157 For Muscle Growth

There is very strong research interest in the application of BPC-157 to improve body composition, with many researchers theorizing that it may minimize body fat accumulation and maximize lean muscle gains. 

As studies on BPC-157 in human subjects are lacking, there are no published figures to indicate the optimum BPC-157 dosage for muscle growth. The only study demonstrating any kind of weight gain was an animal study in which BPC-157 was used to cure short bowel syndrome in rats [17].

Whether these findings can be replicated in human test subjects has yet to be examined, potentially highlighting a fruitful direction for future research. 


BPC-157 For Hair Growth

Animal studies have shown that BPC-157 improves blood flow uniformly [18], leading some researchers to speculate that it may promote hair growth. There is currently no published research involving either animal or human test subjects to support these claims. 

Researchers interested in exploring BPC-157 for hair growth may consult the relevant studies to determine dosage and methods of administration [9].

In summary, the purported benefits of BPC-157 in humans are under-researchers. This indicates that further experimentation is required before drawing conclusions about this peptide’s effects.


Where to Buy BPC-157 Online? | 2022 Guide

Researchers interested in experimenting with BPC-157 will want to ensure that they source this reference material from a legitimate vendor.

The best way to identify a reputable BPC-157 vendor is to look for reviews of third-party websites and check for a legal disclaimer that reads something like this:

“This product is intended for laboratory research purposes and is NOT intended for human or animal consumption. It is meant to be handled by licensed medical professionals only. It should not be labeled or used as a food, drug or cosmetic product”

To assist researchers, our team has tested the top vendors and ranked them according to quality, price, and speed of delivery. 

The winner? 

Peptide Sciences. They have the highest-grade BPC-157 currently available online with purity levels over 99%.

Here are some of the things they do exceptionally well:

  • Analytical lab tests are performed at every stage of the manufacturing process so the accuracy, purity, and identity of each peptide are reliably verified. No additives, fillers, or binding agents are added to the peptides.
  • All of their materials are manufactured in the US and certified for use in clinical trials to demonstrate BPC-157’s potency and therapeutic use.
  • Shipping is FREE on all orders above $100, and a flat fee of $15 is tacked on to any purchase below that amount.
  • Their customer service is truly something to behold, as they are easy to reach and the responses are both speedy and helpful. 

Researchers looking to buy the highest-quality BPC-157 are advised to contact Peptide Sciences. 

Buy TB-500 from our #1 recommended vendor...


Thymosin Beta-4 and BPC-157?

There is currently strong interest among peptide researchers in the purported synergistic effects of BPC-157 and TB-500.

TB-500 is the synthetic version of Thymosin Beta-4, a naturally occurring protein found in every single tissue of the body.

Animal studies have shown that TB-500 may help regenerate various types of tissues and serve other therapeutic purposes such as treating strokes, cardiac damage, and stasis ulcers.

There are two crucial differences between these peptides:

  • TB-500 is systemic in its effects, whereas BPC-157 is localized
  • TB-500 has shown more potential for treating muscle injuries in test subjects while BPC-157 appears better suited to treating inflammation

In past studies, TB-500 has been administered twice a week at 2-4 mg per dose and has been injected either subcutaneously or intramuscularly.

Researchers intent on exploring the potential synergistic effect of TB-500 and BPC-157 may consider using this blend of TB-500 and BPC-157 for their next experiment. 


bpc-157


BPC-157 Dosing | Verdict

Hopefully, researchers interested in calculating the optimum BPC-157 dosage for their next study have found this A-Z guide instructive and informative. As we discussed above, studies on BPC-157 overall are notably lacking and this merits further research. 

Despite the many purported BPC-157 benefits observed in animal studies, little is known about this peptide’s effects and side effects in humans, or the dosage at which it should be administered. 

Researchers planning to explore BPC-157 may consult Peptide Sciences for further guidance and information.

Buy BPC-157 from our #1 recommended vendor...


References

  1. Sikiric P, Hahm KB, Blagaic AB, Tvrdeic A, Pavlov KH, et al. Stable Gastric Pentadecapeptide BPC 157, Robert’s Stomach
  2. Brcic L, Brcic I, Staresinic M, Novinscak T, Sikiric P, et al. Modulatory effect of gastric pentadecapeptide BPC 157 on angiogenesis in muscle and tendon healing. J Physiol Pharmacol. 2009;60 Suppl 7:191-6.
  3. Grabarevic Z, Tisljar M, Artukovic B, Bratulic M, Dzaja P, et al. The influence of BPC 157 on nitric oxide agonist and antagonist induced lesions in broiler chicks. J Physiol Paris. 1997 May-Oct;91(3-5):139-49.
  4. Sikiric P, Seiwerth S, Rucman R, et al. Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications. Curr Neuropharmacol. 2016;14(8):857–865. doi:10.2174/1570159×1
    3666160502153022.
  5. Tudor M, Jandric I, Marovic A, Gjurasin M, Perovic D, et al. Traumatic brain injury in mice and pentadecapeptide BPC 157 effect. Regul Pept. 2010;160(1-3):26-32. doi: 10.1016/j.regpep.2009.
    11.012.
  6. Sikiric P, Sikiric PS, Seiwerth S, Rucman R, Turkovic B, et al. Effect of Pentadecapeptide BPC 157 on Gastrointestinal Tract. Front Gastrointest Res. 2010;30:191-201. doi:10.1159/000338435.
  7. Sikiric P, Seiwerth S, Rucman R, Turkovic B, Rokotov DS, et al. Toxicity by NSAIDs. Counteraction by stable gastric pentadecapeptide BPC 157. Curr Pharm Des. 2013;19(1):76-83.
  8. Suran J, Kolenc D, Crnic AP, Radic B, Drmic I, et al. The effect of pentadecapeptide BPC 157 in metamphetamine-induced dopaminergic neurotoxicity (1143.11). FASEB J. 2014;28:Suppl1.
  9. Keremi B, Lohinai Z, Komora P, Duhaj S, Borsi K, et al. Antiinflammatory effect of BPC 157 on experimental periodontitis in rats. J Physiol Pharmacol. 2009;60 Suppl 1:115-122.
  10. BPC-157. Retrieved March 17, 2020. examine.com
  11. Peptide Mixing and Dosing Calculator. Retrieved March 20, 2020. http://112.196.20.91/re
    alpeptide/peptide-calculator/
  12. Hope M, Saxby TS. Tendon healing. Foot Ankle Clin. 2007;12(4):553-567.
  13. Mikus D, Sikiric P, Seiwerth S, Petricevic A, Aralica G, et al. Pentadecapeptide BPC 157 cream improves burn-wound healing and attenuates burn-gastric lesions in mice. Burns. 2001;27(8):817-827.
  14. Gwyer D, Wragg NM, Wilson SL. Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing. Cell Tissue Res. 2019;377(2):153-159. doi:10.1007/s00441-019-03016-8.
  15. Perovic D, Kolenc D, Vilic V, Somun N, Drmic D, et al. Stable gastric pentadecapeptide BPC 157 can improve the healing course of spinal cord injury and lead to functional recovery in rats. J Orthop Surg Res. 2019;14(1):199. doi:10.1186/s13018-019-1242-6.
  16. Staresinic M, Sebecic B, Patrlj L, Jadrijevic S, Suknaic S, et al. Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tendocytes growth. J Orthop Res. 2003;2196):976-983.
  17. Sever M, Klicek R, Radic B, Brcic L, Zorocic I, et al. Gastric pentadecapeptide BPC 157 and short bowel syndrome in rats. Dig Dis Sci. 2009;54(1):2070-2083. doi:10.1007/s10620-008-0598-y.
  18. Seiwerth S, Sikiric P, Grabarevic Z, Zoricic I, Hanzevacki M, et al. BPC 157’s effect on healing. J Physiol Paris. 1997;91(3-5):173-178.

Table Of Contents