Buy Tesamorelin Online | The A-Z Guide
Tesamorelin is a synthetic analogue of human growth hormone-releasing hormone (GHRH). Used to stimulate the manufacture and release of growth hormone, tesamorelin’s 44 amino acid chain is based on GHRH’s, plus a trans-3-hexenoic acid group that makes it more stable and longer-lasting than natural GHRH.
Highly effective at increasing growth hormone synthesis and release in the body, tesamorelin is an FDA-approved treatment of lipodystrophy in HIV-afflicted individuals. Researchers are now investigating tesamorelin in a variety of fat reduction and body composition improvement contexts.
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What is Tesamorelin?
Tesamorelin is a synthetic peptide that belongs to a class of medications known as growth hormone-releasing hormones (GHRHs) [1, 2, 3].
Because it’s virtually identical to endogenous GHRH in chemical structure, tesamorelin has essentially the same effect as GHRH. It acts as a growth hormone-releasing factor analogue that stimulates the release of human growth hormone (HGH). In 2010, Tesamorelin was approved by the US FDA for the treatment of lipodystrophy in HIV patients, Lipodystrophy refers to a syndrome that involves changes in fat distribution and metabolism, often seen in individuals receiving antiretroviral therapy (ART) for the management of HIV infection.
Why is HGH a big deal?
HGH is essential for humans — it's involved in practically all of the processes related to creating and repairing new tissue [4]. It stimulates cell growth and reproduction.
That means that it's involved in how children develop into adults and affect their growth. But more fundamentally, it's what's at work when muscles are repairing themselves after a workout, when skin is regenerating old cells, and when the body is producing immune cells.
HGH has been implicated in a great number of essential processes:
- Increasing muscle mass
- Promoting lipolysis (the metabolism of fat into energy)
- Increasing protein synthesis
- Stimulating organ growth
- Helping keep body temperature balanced
HGH levels drop with age
As we age, the concentration of HGH in our blood declines. That's part of the reason our body is slower to recover and regenerate as we get older.
Tesamorelin increases HGH concentrations
Tesamorelin is one of a family of GHRHs, including pralmorelin [5] and EP1572 [6], that work by stimulating the subject’s body to produce and secrete more HGH, leading to higher levels of concentration. Increased HGH means increased ability for the subject’s body to grow, regenerate and stay healthy.
Where to Buy Tesamorelin Online? | 2024 Edition
When choosing a tesamorelin vendor online, researchers are advised to look for a company that meets the following standards:
- Conducts in-house and/or third-party testing on products
- Offers evidence of product quality
- Accepts secure payment methods
- Great service and support
Based on our experience with multiple peptide vendors, we wholeheartedly recommend the following company to researchers looking to buy tesamorelin online.
Xcel Peptides
Xcel Peptides offers some of the highest quality peptides that we have tested. They post Certificates of Analysis for all of their peptides online, allowing researchers to verify lab results before placing an order.
What else? Xcel Peptides also offers:
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Best Place to Order Tesamorelin as a Research Peptide
In our experience, the best place to buy tesamorelin online is Xcel Peptides. There are several reasons as to why we hold them in such high regard. Most importantly, they ship high-quality products.
Xcel Peptides offers some of the highest quality peptides that we have tested. They post certificates of analysis for all peptides online so researchers can verify the quality before placing an order.
Researchers interested in buying tesamorelin online are highly advised to contact Xcel Peptides. This vendor ships 100% authentic peptides and has a stellar track record.
How to Order Tesamorelin | Country-By-Country
To find out if researchers can order tesamorelin in certain countries, simply go to the Xcel Peptides website and fill out an order. Choose the product, add it to the cart, and go to the checkout page.
In the shipping information box, researchers will see where to select the country. Open the country dialog box to see if the country is one of the options.
If it is, the researcher is good to go.
Xcel Peptides will ship to many, many countries.
Tesamorelin vs. Ipamorelin?
Tesamorelin and ipamorelin are peptides that stimulate the release of growth hormone (GH). However, there are a couple of key differences that researchers should be aware of before designing their research project.
First, only tesamorelin has been approved by the FDA for human use. Its approved use is to treat HIV-infected patients who suffer from excess abdominal body fat [7]. To date, ipamorelin has not been FDA-approved for this or any other purpose and remains a research peptide.
The second key difference between tesamorelin and ipamorelin is that ipamorelin’s purported benefits come from laboratory animal studies, not human clinical trials. Ipamorelin is a selective growth hormone secretagogue that has been tested on swine and found to increase GHRH stimulation without affecting cortisol plasma or adrenocorticotropic hormone (ACTH) levels [8]. It has also been tested on rats and shown to stimulate body weight gain and GH release [9].
While both of these peptides can stimulate GH levels, these are the two main differences that researchers should bear in mind.
Tesamorelin For Sale | FAQ
Still have a question? Here are some frequently asked questions about buying tesamorelin online:
Who makes tesamorelin?
Tesamorelin was originally developed by a Canadian company called Theratechnologies, Inc. [2], but several firms around the world now market tesamorelin for sale.
How much does tesamorelin cost?
Researchers will find tesamorelin for sale at a range of prices. In our experience, a 10mg vial costs around $79 USD.
Benefits of Tesamorelin
So what are the benefits of tesamorelin — how might research subjects benefit from it?
While tesamorelin has been around for a while, scientists are still coming to understand how it can be used. There has been a lot of research conducted on its particular effects. For example, there has been extensive research on its effects on people taking HIV medications.
But in other areas, research on its full benefits is lacking.
Still, the literature does provide insight into the potential effects of tesamorelin:
- Muscle growth: We know that HGH leads to muscle growth, and there's some indication that tesamorelin does, too. Studies on HIV patients have found that tesamorelin significantly increases muscle density and size in those patients [10].
- Fat loss: The results of two randomized, placebo-controlled trials showed that tesamorelin w can reduce the amount of visceral adipose tissue (VAT) in HIV-infected patients that had received antiretroviral therapy [7].
- Decrease risk of cardiovascular disease: One study found that tesamorelin could “significantly decrease” fat in the abdominal subcutaneous tissues and may decrease cardiovascular risk in HIV patients [11].
- Nerve Damage. Nerve cells don't regenerate easily, but some research suggests that Growth Hormone (GH)-based therapies, such as tesamorelin, may be able to improve nerve regeneration [12].
- Cognitive enhancement. Research suggests there is some promise for tesamorelin in reducing cognitive decline, improving outcomes for individuals with early stages of dementia, and enhancing cognition among healthy individuals [13].
Tesamorelin Side Effects
Tesamorelin has been well-tolerated by most individuals. One 12-week study about the safety of tesamorelin for patients with type 2 diabetes found that it had no effect on glycemic control and “did not alter insulin response” [14].
Another study about the long-term safety and adverse effects of tesamorelin in HIV-infected patients found that tesamorelin decreased triglycerides and visceral adipose tissue (VAT) over 52 weeks “without aggravating glucose” [15].
But, as with almost any substance, there are side effects of which all researchers should be aware. Studies performed on HIV-positive patients indicated that common tesamorelin side effects include [11]:
- redness, itching, pain, swelling, and irritation at the site of injection
- muscle aches
- Diarrhea
- Sweating
More serious side effects can occur as well, but these are less common. They include:
- Neuropathies
- diarrhea with fever and dehydration
- congestive heart failure
- shortness of breath
- muscle or joint pain numbness, tingling, swelling in arms or legs
Bacteriostatic Water and Tesamorelin
When experimenting with peptides like Tesamorelin, researchers can’t neglect the importance of a properly equipped lab.
To adhere to the proper measures of peptide prep and storage, a reseatrch toolkit should include bac water, sterile vials, and more.
While some researchers struggle to equip their labs, spending hours searching the web and navigating low-quality vendors, this is not required.
Tesamorelin For Sale | Verdict
Researchers interested in where to buy tesamorelin online will note that while this peptide’s clinical use in the United States is limited to the treatment of HIV patients with lipodystrophy.
However, current clinical data suggests tesamorelin is effective at increasing HGH in the body and, in theory, this may help test subjects build muscle, burn fat, and regenerate tissue. It may even help with cognitive enhancement.
References
- Food and Drug Administration (2010). Chemistry Reviews: Application 22-505. https://www.accessdata.fda.gov/drugsatfda_docs/nda/2010/022505Orig1s000ChemR.pdf
- Patel, A., Gandhi, H., & Upaganlawar, A. (2011). Tesamorelin: A hope for ART-induced lipodystrophy. Journal of Pharmacy And Bioallied Sciences, 3(2), 319.
- Dhillon, S. (2011). Tesamorelin. Drugs, 71(8), 1071-1091.
- Florini, J. R. (1987). Hormonal control of muscle growth. Muscle & Nerve: Official Journal of the American Association of Electrodiagnostic Medicine, 10(7), 577-598.
- Editorial, A. (2004). Pralmorelin: GHRP 2, GPA 748, Growth Hormone-Releasing Peptide 2, KP-102 D, KP-102 LN, KP-102D, KP-102LN. Drugs in R & D, 5, 236-239.
- Broglio, F., Boutignon, F., Benso, A., Gottero, C., Prodam, F., Arvat, E., ... & Muccioli, G. (2002). EP1572: a novel peptidomimetic GH secretagogue with potent and selective GH-releasing activity in man. Journal of Endocrinological Investigation, 25(8), RC26-RC28.
- Falutz J, Mamputu JC, Potvin D, Moyle G, Soulban G, Loughrey H, Marsolais C, Turner R, Grinspoon S. Effects of tesamorelin (TH9507), a growth hormone-releasing factor analog, in human immunodeficiency virus-infected patients with excess abdominal fat: a pooled analysis of two multicenter, double-blind placebo-controlled phase 3 trials with safety extension data. J Clin Endocrinol Metab. 2010 Sep;95(9):4291-304. doi: 10.1210/jc.2010-0490. Epub 2010 Jun 16. PMID: 20554713.
- Raun K, Hansen BS, Johansen NL, Thøgersen H, Madsen K, Ankersen M, Andersen PH. Ipamorelin, the first selective growth hormone secretagogue. Eur J Endocrinol. 1998 Nov;139(5):552-61. doi: 10.1530/eje.0.1390552. PMID: 9849822.
- Jiménez-Reina, L., Cañete, R., De la Torre, M. J., & Bernal, G. (2002). Chronic in vivo Ipamorelin treatment stimulates body weight gain and growth hormone (GH) release in vitro in young female rats. European Journal of Anatomy, 6(1), 37-45.
- Adrian, S., Scherzinger, A., Sanyal, A., Lake, J. E., Falutz, J., Dubé, M. P., ... & Brown, T. T. (2019). The Growth Hormone Releasing Hormone Analogue, Tesamorelin, Decreases Muscle Fat and Increases Muscle Area in Adults with HIV. The Journal of Frailty & Aging, 8(3), 154-159.
- Falutz, J., Allas, S., Blot, K., Potvin, D., Kotler, D., Somero, M., ... & Turner, R. (2007). Metabolic effects of a growth hormone–releasing factor in patients with HIV. New England Journal of Medicine, 357(23), 2359-2370.
- Tuffaha, S. H., Singh, P., Budihardjo, J. D., Means, K. R., Higgins, J. P., Shores, J. T., ... & Brandacher, G. (2016). Therapeutic augmentation of the growth hormone axis to improve outcomes following peripheral nerve injury. Expert Opinion on Therapeutic Targets, 20(10), 1259-1265.
- Friedman, S. D., Baker, L. D., Borson, S., Jensen, J. E., Barsness, S. M., Craft, S., ... & Vitiello, M. V. (2013). Growth Hormone–Releasing Hormone Effects on Brain γ-Aminobutyric Acid Levels in Mild Cognitive Impairment and Healthy Aging. JAMA Neurology, 70(7), 883-890.
- Clemmons DR, Miller S, Mamputu JC. Safety and metabolic effects of tesamorelin, a growth hormone-releasing factor analogue, in patients with type 2 diabetes: A randomized, placebo-controlled trial. PLoS One. 2017 Jun 15;12(6):e0179538. doi: 10.1371/journal.pone.0179538. PMID: 28617838; PMCID: PMC5472315.
- Falutz J, Allas S, Mamputu JC, Potvin D, Kotler D, Somero M, Berger D, Brown S, Richmond G, Fessel J, Turner R, Grinspoon S. Long-term safety and effects of tesamorelin, a growth hormone-releasing factor analogue, in HIV patients with abdominal fat accumulation. AIDS. 2008 Sep 12;22(14):1719-28. doi: 10.1097/QAD.0b013e32830a5058. PMID: 18690162.
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