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N-Acetyl Selank Amidate is a modified version of the nootropic and anxiolytic peptide Selank. It is acetylated and amidated to improve the peptide's stability and pharmacokinetics. While N-Acetyl Selank Amidate specifically is yet to be studied for its benefits, it is expected to interact with various neurotransmitters and neutrophils in the brain and exert benefits similar to those of Selank.

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    What is N-Acetyl Selank Amidate?

    N-Acetyl Selank Amidate is a purportedly improved version of the nootropic and anxiolytic peptide Selank, a heptapeptide composed of the tetrapeptide tuftsin at the N-terminus and a Pro-Gly-Pro fragment at the C-terminus of the amino acid chain [1].

    The unique composition of Selank and N-Acetyl Selank Amidate enable either iteration to cross the blood-brain barrier (BBB) when administered intranasally or via injections [2].

    N-Acetyl Selank Amidate is further acetylated and amidated for improved stability while preserving the potential effects of Selank.

    Since its modified structure is aimed at changing the pharmacokinetics rather than pharmacodynamics of the Selank peptide, N-Acetyl Selank Amidate is believed to offer benefits such as reduced stress and improved cognition that are comparable or even greater than those of Selank.

    Below we outline the mechanisms behind the benefits observed with Selank and which potentially translate to N-Acetyl Selank Amidate:

    • Selank upregulates gamma amino butyric acid (GABA) signaling in the central nervous system (CNS), reducing neuronal excitability and alleviating anxiety [2].
    • Selank inhibits the enzymes that break down enkephalins, which are ligands for opioid receptors. Their upregulation may have potential benefits in mood and stress management [3, 4, 5].
    • Selank stimulates serotonin metabolism, contributing to mood regulation and emotional well-being [6].
    • Selank has potential effects on neurotransmitters like dopamine and norepinephrine, which may amplify its anxiolytic and nootropic effects [7].
    • The peptide may also enhance the expression of a neurotrophic factor in the CNS called brain-derived neurotrophic factor (BDNF), promoting neuronal survival and resilience against stress [8].

    Currently, N-Acetyl Selank Amidate is available strictly for laboratory research purposes.

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    Benefits of N-Acetyl Selank Amidate

    Scientific data on N-Acetyl Selank Amidate are lacking. Therefore, researchers may have to rely on data from Selank studies for reference on the potential effects of the enhanced version.

    Selank for Improving Cognition and Memory

    Selank research showcasing its effects on memory and cognition may be used as references on the potential nootropic effects of N-Acetyl Selank Amidate:

    • A study in 70 volunteers with anxiety examined the effects of combined treatment with intranasal Selank and the oral drug phenazepam, a long-acting benzodiazepine. The peptide showed cognitive-enhancing properties, reducing the likelihood of side effects from phenazepam, such as drowsiness, dizziness, and difficulty staying focused. Selank also reduced memory lapses, fatigue, and attention deficits in the participants [9].
    • Selank was pitted against the nootropic drug piracetam in a study on rats with neurological deficits. A single Selank dose notably enhanced the rats' learning capacity, with its impact increasing over three consecutive days, surpassing piracetam's effectiveness [10].
    • Another study in rats indicates that Selank can stabilize memory formation in test animals for up to one month post-administration, possibly due to its serotonin-enhancing attributes [11].

    Selank for Attenuating Neurotoxicity and Substance Withdrawal

    Preclinical and clinical research indicates that Selank may possess neuroprotective effects to attenuate withdrawal symptoms following the abuse of addictive substances. These findings may offer valuable insights into the potential of N-Acetyl Selank Amidate:

    • In rats habituated to 10% ethanol for 24 weeks, Selank effectively countered acute 48-hour alcohol withdrawal symptoms. Specifically, a single dose of 0.3 mg/kg Selank alleviated ethanol-induced anxiety and prevented mechanical allodynia without altering ethanol intake, highlighting its potential to mitigate alcohol withdrawal [12].
    • The same researchers also reported that Selank exerted neuroprotective effects against the neurotoxic effects of chronic alcohol consumption. The researchers posited that this was due to the increased expression of BDNF in the brains of the rats exposed to Selank [13].
    • Similarly, using a morphine withdrawal model in rats, Selank reduced withdrawal symptoms significantly. A 0.3mg/kg dose decreased the overall withdrawal syndrome index by nearly 40%, mitigated various symptoms, and enhanced tactile sensitivity ninefold. While its effects were slightly less pronounced than diazepam, Selank still effectively diminished morphine withdrawal effects in opiate-dependent rats [14].

    Selank for Reducing Stress and Anxiety Symptoms

    When using the available data on Selank as a reference, it is essential to consider that Selank is officially approved in Russia as therapy for generalized anxiety disorder (GAD). Therefore, Selank is considered effective for reducing symptoms of anxiety and stress.

    Here are the two most notable Selank studies to use as a reference for N-Acetyl Selank Amidate anxiolytic and anti-stress potential:

    • In a study involving 62 participants with GAD, intranasal Selank was compared to the widely recognized anxiolytic drug medazepam. Results indicated that Selank, administered at doses up to 2700/mcg daily, matched the drug's efficacy in alleviating anxiety [5].
    • Another clinical investigation in 60 adults diagnosed with anxiety disorders demonstrated that a 14-day course of intranasal Selank significantly alleviated their symptoms, with the benefits persisting for one week post-treatment. The study authors also highlighted Selank's mild cognitive-enhancing effects [15].

    N-Acetyl Selank Dosing For Research Only

    Due to the lack of scientific data on N-Acetyl Selank Amidate, this peptide has no safe or effective dosage. Yet, anecdotal reports suggest that it can be administered intranasally similarly to Selank nasal drops.

    As a reference, Selank is used clinically in Russia for therapy in GAD as 0.15% nasal drops. A single drop of this formulation contains 75mcg of Selank.

    According to the Selank's package insert, the dosage is two drops given three times a day (usually morning, noon, and evening) for up to two weeks, followed by a week of washout and another two weeks of therapy if needed. This is equal to a total of six drops a day (450mcg/daily) [16].

    In addition, clinical studies have involved doses of up to 36 drops a day (2700mcg/daily) split into three separate daily administrations [5, 9].

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    Where to Buy N-Acetyl Selank Amidate Online? | 2024 Edition

    Qualified professionals may legally acquire N-Acetyl Selank Amidate online as a reference material.

    To guarantee the integrity of research peptides like N-Acetyl Selank Amidate, researchers must choose vendors that procure peptides from certified facilities before subjecting them to independent laboratory testing for purity validation.

    Researchers must also decide whether they require N-Acetyl Selank Amidate nasal spray or injections, depending on their research objective and study design.

    Here are our highest recommended vendors of both high-quality N-Acetyl Selank Amidate nasal spray and injectable formulations.

    Limitless Life

    Limitless Life earns our endorsement for their N-Acetyl Selank Amidate nasal spray and other intranasal peptides. Here’s why they excel:

    • High-Purity Peptides: Their peptide range, including the N-Acetyl Selank Amidate nasal spray, undergoes stringent third-party analysis, ensuring nasal spray purity levels surpassing 98%.
    • USA-Made Peptides: Limitless Life sources all their peptides, including N-Acetyl Selank Amidate, from fully certified manufacturers in the United States.
    • Swift and Complimentary Shipping: Limitless Life offers complimentary shipping for orders exceeding $350 within the United States. It assures prompt delivery, with most orders processed on the same day they're received.

    Limitless Life is a premier vendor of intranasal peptides, including N-Acetyl Selank Amidate nasal spray.

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    Pure Rawz

    Pure Rawz is as a trusted provider of research-grade injectable nootropics such as N-Acetyl Selank Amidate, boasting several advantages:

    • Third-Party Verification: Quality and purity are paramount for Pure Rawz. All peptides are subjected to rigorous third-party laboratory assessments.
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    Given their impeccable quality and competitive pricing, Pure Rawz remains a preferred supplier of research peptides.

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    N-Acetyl Selank Amidate Side Effects and Safety

    While there is a lack of data on the safety and side effects of intranasal N-Acetyl Selank Amidate, existing research on intranasal Selank may offer some insights.

    Researchers do not report any side effects with intranasal Selank when administered at a maximum dose of 2700mcg/daily for 14-21 days. Moreover, Selank has been reported to counteract the adverse effects of other anxiolytics, such as benzodiazepines [5, 9].

    Regardless of the favorable data from Selank trials, researchers must consider the potential side effects related to the route of administration of N-Acetyl Selank Amidate. Nasal spray formulations of this peptide may be associated with:

    • Increased risk of respiratory infection
    • Nose and throat irritation
    • Rhinitis
    • Nasal dryness
    • Changes in taste

    N-Acetyl Selank Amidate is also available as subcutaneous injections for educational and research purposes. Unfortunately, there is a lack of data on the safety and side effects of administering the peptide via injections.

    Nevertheless, this route of administration may lead to the following reactions at the injection site:

    • Pain
    • Swelling
    • Induration
    • Bleeding

    Some researchers have expressed concerns that Selank may reduce the sensitivity of the GABA receptors. Yet, there are no reports of this side effect occurring following Selank or N-Acetyl Selank Amidate administration [17].

    Still, the long-term safety of Selank and its iterations remains unknown and experts recommend cycling N-Acetyl Selank Amidate off for at least one week after 14 consecutive days of use.

    N-Acetyl Selank Amidate vs. Regular Selank

    Here is a concise breakdown of the main differences between N-Acetyl Selank Amidate and regular Selank.

    • Stability and Pharmacokinetics: Selank can successfully pass the BBB when administered subcutaneously or via injection. Yet, this stability is further enhanced in N-Acetyl Selank Amidate, thanks to the acetylation and amidation processes, which protect the peptide's N- and C-terminal groups from enzymatic degradation, thereby increasing its half-life and bioavailability [18].
    • Research and Approval: Selank was originally developed in Russia and has been studied extensively in that country. Since 2009, Russian authorities have authorized Selank for therapy in GAD [1]. The peptide is also actively studied for its potential nootropic, neuroprotective, and immunomodulatory properties [11, 15, 19]. On the other hand, research on N-Acetyl Selank Amidate is lacking, and it is available strictly as a research chemical.
    • Effects and Benefits: Selank is effective for reducing anxiety and improving cognition. While N-Acetyl Selank Amidate is expected to have similar effects with potentially greater magnitude thanks to its enhanced pharmacokinetics, there is no data to confirm this, save for anecdotal reports.

    N-Acetyl Selank Amidate Nasal Spray vs. Injections

    Researchers looking to investigate N-Acetyl Selank Amidate will need to consider whether a nasal spray or injections will be more suitable for their endeavors.

    Neither formulation has been studied clinically or preclinically. However, researchers may refer to the available data on Selank, which has been clinically studied exclusively in its nasal formulation, while injectable Selank has been used in preclinical studies.

    One such preclinical test directly compared the pharmacokinetics of Selank administered intranasally versus via injection (intraperitoneal) in rats [20].

    Thus, researchers may consider this study’s findings as a reference for the potential differences in the bioavailability and effects of N-Acetyl Selank Amidate nasal spray versus injections. The study reported the following findings for intranasal Selank:

    • Selank quickly penetrates the BBB when administered intranasally, which ensures a rapid onset of effects.
    • It has a bioavailability of 92.8% in the brain.
    • The intranasal route is believed to provide advantages such as convenience, painless application, and direct delivery to the brain via sensory nerves.

    With regard to the injectable administration of Selank, the researchers reported that:

    • The anxiolytic effect of Selank (or its metabolites) following intraperitoneal injection was more pronounced (-43% in the latent time for entering a maze) compared to intranasal administration (-29%).
    • The nootropic effect was modest (10%).

    Regardless of the administration method, the peptide reaches the central nervous system in significant concentrations to exert its effects. Yet, injectable Selank may exert greater anxiolytic effects, while intranasal Selank may be better suited for nootropic research [20].

    Whether these findings translate to the potential differences between N-Acetyl Selank Amidate nasal spray vs. injections is yet to be studied.

    Buying N-Acetyl Selank Amidate Online | Final Thoughts

    N-Acetyl Selank Amidate is an enhanced version of the powerful anxiolytic and cognitive-enhancing peptide Selank. Its modifications are believed to allow N-Acetyl Selank Amidate to retain the potential benefits of Selank while providing increased stability.

    Thus, N-Acetyl Selank Amidate may alleviate anxiety, enhance resilience to stress, and sharpen cognitive abilities, among its potential benefits. Preliminary insights from Selank studies suggest that N-Acetyl Selank Amidate has a favorable safety profile.

    Researchers looking to explore the myriad potential benefits of N-Acetyl Selank Amidate are advised to visit Limitless Life, a trusted provider of research-grade peptides.


    1. Kolomin, T., Shadrina, M., Slominsky, P., Limborska, S., & Myasoedov, N. (2013). A new generation of drugs: synthetic peptides based on natural regulatory peptides. Neuroscience and Medicine, 4(04), 223-252.
    2. Vyunova, T. V., Andreeva, L., Shevchenko, K., & Myasoedov, N. (2018). Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity. Protein and peptide letters, 25(10), 914–923.
    3. Kost, N. V., Sokolov, O. I.u, Gabaeva, M. V., Grivennikov, I. A., Andreeva, L. A., Miasoedov, N. F., & Zozulia, A. A. (2001). Ingibiruiushchee deĭstvie semaksa i selanka na énkefalindegradiruiushchie fermenty syvorotki krovi cheloveka [Semax and selank inhibit the enkephalin-degrading enzymes from human serum]]. Bioorganicheskaia khimiia, 27(3), 180–183.
    4. Le Merrer, J., Becker, J. A., Befort, K., & Kieffer, B. L. (2009). Reward processing by the opioid system in the brain. Physiological reviews, 89(4), 1379–1412.
    5. Zozulia, A. A., Neznamov, G. G., Siuniakov, T. S., Kost, N. V., Gabaeva, M. V., Sokolov, O. I.u, Serebriakova, E. V., Siranchieva, O. A., Andriushenko, A. V., Telesheva, E. S., Siuniakov, S. A., Smulevich, A. B., Miasoedov, N. F., & Seredenin, S. B. (2008). Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 108(4), 38–48.
    6. Semenova, T. P., kozlovskiĭ, I. I., Zakharova, N. M., & Kozlovskaia, M. M. (2009). Eksperimental'naia i klinicheskaia farmakologiia, 72(4), 6–8.
    7. Narkevich, V. B., Kudrin, V. S., Klodt, P. M., Pokrovskiĭ, A. A., Kozlovskaia, M. M., Maĭskiĭ, A. I., & Raevskiĭ, K. S. (2008). Eksperimental'naia i klinicheskaia farmakologiia, 71(5), 8–12.
    8. Inozemtseva, L. S., Karpenko, E. A., Dolotov, O. V., Levitskaya, N. G., Kamensky, A. A., Andreeva, L. A., & Grivennikov, I. A. (2008). Intranasal administration of the peptide Selank regulates BDNF expression in the rat hippocampus in vivo. Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections, 421, 241–243.
    9. Medvedev, V. E., Tereshchenko, O. N., Kost, N. V., Ter-Israelyan, A. Y., Gushanskaya, E. V., Chobanu, I. K., Sokolov, O. Y., & Myasoedov, N. F. (2015). Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 115(6), 33–40.
    10. Kozlovskii, I. I., & Danchev, N. D. (2003). The optimizing action of the synthetic peptide Selank on a conditioned active avoidance reflex in rats. Neuroscience and behavioral physiology, 33(7), 639–643.
    11. Semenova, T. P., Kozlovskiĭ, I. I., Zakharova, N. M., & Kozlovskaia, M. M. (2010). Eksperimental'naia i klinicheskaia farmakologiia, 73(8), 2–5.
    12. Kolik, L. G., Nadorova, A. V., & Kozlovskaya, M. M. (2014). Efficacy of peptide anxiolytic selank during modeling of withdrawal syndrome in rats with stable alcoholic motivation. Bulletin of experimental biology and medicine, 157(1), 52–55.
    13. Kolik, L. G., Nadorova, A. V., Antipova, T. A., Kruglov, S. V., Kudrin, V. S., & Durnev, A. D. (2019). Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats. Bulletin of experimental biology and medicine, 167(5), 641–644.
    14. Konstantinopolsky, M. A., Chernyakova, I. V., & Kolik, L. G. (2022). Selank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in Rats. Bulletin of experimental biology and medicine, 173(6), 730–733.
    15. Medvedev, V. E., Tereshchenko, O. N., Israelian, A. I.u, Chobanu, I. K., Kost, N. V., Sokolov, O. I.u, & Miasoedov, N. F. (2014). Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 114(7), 17–22.
    16. Селанк, капли назальные 0,15 % 3 мл 1 шт [In Russian] (n.d.) Available from:
    17. Doyno, C. R., & White, C. M. (2021). Sedative-Hypnotic Agents That Impact Gamma-Aminobutyric Acid Receptors: Focus on Flunitrazepam, Gamma-Hydroxybutyric Acid, Phenibut, and Selank. Journal of clinical pharmacology, 61 Suppl 2, S114–S128.
    18. Di L. (2015). Strategic approaches to optimizing peptide ADME properties. The AAPS journal, 17(1), 134–143.
    19. Uchakina, O. N., Uchakin, P. N., Miasoedov, N. F., Andreeva, L. A., Shcherbenko, V. E., Mezentseva, M. V., Gabaeva, M. V., Sokolov, O. I.u, Zozulia, A. A., & Ershov, F. I. (2008). Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 108(5), 71–75.
    20. Vasil'eva, E. V., Kondrakhin, E. A., Salimov, R. M., & Kovalev, G. I. (2016). Eksperimental'naia i klinicheskaia farmakologiia, 79(9), 3–11.


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