Hexarelin | Reviews, Clinical Trials, and Safety

Hexarelin is a potent GH-releasing peptide with research applications like improved body composition and enhanced recovery in test subjects.

Table Of Contents
    Add a header to begin generating the table of contents

    Compound Overview

    Class of Compound:


    Mechanism of Action:

    Hexarelin stimulates the production of growth hormone by mimicking ghrelin and binding to the ghrelin/growth hormone secretagogue receptor (GHS-R). It has a slight and dose-dependent effect on prolactin, adrenocorticotropic hormone, and cortisol release in test subjects.

    Notable Studies:

    Also Known As:

    Examorelin, 140703-51-1, EP-23905, MF-6003

    Research Applications:

    • Improved body composition
    • Recovery and sleep enhancement
    • Disease prevention and treatment


    • Water retention
    • Increased cortisol
    • Not FDA approved

    Chemical Structure


    What Is Hexarelin?

    The peptide hexarelin is a synthetic ghrelin analog that stimulates the production of growth hormone [1]. There is much public interest in the use of hexarelin for body composition, since increased growth hormone production may result in increased lean mass.

    Yet research has revealed that hexarelin peptide therapy can provide much more than improved body composition, with researchers noting its potential neuroprotective and cardioprotective effects.

    Hexarelin was originally developed in the 1980s by a team of researchers at Tulane Medical School that were interested in creating a growth hormone secretagogue (GHS) that did not cause incidental elevation of sex hormones, insulin, or glucagon [2].

    The Tulane team found that the pituitary growth hormone stimulating action of hexarelin lasted longer than related larger peptides, increased body weight in treated rats, and did not cause desensitization at the receptor site [2].

    As scientists continue to investigate hexarelin peptide, benefits unrelated to growth hormone secretion are starting to emerge.

    In a recent study on the possible neuroprotective properties of hexarelin, researchers found that the hexapeptide not only decreases inflammation in the brain, thus preventing cell damage and death, but also increases neurogenesis in the hippocampus [3].

    Also of interest is the peptide’s ability to protect the heart. It has been shown to increase the efficiency of cardiac muscle contractions, prevent and reverse heart damage due to reduced blood flow during ischemic events, and increase cardiac output in bypass surgery patients [4].


    What Does Hexarelin Do?

    Notwithstanding its broad spectrum of potential benefits, the main appeal of hexarelin is its powerful growth hormone-stimulating capability [5].

    As humans get older, growth hormone production declines [6]. Since growth hormone is responsible for collagen production, muscle repair, maintaining bone density, body fat storage and distribution, and a host of other processes, there is significant research interest in safely restoring growth hormone levels with compounds like hexarelin [7, 8].

    Let’s have a look at three popular reasons why hexarelin is being studied by researchers today.

    Hexarelin for Recovery

    As a growth hormone secretagogue, hexarelin enables the body to use growth hormone to improve muscle, tendon, and bone repair following injury or intense exercise [9]. When the body is able to rapidly heal from tissue trauma, one can increase training intensity and/or volume without excessive fatigue or muscle damage.

    Sleep is another factor that is crucial to recovery [10]. A lack of circulating growth hormone, especially in aging individuals, is among many reasons as to why sleep might be compromised [11]. The effect of hexarelin on growth hormone secretion can result in deeper restorative sleep, which is invaluable for improving strength and body composition.

    Hexarelin for Fat Loss

    While fat loss is a complex process, one major correlate of obesity is insulin resistance. A 2017 study in Nutrition & Diabetes looked at the insulin sensitivity of two groups of previously overweight women compared to a control group of women who had never been overweight. The group that was successful in maintaining a healthy body weight had insulin sensitivity identical to the control group, while the group of women who had regained their weight were predictably insulin resistant [12].

    Hexarelin has been shown to increase insulin sensitivity (thus increasing effective nutrient partitioning), decrease body fat, increase lean body mass, and decrease blood triglycerides, thereby improving metabolism and body composition in treated subjects [13].

    Hexarelin for Heart Health

    Historically, therapeutic doses of exogenous ghrelin have been given to cardiac patients to facilitate recovery from surgeries and adverse cardiac events. But ghrelin, which is a naturally-occurring peptide in the body, has short-lived effects due to its rapid degradation [4].

    The synthetic hexapeptide hexarelin is superior to exogenous ghrelin in terms of potency, half-life, and number of favorable cardiac effects [4]. Hexarelin has the potential to improve long-term cardiac functioning in patients with chronic heart failure, reverse atherosclerosis, and decrease fibrosis and hypertrophy in the heart [4, 14, 15].

    Hexarelin Benefits | Clinical Trials

    A number of clinical trials demonstrating the effectiveness of hexarelin are available for review. Below we summarize some of the more notable hexarelin studies to date.

    Hexarelin for Muscle Preservation: A study by Sirago et al. (2017) looked at the potential of growth hormone secretagogues to attenuate the extreme loss of muscle (cachexia), which is commonly associated with cancer patients undergoing chemotherapy [16].

    In the study, the scientists administered a chemotherapy agent (cisplatin) to rats to induce the deleterious health markers typically seen in cancer patients. The rats were then divided into three groups: a control group that did not receive hexarelin, a hexarelin group, and a group that received JMV2894 (another GHS).

    The cisplatin resulted in mitochondrial dysfunction and subsequent muscle atrophy in the control group, but the groups that received GHS treatment showed significant resilience against loss of muscle and strength. The researchers attributed this to the effects of hexarelin in improving mitochondrial functioning, reducing inflammatory processes, and regulating cell turnover to maintain healthy muscle mass [16].

    Hexarelin for Weight Loss: Apart from stimulating growth hormone release, hexarelin also improves fat metabolism by its action at the CD36 scavenger receptor [13].

    To further illuminate the fat-burning potential of hexarelin, a team of Canadian researchers examined cell cultures of rodents’ white fat to see how treatment with hexarelin would affect adipocytes. Hexarelin significantly decreased triglyceride accumulation in the treated cells via its action at CD36 while increasing the expression of genes responsible for fat metabolism and concurrently increasing ATP-related energy production in associated genes [17].

    Because the majority of body fat is stored in white fat cells, the effect of hexarelin on lipolysis shows great potential in the weight loss field. Not only might hexarelin increase overweight subjects’ ability to burn fat, but its upregulation of ATP production may result in their feeling more energetic and motivated to perform physical activity.

    Hexarelin for Brain Health: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by mutated neuroblastoma cells. ALS causes neuronal apoptosis in several areas of the nervous system, resulting in loss of motor control, paralysis, and eventually death. While there are currently only palliative treatments for ALS available, researchers hope to find a more effective treatment and eventually a cure for the disease.

    In the pursuit of a possible GHS-based treatment for ALS, researchers treated mutated cells with hexarelin and JMV2894 in a 2023 study. Meanti et al. (2023) chose to include hexarelin in the experiment because of the peptide’s known cytoprotective and anti-inflammatory effects, hoping to slow or reverse cell death and reduce cytotoxic inflammation [3].

    The study showed that hexarelin treatment did improve the apoptosis of mutated cells and increased the survival of healthy cells. While more investigation is needed to understand how growth hormone secretagogues can be used to treat ALS, these results show great promise for future application of hexarelin therapy [3].

    Buy Hexarelin from our top-rated vendor...

    Hexarelin Side Effects

    Because hexarelin has yet to undergo large-scale clinical trials, researchers must take all potential risks into consideration prior to beginning study on this compound.

    Hexarelin injections prompt growth hormone secretion in the body. Similarly, at high doses, hexarelin can elevate levels of adrenocorticotropic hormone (ACTH), cortisol, and prolactin, and increase risks of hypertension and diabetes [18, 19].

    Although a very rare condition, chronic hypercortisolism can result in conditions like androgenic hair growth in women, obesity, infertility, muscle weakness, and more [20].

    Chronic hyperprolactinemia is of particular concern for men as it can cause secondary hypogonadism, or a decrease in male hormone production. This can lead to problems with libido, mood, and bone density, among others [21, 22].

    Most hexarelin researchers report that the peptide leads to sound sleep and greater daytime energy. But there are others who report feelings of fatigue and lethargy during the day, likely due to the timing of growth hormone release caused by hexarelin [10].

    As hexarelin is typically administered as a subcutaneous injection, the following risks typical of injections may occur at the injection site:

    • Pain
    • Redness
    • Swelling
    • Bruising
    • Infection

    Fortunately, these side effects can largely be avoided by adhering to an intelligent hexarelin dosing protocol.

    Is Hexarelin Safe?

    Safety is a foremost consideration when conducting research on test subjects. Fortunately, outcomes continue to show that hexarelin is among the safest GH secretagogues available.

    Hexarelin, when administered in appropriate cycles, seems capable of inducing growth hormone-related benefits without long-term downregulation of endogenous growth hormone [23].

    A study exploring the long-term effectiveness of hexarelin showed that any significant desensitization that occurred during a 16-week administration period returned to baseline after a four-week break from the peptide [24].

    Since hexarelin is potent in relatively small doses and is more selective than other GHSs like synthetic ghrelin, researchers can experience the potential benefits of hexarelin with minimal risk of accompanying effects [4, 18].

    The bottom line is that when administered properly, growth hormone secretagogues like hexarelin can be beneficial and are well-tolerated in most cases [25]. Hexarelin may be considered a safe research chemical in both diseased and healthy subjects alike [3, 4].

    Hexarelin Dosing For Research

    How do you determine the right hexarelin dose for your research?

    These science-backed recommendations should be a good starting point for deciding on a hexarelin dosage and cycle that will get results without compromising safety.

    Hexarelin Cycling

    Hexarelin should be administered in cycles to avoid desensitizing the body to the peptide or interfering with the body’s own growth hormone production [23].

    Notable human studies on hexarelin occurred over a period of 20 weeks, which consisted of 16 weeks of hexarelin treatment with a four-week break [23, 24].

    There was a marked decrease in the participants’ ability to produce their own growth hormone after the 16-week treatment period [24]. However, after a four-week break, the partial desensitization proved to be reversible as GH response was restored to near-baseline. Most qualified professionals recommend limiting research to a 12-week administration period followed by a four-week break.

    This cycle can be repeated until the conclusion of the study or until desired results are achieved.

    Hexarelin Dosage Calculator

    A recommended dose for hexarelin is 300 micrograms (mcg) per day, administered as three daily 100mcg injections given in the morning, mid-day, and at night. It is not recommended to administer the full daily dose all at once, because:

    • Hexarelin has a relatively short half-life of about one hour, so the benefits of the injection would peak then diminish, leaving the test subject at baseline again until the next day’s injection; and
    • Administering the full 300mcg at once may cause a larger-than-necessary spike in growth hormone release, increasing the risk for adverse effects versus giving three smaller doses [18].

    Hexarelin for research purposes typically comes in 5mg vials. On a dosing schedule of 100mcg, thrice daily, for 12 weeks before a four-week break, six 5mg vials would supply a researcher for a 12-week period.

    Where to Buy Hexarelin Online? | 2024 Edition

    Though researchers might find hexarelin for sale from multiple vendors, our team recommends buying only from a source with a solid reputation, commitment to product purity, and great service.

    Here is our top recommendation for researchers looking to source hexarelin:


    PureRawz consistently provides the research community with top-quality compounds created at trusted facilities. In addition to stellar product quality, this vendor keeps its prices competitive to reduce barriers to entry into the peptide world.

    Here’s why we trust this vendor:

    • Transparency: Researchers may rest assured of PureRawz' 99% peptide purity standard. The vendor uses both first- and third-party laboratory testing to verify the quality of the product.
    • Fair Pricing: PureRawz strives to keep product costs on par with competitors. They also offer incentives such as low flat-rate shipping in the U.S., which is waived on orders over $100.
    • Fantastic Service: PureRawz has a dedicated service team ready to help with any other questions that may arise during the buying process. Just send them an email, and the team will respond thoroughly and promptly.

    Readers should note that hexarelin from PureRawz is intended for research use only.

    Buy Hexarelin from our top-rated vendor...

    Is Hexarelin Legal?

    Hexarelin is not approved by the United States Food and Drug Administration for use in humans, and therefore cannot be supplied or administered for that purpose. However, it is legal to purchase and use hexarelin as a research chemical in in vitro studies.

    Peptides like hexarelin often exist in a gray area, with their benefits having been tested, but with the developers lacking the funding to pursue the large-scale trials needed to gain FDA approval.

    Is Hexarelin a Steroid?

    In most settings, “steroid” usually means “anabolic steroid,” which is a chemical that mimics testosterone [32].

    Muscle growth researchers, for example, may take anabolic steroids to increase performance, muscle mass, and recovery. However, anabolic steroids are infamous for their often irreversible adverse effects.

    Understanding this, we know that hexarelin is definitively not a steroid.

    Hexarelin, as discussed, is a growth hormone-releasing peptide that augments the body’s own natural growth hormone production. Hexarelin has limited side effects, most of which are reversible, and will not cause the androgenization that often follows steroid abuse.


    Hexarelin | Reviews

    Hexarelin is a potent growth hormone secretagogue and GHS-R agonist. It has been shown to help subjects decrease fat mass, increase muscle mass, improve cardiac and neurological health, and gain energy.

    Aside from possible side effects related to administering a high dosage and thus inducing too much growth hormone release, hexarelin appears to be a safe and effective compound for optimizing GH levels while minimizing impact on other hormones.

    For researchers looking to source Hexarelin for study should only buy the peptide from a trusted company like our top-rated vendor..



    1. Mosa, R. M., Zhang, Z., Shao, R., Deng, C., Chen, J., & Chen, C. (2015). Implications of Ghrelin and Hexarelin in Diabetes and Diabetes-Associated Heart Diseases. Endocrine, 49(2), 307–323. https://doi.org/10.1007/s12020-015-0531-z.
    2. Bowers, C.,Momany, F., Reynolds, G.,Hong, A. (1984). On the in Vitro and in Vivo Activity of a New Synthetic Hexapeptide that Acts on the Pituitary to Specifically Release Growth Hormone. Endocrinology, 11(5), 1537–1545. https://doi.org/10.1210/endo-114-5-1537
    3. Meanti, R., Licata, M., Rizzi, L., Bresciani, E., Molteni, L., Coco, S., Locatelli, V., Omeljaniuk, R. J., & Torsello, A. (2023). Protective Effects of Hexarelin and JMV2894 in a Human Neuroblastoma Cell Line Expressing the SOD1-G93A Mutated Protein. International Journal of Molecular Sciences, 24(2), 993. https://doi.org/10.3390/ijms24020993
    4. Mao, Y., Tokudome, T., & Kishimoto, I. (2014). The Cardiovascular Action of Hexarelin. Journal of Geriatric Cardiology, 11(3), 253–258. https://doi.org/10.11909/j.issn.1671-5411.2014.03.007
    5. Rahim, A., O'Neill, P. A., & Shalet, S. M. (1998). Growth Hormone Status During Long-Term Hexarelin Therapy. The Journal of Clinical Endocrinology And Metabolism, 83(5), 1644–1649. https://doi.org/10.1210/jcem.83.5.4812.
    6. Bartke A. (2019). Growth Hormone and Aging: Updated Review. The World Journal of Men's Health, 37(1), 19–30. https://doi.org/10.5534/wjmh.180018
    7. Doessing, S., Heinemeier, K. M., Holm, L., Mackey, A. L., Schjerling, P., Rennie, M., Smith, K., Reitelseder, S., Kappelgaard, A. M., Rasmussen, M. H., Flyvbjerg, A., & Kjaer, M. (2010). Growth Hormone Stimulates the Collagen Synthesis in Human Tendon and Skeletal Muscle Without Affecting Myofibrillar Protein Synthesis. The Journal of Physiology, 588(2), 341–351. https://doi.org/10.1113/jphysiol.2009.179325.
    8. Kopchick, J. J., Berryman, D. E., Puri, V., Lee, K. Y., & Jorgensen, J. O. L. (2020). The Effects of Growth Hormone on Adipose Tissue: Old Observations, New Mechanisms. Nature Reviews. Endocrinology, 16(3), 135–146. https://doi.org/10.1038/s41574-019-0280-9
    9. Kraemer, W. J., Ratamess, N. A., & Nindl, B. C. (2017). Recovery Responses of Testosterone, Growth Hormone, and IGF-1 After Resistance Exercise. Journal of Applied Physiology, 122(3), 549–558. https://doi.org/10.1152/japplphysiol.00599.2016.
    10. Vyazovskiy V. V. (2015). Sleep, Recovery, And Metaregulation: Explaining the Benefits of Sleep. Nature And Science of Sleep, 7, 171–184. https://doi.org/10.2147/NSS.S54036
    11. Van Cauter, E., & Copinschi, G. (2000). Interrelationships Between Growth Hormone and Sleep. Growth Hormone & IGF Research: Official Journal of the Growth Hormone Research Society and the International IGF Research Society, 10 Suppl B, S57–S62. https://doi.org/10.1016/s1096-6374(00)80011-8
    12. Clamp, L. D., Hume, D. J., Lambert, E. V., & Kroff, J. (2017). Enhanced Insulin Sensitivity in Successful, Long-Term Weight Loss Maintainers Compared With Matched Controls With No Weight Loss History. Nutrition & Diabetes, 7(6), e282. https://doi.org/10.1038/nutd.2017.31
    13. Mosa, R., Huang, L., Wu, Y., Fung, C., Mallawakankanamalage, O., LeRoith, D., & Chen, C. (2017). Hexarelin, a Growth Hormone Secretagogue, Improves Lipid Metabolic Aberrations in Nonobese Insulin-Resistant Male MKR Mice. Endocrinology, 158(10), 3174–3187. https://doi.org/10.1210/en.2017-00168.
    14. Mao, Y., Tokudome, T., Kishimoto, I., Otani, K., Miyazato, M., & Kangawa, K. (2014). One Dose of Oral Hexarelin Protects Chronic Cardiac Function After Myocardial Infarction. Peptides, 56, 156–162. https://doi.org/10.1016/j.peptides.2014.04.004.
    15. Pang, J., Xu, Q., Xu, X., Yin, H., Xu, R., Guo, S., Hao, W., Wang, L., Chen, C., & Cao, J. M. (2010). Hexarelin Suppresses High Lipid Diet and Vitamin D3-Induced Atherosclerosis in the Rat. Peptides, 31(4), 630–638. https://doi.org/10.1016/j.peptides.2009.11.007
    16. Sirago, G., Conte, E., Fracasso, F., Cormio, A., Fehrentz, J. A., Martinez, J., Musicco, C., Camerino, G. M., Fonzino, A., Rizzi, L., Torsello, A., Lezza, A. M. S., Liantonio, A., Cantatore, P., & Pesce, V. (2017). Growth Hormone Secretagogues Hexarelin and JMV2894 Protect Skeletal Muscle from Mitochondrial Damages in a Rat Model of Cisplatin-Induced Cachexia. Scientific Reports, 7(1), 13017. https://doi.org/10.1038/s41598-017-13504-y
    17. Rodrigue-Way, A., Demers, A., Ong, H., & Tremblay, A. (2007). A Growth Hormone-Releasing Peptide Promotes Mitochondrial Biogenesis and A Fat Burning-Like Phenotype Through Scavenger Receptor CD36 in White Adipocytes. Endocrinology, 148(3), 1009–1018. https://doi.org/10.1210/en.2006-0975
    18. Massoud, A. F., Hindmarsh, P. C., & Brook, C. G. (1996). Hexarelin-Induced Growth Hormone, Cortisol, And Prolactin Release: A Dose-Response Study. The Journal of Clinical Endocrinology and Metabolism, 81(12), 4338–4341. https://doi.org/10.1210/jcem.81.12.8954038.
    19. Hintz R. L. (2004). Growth Hormone: Uses and Abuses. BMJ (Clinical research ed.), 328(7445), 907–908. https://doi.org/10.1136/bmj.328.7445.907
    20. U.S. Department of Health and Human Services. (2018). Cushing’s Syndrome - NIDDK. National Institute of Diabetes and Digestive and Kidney Diseases. https://www.niddk.nih.gov/health-information/endocrine-diseases/cushings-syndrome#symptoms
    21. Thapa, S., & Bhusal, K. (2022). Hyperprolactinemia. In StatPearls. StatPearls Publishing.
    22. Kumar, P., Kumar, N., Thakur, D. S., & Patidar, A. (2010). Male Hypogonadism: Symptoms and Treatment. Journal of Advanced Pharmaceutical Technology & Research, 1(3), 297–301. https://doi.org/10.4103/0110-5558.72420
    23. Rahim, A., & Shalet, S. M. (1998). Does Desensitization to Hexarelin Occur? Growth Hormone & IGF Research: Official Journal of The Growth Hormone Research Society and The International IGF Research Society, 8 Suppl B, 141–143.
    24. Rahim, A., O'Neill, P. A., & Shalet, S. M. (1998). Growth Hormone Status During Long-Term Hexarelin Therapy. The Journal of Clinical Endocrinology And Metabolism, 83(5), 1644–1649. https://doi.org/10.1210/jcem.83.5.4812.
    25. Sigalos, J. T., & Pastuszak, A. W. (2018). The Safety and Efficacy of Growth Hormone Secretagogues. Sexual Medicine Reviews, 6(1), 45–53. https://doi.org/10.1016/j.sxmr.2017.02.004
    26. Freeze-Drying: Producing Stable Peptides. (2023). Manufacturing Chemist. https://www.manufacturingchemist.com/news/article_page/Freeze-drying_producing_stable_peptides/206036.
    27. Sterile Water for Injection, USP - Food and Drug Administration. (2022). https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/018632s051lbl.pdf.
    28. National Institutes of Health. (2014). Bacteriostatic Water. U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=ccadcf46-6a6f-436b-9bbc-17e2983a335f&type=display.
    29. Peptide Handling, Dissolution, and Storage. NIBSC. (2003). https://www.nibsc.org/science_and_research/virology/cjd_resource_centre/available_samples/peptide_library/peptide_storage.aspx.
    30. De Marinis, L., Mancini, A., Valle, D., Izzi, D., Bianchi, A., Gentilella, R., Giampietro, A., Desenzani, P., & Giustina, A. (2000). Role Of Food Intake In The Modulation Of Hexarelin-Induced Growth Hormone Release In Normal Human Subjects. Hormone And Metabolic Research, 32(4), 152–156. https://doi.org/10.1055/s-2007-978611.
    31. U.S. National Library of Medicine. (2021). Subcutaneous (SQ) Injections: Medlineplus Medical Encyclopedia. MedlinePlus. https://medlineplus.gov/ency/patientinstructions/000430.htm
    32. U.S. Department of Health and Human Services. (2023). Anabolic Steroids and Other Appearance and Performance Enhancing Drugs (APEDs). National Institutes of Health. https://nida.nih.gov/research-topics/anabolic-steroids#types