Titus Thorne

Last Updated May 11, 2022

Titus Thorne

 May 11, 2022

Looking for information about Fragment 176-191 dosage?

If so, you’ve come to the perfect place.

HGH Fragment 176-191 offers a myriad of potential fat loss and weight management benefits, but finding the right dose is far from clear.

In this guide, we’ll explain HGH Fragment 176-191’s potential uses and side effects. We’ll then summarize how Fragment 176-191 has been dosed in clinical trials to date, and explain how best this peptide may be administered in a research setting.

At the end, we’ll reveal our go-to supplier of this exciting research peptide.

Let’s begin!

Buy Fragment 176-191 from our #1 recommended vendor...

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What is Fragment 176-191?

Fragment 176-191 refers to the peptide fragment of human growth hormone (hGH) comprising HGH amino acids 176 to 191. This section of hGH is known as the C-terminus and is believed to be responsible for the main fat-reducing benefits of hGH [1]. Clinical trials have shown that Fragment 176-191 administration can reduce fat mass and overall body weight [1].

The fat loss and metabolic benefits of intact hGH have been widely researched and are well understood [2, 3]. However, severe side effects associated with long-term hGH treatment, such as glucose intolerance and hypertension, have made long-term research using intact hGH unviable. Based on the literature, Fragment 176-191 has a favorable tolerance and safety profile compared to intact hGH. In the following section, we’ll look more closely at the potential benefits offered by this research peptide.


Fragment 176-191


Fragment 176-191 Benefits and Uses

Based on data from clinical trials, HGH Fragment 176-191 appears to offer a number of benefits. In this section, we’ll outline the main potential benefits and uses of this peptide according to the available evidence.

1. Potential alternative to intact hGH

All published evidence points toward HGH Fragment 176-191 having a good safety profile in both animals and humans. Its use is not associated with hGH side effects like insulin resistance, and it appears to be a safer alternative for researchers who want to investigate the fat-reducing properties of hGH without using intact hGH and exposing test subjects to its risks.

The carboxy-terminus of hGH, known as hGH 177-191, appears to have a strong impact in terms of mobilizing lipids in the body—a key benefit of hGH [1]. On the other hand, there is no evidence that the Fragment 176-191 presents some of the hGH-associated risks like edema, hypertension, acromegaly, diabetes, or glucose intolerance. In fact, data from clinical trials shows that this peptide produces adverse events at a rate indistinguishable from placebos [1].

2. Strong effect on lipid mobilization

The second potential benefit of HGH Fragment 176-191 is its strong impact on lipid mobilization. Studies on intact hGH have shown that it helps inhibit lipoprotein lipase activity in adipose tissue [4] and promotes lipolysis in adipocytes. Other studies have shown a positive impact on fat mass cells [5], fat mass [6], and overall fat distribution [7]. Research involving HGH Fragment 176-191 has shown that it temporarily increases blood glucose and causes a sustained rise in plasma insulin levels [8].

A 2001 study invovling obese mice and beta(3)-AR knock-out mice found that Fragment 176-191 increased thermogenic activity in the rodents’ skeletal muscle [9]. This finding suggests that Fragment 176-191’s potential uses could include treating prediabetes, Type 2 diabetes, and obesity in humans [1].

3. Enhanced cartilage regeneration

A 2013 study found that when white rabbits suffering from osteoarthritis (OA) were injected with Fragment 176-191 in conjunction with hydrochloric acid (HA), they experienced enhanced cartilage growth compared with those receiving HA injections alone [10]. While these results have yet to be replicated in human clinical trials, the study’s authors suggested that as Fragment 176-191 does not stimulate the production of IGF-1, it “may be safer than human recombinant GH for the long-term treatment of OA” [10].

In the following section, we will review the potential side effects of HGH Fragment 176-191.


Fragment 176-191 Side Effects

At the time of writing, a total of six clinical trials involving HGH Fragment 176-191 have been conducted. Data from these trials shows that this peptide has a positive safety profile and does not produce a high rate of adverse events (AEs) [1].

The six trials involved fewer than 900 participants and all were given regular physical examinations including vital sign tests, ECG tests, blood glucose tests, and IGF-1 tests. Two trials involved intravenous injections of Fragment 176-191 dosed between 25 µg – 400 µg/kg body weight, while four trials involved orally administered (tablets or pills) Fragment 176-191 dosed between 9 mg – 54 mg.

Researchers found that subjects receiving Fragment 176-191 experienced no increases in IGF-1 levels, and no negative impact on carbohydrate metabolism, glucose tolerance, or insulin resistance [1]. Further, the rate and type of AEs experienced by the volunteers were indistinguishable from those experienced by the group receiving the placebo.

Apart from the lack of the more severe effects typically associated with hGH use, minor side effects from Fragment 176-191 injections could include irritation or pain at the site of injection.

In the following section, we’ll take a look at how HGH Fragment 176-191 was dosed in these trials and explore how researchers may dose this peptide in their own studies.


Fragment 176-191 Dosage Calculator and Guide

For researchers interested in how best to dose HGH Fragment 176-191, the below dosage calculator and guide should help calculate an appropriate dosage for study participants.

How Do You Administer HGH Fragment?

HGH Fragment 176-191 typically comes in dry powder form and must be reconstituted with bacteriostatic water before being injected subcutaneously or intramuscularly.

However, in two of the six clinical trials conducted to date, HGH Fragment 176-191 was administered intravenously, and in the remaining four trials it was administered orally via capsules or tablets.

What Dose of Fragment 176-191 Should You Administer?

For fat loss research, a common HGH Fragment 176-191 dose is 200-500mcg per day, administered subcutaneously, with lower doses advisable for certain subjects. Note that the clinical trials on Fragment 176-191 to date have not involved administration via subcutaneous injection.

When Should HGH Fragment Be Administered?

HGH Fragment 176-191 is commonly administered on an empty stomach, 1-2 times daily. If administered once, it should be done in the AM, at least one hour before breakfast. If it’s administered twice per day, the second dose should come in the PM, a couple of hours after that day’s final meal.

How Often Should Fragment 176-191 Be Administered?

Based on data from the second clinical trial involving intravenous HGH Fragment 176-191 injections, doses can be safely administered daily for up to four weeks—either once or twice per day. This protocol would result in 28-56 injections spread over the course of four weeks.

However, as Fragment 176-191 is a research chemical and in vivo testing is prohibited, there remains a paucity of published data on administration via subcutaneous injection.

How Long Should Fragment 176-191 Be Administered?

Based on data from the second clinical trial involving intravenous HGH Fragment 176-191 injections, doses can be safely administered daily for up to four weeks. As Fragment 176-191 is a research chemical and in vivo testing is prohibited, there is no data regarding long-term administration.


Where to Buy Fragment 176-191 Online? | 2021 Guide

HGH Fragment 176-191 is freely available as a research chemical to qualified researchers. In our tests, however, the quality of this peptide can vary from one vendor to the next. Our team has extensively reviewed many peptide suppliers, concluding that Peptide Sciences currently offers the best value for money and the highest quality peptides.

Here are some of the reasons why we rate Research Peptides so highly:

  • Third-Party Testing: Peptide Sciences is the only vendor we’ve found that gets every batch of peptides tested by a third-party lab before putting them on sale. Customers can review the lab results of each batch before making a purchase.
  • Huge Discounts on Bulk Orders: Peptide Sciences charges just $65 for a single 10 mg vial of Fragment 176-191. However, customers who place a bulk order or more than 10 vials can enjoy a further 10 percent discount.
  • Superb Customer Service Team: Peptide Sciences’ customer service team is second to none. They offer 24/7 phone and email support so you can be assured that any question or issue you have will be swiftly resolved.
  • High-Security Website: Peptide Sciences’ website is SSL secure, meaning that no data or personal information will be exposed. Customers’ confidentiality is highly valued and protected at all times.
  • Free Shipping on US Orders: All US orders over $200 ship free while worldwide orders attract a $15 flat shipping rate.

Peptide Sciences is the best option for researchers looking for research-grade HGH Fragment 176-191 in 2021 and beyond. They are the only vendor that offers verifiable lab reports about the quality and safety of their peptides. And they offer reasonable prices and fast, reliable shipping. If you’re looking for a vendor for your Fragment 176-191 research, Peptide Sciences is definitely worth a look.

Buy Fragment 176-191 from our #1 recommended vendor...


How to Order HGH Fragment in Your Country

No matter where in the world you are located, ordering HGH Fragment 176-191 from Peptide Sciences is simple. Simply navigate to their homepage and choose the number of vials you wish to order. Click “Add to Cart” to continue.

Next, click “Proceed to Checkout” and you’ll be directed to the order form.

To complete your purchase, simply enter your:

  • Billing information
  • Shipping information
  • Shipping methods
  • Payment methods

Once complete, click “Place Order” and you’ll receive a confirmation email. If you have any questions or concerns, Peptide Sciences’ customer service team will be happy to assist.


Fragment 176-191 Dosage | The Verdict?

If you were curious about HGH Fragment 176-191 dosage, we hope that this guide has provided a good overview of how this peptide may be dosed in a research setting.

Fat loss research on Fragment 176-191 commonly involves the subcutaneous administration of 200-500 mcg per day. The total dose may be delivered once in the AM, or it may spread across two doses—one in the AM and another in the PM, in both cases on an empty stomach. Research involving Fragment 176-191 is usually conducted over the course of four weeks.

HGH Fragment 176-191 clearly offers avenues for research in areas such as weight management and fat loss without causing typical hGH-related side effects. If you believe that Fragment 176-191 could be the right peptide for your research, be sure to check out Peptide Sciences for the highest-purity research chemicals at the best possible prices.


Fragment 176-191


References

  1. Stier, Heike et al. “Safety And Tolerability Of The Hexadecapeptide AOD9604 In Humans”. Jofem.Org, 2021, https://www.jofem.org/index.php/jofem/article/view/157.
  2. Ho KK, O'Sullivan AJ, Hoffman DM. Metabolic actions of growth hormone in man. Endocr J. 1996 Oct;43 Suppl:S57-63. doi: 10.1507/endocrj.43.suppl_s57. PMID: 9076343.
  3. Vijayakumar A, Novosyadlyy R, Wu Y, Yakar S, LeRoith D. Biological effects of growth hormone on carbohydrate and lipid metabolism. Growth Horm IGF Res. 2010;20(1):1-7.
  4. Gravhølt CH, Schmitz O, Simonsen L, Bülow J, Christiansen JS, Møller N. Effects of a physiological GH pulse on interstitial glycerol in abdominal and femoral adipose tissue. Am J Physiol. 1999 Nov;277(5):E848-54. doi: 10.1152/ajpendo.1999.277.5.E848. PMID: 10567011.
  5. Rodríguez-Arnao J, Jabbar A, Fulcher K, Besser GM, Ross RJ. Effects of growth hormone replacement on physical performance and body composition in GH deficient adults. Clin Endocrinol (Oxf). 1999 Jul;51(1):53-60. doi: 10.1046/j.1365-2265.1999.00737.x. PMID: 10468965.
  6. Takahashi S, Satozawa N. The 20-kD human growth hormone reduces body fat by increasing lipolysis and decreasing lipoprotein lipase activity. Horm Res. 2002;58(4):157-64. doi: 10.1159/000065488. PMID: 12324712.
  7. Rosenbaum M, Gertner JM, Leibel RL. Effects of systemic growth hormone (GH) administration on regional adipose tissue distribution and metabolism in GH-deficient children. J Clin Endocrinol Metab. 1989 Dec;69(6):1274-81. doi: 10.1210/jcem-69-6-1274. PMID: 2685009.
  8. Ng FM, Bornstein J. Hyperglycemic action of synthetic C-terminal fragments of human growth hormone. Am J Physiol. 1978 May;234(5):E521-6. doi: 10.1152/ajpendo.1978.234.5.E521. PMID: 645904.
  9. Heffernan M, Summers RJ, Thorburn A, Ogru E, Gianello R, Jiang WJ, Ng FM. The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice. Endocrinology. 2001 Dec;142(12):5182-9. doi: 10.1210/endo.142.12.8522. PMID: 11713213.
  10. Kwon DR, Park GY. Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model. Ann Clin Lab Sci. 2015 Summer;45(4):426-32. PMID: 26275694.
  11. Cameron CM, Kostyo JL, Adamafio NA, Dunbar JC. Metabolic basis for the diabetogenic action of growth hormone in the obese (ob/ob) mouse. Endocrinology. 1987 Apr;120(4):1568-75. doi: 10.1210/endo-120-4-1568. PMID: 3549265.
  12. Ng FM, Sun J, Sharma L, Libinaka R, Jiang WJ, Gianello R. Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone. Horm Res. 2000;53(6):274-8. doi: 10.1159/000053183. PMID: 11146367.
  13. Heffernan MA, Thorburn AW, Fam B, Summers R, Conway-Campbell B, Waters MJ, Ng FM. Increase of fat oxidation and weight loss in obese mice caused by chronic treatment with human growth hormone or a modified C-terminal fragment. Int J Obes Relat Metab Disord. 2001 Oct;25(10):1442-9. doi: 10.1038/sj.ijo.0801740. PMID: 11673763.

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