Titus Thorne

Last Updated October 3, 2022

Titus Thorne

 October 3, 2022

Researchers interested in experimenting with sermorelin may be curious about the best way to administer this peptide. This sermorelin dosage calculator and guide draws upon past research and summarizes the doses used in previous sermorelin studies. By consulting this data, peptide researchers may gain an insight into how to dose sermorelin in future experiments and trials. 

For researchers unfamiliar with sermorelin, this guide will also offer a complete overview of the benefits and side effects associated with this compound and any statistically significant benefits observed in past research. 

Those interested in pursuing sermorelin research can find details of our preferred peptide vendor at the end of this guide. This vendor can ship research-grade sermorelin to researchers worldwide and come highly recommended. 

Let’s get started. 

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What is Sermorelin?

Sermorelin acetate is a peptide made up of a chain of 29 amino acids. It is commonly referred to as “sermorelin” and was previously sold under the brand names “Geref” and “Gerel”. It is synthesized to resemble endogenous growth hormone-releasing hormone (GHRH) [1]. 

Sermorelin works by interacting with the body’s endocrine system. Since it resembles endogenous GHRH, it produces a similar effect, which is to bind to receptors that tell the pituitary gland to release more growth hormone into the bloodstream.

The result? Growth hormone (GH) levels increase.

What is growth hormone? An essential part of the body’s tissue construction process.

Growth hormone, also called human growth hormone (HGH), is involved in many biological functions including the reproduction of cells and the repair of tissue [2]. Because GH is so important for the growth and repair of tissue, there is currently strong research interest in the extent to which HGH may improve body composition and performance.

However, administering exogenous HGH directly to test subjects can produce a range of serious side effects, including swelling, joint pain, carpal tunnel syndrome, and an increased risk of diabetes [3]. It may also increase the risk of certain types of cancer, such as Hodgkin’s Lymphoma [4]. These risks mean that HGH research is strictly regulated and tightly controlled. 

That’s the beauty of sermorelin research.

Rather than administering HGH directly, researchers can use sermorelin to increase HGH levels in test subjects by naturally stimulating the pituitary gland to release more endogenous HGH. Instead of spiking HGH to supraphysiological levels, sermorelin is believed to produce a gradual increase in HGH in a stable, predictable way.

In the next section, we’ll take a look at the main benefits and uses of sermorelin. 


Sermorelin Acetate


Sermorelin Benefits and Uses

So, what are the Sermorelin benefits? Well, there are quite a few.

In 1997, sermorelin received U.S. Food and Drug Administration (FDA) approval for the treatment of growth hormone deficiency (GHD) in child and adult patients. It was available under the trade name “Geref” and was also used as a diagnostic agent to check pituitary gland function. 

However, the USFDA withdrew approval for Geref in 2008 and it was subsequently discontinued. While the manufacturer stressed that this was for “reasons unrelated to safety or efficacy”, the simple fact is that sermorelin no longer has any recognizer therapeutic use. In other words, it is a research chemical and is not approved for human use. 

As sermorelin is able to increase GH levels in human test subjects, there is strong interest among peptide researchers as to whether it may offer the following benefits: 

  • Purported anti-aging effects: Some studies have investigated sermorelin peptide’s effect on collagen production. Collagen is a protein found throughout the body and is responsible for making the skin appear smooth and youthful [5, 6]. By increasing HGH levels, some researchers theorize that sermorelin may help reduce fine lines and wrinkles that occur with age [7]. Research in this area is ongoing. 
  • Body composition: One study found that GH increases lean muscle mass and reduces adipose tissue (body fat) in elderly test subjects. This study found that GH administration led to an 8.8% increase in lean muscle mass and a 14% decrease in body fat [6]. While these results have yet to be replicated in healthy, non-elderly test subjects, some researchers are actively investigating sermorelin’s potential for bodybuilding and improvements in body composition. 
  • Improving bone health: Research has shown that sermorelin can help increase bone density, and this may be especially useful for test subjects with osteoporosis. One study found that higher levels of HGH can help increase bone mineral density [6], and, since sermorelin can increase HGH levels [1, 8], the possibility that sermorelin may be an effective way of improving bone health is open to further investigation. 
  • Assisting cardiac tissue repair: Several animal studies have suggested that sermorelin HGH could be useful to test subjects with heart issues. A study in pigs found that it helped to reduce cardiac tissue death and increase the number of blood vessels providing nutrients to the heart [9]. Another study found that it could reduce heart scar sizes [10]. At this point, these results are speculative and have yet to be explored in human studies. 
  • Sleep regulation: Research from animal studies suggests that sermorelin may help to regulate some of the chemicals, like Orexin, that play a role in sleep [11]. 

In summary, while sermorelin is a research chemical and no longer has FDA approval, ongoing research indicates that it may offer a wide range of benefits. Hopefully, researchers interested in exploring sermorelin can consult the relevant literature when calculating sermorelin dosage. 

We’ll now explore the documented sermorelin side effects. 


Sermorelin Side Effects

Sermorelin appears to offer several benefits, but are there any sermorelin side effects?

Firstly, researchers need to know that the decision to withdraw sermorelin’s FDA approval was for reasons other than safety or efficacy. There is no research to date that has linked sermorelin to any clinically significant adverse effects in test subjects.  

In general, sermorelin is considered by most researchers to be well-tolerated by test subjects [12]. Side effects from sermorelin administration are rare and not severe. Some of these more mild side effects include:

  • Facial flushing
  • Swelling, redness, pain, or irritation at the injection site
  • Headache
  • Nausea
  • Aggression
  • Strange mouth tastes
  • Vomiting

More rarely, some test subjects have reported the following side effects:

  • Rash, itchiness, or hives
  • Difficulty breathing
  • Tightness in chest
  • Swelling in the mouth

To minimize the risk of test subjects experiencing side effects as a result of sermorelin administration, researchers are advised to consult the relevant literature when designing an experiment. 

In the following section, we’ll outline how this research chemical has been used in past studies. 


Sermorelin Acetate


Sermorelin Dosage Calculator

Researchers interested in working with sermorelin may use this sermorelin dosage calculator during the design and planning phases of the research process. Below, the main doses used in past sermorelin studies are highlighted along with any general guidance that researchers may need to be aware of. 

Using and storing sermorelin acetate

Sermorelin acetate usually comes in powder form. Prior to administration, researchers must first reconstitute it with bacteriostatic water by injecting water with a large mixing syringe against the glass wall of the vial. This water must be swirled, gently, around the vial until all of the powder is dissolved. 

Researchers should follow the directions for how much water to add. For a 15 mg vial of sermorelin acetate, 7.5 ml of bacteriostatic water is typically required. Note that 10 units on an insulin syringe usually equates to 200 mcg of sermorelin.

Reconstituted sermorelin must be refrigerated and kept away from heat, light, moisture. It can be stored for up to 90 days. Researchers are advised to discard any sermorelin that is cloudy or contains particles. 

Sermorelin administration | General tips

When sermorelin held FDA approval as a treatment for GHD, it was administered intravenously as a subcutaneous injection. However, sermorelin may also be administered into the muscle as an intramuscular injection. 

In terms of the timing of these injections, sermorelin has been administered to test subjects In past studies at night, at least two hours after eating. As HGH levels naturally peak at night, this protocol is believed to enhance HGH secretion.

Sermorelin dosage | Recovery

During the period when sermorelin held FDA approval and was used to diagnose idiopathic GHD in children, it was administered intravenously at a dose of 1mcg per kilogram of body weight. 

To date, sermorelin has not been approved for any other purpose and is currently classified as a research chemical. Therefore, based on the available data, researchers interested in experimenting with sermorelin for its purported recovery benefits may administer it in the following way: 

  • 1mcg of sermorelin per kilogram of bodyweight per injection
  • One injection per day, ideally at night
  • Cycle for 8 to 12 weeks
  • Cycle off for 1 month

Sermorelin dosage | Anti-aging and weight loss

While there is strong research interest in the application of sermorelin to improve the appearance of skin and reduce body fat, there is no published research to indicate the dosage at which it may be administered to this end.

Researchers interested in experimenting with sermorelin may consult the available literature regarding the past use of sermorelin as a treatment for GHD. This research indicates that a dose of 1mcg/kg of body weight provides a clinically significant effect in test subjects. 

Sermorelin dosage | Bodybuilding

As with anti-aging and weight loss, there is currently very strong research interest in the application of sermorelin to lean muscle increase and athletic performance in test subjects. However, to date, no research has been published to indicate the dosage at which sermorelin may be administered for this purpose. 

Based on the available data, doses of 1mcg/kg of bodyweight appear to produce a discernible effect. Researchers interested in exploring these purported benefits of sermorelin may consider this as a starting dose for any experiment they decide to conduct. 


Where to Buy Sermorelin Online? | 2022 Guide

Researchers interested in experimenting with sermorelin should note that while this peptide has previously held USFDA approval as a treatment for GHD, it is currently classified as a research chemical and has no recognized therapeutic use. 

The best place to buy sermorelin online is Peptide Sciences, a U.S.-based company that provides high-quality, research-grade peptides without additives or fillers.

We love Peptide Sciences because they have a solid track record and get every batch of peptides tested by an independent lab before putting them up for sale. 

Here are a few things they do exceptionally well: 

  • Worldwide shipping: Peptide Sciences offer fast, secure, worldwide shipping on all orders.
  • Strong customer service: They offer accessible customer service and reply to emails within 24 hours. 
  • Convenient, secure payment options: They accept credit cards and several types of cryptocurrencies.

Researchers interested in exploring the benefits and side effects of sermorelin may consult Peptides Sciences to discuss their needs. 

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Bacteriostatic Water for Injection

To comply with standard guidelines for handling peptides such as [peptide], a researcher must have certain essential materials available.

The processes of peptide injection, reconstitution, and storage call for items like insulin syringes, sterile vials, and bacteriostatic water, among others.

Trying to source all these requisite materials may present a challenge, as few credible retailers carry the full set of products. To address this, we at Peptides.org have elected a single reputable supplier that carries the standard range of materials for peptide research.

BacteriostaticWater.org

This online retailer scores top marks for its convenient kits that supply all necessary research materials. BacteriostaticWater.org eliminates the need to search for products from multiple sources, delivering complete research kits to your door.

Choose from two options; the first is the starter research kit, which contains:

  • Bacteriostatic Water (30mL) – 3x
  • Insulin Syringes (0.5 cc/mL x 29g x ½) – 100x
  • Alcohol Prep Pads – 200x
  • Sterile Empty Glass Vial (10mL) – 1x
  • Large Needles + Syringes Combo (3cc x 21g x 1) – 10x

The second option is the premium research kit, including:

  • Bacteriostatic Water (30mL) – 5x
  • Insulin Syringes (0.5 cc/mL x 29g x ½) – 200x
  • Alcohol Prep Pads – 200x
  • Sterile Empty Glass Vial (10mL) – 2x
  • Large Needles + Syringes Combo (3cc x 21g x 1) – 20x

Your research will receive a boost with a convenient and comprehensive supply kit from this esteemed distributor.

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Sermorelin Dosage | The Verdict?

Hopefully, this sermorelin dosage calculator and guide has provided a useful starting point for researchers interested in working with this peptide. Although sermorelin is no longer FDA approved, past research findings indicate that further research may be warranted, especially with regards to GHD treatment, long-term safety, and anti-aging effects. 

Those interested in finding a reliable, trustworthy sermorelin vendor may consider contacting our preferred supplier, Peptide Sciences.


Sermorelin Acetate


References

  1. Prakash, A., & Goa, K. L. (1999). Sermorelin. BioDrugs, 12(2), 139-157.
  2. Erotokritou-Mulligan, I., Holt, R. I., & Sönksen, P. H. (2011). Growth hormone doping: A review. Open access journal of sports medicine, 2, 99.
  3. Liu, H., Bravata, D. M., Olkin, I., Nayak, S., Roberts, B., Garber, A. M., & Hoffman, A. R. (2007). Systematic review: the safety and efficacy of growth hormone in the healthy elderly. Annals of internal medicine, 146(2), 104-115.
  4. Freedman, R. J., Malkovska, V., LeRoith, D., & Collins, M. T. (2005). Hodgkin lymphoma in temporal association with growth hormone replacement. Endocrine journal, 52(5), 571-575.
  5. Proksch, E., Schunck, M., Zague, V., Segger, D., Degwert, J., & Oesser, S. (2014). Oral intake of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis. Skin pharmacology and physiology, 27(3), 113-119.
  6. Rudman, D., Feller, A. G., Nagraj, H. S., Gergans, G. A., Lalitha, P. Y., Goldberg, A. F., … & Mattson, D. E. (1990). Effects of human growth hormone in men over 60 years old. New England Journal of Medicine, 323(1), 1-6.
  7. Doessing, S., Heinemeier, K. M., Holm, L., Mackey, A. L., Schjerling, P., Rennie, M., … & Flyvbjerg, A. (2010). Growth hormone stimulates the collagen synthesis in human tendon and skeletal muscle without affecting myofibrillar protein synthesis. The Journal of physiology, 588(2), 341-351.
  8. Laron, Z. (1995). Growth hormone secretagogues. Drugs, 50(4), 595-601.
  9. Bagno, L. L., Kanashiro‐Takeuchi, R. M., Suncion, V. Y., Golpanian, S., Karantalis, V., Wolf, A., … & Valdes, D. (2015). Growth hormone–releasing hormone agonists reduce myocardial infarct scar in swine with subacute ischemic cardiomyopathy. Journal of the American Heart Association, 4(4), e001464.
  10. Kanashiro-Takeuchi, R. M., Szalontay, L., Schally, A. V., Takeuchi, L. M., Popovics, P., Jaszberenyi, M., … & Hare, J. M. (2015). New therapeutic approach to heart failure due to myocardial infarction based on targeting growth hormone-releasing hormone receptor. Oncotarget, 6(12), 9728.
  11. Shepherd, B. S., Johnson, J. K., Silverstein, J. T., Parhar, I. S., Vijayan, M. M., McGuire, A., & Weber, G. M. (2007). Endocrine and orexigenic actions of growth hormone secretagogues in rainbow trout (Oncorhynchus mykiss). Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 146(3), 390-399
  12. Drugs.com (2015). Sermorelin acetate. https://www.drugs.com/cdi/sermorelin-acetate.html

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