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Selank is a synthetic analog of the natural immunopeptide tuftsin, and used clinically in Russia for the treatment of generalized anxiety disorder. It may reduce anxiety by modulating neurotransmitters and influencing the gene expression of neural receptors. Selank has additional potential to improve learning and memory, reduce pain and stress, and act as a mood stabilizer.

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    What is Selank?

    Selank is a synthetic compound designed to mimic the endogenous tetrapeptide tuftsin, but with an added three-amino acid elongation that makes it more stable and longer-acting [1].

    It has primarily been studied for its anti-anxiety properties. Three notable human experiments documented the following effects of Selank administration [2, 3, 4]:

    • Reduction in blood serum levels of interleukin-6, an inflammatory cytokine associated with depression;
    • Increased levels of tau(1/2) leu-enkephalin when levels were lower than normal in patients with generalized anxiety disorder and neurasthenia;
    • Inhibition of enkephalinase, the enzyme that breaks down enkephalin, which is an endogenous peptide that regulates pain perception and cognitive processes.

    More Selank data gathered from animals studies indicates that the peptide may also [5, 6, 7]:

    • Decrease stress-related corticosterone and its negative physiological effects;
    • Rebalance the immune system after stressful incidents;
    • Prevent brain damage resulting from alcohol abuse.

    No notable side effects have been reported during Selank studies that were definitively correlated with the peptide treatment. However, studies to date have been over short time periods with no known longitudinal studies or follow-ups to determine the long-term effects of Selank usage.

    While the United States Food and Drug Administration has not reviewed nor approved Selank for human use, qualified researchers may purchase this purported nootropic for laboratory experimentation.

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    Benefits of Selank

    Selank shows potential for a range of medical applications. Below are a few of the purported benefits of Selank.

    Selank as a benzodiazepine alternative

    Benzodiazepines are drugs utilized for their anxiety- and pain-relieving effects, which occur via enhancement of the inhibitory action of GABA by allosteric modulation of the GABA receptors [8]. Selank has been shown to work similarly to benzodiazepines like diazepam and phenazepam, although without their same side effects and addiction potential [9].

    Even if Selank cannot completely supplant benzodiazepine treatment for some people, there is evidence that the peptide can augment the action of phenazepam, which is used to treat anxiety disorders.

    When researchers administered Selank concurrently with phenazepam to human volunteers with anxiety spectrum disorders, the patients experienced all the expected benefits of phenazepam—yet the drug’s usual adverse effects, like memory loss and sleepiness, were significantly decreased by the addition of Selank [10].

    Selank as an antiviral agent

    Selank, like tuftsin, exerts immunomodulatory effects by influencing the receptors on monocytes, leukocytes, and macrophages. But Selank also acts in the central nervous system pathway to regulate cytokines and cellular immune responses, thus increasing resistance to viruses [11].

    When a rat study compared the effectiveness of Selank to the antiviral drug recombinant interferon-α (IFN-α) for the treatment of an influenza virus, Selank outperformed IFN-α at suppressing the reproduction of the virus in vitro, especially when administered prophylactically. In vivo, the prophylactic use of Selank improved the survival rate of animal subjects that had been infected with the same virus [12].

    Selank’s potential neuroprotective benefits

    Selank is a purported nootropic, or cognitive-enhancing substance, which has also shown its potential to prevent or reverse damage to the brain caused by a variety of injuries.

    Notably, Selank appears to offer a degree of protection against memory impairment resulting from elevated levels of brain-derived neurotrophic factor (BDNF) in the hippocampus and frontal cortex due to alcohol misuse.

    In a study involving rats subjected to a 30-week alcohol consumption regimen, those administered Selank alongside alcohol demonstrated enhanced performance in object recognition tasks, a lack of memory and attention deficits, and no elevation in BDNF levels, unlike the untreated rats [7].

    Selank Side Effects

    Selank is not an approved drug outside of Russia and the CIS, so researchers need to approach it with caution. Nevertheless, studies conducted thus far have reported minimal adverse effects when administering Selank to either human or animal subjects.

    Possible Side Effects

    To date, there are no confirmed Selank-related side effects that have been validated in human studies.

    Results from studies on the synergistic effects of Selank when used with these medications showed that Selank actually improved the desired outcomes of therapy while reducing the other drugs’ side effects [9, 10].

    Independent researchers occasionally report unwanted symptoms when administering Selank, though not necessarily related to Selank itself. Here is a list of some of these complaints:

    • Sinus irritation
    • Fatigue
    • Pain at injection site
    • Nausea
    • Headaches

    These side effects are likely due to the route of administration, which would typically be a nasal spray or subcutaneously

    Frequency and Severity of Side Effects

    Again, data on the side effects related to Selank administration is sparse. The lack of data on adverse events could be attributed to a number of reasons, including:

    • Limited number of human trials
    • Short study duration
    • Confounding factors, such as the method of administration or concurrent drug therapy

    The frequency of Selank side effects is low and the severity of any reported side effects has been mild.

    Managing Side Effects

    Researchers may take the following steps to minimize the possibility of adverse effects during Selank administration:

    • Administer the lowest effective dose of Selank
    • Follow a proper Selank dosing protocol
    • Maintain a sanitized work area and disinfect hands before administering Selank
    • Use medical-grade equipment for administering Selank
    • Discontinue Selank experimentation immediately if serious adverse effects become apparent
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    Selank Routes of Administration

    There are two scientifically-backed routes of administration for Selank:

    Intranasally via a spray or dropper, or subcutaneously. We’ll briefly summarize both routes.

    Selank Nasal Spray

    Intranasal administration is the preferred efficacious delivery route for Selank [13].

    Selank nasal spray represents an easy way to administer the peptide without the need for injections. Insufflated Selank rapidly penetrates the blood-brain barrier and almost immediately works in the central nervous system. The downside to nasal administration is rapid metabolism of the peptide, which may necessitate multiple doses throughout the day.

    Selank administered in nasal spray form acts slightly differently than when administered as injections. For example, one study on mice found that intranasal Selank increased the binding sites for NMDA without affecting GABA receptors while injected Selank did the opposite, even though both routes resulted in similar anxiolytic and nootropic outcomes [14].

    Injectable Selank

    Selank injections into fat tissue may have a slower and more sustained action in the body [14]. This route of administration is preferred by researchers who may seek a more systemic effect and/or wish to administer a lower, single dose compared to the intranasal route.

    Choosing the Right Form for Research Needs

    Here is a table summarizing the pros and cons of both methods:

    Selank Nasal Spray Selank Injections
    Pros easy to administer effective at low doses
    no needles or reconstitution required effects last longer than nasally administered Selank
    Cons short-acting injection-related risks (infection, pain/swelling, etc.)
    potential for sinus/nasal irritation less convenient and more time-consuming to prepare
    larger dose needed compared injectable Selank may be unsuitable for some research subjects

    When deciding on which form of Selank to purchase, researchers must consider the goals of their experimentation, their own comfort level administering Selank, and the comfort level of subjects with the different types of administration.

    Selank Quality and Purity Considerations

    Researchers are well-advised to source their Selank from a vendor that guarantees purity and quality.

    Unfortunately, Selank purchased online may contain contaminants or impurities. This is why professionals should always buy their peptides from a vendor that sources their materials from accredited facilities and uses in-house and/or third-party testing to verify product purity.

    Some common contaminants or impurities that can be found in low-purity peptides may include:

    • Residual Solvents
    • Peptide Fragments
    • Microbial Contaminants
    • Heavy Metals

    Some of the most reliable testing methods used to assess the purity and quality of pharmaceuticals are high-performance liquid chromatography and mass spectrometry
    [15, 16].

    Our recommended vendors for Selank employ independent third-party laboratories to conduct the above assessments and provide a detailed Certificate of Analysis for each compound they sell.

    Where to Buy Selank Online? | 2024 Edition

    At, our team is constantly on top of the peptide market and are aware of the best places to buy research chemicals online.

    We recommend two trusted Selank suppliers based on product type:

    Limitless Life

    Limitless Life is our retailer of choice for Selank nasal spray. Here is why we trust this company to provide consumers with legitimate products:

    • Verified Reviews: Limitless Life has a loyal group of devoted researchers who continue to give the company 5-star reviews for their service, product quality, and affordability. The company earns top marks for their high-quality nasal sprays, which are all held to 98.5%+ purity.
    • Great Support: Limitless Life provides fast customer support by email and telephone. If contacted outside normal business hours, they will respond to the message as soon as possible. They strive to be quick and efficient in their communications with all customers, whether prospective or repeat.
    • Shipping and Returns: The vendor typically dispatches orders within one to two days of payment confirmation. After that, researchers receive an email with tracking information. Shipping costs vary based on the courier and speed, but most orders are subject to a flat fee of $10. The company accepts returns and exchanges at its discretion.

    Buy Selank Nasal Spray from a top-rated vendor...

    Xcel Peptides

    Our long-time preferred vendor for lyophilized peptides is Xcel Peptides.

    Their Selank powder is held to a 99% purity standard and is shipped ready for reconstitution. Here are a few reasons we trust this company:

    • Verified Reviews: Xcel Peptides has carved a loyal niche in the peptide research community. Researchers praise the vendor’s transparency, professionalism, and high-quality products.
    • Service and Support: Xcel Peptides prioritizes satisfaction even before the purchase is made. The company has a team of experts who create informative content tailored to researchers interested in peptides. Their friendly staff can be reached by phone or email and will get back to researchers with a solution within two business days.
    • Shipping and Returns: Xcel Peptides typically dispatches orders within 24 hours and offers a variety of shipping rates and speeds within the United States. If researchers spend over $200, the shipping fee is waived.

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    Selank Nasal Spray vs. Injections

    By now you’re aware that if you wish to conduct Selank research you’ll need to choose between a nasal spray formulation and injections.

    Here is a recap of the differences between the two routes to help inform your decision:

    Absorption and Bioavailability: Intranasal administration of Selank is the faster-acting method of delivery [13]. Although nasal spray will produce speedy results, the body’s rapid metabolism of Selank means that you may need to dose the peptide throughout the day.

    Subcutaneous Selank injection is associated with excellent bioavailability [13]. When injected into adipose tissue, a low dose of Selank will release steadily into the subject’s system for subtler, longer-lasting effects [14].

    Safety: Most reported side effects of Selank have been related to the chosen route of administration. Reports of side effects have been rare. Some nasal spray users have complained of sinus pain, headaches, and hoarseness. Some injected subjects felt pain where they were injected, experienced bruising or swelling, or had skin flushing and nausea.

    Cost and Accessibility: If we look at the cost difference between our two preferred vendors, it is slightly more economical to purchase and use the injectable form of Selank. However, Selank nasal spray could be more accessible for a variety of reasons, and bypasses the need for reconstitution while increasing compliance.

    Bacteriostatic Water and Selank

    If researchers opt to order lyophilized Selank powder for injection, they will also need certain supplies:

    • Alcohol prep pads
    • Bacteriostatic water

    This list is not comprehensive.

    When it comes to reconstituting peptides, bacteriostatic water is considered superior to all other solvents. This is due to the presence of benzyl alcohol, a preservative in bacteriostatic water that helps prevent bacterial contamination and thereby extends the dissolved peptide’s shelf life [19].

    Verdict | Buying Selank Online

    Selank is a tuftsin analog with reported anxiolytic, antiviral, immunomodulatory, and nootropic effects.

    More human studies on Selank must be conducted to establish its long-term safety. However, the research published to date indicates that Selank is well-tolerated and has few notable adverse effects in short-term studies.

    Selank cannot be administered as a sublingual or oral treatment but has high bioavailability via nasal spray and subcutaneously.

    Whether a researchers chooses to experiment with Selank nasal spray or injectable Selank, do make sure the vendor holds itself and its manufacturing partners to the highest of standards.


    1. Ashmarin, I. P., Samonina, G. E., Lyapina, L. A., Kamenskii, A. A., Levitskaya, N. G., Grivennikov, I. A., Dolotov, O. V., Andreeva, L. A., & Myasoedov, N. F. (2005). Natural and hybrid ("chimeric") stable regulatory glyproline peptides. Pathophysiology: the official journal of the International Society for Pathophysiology, 11(4), 179–185.
    2. Uchakina, O. N., Uchakin, P. N., Miasoedov, N. F., Andreeva, L. A., Shcherbenko, V. E., Mezentseva, M. V., Gabaeva, M. V., Sokolov, O. I.u, Zozulia, A. A., & Ershov, F. I. (2008). Immunomodulatry effects of selank in patients with anxiety-asthenic disorders. S.S. Korsakova, 108(5), 71–75.
    3. Zozulia, A. A., Neznamov, G. G., Siuniakov, T. S., Kost, N. V., Gabaeva, M. V., Sokolov, O. I.u, Serebriakova, E. V., Siranchieva, O. A., Andriushenko, A. V., Telesheva, E. S., Siuniakov, S. A., Smulevich, A. B., Miasoedov, N. F., & Seredenin, S. B. (2008). Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia. S.S. Korsakova, 108(4), 38–48.
    4. Kost, N. V., Sokolov, O. I.u, Gabaeva, M. V., Grivennikov, I. A., Andreeva, L. A., Miasoedov, N. F., & Zozulia, A. A. (2001). Semax and selank inhibit the enkephalin-degrading enzymes from human serum. Bioorganicheskaia khimiia, 27(3), 180–183.
    5. Mukhina, A. Y., Mishina, E. S., Bobyntsev, I. I., Medvedeva, O. A., Svishcheva, M. V., Kalutskii, P. V., Andreeva, L. A., & Myasoedov, N. F. (2020). Morphological changes in the large intestine of rats subjected to chronic restraint stress and treated with selank. Bulletin of Experimental Biology and Medicine, 169(2), 281–285.
    6. Yasenyavskaya, A.L. & Samotrueva, M.A. & Myasoedov, N.F. & Andreeva, L.A.. (2022). The experimental study of the immunomodulating action of Semax and Selank on the model of social stress. European Pharmaceutical Journal. 69. 54-60. 10.2478/afpuc-2022-0004.
    7. Kolik, L. G., Nadorova, A. V., Antipova, T. A., Kruglov, S. V., Kudrin, V. S., & Durnev, A. D. (2019). Selank, peptide analogue of tuftsin, protects against ethanol-induced memory impairment by regulating of BDNF content in the hippocampus and prefrontal cortex in rats. Bulletin of experimental biology and medicine, 167(5), 641–644.
    8. Nielsen S. Benzodiazepines. Curr Top Behav Neurosci. 2017;34:141-159. doi: 10.1007/7854_2015_425. PMID: 26695165.
    9. Volkova, A., Shadrina, M., Kolomin, T., Andreeva, L., Limborska, S., Myasoedov, N., & Slominsky, P. (2016). Selank administration affects the expression of some genes involved in GABAergic neurotransmission. Frontiers in pharmacology, 7, 31.
    10. Medvedev, V. E., Tereshchenko, O. N., Kost, N. V., Ter-Israelyan, A. Y., Gushanskaya, E. V., Chobanu, I. K., Sokolov, O. Y., & Myasoedov, N. F. (2015). Optimization of the treatment of anxiety disorders with selank. S.S. Korsakova, 115(6), 33–40.
    11. Koroleva, S. V., & Mjasoedov, N. F. (2019). Physiological Effects of Selank and Its Fragments. Biology Bulletin, 46(4), 407–414.
    12. Ershov, F. I., Uchakin, P. N., Uchakina, O. N., Mezentseva, M. V., Alekseeva, L. A., & Miasoedov, N. F. (2009). Antiviral activity of immunomodulator Selank in experimental influenza infection. Voprosy virusologii, 54(5), 19–24.
    13. Ashmarin, I.P., Baglikova, K.E., Edeeva, S.E. et al. (2008). A comparative analysis of the distribution of glyprolines after their administration by different ways. Russ J Bioorg Chem 34, 415–420.
    14. Vasil'eva, E. V., Kondrakhin, E. A., Salimov, R. M., & Kovalev, G. I. (2016). Comparison of pharmacological effects of heptapeptide Selank after intranasal and intraperitoneal administration to BALB/c and C57BL/6 mice. Eksperimental'naia i klinicheskaia farmakologiia, 79(9), 3–11.
    15. Clevett K. J. (1990). High-performance liquid chromatography. Bioprocess technology, 6, 47–73.
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    17. Zach W gave Peptidesciences 5 stars. Check out the full review... (2023, April 3). Trustpilot.
    18. Sciences gave Peptidesciences 5 stars. Check out the full review... (2021, November 6). Trustpilot.
    19. National Institutes of Health. (2014). Bacteriostatic Water. U.S. National Library of Medicine.


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