Class of Compound:
Mechanism of Action:
Semax is known to stimulate neurotrophic factors in the central nervous system, namely Brain-Derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF). It further appears to impact serotonin, dopamine, and enkephalin signaling.
Also Known As:
MEHFPGP, I5FAL2585H, Pro-Gly-Pro-ACTH(4-7), ACTH(4–7)PGP
- Cognitive performance
- Mood Regulation
- Limited clinical studies
- No FDA review or approval
- Injection site reactions (for injectable Semax)
What is Semax?
Semax is a synthetic peptide that was first developed by Russian researchers in the 1980s. It is authorized in Russia and Ukraine for indications including ischemic brain stroke, encephalopathy, optic nerve atrophy, and cognitive disorders such as dementia.
Structurally, Semax is made of seven amino acids, including a four amino acid fragment (Met-Glu-His-Phe) from ACTH (4-7) and a Pro-Gly-Pro fragment attached at the C-terminus. This structure allows the peptide to cross the blood-brain barrier [4, 5].
Modern researchers report that Semax can reach significant concentrations in central nervous tissues and exert its purported benefits on the brain, such as neuroprotection and enhanced cognitive performance [6, 7].
Semax is also frequently modified via acetylation and amidation, leading to the formation of N-Acetyl Semax Amidate. This alteration may modulate its interaction with substances like copper ions and redox agents, possibly enhancing its stability in the process [8, 9].
Before purchasing Semax for research purposes, it is critical to understand this peptide’s side effects, risks, dosing guidelines, and legal status.
Our team of researchers covers all of these considerations below before providing our top recommendations for where to buy Semax online as a reference material.
How Does Semax Work?
Semax is a research peptide that is designed to cross the blood-brain barrier (BBB) while avoiding the hormonal effects of ACTH [5, 10, 11]. Instead, Semax may improve overall brain health and enhance cognitive performance via the following mechanisms:
- Interacting with dopamine, serotonin, and enkephalin signaling [12, 13], and
- Elevating Brain-Derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF) levels in the brain for enhanced neurogenesis and neuroregeneration .
Researchers report that Semax may exert its neuroprotective benefits by upregulating both BDNF levels and the corresponding tropomyosin-related kinase B (trkB, aka tropomyosin receptor kinase B) receptors found in brain cells .
BDNF is a neurotrophic growth factor that is key to brain cell survival and neuroplasticity. Semax appears to upregulate BDNF levels 1.4-fold and the trkB receptor expression 2-fold .
Further, studies reveal that the peptide may interact with serotonin and dopamine signaling in the brain, although the potential effect of these interactions is not well-studied . Some studies also report an upregulating effect of Semax on enkephalins—the physiological ligands of opioid receptors [13, 16].
Interacting with these neuromodulators in the brain may have effects on mood, stress, cognition, and reward-related behavior [12, 13]. However, researchers are yet to investigate whether Semax has any related benefits. So far, only test animal experiments report potential protective effects of Semax against anxiogenic substances .
Semax may also provide benefits outside the nervous system, such as regulating blood flow, microcirculation, and vascular permeability in the gastrointestinal system. As a result, the peptide may have anti-ulcer effects, but more research is required to confirm these benefits .
Researchers are actively investigating the potential effects of Semax on the brain and other organs. Preliminary research suggests that potential benefits of Semax include:
- Cognitive enhancement
- Mood regulation
- Neuroprotective properties
Below, we will take a closer look at each of these potential benefits.
Semax for Cognitive Enhancement
The available clinical data suggest that there is a potential effect of Semax on cognition. One study examined the impact of intranasal Semax on the cognitive functions of healthy but fatigued study volunteers who had completed 8-hour work shifts .
Following a single intranasal administration of the peptide at a dosage of 16mcg/kg of body weight, the effects lasted for 24 hours. According to the researchers' findings, participants who received Semax demonstrated a 71% accuracy rate on a memory test, in stark contrast to the average 41% rate observed in the control group .
Another trial investigated the impact of Semax on the default mode network (DMN) of the brain in 24 middle-aged individuals using fMRI. DMN is associated with the evaluation and processing of emotions, episodic memory, and capacity for social interactions. The participants received either a 1% Semax solution or placebo via intranasal application, and fMRI scans were conducted before administration, as well as 5 and 20 minutes afterward .
The results indicated that the Semax group exhibited increased volume in the rostral subcomponent of the DMN, specifically within the medial frontal cortex, compared to the control group. Semax was thus speculated to provide potential benefits for associated functions such as information processing and episodic memory .
Semax for Mood Regulation
Currently, the evidence on the potential of Semax for mood regulation in conditions such as anxiety and depression is scarce.
An animal study explored the effects of intranasal Semax (50 and 500mcg/kg) on anxiety and depression in rats, both in their normal state and under stress induced by CCK-4 (cholecystokinin-tetrapeptide)—an anxiogenic substance commonly used to simulate anxiety disorders.
While Semax had no effect on rats in their normal state, it was able to normalize disrupted behavior caused by CCK-4, suggesting potential anxiolytic and antidepressant effects when anxiety and depression levels are elevated .
Semax for Neuroprotection
Semax has been studied primarily for its potential neuroprotective effects. Several preclinical and clinical trials support the peptide's benefits for various neurodegenerative and neuroinflammatory conditions, including stroke.
For example, in a trial involving 110 stroke patients, intranasal administration of Semax in two 10-day courses of 6000mcg/day showed increased plasma BDNF levels. This led to improved motor performance and enhanced functional independence as assessed by Barthel index scores—an index for assessing functional independence in stroke patients .
Another trial conducted on patients with acute stroke patients also demonstrated significant anti-inflammatory benefits of Semax. The study indicated that Semax contributed to an increased prevalence of anti-inflammatory mediators (such as interleukin-10 and tumor necrosis factor-alpha) while reducing proinflammatory factors (such as interleukin-8 and C-reactive protein) .
In a smaller study involving 30 patients with chronic brain ischemia, a condition often associated with dementia, Semax was administered in conjunction with adenosine diphosphate (ADP) and collagen. The treatment group exhibited better recovery outcomes than the control group. The study authors reported that the peptide improved the patients' conditions by exerting both neurotrophic and anti-platelet effects .
Clinical trials also report that intranasal Semax has been shown to protect against pressure-induced nerve damage in glaucoma patients .
Further, the peptide may provide benefits versus various neurotoxins. For example, one clinical trial suggests that the peptide protects against the neurotoxic effect of alcohol intoxication .
Pre-clinical trials have also reported protective effects of Semax in a rat model of Parkinson's induced by the neurotoxin MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) .
Semax for Gastroprotection
According to Ivanikov et al. (2002), Semax has potential gastroprotective and anti-ulcer effects. The study showed that intranasal administration of a 1% Semax solution was nearly three times more effective than placebo in promoting the healing of peptic ulcers.
Participants in the treatment group received 2-4 drops of Semax in each nostril three times daily for 10 days, and experienced a healing rate of approximately 90%, compared to just over 30% in the placebo group .
As mentioned, the researchers postulated that these positive outcomes may be attributed to an unexplored influence of Semax on the regulation of blood flow, microcirculation, and vascular permeability. However, more research is needed to confirm these mechanisms .
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Semax Dosage and Administration
It's critical to understand data on Semax dosing prior to using the peptide in research. Intranasal Semax is officially approved in Russia as two different formulations: a 0.1% solution and a 1% solution, which differ in indications and dosing recommendations .
According to the official recommendations on the Semax Nasal Drops 0.1%, the peptide is administered as follows :
- Mental fatigue: 400–900mcg/day split between two or three administrations for 3-5 days.
- Mild cognitive dysfunctions in children and adolescents aged 7-18: 200–400mcg split between 2 administrations per day for 30 days.
- Optic nerve disorders: The daily dose is 600–900mcg, split between two to three administrations for 7–10 days.
- Amnestic cognitive impairment (cerebrovascular lesions, dyscirculatory encephalopathy, etc.): 200–2000mcg (3–30mcg/kg)/dose, applied four times daily for 10-14 days. The total daily dose is 800–8000mcg (7–70mcg/kg).
Semax Nasal Drops 1% are clinically administered as follows :
- Stroke of moderate severity: 2000mcg-3000mcg administered three to four times a day, with 3-4 hour intervals between each application, for 10 days. The total daily dose is 6000mcg-12000mcg.
- Severe stroke: 3000mcg-4000mcg administered four to six times daily, at intervals of 2.5–3 hours, for up to 10 days. The total daily dose is 12000mcg-20000mcg.
Some trials have also employed 1% Semax nasal spray cycling, involving 10 days on and 20 days off, followed by 10 days of administration, at doses of 6000mcg/daily in stroke patients .
On the other hand, 0.1% intranasal Semax has been used for up to 30 days in adult glaucoma patients .
Unfortunately, there are no officially approved dosing guidelines or clinical studies examining the potential dosage of injectable Semax. Further, it may be difficult to extrapolate the data from the dosing of intranasal Semax to injectable Semax.
Therefore, scientists and qualified professionals may consider employing a dosing regimen of 1000mcg/daily or less in their research with injectable Semax.
- Daily Injectable Dosage: 500mcg-1000mcg of Semax, injected subcutaneously, depending on the subjects' responsiveness.
- Study Duration: Up to 30 days at doses of 1000mcg/daily. Researchers may also consider 500mcg/daily for up to 60 days.
- Semax Cycle: Ensure a rest period at least equivalent to the study duration.
- Notes: A 30mg vial of Semax for reconstitution provides 30 doses of 1000mcg/daily or 60 doses of 500mcg/daily. Monitor subjects' neurological, psychological, and physical status and EEG signs.
How To Administer Semax Nasal Spray
Semax was originally developed in Russia and approved in nasal drop format. This remains a common administration method in research settings. Compared to injections, intranasal sprays and droppers are painless and do not carry a risk of adverse reactions at the injection site.
Here are the required steps for administering Semax nasal spray:
- Preparation: Clean the application nozzle with an alcohol swab, and gently roll the solution to ensure it is properly mixed. Do not shake. Instruct each test subject to blow their nose and determine which nostril is more open.
- Positioning: Tilt the subject's head, gently close one nostril using the non-dominant hand, and grasp the nasal spray in the dominant hand.
- Administration: Insert the nozzle into the open nostril, as far as possible into the subject's nose. Press down on the spray bottle to release a single spray. Instruct subjects to inhale through their nose slowly and gently.
- Repeat: Wait 30-60 seconds in between sprays to prevent oversaturation of the mucosa, and repeat for the desired number of doses (if necessary).
- Aftercare: After administering the dose, clean the nozzle with an alcohol swab.
Semax nasal spray is painless and easy to administer, making it extremely popular among peptide researchers.
How To Administer Semax Injections
Subcutaneous injections are a common administration route for scientists studying the effects of research peptides such as Semax.
Researchers should note that injectable Semax for investigation is available as a lyophilized powder that must be reconstituted with an appropriate solvent before use.
Usually, bacteriostatic water is the best option for reconstituting research peptides as it contains 0.9% benzyl alcohol as a preservative .
This will ensure that the reconstituted vial of Semax remains viable for up to four weeks when refrigerated properly at 36 to 46 degrees F.
Here is a step-by-step guide for administering Semax injections to test subjects:
- Preparation: Gather all necessary items, including the reconstituted Semax vial, sterile needles and syringes for subcutaneous injection, alcohol swabs, and a sharps container.
- Drawing the solution: Disinfect the stopper of the vial. Draw the desired dosage using the sterile syringe. Do not shake or tap the syringe, as doing so may damage the peptide.
- Choosing an injection site: Peptides can be injected subcutaneously in the abdomen, thigh, or upper arm. Remember to rotate the injection sites with each use for all subjects.
- Preparing the injection site: Disinfect the research subject's skin at the injection site and pinch the subject's skin with the fingertips of the non-dominant hand. Take into account subcutaneous fat variations.
- Administering the injection: Insert the needle at a 45-degree angle with the bevel up, and slowly depress the plunger.
- Aftercare: Wait a few seconds after injecting the peptide and withdraw the syringe, dispose of the used needle and syringe using the sharps container, and apply light pressure to the injection site using an alcohol swab. Always use a new sterile needle and syringe for each injection.
Semax Side Effects and Safety Precautions
Researchers have safely administered intranasal Semax in doses from 600mcg/daily to 12mg/daily for up to 10 consecutive days [23, 32]. Longer Semax safety trials also report that the peptide is not associated with any side effects following 30 days of intranasal administration in glaucoma patients as a 0.1% spray .
Another study reporting on the peptide’s nootropic effects in healthy individuals suggests that an intranasal dose of 16.0mcg/kg of body weight may have stimulant-like effects and lead to slightly elevated anxiety levels .
Several studies exploring the potential adverse effects of heightened brain-derived neurotrophic factor (BDNF) levels have also reported a potential link to increased hair loss in men predisposed to baldness . While Semax enhances BDNF, the specific impact on androgenetic alopecia remains uncertain.
On the other hand, the safety of injectable Semax has not been evaluated in clinical settings. Instead, it has been conducted primarily on test animals and the available data do not reveal any safety signal [7, 10, 26, 34].
It is important to note that clinical trials with Semax are scarce, and more research is needed to evaluate its safety. Here are some steps that researchers may consider to reduce the risk of unexpected negative side effects from Semax in their research subjects:
- Optimize dosing: Researchers should consider starting with the lowest effective dose, such as 600mcg/daily intranasally or 500mcg/daily subcutaneously, and titrate based on the test subject’s response and research objective.
- Stay hydrated: Encourage research subjects to stay hydrated by drinking sufficient water throughout the day.
- Limit use of other nootropics: Semax may be "stacked" or combined with other nootropics. However, this may increase the risk of short-term side effects and may not be optimal for all research participants.
- Maintain a healthy diet: Encourage all research participants to maintain a healthy diet for the duration of the study.
- Limit caffeine intake: Semax acts as a mild stimulant. Research subjects should be encouraged to limit caffeine intake to reduce the risk of side effects.
Following these steps is imperative to reducing the risk of side effects in research studies.
Where to Buy Semax Online? | 2024 Version
Qualified researchers interested in studying Semax are advised to purchase this research peptide from a trustworthy vendor committed to peptide purity and customer satisfaction.
We've reviewed dozens of Semax suppliers, and after extensive research, our verdict is clear: Limitless Life and Core Peptides are two of the best online Semax suppliers worldwide.
Limitless Life is our preferred option for Semax nasal spray, while Core Peptides is our #1 choice for high-quality Semax injections.
When looking for high-quality intranasal peptides, such as a Semax nasal spray, researchers should look no further than Limitless Life.
Here are just a few of the reasons as to why we recommend purchasing Semax nasal spray from this vendor:
- Lab-Tested Semax: All products are tested by both in-house and 3rd party labs for a minimum 98% purity. Each batch of Semax has a certificate of analysis showcasing product purity.
- Payments & Shipping: They accept payments via Revolut, CashApp, Zelle, and credit cards. Shipping is lighting fast, with most orders processed the same day they are placed.
- Incredible Customer Support: The Limitless Life team is available by phone and email and will promptly address all product- and order-related questions.
In addition, the vendor also offers an N-Acetyl Semax Amidate nasal spray, which may potentially exert increased stability and effectiveness. Purchase intranasal Semax with confidence from Limitless Life.
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Core Peptides is another highly trusted vendor of research peptides, and here’s why we love them for injectable Semax:
- Made in the USA: Core Peptides compounds are sourced from accredited facilities located in the United States and are free of fillers and contaminants commonly found in imported products.
- Lab Reports: This vendor provides detailed lab reports demonstrating product purity and consistency via independent third-party testing, including high-performance liquid chromatography and mass spectrometry (HPLC-MS).
- Customer Satisfaction: Additional benefits about this company include free shipping for orders above $200, secure SSL-protected shopping, and reliable 24/7 customer service.
Core Peptides provides world-class Semax reference material that is perfect for researchers studying the effects of this breakthrough peptide.
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Semax Nasal Spray vs. Semax Injections
Researchers may be wondering about the differences between Semax nasal spray and injections, including which will be the better option for conducting their research.
In reality, the better option will depend on factors such as the research objective, test subjects' tolerance to injections, and availability of reference materials.
Leading researchers have successfully incorporated both options into their research, so it's important to understand the pros and cons of each before making a final decision on the route of administration.
Overall, Semax nasal spray is the more researched of the two. However, the subcutaneous route of administration has well-known advantages over other strategies that should also be considered. Here's why:
- Injections: Although clinical research with injectable Semax is lacking, subcutaneous administration is usually associated with more precise and reliable dosing, as there are fewer factors that may interfere with the peptide’s absorption and bioavailability.
- Nasal Spray: Semax nasal spray may have varying absorption rates between individuals, making it harder to study the precise therapeutic benefits achieved at different dosages.
While both forms of Semax appear to be suitable for conducting successful research, there is significantly greater variation in absorption and bioavailability between individuals when using the nasal spray.
This means Semax injections are the clear choice for researchers looking to study the peptide while ensuring consistent absorption and bioavailability among test subjects.
Differences in Administration
Semax nasal spray offers several advantages in terms of ease of administration. Here's why:
- Nasal Spray: Semax nasal spray is incredibly easy and painless to administer.
- Injections: Some test subjects may find Semax injections painful, unpleasant, or poorly tolerated due to reactions at the injection site, which reduces overall compliance.
If ease of administration is the determining factor, then researchers are encouraged to use Semax nasal spray in their research studies.
Side Effect Profiles
Overall, Semax nasal spray has been thoroughly investigated in clinical trials regarding potential side effects, while research on the safety of Semax injections is scarce. Further, the administration via subcutaneous injections carries a risk of specific side effects.
- Nasal Spray Side Effects: Semax nasal spray has an excellent side effect profile, and the available clinical research does not report any side effects. Nasal discomfort may be possible [19, 30, 32, 33].
- Injectable Form Side Effects: Potential side effects of Semax injections include local reactions such as pain at the injection site, skin irritation, redness, bleeding, swelling, and infections. Other potential side effects are unknown.
Semax injections may have a greater risk for side effects, and more research is needed to evaluate their safety compared to intranasal Semax.
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Preclinical and clinical research has reported a wide range of potential benefits in test subjects.
Upon reviewing the available evidence on Semax, the results can be presented as a short summary of the pros and cons of this research peptide:
Pros of Semax
- Improved cognitive function: Semax has been suggested to improve cognitive function, including short-term and long-term memory, learning ability, and concentration [19, 20].
- Neuroprotection: Semax appears to protect neurons from inflammation and oxidative stress [21, 23, 25, 26, 30].
- Increased BDNF and NGF: Semax increases levels of BDNF (brain-derived neurotrophic factor) and NGF (nerve growth factor)—two molecules that play a crucial role in neural health and neuroplasticity .
- Antidepressant and anxiolytic effects: The peptide may modulate stress and anxiety responses to stress in preliminary research. This may be mediated by its effects on various neurotransmitters .
- Gastroprotection: Semax may provide anti-ulcer effects via regulation of blood flow, microcirculation, and vascular permeability in gastrointestinal tissues .
Cons of Semax
- Limited research: Few long-term human trials have been performed on Semax thus far. More research is needed to better understand its therapeutic benefits and side effects.
- Side effects: Scientists hypothesize that Semax may exert stimulant-like effects leading to increased anxiety in some individuals .
- Lack of regulatory oversight: Semax is not an FDA-approved drug or medication. As such, it should only be used by experienced researchers looking to study the effects of Semax in a controlled environment.
Semax. Just. Works.
Semax offers a range of potential cognitive and neurological benefits, including neuro-regeneration, improved neuroplasticity, and increased memory and attention span.
This guide summarizes what researchers must know about this breakthrough research peptide, including dosing guidelines and findings from the latest clinical studies.
Researchers should be aware that Semax is classified as a research peptide in most of the world, and more clinical data is needed to identify all potential benefits and side effects. For now, caution is required while handling Semax. This is true when administering either Semax injections or a Semax nasal spray.
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- Chang CH, Tsai WC, Hsu YH, Pang JH. Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts. Molecules. 2014;19(11):19066-19077. Published 2014 Nov 19. doi:10.3390/molecules191119066
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- Strinic D, Belosic Halle Z, Luetic K, Nedic A, Petrovic I, Sucic M, Zivanovic Posilovic G, Balenovic D, Strbe S, Udovicic M, Drmic D, Stupnisek M, Lovric Bencic M, Seiwerth S, Sikiric P. BPC 157 counteracts QTc prolongation induced by haloperidol, fluphenazine, clozapine, olanzapine, quetiapine, sulpiride, and metoclopramide in rats. Life Sci. 2017 Oct 1;186:66-79. doi: 10.1016/j.lfs.2017.08.006. Epub 2017 Aug 7. PMID: 28797793.
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