Titus Thorne

Last Updated April 13, 2023

Titus Thorne

 April 13, 2023

Researchers looking to incorporate a GH secretagogue into their work may be unclear on the matter of ipamorelin dosage.

Ipamorelin is among the most studied growth hormone stimulators, and has been shown to yield benefits like: 

  • Improved body composition 
  • Repair of muscular and skeletal tissue 
  • Improved bone health 

This ipamorelin dosage calculator and guide will offer a summary of the available research and highlight key findings that may help inform the design of future experiments. 

Read through the end as we reveal our preferred source of research-grade ipamorelin online.

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Disclaimer: Peptides.org contains information about products that are intended for laboratory and research use only, unless otherwise explicitly stated. This information, including any referenced scientific or clinical research, is made available for educational purposes only. Peptides.org makes every effort to ensure that any information it shares complies with national and international standards for clinical trial information and is committed to the timely disclosure of the design and results of all interventional clinical studies for innovative treatments publicly available or that may be made available. However, research is not considered conclusive. Peptides.org makes no claims that any products referenced can cure, treat or prevent any conditions, including any conditions referenced on its website or in print materials.

What is Ipamorelin?

Ipamorelin is a synthetic ‘pentapeptide’ which means it contains a string of five amino acids [1]. Generally speaking, peptides are compounds made up of amino acids that stimulate biological functions. Ipamorelin mimics ghrelin and has a strong effect on growth hormone (GH) and insulin-like growth factor 1 (IGF-1). 

In essence, ipamorelin is what’s known as a growth hormone (GH) secretagogue, or GHS. A GHS is a type of peptide that promotes the body to produce growth hormone (GH) also known as human growth hormone (HGH). Ipamorelin binds to the same receptors as ghrelin (GHSR-1a receptors) and increases levels of GH and IGF-1 [2]. 

To give a fuller explanation, HGH is produced and distributed by the pituitary gland, the part of the body that is responsible for controlling and maintaining the endocrine system. It regulates hormone levels for the thyroid system, spleen, reproductive organs, and the development of bone growth during human development.

Ipamorelin works by simulating the function of particular hormones and molecules, which then prompt the body to produce and distribute more natural human growth hormone (HGH) [3].

At the same time, it controls the amount of a growth hormone inhibiting hormone (GHIH), known as somatostatin, which inhibits the natural output of GH. By suppressing the body’s somatostatin levels, ipamorelin increases levels of GH in test subjects [4].


Ipamorelin Benefits and Uses

So, what are some of the benefits and uses of ipamorelin?

In humans, ipamorelin does not have any recognized therapeutic uses. It is not approved for human use and is currently classified as a research chemical. 

The majority of the research conducted on ipamorelin’s benefits has taken place in lab settings on animals. There is limited research data from human trials and ipamorelin has yet to pass Phase II trials. 

Here’s a brief review of the main ipamorelin research conducted to date:

  • Aids in bone growth and formation: Studies in rats show that ipamorelin can stimulate long-term bone growth depending on the dosage. Researchers have theorized that ipamorelin may be an effective way to both assist in childhood growth and lower the effects of osteoporosis later in life [4, 5].
  • Decreases body fat: Ipamorelin appears to speed up the growth hormone levels necessary for lipolysis, which is the process by which fats are broken down in our bodies through enzymes and water, or hydrolysis [6].
  • Increases lean muscle mass and body composition: Evidence suggests that ipamorelin can encourage the body to produce more lean muscle mass, likely due to the way that it increases natural GH levels [7]. 
  • Reduces constipation and promotes gut healing: Some research has demonstrated that using ipamorelin post-intestinal/bowel surgery speeds up recovery rates and leads to more immediate bowel movements, in addition to improved patient outcomes in general [8].
  • Diminished signs of aging: Studies have shown that ipamorelin can promote the liver to generate IGF-1, which stimulates the regeneration of bone and body tissue [9].
  • Better sleep quality: There is some support for ipamorelin HGH as a sleep aid, in that it facilitates longer, deeper sleep by encouraging natural GH production and stimulating the body’s natural ability to recover and revitalize from daily activities [10]. 

While this research may appear encouraging, ipamorelin currently has no officially recognized uses. This suggests that further research, especially well-designed, long-term clinical trials, may be warranted. 

Let’s take a look at some of the side effects associated with ipamorelin. 

Ipamorelin Side Effects

Researchers curious about potential ipamorelin side effects should note that human experiments with this research chemical are not permitted. We can, however, discuss past studies to get a sense of its overall safety profile and how well it is tolerated by test subjects. 

The existing research shows that ipamorelin is generally well-tolerated by test subjects [11]. Some researchers have theorized that since ipamorelin stimulates the production of GH in a way that mimics the body’s natural GH secretion patterns, it is discharged in a more consistent manner that is less intense than other Growth Hormone-Releasing Peptides (GHRPs). 

Unfortunately, studies involving human test subjects have been of short duration and little is known about the long-term effects of ipamorelin administration. This suggests that there is still a need for more human research trials to produce definitive results [12]. 

Based on the available research, it appears that any side effects experienced by test subjects as a result of ipamorelin administration are minor and dose-dependent. The data shows that when taken in low and moderate dosages, ipamorelin causes mild side effects such as:

  • Temporary redness, itching, or sensitivity at the site of the injection
  • Dry mouth
  • Nausea
  • Weight gain, usually associated with increased muscle mass and body fat loss

In rare cases, some severe side effects have been observed, including:

  • Water retention
  • Tingling/numbness in the hands and feet
  • Insulin resistance
  • Hypertension

This indicates that researchers interested in experimenting with ipamorelin would be well-advised to exclude test subjects with pre-existing conditions such as diabetes and hypertension.

Let’s now turn our attention to the question at hand: how should researchers calculate the correct dosage for ipamorelin? 

Ipamorelin Dosage Calculator and Guide

Researchers interested in exploring the effects and side effects of ipamorelin will note that this research chemical has no safe dosage. While it may be purchased as a reference material, it has not been approved for human research and there are no clear guidelines for how it should be dosed or administered to humans. 

Researchers can consult the relevant literature from past trials to see how it has been dosed in past studies. Here is a brief guide to how ipamorelin has been dosed in previous studies. 

Ipamorelin dosing forms

Ipamorelin can be found in a few different forms, including oral, nasal, powder, and liquid. The most commonly used method of delivery is by injection, either subcutaneously (into a fatty area like the thigh) or intramuscularly (right into a muscle like a bicep), since this is the most quickly absorbed by the body with the most immediate results.

Ipamorelin dosage calculator for new researchers

Despite strong research interest in ipamorelin’s purported benefits, there is no published research to indicate the dose at which new researchers should administer this peptide to test subjects. 

Researchers may consult the findings of a 2014 study by Beck et al. that explored the use of ipamorelin in bowel resection patients for the management of postoperative ileus. Researchers administered ipamorelin twice daily at a dose of 0.03 mg per kilogram of body weight [13]. 

In this study, ipamorelin was administered via intravenous infusion on postoperative days 1 to 7. Researchers noted that ipamorelin was “well-tolerated” by test subjects and produced no serious adverse events (AEs) [13].  

Using the design of this study as a guide, researchers may observe that 0.03mg/kg can be used as a starting point for future experiments. At this dosage, an 80 kg test subject would be administered 2.4 mg of ipamorelin twice per day for the duration of the experiment. 

The short-term nature of this study (seven days) does not help inform the optimum duration of future experiments, nor what side effects test subjects may experience as a result of long-term ipamorelin administration. 

Typical ipamorelin dosing

Based on the available evidence, there is no “typical” or “recommended” dose at which ipamorelin may be administered. However, the practice of dividing a test subjects’ daily dose into two or three smaller doses has been followed in multiple studies [14]. There is no evidence of any study lasting longer than eight weeks. This suggests that researchers may wish to limit experiments to within this time frame. 

Ipamorelin bodybuilding and athlete dosing

While there is strong research interest in the application of ipamorelin to improve athletic performance and bodybuilding, there are currently no published figures to indicate the dosage at which this peptide should be administered to these ends [15].  

As studies on ipamorelin in human test subjects are lacking, further research may be warranted. The absence of research suggests that research may consider the dosage used in the study by Beck et al. (0.03 mg/kg) as a starting point when designing future experiments. 

Ipamorelin dosage rest cycle

The only published trial data (Beck et al.) examined the use of ipamorelin for a very short period of time (7 days) and little is known about the long-term effects of this peptide in human test subjects. To date, no studies have examined the length of time that test subjects may need to rest between different cycles of ipamorelin.

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CJC 1295 + Ipamorelin Blend Dosage

There is strong research interest in the effects of CJC-1295 combined with ipamorelin and many researchers are curious about whether these two research peptides work synergistically. 

CJC 1295 is a peptide hormone that appears to stimulate growth hormone emission, improve the immune system, lessen recovery time, and offer anti-aging effects [16]. In addition, it appears to upregulate the body’s GH levels while keeping them stable.

As previously stated, ipamorelin specifically stimulates GH without activating other hormones, thereby reducing the likelihood of negative side effects. Similarly, CJC 1295 selectively activates GH.

There is some clinical evidence to support the idea that administering a CJC 1295 + ipamorelin blend dosage may be more effective than administering either of them alone [17]. In combination, CJC 1295 and ipamorelin stimulate GH via divergent routes. By attaching to different receptors, CJC 1295 and ipamorelin may have an additive effect and intensify GH discharge and activity resulting in a significant boost in GH concentration.

Some researchers have theorized that this combination treatment may be especially helpful in managing the signs and symptoms of aging, as well as aiding in the relief of inflammatory conditions.


Where to Buy Ipamorelin Online? | 2023 Guide

Researchers will find that ipamorelin can easily be ordered online. However, since it is not a regulated product, it is recommended that researchers seek out reputable suppliers to ensure that they get the best quality peptides possible.

Our favorite supplier is Peptide Sciences. Here’s what we like about them:

  • Research-grade peptides: They sell 99%+ pure ipamorelin without any additives or fillers. 
  • Fast shipping: Orders within the US arrive in 2-3 days. International orders can take 7-10 days. There’s a $15 fee for shipping, but this is waived for orders over $100.
  • Payment is easy: They have a secure payment system and accept most major credit cards and a range of cryptocurrencies. 
  • Great customer service: These guys are professional and answer all their customers’ questions themselves.

They’re the best we’ve come across so far, so we fully recommend them.

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Bacteriostatic Water for Injection

Every researcher can attest to the importance of having the right tools available. This is especially true for researchers with experience handling Ipamorelin and other peptides.

To successfully administer peptides, a researcher needs items such as bacteriostatic water, insulin syringes, and sterile vials for reconstitution and storage.

Gathering the required materials can take up time and effort, putting a damper on research activities.

In an effort to facilitate your research, the Peptides.org team has selected your single best source for auxiliary materials online.


Enjoy the convenience of receiving all required research supplies in a deluxe kit from BacteriostaticWater.org. The trusted site offers two research kit options, saving you the headache of searching for the full set of products from various retailers.

Included in the starter research kit are the following:

  • Bacteriostatic Water (30mL) – 3x
  • Insulin Syringes (0.5 cc/mL x 29g x ½) – 100x
  • Alcohol Prep Pads – 200x
  • Sterile Empty Glass Vial (10mL) – 1x
  • Large Needles + Syringes Combo (3cc x 21g x 1) – 10x

In the premium research kit, you will find:

  • Bacteriostatic Water (30mL) – 5x
  • Insulin Syringes (0.5 cc/mL x 29g x ½) – 200x
  • Alcohol Prep Pads – 200x
  • Sterile Empty Glass Vial (10mL) – 2x
  • Large Needles + Syringes Combo (3cc x 21g x 1) – 20x

Expedite your peptide research with a top-notch supply kit from our number one recommendation.

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Ipamorelin Dosage | The Verdict

So what does the evidence suggest about ipamorelin dosage?

Ipamorelin studies are lacking overall and this merits further research, but what limited data exists suggests that ipamorelin offers some promising benefits in the area of body composition and recovery rates. The limited nature of the studies conducted to date points to the need for long-term, placebo-controlled clinical trials to test the safety and efficacy of ipamorelin. 

Researchers interested in exploring ipamorelin’s benefits and side effects in greater detail may consider contacting Peptide Sciences to discuss their research needs.


  1. Raun, K, Hansen, B., Johansen, N., Thogersen, H, Madsen, K, Ankersen, M, & Andersen, P. (1998). Ipamorelin, the first selective growth hormone secretagogue. European Journal of Endocrinology. 139 (5): 552–561.
  2. Gobburu, J.V. S., Agersø, H., Jusko, William J., & Ynddal, Lars (1999). Pharmacokinetic-Pharmacodynamic Modeling of Ipamorelin, a Growth Hormone Releasing Peptide, in Human Volunteers. Pharmaceutical Research. 16 (9): 1412–1416.
  3. Estrada, R. Cañete; Jiménez-Reina, L.; de la Torre, M.J.; Bernal, J. (2002). “Chronic In Vivo Ipamorelin Treatment Stimulates Body Weight Gain and Growth Hormone (GH) Release In Vitro in Young Female Rats. European Journal of Anatomy. 6 (1): 37–46.
  4. Johansen, P.B., Nowak, J., Skjaerbaek, C., FLyvbjerg, A., Andreassen, T.T., Wilken, M., & Orskov, H. (1999). Ipamorelin, a New Growth-Hormone-Releasing Peptide, Induces Longitudinal Bone Growth in Rats. Growth Hormone & IGF Research. 9(2): 106-113.
  5. Svensson, J., Lall, S., & Dickson, S.L. (2000). The GH Secretagogues Ipamorelin and GH-Releasing Peptide-6 Increase Bone Mineral Content in Adult Female Rats. Journal of Endocrinology. 165(3): 569-577.
  6. Howick, K., Griffin, B.T., Cryan, J.F., & Schellekens, H. (2017). From Belly to Brain: Targeting the Ghrelin Receptor in Appetite and Food Intake Regulation. International Journal of Molecular Sciences. 18(2): 273.
  7. Anderson, N.B., Malmlof, K., Johansen, P.B., Andreassen., T.T., Ortoft, G., & Oxlund, H. (2001). The Growth Hormone Secretagogue Ipamorelin Counteracts Glucocrticoid-Induced Decrease in Bone Formation of Adult Rats. Growth Hormone & IGF Research. 11(5): 266-272.
  8. Mosinka, P., Zatorski, H., Storr, M., & Fichna, J. (2017). Future Treatment of Constipation-Associated Disorders: Role of Relamorelin and Other Ghrelin Receptor Agonists. Journal of Neurogastroenterol and Motility. 23(2): 171-179.
  9. Merriam, G.R., Barsness, S., Buchner, D., Kletke, M., Larsen, L.H., Moe, K.E., Schwartz, R.S., & Vitiello, M.V.. (2004). Growth Hormone Releasing Hormone Treatment Normal Aging. Journal of Anti-Aging Medicine. 4(4): 331-343.
  10. Isidro, M.L. & Cordido, F. (2006). Growth Hormone Secretagogues. Combinatorial Chemistry & High Throughput Screening. 9(3): 175-180.
  11. Moulin, A., Ryan, J., Martinez, J., & Fehrentz, J.A. (2007). Recent Developments in Ghrelin Receptor Ligands. ChemMedChem. 2(9) 1242-1259.
  12. Aagaard, N.K., Grofte, T., Griesen, J., Malmlof, K., Johansen, P.B., Gronbaek, H., Orskov, H., Tygstrup, N., & Vilstrup, H. (2009). Growth Hormone and Growth Hormone Secretagogue Effects on Nitrogen Balance and Urea Synthesis in Steroid Treated Rats. Growth Hormone and IGF Research. 19(5): 426-431.
  13. Beck, D.E., Sweeney, W.B., & McCarter, M.D. (2014). Prospective, Randomized, Controlled, Proof-of-Concept Study of the Ghrelin Mimetic Ipamorelin for the Management of Postoperative Ileus in Bowel Resection Patients. International Journal of Colorectal Disease. 29: 1527-1534.
  14. Pinyot, A., Nikolovski, Z., Bosch, J., Segura, J., & Gutiérrez-Gallego, R. (2010). On the use of cells or membranes for receptor binding: growth hormone secretagogues. Analytical biochemistry, 399(2), 174-181.
  15. Ipamorelin peptide (n.d.). Ipamorelin dosage. https://Ipamorelin-peptide.com/Ipamorelin-dosage/
  16. Teichman, S.L., Neale, A., Lawrence, B., Gagnon, C., Castaigne, J.P., & Frohman, L.A. (2006). Prolonged Stimulation of Growth Hormone (GH) and Insulin-Like Growth Factor I Secretion by CJC01295, a Long-Acting Analog of GH-releasing Hormone, in Healthy Adults. Journal of Clinical Endocrinology & Metabolism. 91(3): 799-805.
  17. Fitness Edge. (2020). Ipamorelin overview. https://fitnessedge.net/Ipamorelin-overview/

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