Titus Thorne

Last Updated November 17, 2021

Titus Thorne

 November 17, 2021

Looking for an Ipamorelin dosage calculator and guide? You’re in the right place.

Ipamorelin is a peptide that’s been commonly used among athletes to enhance training and conditioning [1]. More recently, it has gained popularity as an anti-aging treatment, as well as a way to support weight loss and help with inflammatory issues with seemingly minimal side effects.

That being said, the anticipated outcomes of Ipamorelin will vary from person to person depending on how it is utilized, particularly when it comes to the Ipamorelin dosage that you use.

So, let’s shed some light on Ipamorelin dosing and what you need to know!

Buy Ipamorelin from the #1 online Peptides vendor in the world: Peptides Sciences

Disclaimer: ResearchPeptides.org contains information about products that are intended for laboratory and research use only, unless otherwise explicitly stated. This information, including any referenced scientific or clinical research, is made available for educational purposes only. ResearchPeptides.org makes every effort to ensure that any information it shares complies with national and international standards for clinical trial information and is committed to the timely disclosure of the design and results of all interventional clinical studies for innovative treatments publicly available or that may be made available. However, research is not considered conclusive. ResearchPeptides.org makes no claims that any products referenced can cure, treat or prevent any conditions, including any conditions referenced on its website or in print materials.

What is Ipamorelin?

Ipamorelin is a simple, synthetically created peptide [2].

Generally, peptides are compounds made up of amino acids that stimulate biological functions. Ipamorelin is a growth hormone secretagogue, a type of peptide that promotes the body to produce growth hormone (GH) also known as human growth hormone (HGH).

HGH is produced and distributed by the pituitary gland, the part of the body that is responsible for controlling and maintaining the endocrine system. It regulates hormone levels for the thyroid system, spleen, reproductive organs, and the development of bone growth during human development.

Ipamorelin works by simulating the function of particular hormones and molecules, which then prompt the body to produce and distribute more natural human growth hormone (HGH) [3].

At the same time, it controls the amount of a growth hormone inhibiting hormone (GHIH), known as somatostatin, which inhibits the natural output of GH. By suppressing the body’s somatostatin levels, Ipamorelin is able to help the body increase its GH levels naturally [4].


Ipamorelin Benefits and Uses

So, what are some of the usages and benefits of Ipamorelin?
Although the majority of the research on Ipamorelin benefits and usage has been conducted in lab settings on animals with limited research in humans, there is still lots of evidence that Ipamorelin’s stimulates HGH production.
Here’s some of the stuff it can do:

  • Aids in bone growth and formation: Studies in rats show that Ipamorelin can stimulate long-term bone growth depending on dosage, which may be an effective way to both assist in childhood growth and lower the effects of osteoporosis later in life [4, 5].
  • Decreases body fat: Ipamorelin appears to speed up the growth hormone levels necessary for lipolysis, which is the process by which fats are broken down in our bodies through enzymes and water, or hydrolysis [6].
  • Increases lean muscle mass and body composition [7]: Evidence suggests that it can encourage your body’s lean muscle mass, likely because Ipamorelin can effectively raise natural GH levels. This increase in muscle mass also has the additional benefit of enhancing your metabolism, aiding in faster weight loss.
  • Reduces constipation and promotes gut healing [8]: Some research has demonstrated that using Ipamorelin post-intestinal/bowel surgery is related to faster recovery rates and more immediate bowel movements, in addition to a speedier recovery and better patient outcomes in general.
  • Diminishes signs of aging [9]: Studies have shown that Ipamorelin can promote the liver to generate IGF-1, which stimulates the regeneration of bone and body tissue.
  • Better sleep quality [10]: There is some support for Ipamorelin HGH as a sleep aid, in that it facilitates longer, deeper sleep by encouraging natural GH production and stimulating the body’s natural ability to recover and revitalize from daily activities.

Ipamorelin Side Effects

There appear to be numerous benefits to using Ipamorelin. However, what are the potential Ipamorelin side effects?

Ipamorelin is generally known for being the most well-tolerated growth hormone secretagogue [11]. Since Ipamorelin promotes the production of GH in a way that mimics the body’s natural GH secretion patterns resulting in the GH to be discharged in a more consistent manner that is less intense than other Growth Hormone Releasing Peptides (GHRPs), there are few side effects reported by the majority of its users.

Although there is still a need for more human research trials to produce definitive results [12], it appears that any side effects experienced by users are minor and dependant upon dosage. When taken in low and moderate dosages, mild side effects can include:

  • Temporary redness, itching, or sensitivity at the site of the injection
  • Dry mouth
  • Nausea
  • Weight gain, usually associated with increased muscle mass and body fat loss

Although uncommon in most Ipamorelin users, there are some more severe side effects that are indicative of high/excessive dosages which can include:

  • Water retention
  • Tingling/numbness in the hands and feet
  • Insulin resistance
  • Hypertension

There is also the potential for mild to severe side effects if you are taking other medications or supplements, particularly if any of them operate biological routes similar to those used by Ipamorelin.

Because it can affect your body’s blood sugar and blood pressure, you should avoid this if you have diabetes or high blood pressure.

Ipamorelin Dosage Calculator and Guide

As always, before beginning any new medications, supplements, vitamins, or other alternative treatments, please make sure you consult with your doctor/health care professional regarding dosages and usage.

Ipamorelin Dosing Forms

Ipamorelin can be found in a few different forms, including oral, nasal, powder, and liquid. The most commonly used method of delivery is by injection, either subcutaneously (into a fatty area like the thigh) or intramuscularly (right into a muscle like a bicep), since this is the most quickly absorbed by the body with the most immediate results.

Most growth hormone secretagogue types are dosed using 1 microgram (mcg) per kilogram (kg) of body weight [13], there is some evidence suggesting that the effectiveness of Ipamorelin increases with intake levels. Dosage also depends on the results you are trying to achieve (e.g., weight loss, muscle gains).

Ipamorelin Dosage Calculator For New Users

For new users, it is recommended that you start taking Ipamorelin once a day (morning is best to trigger an initial release). Take it at the same time every day to ensure that you are introducing it to your body at a constant level. This will maximize your results and minimize potential side effects.

In addition, it is suggested that you take the Ipamorelin within a few minutes of eating as this helps it absorb and flow into your bloodstream.

Beginners should start with lower Ipamorelin dosages for their first cycle.

  • A standard starting dosage is around 100mcg to 150mcg per day using a single injection for general health benefits.
  • Try a cycle of 8 to 12 weeks.

During your first cycle, the Ipamorelin HGH should rise organically as it is promoting your body’s natural GH production.

A standard starting dosage is around 100mcg to 150mcg per day using a single injection for general health benefits.

Typical Ipamorelin Dosing

On average, most Ipamorelin users end up using approximately 200mcg to 300mcg per dosage [14], injecting two to three times per day.

  • 200mcg to 300mcg per day
  • Split into two to three times per day
  • Cycle of 8 to 12 weeks
  • 1 month off

Again, this depends on what your goals are. The higher the dosage, the more significant the boost in growth hormone production which enables more muscle growth, fat loss, and faster healing from training and injury.

For weight loss and anti-aging benefits, it is recommended that you take a lower dosage (e.g., 150mcg to 200mcg once a day) to enable a more natural and steady release.

Experienced users may choose to use an “all day” sustained release (taking doses in the morning, afternoon, and evening at equal time intervals). Other users space out their dosages at the time intervals that are most conducive to their overall goals and level of expertise with usage.

Ipamorelin Bodybuilding and Athlete Dosing

For athletes and bodybuilders who work out regularly [15], Ipamorelin is typically taken:

  • Two to three times daily
  • At an average of 200mcg to 300mcg per dose
  • As part of a stacking regiment

For best results for Ipamorelin bodybuilding, one of the doses is taken approximately forty minutes prior to a workout in order to provide a performance boost during high-intensity workouts.

Regardless of the frequency and strength of dosages, it is recommended that users wait at least three hours in between if taking multiple doses per day.

Ipamorelin Dosage Rest Cycle

It is recommended that you take a 30-day break after your first cycle before starting up again or increasing your dosage to prevent receptor sensitization.

At this point, your doctor/health care professional can increase your dosage depending on your results and tolerance.

Do not try to adjust your dosage in the middle of the cycle, as this will increase the likelihood of negative side effects.

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CJC 1295 + Ipamorelin Blend Dosage

Combining two or more compounds can often increase the effectiveness of the compounds and yield better results.

CJC 1295 is another peptide hormone that appears to stimulate growth hormone emission, improve the immune system, lessen recovery time, and has anti-aging effects [16]. In addition, it is also useful for upregulating the body’s GH levels while keeping the natural stability levels.

As previously stated, Ipamorelin specifically stimulates GH without activating other hormones, thereby reducing the likelihood of negative side effects. Similarly, CJC 1295 selectively activates GH.

There is some clinical evidence to support that using a CJC 1295 + Ipamorelin blend dosage being more effective than using either of them alone [17]. In combination, CJC 1295 and Ipamorelin stimulate GH via divergent routes. By attaching to different receptors, CJC 1295 and Ipamorelin may have an additive effect and intensify GH discharge and activity resulting in a significant boost in GH concentration.

This combination treatment may be especially helpful in managing the signs and symptoms of aging, as well as aiding in the relief of inflammatory conditions.

Where to Buy Ipamorelin Online? | 2021 Guide

Ipamorelin is easily accessible to order online. However, since it is not a regulated product, it is recommended that you research reputable suppliers to ensure that you get the best quality peptides possible.

Our favorite supplier is Peptide Sciences. Here’s what we like about them:

  • They sell the best quality peptides: They sell the stuff that researchers buy, so you know it’s high quality. It’s 99% pure and doesn’t have additives or fillers.
  • It gets to you fast: Orders within the US arrive in 2-3 days. International orders can take 7-10 days. There’s a $15 fee for shipping, but they waive it if your order is over $200.
  • Payment is easy: They have a secure payment system and accept most major credit cards as well as cryptocurrency.
  • Great customer service: These guys are professional and answer all their customers’ questions themselves. If you need help, you talk to real, friendly people.

They’re the best we’ve come across so far, so we fully recommend them.

Buy Ipamorelin from our #1 recommended vendor...

Ipamorelin Dosage | The Verdict

So what does the evidence suggest about Ipamorelin dosage?

Although not conclusive given there is still limited clinical research with humans, Ipamorelin usage has some promising potential benefits from reducing the signs of aging to having a positive effect on body composition and fat loss with minimal negative side effects.

It also appears to have increased effectiveness when combined with CJC-1295.

As always, please consult with a physician or certified medical professional before making a final decision about using any new supplements and to make sure you are using them safely.


  1. Raun, K, Hansen, B., Johansen, N., Thogersen, H, Madsen, K, Ankersen, M, & Andersen, P. (1998). Ipamorelin, the first selective growth hormone secretagogue. European Journal of Endocrinology. 139 (5): 552–561.
  2. Gobburu, J.V. S., Agersø, H., Jusko, William J., & Ynddal, Lars (1999). Pharmacokinetic-Pharmacodynamic Modeling of Ipamorelin, a Growth Hormone Releasing Peptide, in Human Volunteers. Pharmaceutical Research. 16 (9): 1412–1416.
  3. Estrada, R. Cañete; Jiménez-Reina, L.; de la Torre, M.J.; Bernal, J. (2002). “Chronic In Vivo Ipamorelin Treatment Stimulates Body Weight Gain and Growth Hormone (GH) Release In Vitro in Young Female Rats. European Journal of Anatomy. 6 (1): 37–46.
  4. Johansen, P.B., Nowak, J., Skjaerbaek, C., FLyvbjerg, A., Andreassen, T.T., Wilken, M., & Orskov, H. (1999). Ipamorelin, a New Growth-Hormone-Releasing Peptide, Induces Longitudinal Bone Growth in Rats. Growth Hormone & IGF Research. 9(2): 106-113.
  5. Svensson, J., Lall, S., & Dickson, S.L. (2000). The GH Secretagogues Ipamorelin and GH-Releasing Peptide-6 Increase Bone Mineral Content in Adult Female Rats. Journal of Endocrinology. 165(3): 569-577.
  6. Howick, K., Griffin, B.T., Cryan, J.F., & Schellekens, H. (2017). From Belly to Brain: Targeting the Ghrelin Receptor in Appetite and Food Intake Regulation. International Journal of Molecular Sciences. 18(2): 273.
  7. Anderson, N.B., Malmlof, K., Johansen, P.B., Andreassen., T.T., Ortoft, G., & Oxlund, H. (2001). The Growth Hormone Secreatgoge Ipamorelin Counteracts Glucocrticoid-Induced Decrease in Bone Formation of Adult Rats. Growth Hormone & IGF Research. 11(5): 266-272.
  8. Mosinka, P., Zatorski, H., Storr, M., & Fichna, J. (2017). Future Treatment of Constipation-Associated Disorders: Role of Relamorelin and Other Ghrelin Receptor Agonists. Journal of Neurogastroenterol and Motility. 23(2): 171-179.
  9. Merriam, G.R., Barsness, S., Buchner, D., Kletke, M., Larsen, L.H., Moe, K.E., Schwartz, R.S., & Vitiello, M.V.. (2004). Growth Hormone Releasing Hormone Treatment Normal Aging. Journal of Anti-Aging Medicine. 4(4): 331-343.
  10. Isidro, M.L. & Cordido, F. (2006). Growth Hormone Secretagogues. Combinatorial Chemistry & High Throughput Screening. 9(3): 175-180.
  11. Moulin, A., Ryan, J., Martinez, J., & Fehrentz, J.A. (2007). Recent Developments in Ghrelin Receptor Ligands. ChemMedChem. 2(9) 1242-1259.
  12. Aagaard, N.K., Grofte, T., Griesen, J., Malmlof, K., Johansen, P.B., Gronbaek, H., Orskov, H., Tygstrup, N., & Vilstrup, H. (2009). Growth Hormone and Growth Hormone Secretagogue Effects on Nitrogen Balance and Urea Synthesis in Steroid Treated Rats. Growth Hormone and IGF Research. 19(5): 426-431.
  13. Beck, D.E., Sweeney, W.B., & McCarter, M.D. (2014). Prospective, Randomized, Controlled, Proof-of-Concept Study of the Ghrelin Mimetic Ipamorelin for the Management of Postoperative Ileus in Bowel Resection Patients. International Journal of Colorectal Disease. 29: 1527-1534.
  14. Pinyot, A., Nikolovski, Z., Bosch, J., Segura, J., & Gutiérrez-Gallego, R. (2010). On the use of cells or membranes for receptor binding: growth hormone secretagogues. Analytical biochemistry, 399(2), 174-181.
  15. Ipamorelin peptide (n.d.). Ipamorelin dosage. https://Ipamorelin-peptide.com/Ipamorelin-dosage/
  16. Teichman, S.L., Neale, A., Lawrence, B., Gagnon, C., Castaigne, J.P., & Frohman, L.A. (2006). Prolonged Stimulation of Growth Horomne (GH) and Insulin-Like Growth Factor I Secretion by CJC01295, a Long-Acting Analog of GH-releasing Hormone, in Healthy Adults. Journal of Clinical Endocrinology & Metabolism. 91(3): 799-805.
  17. Fitness Edge. (2020). Ipamorelin overview. https://fitnessedge.net/Ipamorelin-overview/

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