Last Updated November 14, 2023

 November 14, 2023

Researchers looking to incorporate a GH secretagogue into their work may be unclear regarding ipamorelin dosage.

Ipamorelin is among the most studied growth hormone stimulators, and has been shown to yield research benefits like: 

  • Improved body composition 
  • Repair of muscular and skeletal tissue 
  • Improved bone health 

This ipamorelin dosage calculator and chart will offer a summary of the available research and highlight key findings that may help inform the design of future experiments. 

Read through the end as we reveal our preferred source of research-grade ipamorelin online.

Buy Ipamorelin from the top-rated research peptides vendor...

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Ipamorelin Dosage Chart | Quick Breakdown

Timeline Ipamorelin Dosage for Muscle Growth Research
8-12 weeks 100mcg per injection, administered 2-3 times a day
4-8 weeks Washout period
8-12 weeks 100mcg per injection, administered 2-3x daily

What is Ipamorelin?

Ipamorelin is a synthetic ‘pentapeptide’ which means it contains a string of five amino acids [1]. Generally speaking, peptides are compounds made up of amino acids that stimulate biological functions. Ipamorelin mimics ghrelin and has a strong effect on growth hormone (GH) and insulin-like growth factor 1 (IGF-1). 

Ipamorelin is a growth hormone (GH) secretagogue, or GHS. A GHS is a type of peptide that promotes the body to produce growth hormone (GH) also known as human growth hormone (hGH). Ipamorelin binds to the same receptors as ghrelin (GHSR-1a receptors) and increases levels of GH and IGF-1 [2].

GH is produced and distributed by the pituitary gland, the part of the body that is responsible for controlling and maintaining the endocrine system. It regulates hormone levels for the thyroid system, spleen, reproductive organs, and the development of bone growth during human development.

Ipamorelin works by simulating the function of particular hormones and molecules, which then prompt the body to produce and distribute endogenously-produced GH [3].

At the same time, it controls the amount of a growth hormone inhibiting hormone (GHIH), known as somatostatin, which downregulates pituitary GH secretion. By suppressing the body’s somatostatin levels, ipamorelin increases levels of GH in test subjects [4].


Ipamorelin Dosage Calculator


Ipamorelin Benefits and Uses

So, what are some of the benefits and uses of ipamorelin?

In humans, ipamorelin does not have any recognized therapeutic uses. It is not approved for human use and is currently classified as a research chemical.

The majority of the research conducted on ipamorelin’s benefits has taken place in lab settings on nonhuman animals. Research data from human trials is lacking and ipamorelin has yet to pass phase II trials.

Here’s a brief review of the main ipamorelin research conducted to date:

  • Aids in bone growth and formation: Studies in rats show that ipamorelin can stimulate long-term bone growth depending on the dosage. Researchers have theorized that ipamorelin may be an effective way to both assist in childhood growth and lower the effects of osteoporosis later in life [4, 5].
  • Decreases body fat: Ipamorelin appears to speed up the growth hormone levels necessary for lipolysis, which is the process by which fats are broken down in our bodies through enzymes and water, or hydrolysis [6].
  • Increases lean muscle mass and body composition: Evidence suggests that ipamorelin can encourage the body to produce more lean muscle mass, likely due to the way that it increases GH levels [7]. 
  • Reduces constipation and promotes gut healing: Some research has demonstrated that using ipamorelin post-intestinal/bowel surgery speeds up recovery rates and leads to more immediate bowel movements, in addition to improved patient outcomes in general [8].
  • Diminished signs of aging: Studies have shown that ipamorelin can promote the liver to generate IGF-1, which stimulates the regeneration of bone and body tissue [9].
  • Better sleep quality: There is some support for ipamorelin as a sleep aid, in that it facilitates longer, deeper sleep by encouraging GH production and stimulating the body’s ability to recover and revitalize from daily activities [10]. 

While this research may appear encouraging, ipamorelin currently has no officially recognized uses. This suggests that further research, especially well-designed, long-term clinical trials, may be warranted. 

Let’s take a look at some of the side effects associated with ipamorelin. 


Ipamorelin Side Effects

Researchers curious about potential ipamorelin side effects should note that human experiments with this research chemical are not permitted. We can, however, discuss past studies to get a sense of its overall safety profile and how well it is tolerated by test subjects. 

The existing research shows that ipamorelin is generally well-tolerated by test subjects [11]. Some researchers have theorized that since ipamorelin stimulates the production of GH in a way that mimics the body’s own GH secretion patterns, it is discharged in a more consistent manner that is less intense than other Growth Hormone-Releasing Peptides (GHRPs). 

Unfortunately, studies involving human test subjects have been of short duration and little is known about the long-term effects of ipamorelin administration. This suggests that there is still a need for more human research trials to produce definitive results [12]. 

Based on the available research, it appears that any side effects experienced by test subjects as a result of ipamorelin administration are minor and dose-dependent. The data shows that when taken in low and moderate dosages, ipamorelin causes mild side effects such as:

  • Temporary redness, itching, or sensitivity at the site of the injection
  • Dry mouth
  • Nausea
  • Weight gain, usually associated with increased muscle mass and body fat loss

In rare cases, some severe side effects have been observed, including:

  • Water retention
  • Tingling/numbness in the hands and feet
  • Insulin resistance
  • Hypertension

This indicates that researchers interested in experimenting with ipamorelin would be well-advised to exclude test subjects with pre-existing conditions such as diabetes and hypertension.

Let’s now turn our attention to the question at hand: how should researchers calculate the correct dosage for ipamorelin? 


Ipamorelin Dosage Calculator and Guide

Researchers interested in exploring the effects of ipamorelin will note that this research chemical has no officially approved dosage.

While it may be purchased as a reference material, it has not been approved for human research and there are no clear guidelines for how it should be dosed or administered.

Researchers may consult the relevant literature from past trials to see how it has been dosed in past studies. Here is a brief guide.

Ipamorelin dosing forms

Ipamorelin is available as a lyophilized powder that must be reconstituted into liquid form and then administered via injections to ensure adequate bioavailability.

Clinical studies have involved intravenous administration of the peptide. However, subcutaneous injections are considered a much safer and more convenient form of peptide application in experimental settings.

Therefore, ipamorelin is best administered as subcutaneous injections, usually several times a day due to its short-half life of just 2 hours [2].

Ipamorelin dosage calculator

Researchers may consult the findings of a 2014 study by Beck et al. that explored the use of ipamorelin in bowel resection patients for the management of postoperative ileus. Researchers administered ipamorelin twice daily at a dose of 0.03mg per kilogram of body weight [13].

In this study, ipamorelin was administered via intravenous infusion on postoperative days 1 to 7. Researchers noted that ipamorelin was “well-tolerated” by test subjects and produced no serious adverse events (AEs) [13].

The short-term nature of this study (seven days) does not help inform the optimum duration of future experiments, nor what side effects test subjects may experience as a result of long-term ipamorelin administration.

Therefore, researchers should consider using lower doses when administering the peptide subcutaneously for longer periods of time.

Anecdotal reports suggest that the peptide may be administered in doses of 200 mcg to 300 mcg per day, split in 2-3 injections. At this dosage, the duration of such trials should last no longer than 8-12 weeks.

Sample ipamorelin dosing protocol

Based on the anecdotal reports mentioned above, here is a sample dosage protocol to use as a reference for ipamorelin dosing in body composition research:

  • Daily Dose: 200-300 mcg.
  • Frequency: Split this in 2-3 daily injections, 100mcg each.
  • Research Study Duration: 8-12 weeks.
  • Notes: Administer subcutaneously.

Ipamorelin research cycle

The only published trial data (Beck et al.) examined the use of ipamorelin for a very short period of time (7 days) and little is known about the long-term effects of this peptide.

To date, no studies have examined the length of time that test subjects may need to rest between different cycles of ipamorelin.

Yet, anecdotal reports suggest that ipamorelin cycles for research should last 8-12 weeks, followed by at least 4-8 weeks of washout period before repeating the trial.


CJC 1295 + Ipamorelin Blend Dosage

There is strong research interest in the effects of CJC-1295 and ipamorelin and many researchers are curious about whether these two research peptides work synergistically.

CJC-1295 is a peptide hormone and a growth hormone-releasing hormone (GHRH) analogue, that appears to stimulate growth hormone emission, improve the immune system, lessen recovery time, and offer anti-aging effects [14]. In addition, it appears to upregulate the body’s GH levels while keeping them stable.

As previously stated, ipamorelin specifically stimulates GH without activating other hormones, thereby reducing the likelihood of negative side effects. Similarly, CJC-1295 selectively activates GH.

There is some clinical data to suggest that the combination of a GHRH analogues with GHS such as ipamorelin may result in a greater production of GH [15]. In combination, CJC-1295 and ipamorelin stimulate GH via divergent routes.

By attaching to different receptors, CJC-1295 and ipamorelin may have an additive effect and intensify GH discharge and activity resulting in a significant boost in GH concentration.

Some researchers have theorized that this combination treatment may be especially helpful in managing the signs and symptoms of aging, as well as aiding in the relief of inflammatory conditions.


Ipamorelin Dosage Calculator


Where to Buy Ipamorelin Online? | 2024 Edition

Several peptide vendors stock research-grade ipamorelin for purchase by qualified researchers and laboratory professionals.

We strongly recommend that researchers seek out a reputable supplier of ipamorelin to ensure that they get the best product possible.

In our experience, the two following vendors are trusted sources of ipamorelin and other research peptides.

Core Peptides

Here’s why Core Peptides is one of our go-to vendors:

  • Research-Grade Ipamorelin:Core Peptides sells only 99%+ pure ipamorelin that is produced in certified American facilities and third-party tested for identity and purity.
  • Fast Shipping: Orders within the US typically arrive in 2-3 days and are subject to a $9.25 shipping fee, which is waived for purchases over $200.
  • Researcher Care: Core Peptides’ friendly staff are highly knowledgeable and undertake to address all research questions and queries as quickly as possible.

Buy Ipamorelin from the top-rated research peptides vendor...


Limitless Life

 Limitless Life is another highly regarded peptide vendor and one that we use frequently.

Here’s why they stand out:

  • Quality Control: Limitless Life makes use of third-party lab testing to check the purity and potency of all of their peptide products.
  • Discounts & Perks: Discounts are available for certain payment options and for signing up to the Limitless Life newsletter.
  • Quick Shipping: Limitless Life offers 24-48 hour delivery via their express shipping option, and the standard $10 fee is waived on orders of $350+.

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Bacteriostatic Water for Ipamorelin

Every researcher can attest to the importance of having the right tools available. This is especially true for researchers with experience handling Ipamorelin and other peptides.

To successfully handle peptides, a researcher needs items such as bacteriostatic water, sterile vials, alcohol swabs, and more.

Gathering the required materials can take up time and effort, putting a damper on research activities. However, it is vital to the study.


Ipamorelin Dosage | Verdict

So, what does the evidence suggest about ipamorelin dosage?

Ipamorelin studies are lacking overall and this merits further research, but what limited data exists suggests that ipamorelin offers some promising benefits in the area of body composition and recovery rates.

The limited nature of the studies conducted to date points to the need for long-term, placebo-controlled clinical trials to test the safety and efficacy of ipamorelin.

To source Ipamorelin, qualified researchers may visit our top-rated vendor.


References

  1. Raun, K, Hansen, B., Johansen, N., Thogersen, H, Madsen, K, Ankersen, M, & Andersen, P. (1998). Ipamorelin, the first selective growth hormone secretagogue. European Journal of Endocrinology. 139 (5): 552–561.
  2. Gobburu, J.V. S., Agersø, H., Jusko, William J., & Ynddal, Lars (1999). Pharmacokinetic-Pharmacodynamic Modeling of Ipamorelin, a Growth Hormone Releasing Peptide, in Human Volunteers. Pharmaceutical Research. 16 (9): 1412–1416.
  3. Estrada, R. Cañete; Jiménez-Reina, L.; de la Torre, M.J.; Bernal, J. (2002). “Chronic In Vivo Ipamorelin Treatment Stimulates Body Weight Gain and Growth Hormone (GH) Release In Vitro in Young Female Rats. European Journal of Anatomy. 6 (1): 37–46.
  4. Johansen, P.B., Nowak, J., Skjaerbaek, C., FLyvbjerg, A., Andreassen, T.T., Wilken, M., & Orskov, H. (1999). Ipamorelin, a New Growth-Hormone-Releasing Peptide, Induces Longitudinal Bone Growth in Rats. Growth Hormone & IGF Research. 9(2): 106-113.
  5. Svensson, J., Lall, S., & Dickson, S.L. (2000). The GH Secretagogues Ipamorelin and GH-Releasing Peptide-6 Increase Bone Mineral Content in Adult Female Rats. Journal of Endocrinology. 165(3): 569-577.
  6. Howick, K., Griffin, B.T., Cryan, J.F., & Schellekens, H. (2017). From Belly to Brain: Targeting the Ghrelin Receptor in Appetite and Food Intake Regulation. International Journal of Molecular Sciences. 18(2): 273.
  7. Anderson, N.B., Malmlof, K., Johansen, P.B., Andreassen., T.T., Ortoft, G., & Oxlund, H. (2001). The Growth Hormone Secretagogue Ipamorelin Counteracts Glucocrticoid-Induced Decrease in Bone Formation of Adult Rats. Growth Hormone & IGF Research. 11(5): 266-272.
  8. Mosinka, P., Zatorski, H., Storr, M., & Fichna, J. (2017). Future Treatment of Constipation-Associated Disorders: Role of Relamorelin and Other Ghrelin Receptor Agonists. Journal of Neurogastroenterol and Motility. 23(2): 171-179.
  9. Merriam, G.R., Barsness, S., Buchner, D., Kletke, M., Larsen, L.H., Moe, K.E., Schwartz, R.S., & Vitiello, M.V.. (2004). Growth Hormone Releasing Hormone Treatment Normal Aging. Journal of Anti-Aging Medicine. 4(4): 331-343.
  10. Isidro, M.L. & Cordido, F. (2006). Growth Hormone Secretagogues. Combinatorial Chemistry & High Throughput Screening. 9(3): 175-180.
  11. Moulin, A., Ryan, J., Martinez, J., & Fehrentz, J.A. (2007). Recent Developments in Ghrelin Receptor Ligands. ChemMedChem. 2(9) 1242-1259.
  12. Aagaard, N.K., Grofte, T., Griesen, J., Malmlof, K., Johansen, P.B., Gronbaek, H., Orskov, H., Tygstrup, N., & Vilstrup, H. (2009). Growth Hormone and Growth Hormone Secretagogue Effects on Nitrogen Balance and Urea Synthesis in Steroid Treated Rats. Growth Hormone and IGF Research. 19(5): 426-431.
  13. Beck, D.E., Sweeney, W.B., & McCarter, M.D. (2014). Prospective, Randomized, Controlled, Proof-of-Concept Study of the Ghrelin Mimetic Ipamorelin for the Management of Postoperative Ileus in Bowel Resection Patients. International Journal of Colorectal Disease. 29: 1527-1534.
  14. Teichman, S.L., Neale, A., Lawrence, B., Gagnon, C., Castaigne, J.P., & Frohman, L.A. (2006). Prolonged Stimulation of Growth Hormone (GH) and Insulin-Like Growth Factor I Secretion by CJC01295, a Long-Acting Analog of GH-releasing Hormone, in Healthy Adults. Journal of Clinical Endocrinology & Metabolism. 91(3): 799-805.
  15. Veldhuis, J. D., & Keenan, D. M. (2008). Secretagogues govern GH secretory-burst waveform and mass in healthy eugonadal and short-term hypogonadal men. European journal of endocrinology, 159(5), 547–554. https://doi.org/10.1530/EJE-08-0414

Scientifically Fact Checked by:

David Warmflash, M.D.

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