Titus Thorne

Last Updated November 5, 2022

Titus Thorne

 November 5, 2022

Curious about BPC-157 benefits?

BPC-157 has been demonstrated to provide beneficial effects on wound healing, tissue formation, and even neuroprotection. This guide will provide an overview of the main research findings on BPC-157, with a detailed focus on the benefits associated with administration of this peptide.

Our team has also included information on how BPC-157 has been dosed in past studies and how it has been administered to test subjects. Researchers looking for details on where to purchase BPC-157 online from a reliable, vetted source can find a complete summary of our recommended vendor at the end of this guide.

Buy BPC-157 from the #1 online Peptides vendor in the world...

Disclaimer: Peptides.org contains information about products that are intended for laboratory and research use only, unless otherwise explicitly stated. This information, including any referenced scientific or clinical research, is made available for educational purposes only. Peptides.org makes every effort to ensure that any information it shares complies with national and international standards for clinical trial information and is committed to the timely disclosure of the design and results of all interventional clinical studies for innovative treatments publicly available or that may be made available. However, research is not considered conclusive. Peptides.org makes no claims that any products referenced can cure, treat or prevent any conditions, including any conditions referenced on its website or in print materials.


What is BPC-157?

BPC-157 is a pentadecapeptide composed of a string of 15 amino acids. It was first isolated in 1991 and is a fragment of the Body Protection Compound that occurs naturally in human gastric juice. BPC-157 is primarily known for its healing and restorative properties, such as promoting angiogenesis—the process of forming new blood vessels.

While the mechanism of action for BPC-157 is still unclear, it is believed to entail the upregulation of growth factors, the modulation of nitric oxide (NO) synthesis, and the control of functions of collagen fragments that are associated with bone morphogenic proteins [1].

BPC-157 can play an essential role in the functioning of the GI tract, where it can combat adverse conditions such as gastro-intestinal cramps, leaky gut, and Crohn’s disease [2]. In addition, BPC-157 has also been shown to accelerate recovery in tendon injuries and burns to the skin by promoting blood flow to affected areas, as well as offering neuroprotective properties and enhanced muscle growth.


bpc-157 Benefits


BPC-157 Benefits

A number of studies have indicated that BPC-157 can provide beneficial effects when administered to test subjects, including:

Protects stomach cells, maintains gastric integrity, and prevents stomach ulcers

Naturally occurring BPC is continuously present in human gastric juice and is stable. According to a recent study, BPC-157 is an anti-ulcer peptidergic agent that “protects stomach cells and maintains gastric integrity” [3]. It has been proven in clinical trials to be safe for the treatment of inflammatory bowel disease [4].

Improves energy levels, blood flow, and vessel recruitment

Studies have shown that BPC-157 helps reestablish the integrity of blood flow by improving blood vessel recruitment [3]. It promotes the formation of blood vessels via a process known as angiogenesis, and upregulates vascular endothelial growth factor (VEGF), a protein that stimulates blood vessel growth.

Animal studies have shown that BPC-157 has a modulatory effect on angiogenesis in muscle and tendon healing [5]. An early study involving chicks found that BPC-157 increased the production of nitric oxide (NO) and helped to prevent the development of pulmonary hypertension syndrome and tissue lesions [6]. In addition, this activation of NO pathways can provide increased energy levels—NO activators are also common ingredients in pre-workout supplements.

Provides neuroprotective properties

One rat study indicates that BPC-157 may offer neuroprotective properties [7]. The peptide appears to repair nerve damage caused by alcohol intoxication and reduce rates of depression in animals exposed to chronic stress.

In addition, a 2014 study found that BPC-157 limited the severity of the damage done by methamphetamine-induced neurotoxicity in rats [8].

BPC-157 also appears to protect the skin, heart, liver, pancreas, and brain against “the adverse effects of alcohol and nonsteroidal anti-inflammatory drugs (NSAIDs)” [3]. Another 2013 study noted that “BPC-157 may be used as an antidote against NSAIDs” [4] and research interest in BPC-157 for this purpose remains strong.

Offers treatment for wound healing and traumatic brain injury

In studies involving mice with traumatic brain injury (TBI), BPC-157 has been shown to have a positive effect on survival rates compared with placebo and reduced levels of post-injury damage [9, 10]. The angiogenic properties of BPC-157 allow the peptide to expedite wound healing as a result of increased blood flow to the affected area.

Combats inflammation

Animal studies have shown that BPC-157 has a significant anti-inflammatory effect on periodontal tissues in rats with ligature-induced periodontitis. Researchers noted that “BPC-157 treatment significantly reduced both plasma extravasation, histological alterations and alveolar bone resorption” without negatively affecting blood circulation [11].

Stimulates muscle and tissue growth

BPC-157 has been shown in test tube studies to stimulate growth hormone receptor expression. Administration of this peptide can promote the growth of new tissue, with the potential of also stimulating bone, skin, and muscular growth [1].


BPC-157 Side Effects

Most research involving BPC-157 has involved animal models in which certain side effects have occasionally been observed. One study concluded that “clinical trials involving BPC-157 have shown that it is a safe treatment for inflammatory bowel disease” [3]. Further evidence also states that “stable gastric pentadecapeptide BPC 157 is an anti-ulcer peptidergic agent, proven in clinical trials to be both safe in inflammatory bowel disease and wound healing, stable in human gastric juice, with no toxicity being reported” [12].

Based on the limited research available we can see that documented BPC-157 side effects include [4]:

  • Injection site injuries (redness, scarring, etc)
  • Nausea
  • Fatigue
  • Sweating
  • Light-headedness

Research into BPC-157’s long-term side effects is lacking, warranting further investigation.


BPC-157 Dosage Guide

Despite strong research interest in BPC-157 dosage, there have yet to be standardized and universally agreed upon recommended dosage guidelines for BPC-157 in test subjects. However, by drawing on data in published studies, we can summarize the main ways that researchers have dosed BPC-157 in past experiments.

How is BPC-157 administered?

While oral solutions and transdermal patches containing BPC-157 have been tested in past trials, the generally preferred route of BPC-157 administration is via injection (IM or subcutaneous).

Researchers interested in studying BPC-157 should abide by all established safety protocols when administering this peptide, including the using sterile needles for injection and bacteriostatic water for reconstitution, and refrigerating the peptide following its reconstitution.

Recommended dose?

The recommended dose for BPC-157 can vary depending on the test subject and the research objective. In animals studies, BPC-157 has been administered in the following ways:

  • To rats at a dose of 10 mcg/kg via injection [12]
  • To mice at a dose of 10 μg or 10 ng/kg body weight intraperitoneally (i.p.) via injection [14]
  • To mice as a thin layer of cream topically (50 μg of BPC 157 dissolved in 2 ml of distilled water with 50 g of commercial neutral cream and 1% white silver sulfadiazine).

BPC-157 has been administered at similar doses in four other rat experiments:

  • To investigate its role in accelerating musculoskeletal soft tissue healing in rats [15]
  • To improve the healing course of spinal cord injury and lead to functional recovery in rats [16]
  • To investigate the speed at which tendons healed in rats [17]
  • To test its effects on short bowel syndrome in rats [18]

It should be noted that per kg dosage for rodents does not scale to humans.

Sample BPC-157 protocol

Based on the research we have covered herein, a total daily dose of injectable BPC-157 should generally not exceed 1mg. We provide the following sample BPC-157 injury recovery protocol for reference purposes only:

  • Daily Dosage: 250mcg-750mcg of BPC-157
  • Frequency: For first half of study, administer two to three injections of 250mcg each, spread throughout the day. For second half of study, administer one to two injections of 250mcg each.
  • Study Duration: Four to six weeks, depending on subject’s responsiveness and nature of injury.
  • BPC-157 Cycle: BPC-157 is typically not “cycled” in injury recovery contexts; rather, it is studied for its ability to achieve a given outcome.
  • Notes: Our preferred vendor, presented below, sells vials of 5mg BPC-157 and 10mg BPC-157—the 5mg vial would suffice for most injury recovery studies based on this protocol. For advanced injury recovery, BPC-157 is typically administered alongside TB-500.

bpc-157 Benefits


Where to Buy BPC-157 Online? | 2022 Guide

While BPC-157 is readily available online, some researchers may be curious about the best place to source this reference material. To answer this question, our team made small test orders from various vendors to see which ones offered the highest quality peptides, fastest shipping times, and most reasonable refund policy.

Our team has determined that Peptide Sciences is one of the top vendors. They currently sell 99% pure BPC-157 to researchers worldwide and have a stellar reputation.
Here’s what they do very well:

  • Third-Party Testing: Peptide Sciences is the only vendor that gets every batch of BPC-157 tested by a third-party lab. This ensures that researchers know exactly what they are buying.
  • Made In The USA: All reference materials are manufactured in the US and certified for use in clinical trials. This eliminates the need to worry about receiving adulterated or low-purity BPC-157 from an unscrupulous overseas vendor.
  • Fast Shipping: Shipping is FREE on all U.S. orders above $200, and costs just $15 for researchers based internationally.
  • Friendly customer service: Researchers can email a dedicated support team with any peptide or order-related questions and expect a personalized response within 24 hours.

Researchers looking to buy high-quality BPC-157 for their next study are advised to check out Peptide Sciences, the best in the business.

Buy BPC-157 from our #1 recommended vendor...


Bacteriostatic Water for Injection

In addition to your BPC-157, you will need to have the right supplies on hand for proper handling. The procedures of peptide reconstitution and storage call for a handful of items, namely bacteriostatic water, sterile essentials (vials, needles, syringes), and sterilizing alcohol wipes.

The task of gathering all the necessary supplies can be a drag and an obstacle in your research, as it is challenging to find a single reputable source for the full range of items.

However, you are in luck! The Peptides.org team has done the market research for you to identify the best online retailer of your research supply essentials.

BacteriostaticWater.org

This site is a solution to your supply challenges, offering comprehensive research kits that are furnished with the requisite tools for peptide handling. Select your choice of deluxe supply sets from BacteriostaticWater.org to conveniently receive the full range of items.

You can’t go wrong with the complete starter research kit, which has:

  • Bacteriostatic Water (30mL) – 3x
  • Insulin Syringes (0.5 cc/mL x 29g x ½) – 100x
  • Alcohol Prep Pads – 200x
  • Sterile Empty Glass Vial (10mL) – 1x
  • Large Needles + Syringes Combo (3cc x 21g x 1) – 10x

Or load up on essentials with the premium research kit, including:

  • Bacteriostatic Water (30mL) – 5x
  • Insulin Syringes (0.5 cc/mL x 29g x ½) – 200x
  • Alcohol Prep Pads – 200x
  • Sterile Empty Glass Vial (10mL) – 2x
  • Large Needles + Syringes Combo (3cc x 21g x 1) – 20x

Get the most out of your research with a comprehensive supply kit from this recommended source.

Buy Bacteriostatic Water from our #1 recommended vendor...


BPC-157 Benefits | Verdict

Research conducted on BPC-157 indicates that this peptide has a number of beneficial effects when administered to test subjects, such as increased rates of wound healing, neuroprotective properties, and even raising energy levels. This guide has summarized the findings of published studies and highlighted areas where further research may be warranted.

Those who choose to conduct research with BPC-157 should keep in mind that while this peptide can confer several benefits, there is also a risk of test subjects incurring mild side effects, such as nausea, fatigue, sweating, and light-headedness.

Due to the limited availability of relevant data, the long-term side effects of BPC-157 are mostly unknown, and so caution is advised when evaluating the effects of this peptide. To obtain research-grade BPC-157 at a fair price, head over to Peptide Sciences.


References

  1. Chang, C. H., Tsai, W. C., Hsu, Y. H., & Pang, J. H. (2014). Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts. Molecules (Basel, Switzerland), 19(11), 19066–19077.
  2. Klicek, R., Sever, M., Radic, B., Drmic, D., Kocman, I., Zoricic, I., Vuksic, T., Ivica, M., Barisic, I., Ilic, S., Berkopic, L., Vrcic, H., Brcic, L., Blagaic, A. B., Coric, M., Brcic, I., Rokotov, D. S., Anic, T., Seiwerth, S., & Sikiric, P. (2008, September 25). Pentadecapeptide BPC 157, in clinical trials as a therapy for inflammatory bowel disease (PL14736), is effective in the healing of colocutaneous fistulas in rats: Role of the nitric oxide-system. Journal of Pharmacological Sciences.
  3. Sikiric P, Hahm KB, Blagaic AB, Tvrdeic A, Pavlov KH, Petrovic A, Kokot A, Gojkovic S, Krezic I, Drmic D, Rucman R, Seiwerth S. Stable Gastric Pentadecapeptide BPC 157, Robert's Stomach Cytoprotection/Adaptive Cytoprotection/Organoprotection, and Selye's Stress Coping Response: Progress, Achievements, and the Future. Gut Liver. 2020 Mar 15;14(2):153-167. doi: 10.5009/gnl18490. PMID: 31158953; PMCID: PMC7096228.
  4. Sikiric P, Seiwerth S, Rucman R, Turkovic B, Rokotov DS, Brcic L, Sever M, Klicek R, Radic B, Drmic D, Ilic S, Kolenc D, Aralica G, Safic H, Suran J, Rak D, Dzidic S, Vrcic H, Sebecic B. Toxicity by NSAIDs. Counteraction by stable gastric pentadecapeptide BPC 157. Curr Pharm Des. 2013;19(1):76-83. doi: 10.2174/13816128130111. PMID: 22950504.
  5. Brcic L, Brcic I, Staresinic M, Novinscak T, Sikiric P, Seiwerth S. Modulatory effect of gastric pentadecapeptide BPC 157 on angiogenesis in muscle and tendon healing. J Physiol Pharmacol. 2009 Dec;60 Suppl 7:191-6. PMID: 20388964.
  6. Grabarevic Z, Tisljar M, Artukovic B, Bratulic M, Dzaja P, Seiwerth S, Sikiric P, Peric J, Geres D, Kos J. The influence of BPC 157 on nitric oxide agonist and antagonist induced lesions in broiler chicks. J Physiol Paris. 1997 May-Oct;91(3-5):139-49. doi: 10.1016/s0928-4257(97)89478-8. PMID: 9403788.
  7. Sikiric P, Seiwerth S, Rucman R, et al. Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications. Curr Neuropharmacol. 2016;14(8):857-865. doi:10.2174/1570159×13666160502153022
  8. Suran J, Kolenc D, Crnic AP, Radic B, Drmic I, et al. The effect of pentadecapeptide BPC 157 in metamphetamine-induced dopaminergic neurotoxicity (1143.11). FASEB J. 2014;28:Suppl1.
  9. Tudor M, Jandric I, Marovic A, Gjurasin M, Perovic D, Radic B, Blagaic AB, Kolenc D, Brcic L, Zarkovic K, Seiwerth S, Sikiric P. Traumatic brain injury in mice and pentadecapeptide BPC 157 effect. Regul Pept. 2010 Feb 25;160(1-3):26-32. doi: 10.1016/j.regpep.2009.11.012. Epub 2009 Nov 18. PMID: 19931318.
  10. Filaretova LP, Takeuchi K (eds): Cell/Tissue Injury and Cytoprotection/Organoprotection in the Gastrointestinal Tract: Mechanisms, Prevention and Treatment. Front Gastrointest Res. Basel, Karger, 2012, vol 30, pp 191–201. doi: 10.1159/000338435
  11. Keremi B, Lohinai Z, Komora P, Duhaj S, Borsi K, Jobbagy-Ovari G, Kallo K, Szekely AD, Fazekas A, Dobo-Nagy C, Sikiric P, Varga G. Antiinflammatory effect of BPC 157 on experimental periodontitis in rats. J Physiol Pharmacol. 2009 Dec;60 Suppl 7:115-22. PMID: 20388954.
  12. Sikiric, Predrag, Sven Seiwerth, Rudolf Rucman, Branko Turkovic, Dinko Stancic Rokotov, Luka Brcic, Marko Sever, et al. “Stable Gastric Pentadecapeptide BPC 157: Novel Therapy in Gastrointestinal Tract.” Latest TOC RSS. Bentham Science Publishers, January 1, 1970.
  13. BPC-157. Retrieved March 17, 2020. Examine.com
  14. Mikus D, Sikiric P, Seiwerth S, Petricevic A, Aralica G, et al. Pentadecapeptide BPC 157 cream improves burn-wound healing and attenuates burn-gastric lesions in mice. Burns. 2001;27(8):817-827.
  15. Gwyer D, Wragg NM, Wilson SL. Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing. Cell Tissue Res. 2019;377(2):153-159. doi:10.1007/s00441-019-03016-8.
  16. Perovic D, Kolenc D, Vilic V, Somun N, Drmic D, et al. Stable gastric pentadecapeptide BPC 157 can improve the healing course of spinal cord injury and lead to functional recovery in rats. J Orthop Surg Res. 2019;14(1):199. doi:10.1186/s13018-019-1242-6.
  17. Staresinic M, Sebecic B, Patrlj L, Jadrijevic S, Suknaic S, et al. Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tendocytes growth. J Orthop Res. 2003;2196):976-983.
  18. Sever M, Klicek R, Radic B, Brcic L, Zorocic I, et al. Gastric pentadecapeptide BPC 157 and short bowel syndrome in rats. Dig Dis Sci. 2009;54(1):2070-2083. doi:10.1007/s10620-008-0598-y.

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