BPC-157 Nasal Spray vs. Injections | A-Z Guide

BPC-157 Nasal Spray

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Titus Thorne

Last Updated March 16, 2023

BPC-157

Titus Thorne

 March 16, 2023

Curious about BPC-157 nasal spray vs. injections?

If so, then you are in luck! This guide has you covered.

Below, our panel of experts will detail all the key info on BPC-157 nasal spray and injections, including…

  • What is BPC-157?
  • BPC-157 nasal spray basics
  • BPC-157 nasal spray versus injections
  • BPC-157 nasal spray versus capsules
  • Top BPC-157 products

For researchers interested in BPC-157, this is your definitive review of the optimal routes of administration. Plus, we will give you our highest recommendation for sourcing the best BPC-157 the web has to offer!

Buy peptides from Pure Rawz, a top-rated vendor...

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What is BPC-157?

BPC-157 (Body Protection Compound-157), otherwise known as bepecin, is a synthetic peptide that is under clinical investigation for numerous therapeutic applications.

A derivative of the naturally occurring gastric protein called Body Protection Compound (BPC), BPC-157 is classed as a pentadecapeptide, composed of 15 amino acids. Endogenous BPC is produced in the gastrointestinal tract and is essential to proper digestive function. It maintains the lining of the GI tract, healing and preventing lesions while combating oxidative stress. This regenerative peptide is shown to promote angiogenesis, cellular repair, tissue growth, and improved inflammatory response [1, 2, 3].

Therapeutic Considerations

BPC-157 is more stable than its parent compound, and studies indicate that it does not require a carrier agent to elicit systemic effects. Like endogenous BPC, it exhibits powerful cytoprotective properties, fortifying, protecting, and healing the lining of the GI tract. Research shows that its angiogenic and anti-inflammatory benefits may extend beyond the digestive system even in small doses.

In stimulating vascular growth and fibroblast proliferation, BPC-157 is linked with faster injury and wound healing in multiple tissue types. These include hepatic and nervous tissues, as well as muscle, bone, and tendon. BPC-157 is further shown to have powerful anti-inflammatory effects throughout the GI tract and systemically, lending it potential in the treatment of inflammatory and metabolic diseases [2, 3, 4, 5, 6].

Clinical Background

BPC-157 was introduced in 1993 and initially studied as a potential treatment for inflammatory bowel disease due to its anti-ulcer effects. Although it entered phase I clinical trials in this regard, BPC-157 is not certified by the US Food and Drug Administration (FDA) for medical use. As such, substantial data on BPC-157 administration in humans is lacking. However, research to date suggests that BPC-157 is non-toxic and well-tolerated when properly handled in qualified settings [1–7].

Routes of Administration

Like many research peptides, injection of BPC-157 has historically been the favored route of administration due to the compound’s instability and consequent low oral bioavailability. However, a highly stable form of BPC-157 called BPC-157 arginate has recently been developed, exhibiting oral bioavailability of over 90%. Given the peptide’s notable gastroprotective effects, it may be well suited to this novel capsular form [8, 9, 10].

BPC-157 has also been applied topically in several animal studies into its wound-healing capabilities. Although research on intranasal administration of BPC-157 is extremely limited, broad studies on the potential benefits of intranasally administered peptide therapeutics suggest that this may be a beneficial RoA [11, 12].

Nasal formulas from reputable peptide sources have recently become available for researchers to explore this promising means of application, as detailed below.

Continue reading to learn more about the benefits of intranasal BPC-157 use, as well as how it compares to oral and parenteral routes.

BPC-157 Nasal Spray 3

BPC-157 Nasal Spray | What Researchers MUST Know

Clinical interest in nasal drug delivery has increased in recent years due to its unique advantages in certain therapeutic contexts. Intranasal administration is valued as a non-invasive means of both systemic and local administration with good bioavailability, rapid onset, and targeted effects on the central nervous system [13, 14].

Nasal delivery may be particularly effective in the treatment of neurological diseases due to the direct nose-to-brain pathway. This includes neurodegenerative diseases such as Alzheimer’s, as well as mental health conditions like schizophrenia. However, intranasal administration is also considered an efficient route for systemic effects due to the dense vasculature of the nasal mucosa. Researchers note that intranasal delivery may especially increase the bioavailability of peptide therapeutics and present an appealing alternative to injection [14, 15, 16].

BPC-157 and Nasal Delivery

Despite mounting research on nasal peptide administration, studies on nasal delivery of BPC-157 are lacking. Yet, the few trials to date are promising.

In one study, BPC-157 was shown to reduce brain swelling and inflammation with topical application in rats with superior sagittal thrombosis. Another study on intranasal administration of BPC-157 in rats with rhinitis elicited anti-inflammatory effects in the nasal lining [17, 18].

Given the evidenced benefits of BPC-157 on neurological health, including neuroprotection, neurotransmitter modulation, and the maintenance of systemic homeostasis via the brain-gut axis, it may be particularly suited to nasal administration. As such, leading peptide brands have begun to develop BPC-157 nasal spray formulas, such as Pure Rawz’ BPC-157/TB-500 Repair Spray, for innovative researchers to enjoy [19, 20].

Next, we will explore how intranasal BPC-157 delivery compares to other common routes of administration.

Comparison: BPC-157 Nasal Spray vs. Injections

Is one method better than another when administering BPC-157? The answer may be complicated. Let’s look at the main factors to consider.

Bioavailability

Traditionally, injection has been considered the most efficient route of administering peptide drugs due to their instability and rapid degradation with oral, topical, and other delivery methods.

BPC-157 has been shown in animal models to adhere to the metabolic process of standard peptide-based drugs, suggesting that injections are the most bioavailable route of delivery. Indeed, studies on BPC-157 to date have more often featured injection rather than nasal delivery [21, 22].

However, emerging research and novel formulations may alter these dynamics. For example, a more stable and highly orally available form of BPC-157 known as BPC157 arginate has recently been developed.

Further, clinicians have only recently begun to consider the unique advantages of nasal administration, spurring the development of pharmaceuticals that are highly bioavailable via the nasal mucosa. Compared with injection, intranasal delivery is favorably recognized as a less invasive method of bypassing the blood-brain barrier [10, 13, 23].

Therapeutic Context

Research findings suggest that the optimal use of BPC-157 is in many cases dependent on the therapeutic target, as different routes of delivery and dosages elicit varying effects. For gastroprotective benefits, oral delivery may be the best. Meanwhile, as noted above, targeted neurological effects may best be achieved with nasal sprays. In contexts of vascular disease or global effects, injection may remain the preferred method. [2, 20, 24, 25].

Additional considerations include the comfort of the subject. Nasal sprays are less invasive than injections and therefore more suited to regular use. Consequently, this format may be more marketable and thus likely to receive increased development interest and regulatory approval [13].

In short, researchers are strongly encouraged to become familiar with relevant findings on the best handling and administration protocols for specific uses of BPC-157, as optimal delivery methods are subject to change.

BPC-157 Nasal Spray

Comparison: BPC-157 Nasal Spray vs. Capsules

While nasal sprays evidence substantial utility for targeted neurological effects, when it comes to gastrointestinal benefits, orally delivered BPC-157 capsules may be the best option. Breakthrough BPC-157 arginate formulas that are highly stable, bioavailable, and long-acting have great therapeutic potential. Like nasal sprays, capsules are non-invasive and appealing for regular use [10, 24, 26].

The most promising recent developments in BPC-157 capsules are the following from Peptide Sciences, made with highly stable and orally effective BPC-157 and additional therapeutic compounds for enhanced benefits.

The star ingredient of this cutting-edge preparation is BPC-157 arginate, exhibiting significantly greater stability and oral activity than the original form, BPC-157 acetate. It is resistant to gastric acids and maintains the therapeutic action of the standard iteration.

This ultra-healing peptide is partnered with a derivative of another potent regenerative peptide called thymosin beta-4 (TB4), also known as TB-500. Featured in a smaller, fragmentary form for easier GI tract absorption, it imparts further anti-inflammatory and immunomodulating benefits for a synergistic healing effect [10, 27, 28, 29].

This formula is sure to be of interest to researchers interested in enhanced injury recovery, as well as addressing symptoms of inflammatory, cardiovascular, and neurological diseases.

This potent formula combines a trio of anti-inflammatory compounds with orally active BPC-157 arginate for focused healing of the gastrointestinal tract. Each one of the naturally-occurring ingredients is shown to combat GI inflammation through distinct mechanisms, eliciting synergistic benefits. KPV and tributyrin partner to regulate damaging cytokines associated with inflammatory bowel disease, while BPC-157 and PEA calm and fortify the GI lining [8, 30, 31, 32].

Well-suited to research into GI health and reducing gut inflammation, this innovative blend may also have systemic healing effects.

A Note on BPC-157 Injections

Although more definitive studies into the administration of BPC-157 in humans are needed, researchers may benefit from known clinical findings to guide safe and proper handling. When it comes to BPC-157 injections, there is slightly more data to pull from. This is fortunate, due to the invasive nature of this delivery method.

Here, we will briefly cover routine considerations for researchers considering BPC-157 application via injection.

Administration and Dosage

Although subcutaneous injections are utilized, intramuscular is observed to be the most efficient. It is advised to begin with a low dose and increase incrementally. A widely observed daily dose is 250mcg, or 2-4mcg per kg. Many studies involve dosage cycles, which vary with the therapeutic target. Researchers are advised to consult all relevant literature for guidelines on the exact courses of therapy.

Reconstitution

Most peptides are available as lyophilized powders and must be reconstituted with a sterile solvent to be injected. Experts recommend the use of bacteriostatic water for this purpose. Composed of a natural preservative and sterile water, bacteriostatic water reduces the risk of contamination, extends the shelf life of solutions, and efficiently dissolves peptides while maintaining their purity levels. Additional materials are required for safe reconstitution and injection, available at the link provided.

No matter which route of administration is used, it is imperative to source BPC-157 from a legitimate supplier of quality peptides. 

Click here to learn more about BPC-157 dosages.

Where to Buy BPC-157 Online | 2023 Guide

Peptide quality is key for both safety and success in your research. As such, we have combed the net for the best suppliers of BPC-157 nasal sprays, injectables, and capsules.

When it comes to BPC-157 nasal spray, your best option is this high-quality offering from PureRawz, a leading research peptide brand and a favorite here at Peptides.org.

This vendor verifies peptide purity with third-party Certificates of Analysis (CoAs) and offers rapid international shipping on top-quality items.

Researchers interested in BPC-157 for injection or oral administration should look no further than these great offerings from another of our preferred peptide suppliers, Peptide Sciences!

BPC-157 capsules:

BPC-157 for injection:

Peptide Sciences is the go-to supplier of scientists around the world due to its quality guarantee, competitive prices, international shipping, and total commitment to customer satisfaction! Plus, check out is rapid and safe, and many payment options are accepted.

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BPC-157 Benefits

The known benefits of BPC-157 are many, and ongoing studies are sure to add! Here is a quick rundown of the most notable benefits of BPC-157 in current findings.

GI Function

In its natural element as a gastro peptide, BPC-157 contributes greatly to the structural integrity and function of the entire gastrointestinal tract. It is shown to fortify the gut lining while rapidly healing and protecting against lesions, also reducing inflammation and influencing global health by acting on the gut-brain axis. Human studies show its marked anti-ulcer effects and utility in the treatment of inflammatory bowel disease [2, 4, 33].

Improved Healing

Animal studies indicate that BPC-157 stimulates the proliferation of fibroblasts to enhance healing in many tissue types. These include the GI lining, as well as bones, skin, tendons, ligaments, and muscles [3, 33]

Angiogenesis

BPC-157 has been shown in animal models to increase angiogenesis through upregulating endothelial growth factor. This contributes to injury recovery and has the potential to boost cardiovascular health, increasing circulation and stabilizing blood pressure [33, 34, 35].

Neurological Health

BPC-157 is also evidenced to have neuroprotective effects, reducing nerve damage due to strokes and injuries while regulating neurotransmitters to attenuate symptoms of Parkinson’s disease, schizophrenia, and depression [2, 33, 36].

Treating Drug Toxicity

Similarly, BPC-157 effectively reduces the toxic effects of numerous drugs, including insulin, alcohol, NSAIDs, and neuroleptics. These protective benefits have been observed in the GI tract, liver, cardiovascular system, and brain [20, 36].

Powerful Anti-Inflammatory

Anti-inflammatory benefits have been evidenced with BPC-157 administration in many tissue types, including the lungs, liver, nervous system, and gastrointestinal tract [33, 34].

This is not an exhaustive list of the therapeutic effects observed in BPC-157. Emerging research further points to its anti-aging effects through collagen synthesis, as well as analgesic benefits [37, 38].

Is BPC-157 Safe?

Bearing in mind that there is a lack of data on BPC-157 use in humans, research suggests that it is safe and well-tolerated when properly handled. When adverse reactions have occurred, they have been mild and transient. These include [6, 34, 39]:

  • Irritation at the site of injection
  • Fatigue
  • Nausea
  • Light-headedness
  • Sweating

Adverse effects are often attributable to low-grade peptides. For this reason, peptides must be sourced from legitimate retailers. When handling BPC-157, researchers are encouraged to consult all relevant research and adhere to expert guidelines for safety and efficacy.

BPC-157 Nasal Spray | Verdict

In closing, intranasal administration represents a promising yet under-studied avenue of research into the therapeutic use of BPC-157.

However, a review of recent studies indicates that this is soon to change as more clinicians become aware of the unique advantages of nasal delivery of peptides and other therapeutics. These include targeted action on the central nervous system, excellent bioavailability, and the rapid onset of systemic effects. BPC-157 may be particularly suited to this route of administration due to its known neuroprotective benefits.

With great offerings such as the Repair nasal spray from PureRawz, researchers can seize the opportunity to conduct cutting-edge investigations into the great therapeutic potential of nasal BPC-157 administration!

Buy peptides from Pure Rawz, a top-rated vendor...

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References

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  2. Vukojevic J, Milavić M, Perović D, Ilić S, Čilić AZ, Đuran N, Štrbe S, Zoričić Z, Filipčić I, Brečić P, Seiverth S, Sikirić P. Pentadecapeptide BPC 157 and the central nervous system. Neural Regen Res. 2022 Mar;17(3):482-487. doi: 10.4103/1673-5374.320969. PMID: 34380875; PMCID: PMC8504390.
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  36. Sikiric P, Seiwerth S, Rucman R, Turkovic B, Rokotov DS, Brcic L, Sever M, Klicek R, Radic B, Drmic D, Ilic S, Kolenc D, Aralica G, Safic H, Suran J, Rak D, Dzidic S, Vrcic H, Sebecic B. Toxicity by NSAIDs. Counteraction by stable gastric pentadecapeptide BPC 157. Curr Pharm Des. 2013;19(1):76-83. doi: 10.2174/13816128130111. PMID: 22950504.
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