Last Updated January 28, 2024

 January 28, 2024

Wondering about the therapeutic benefits of BPC-157 and TB-500 capsules?

If so, this is the right place.

Below, our expert team covers what researchers need to know about this orally administered peptide blend, including:

  • What is BPC-157 + TB-500?
  • BPC-157 + TB-500 benefits
  • BPC-157 + TB-500 safety
  • Capsules vs. injections vs. nasal sprays

Read on to learn more about oral BPC-157 and TB-500 peptide therapy, from the combo’s documented regenerative benefits to proper handling methods and more.

Buy BPC-157 + TB-500 Capsules from our top-rated vendor...

Disclaimer: Peptides.org contains information about products that are intended for laboratory and research use only, unless otherwise explicitly stated. This information, including any referenced scientific or clinical research, is made available for educational purposes only. Likewise, any published information relative to the dosing and administration of reference materials is made available strictly for reference and shall not be construed to encourage the self-administration or any human use of said reference materials. Peptides.org makes every effort to ensure that any information it shares complies with national and international standards for clinical trial information and is committed to the timely disclosure of the design and results of all interventional clinical studies for innovative treatments publicly available or that may be made available. However, research is not considered conclusive. Peptides.org makes no claims that any products referenced can cure, treat or prevent any conditions, including any conditions referenced on its website or in print materials.


What is BPC-157 + TB-500?

BPC-157 + TB-500 is a peptide blend that has garnered attention in regenerative medicine and sports performance enhancement.

BPC-157, also known as Body Protection Compound 157, has shown healing and regenerative outcomes, making it a promising therapeutic agent.

Synthetically derived from the native gastro peptide called Body Protection Compound, BPC-157 promotes the formation of blood vessels, stimulates collagen synthesis, and encourages the growth of cells across multiple tissue types [1].

TB-500 is another synthetic peptide derived from a naturally occurring protein called thymosin beta-4, which plays a crucial role in tissue repair and regeneration [2]. This peptide is of clinical interest in the context of muscle repair and recovery. It stimulates cell migration, facilitates tissue remodeling, and aids in healing damaged tissues [3, 4].

When these two peptides are combined, they exhibit a synergistic effect. This powerful combination has the potential to expedite the recovery process and support tissue repair while enhancing athletic performance, among other therapeutic endpoints [5].

Further studies are required on the use of BPC-157 and TB-500 for therapeutic purposes. Ongoing research suggests a growing number of potential applications.

Continue reading to learn more about the documented benefits of these popular research peptides, as well as proper handling, safety, and sourcing.


bpc-157 tb-500 capsules


BPC-157 + TB-500 Benefits

Here are some key benefits associated with the concurrent administration of BPC-157 and TB-500:

Accelerated Healing

Both BPC-157 and TB-500 have demonstrated abilities to expedite the body's repair and healing processes. BPC-157 stimulates blood vessel formation, collagen synthesis, and cell proliferation, while TB-500 aids in cellular migration and tissue remodeling [1].

These two compounds combine synergistically to enhance the body's natural healing mechanisms, potentially leading to improved recovery times from injuries or surgical procedures [1].

Tissue Regeneration

BPC-157 promotes the development of cells and tissues through several distinct mechanisms. Additionally, TB-500 acts as a muscle repair agent, rebuilding damaged tissues.

For example, a study conducted by Hsieh et al. (2017) examined the pro-angiogenic mechanism of BPC-157 in rats with hind limb ischemia. It was observed that BPC-157 facilitated the recovery of blood flow and angiogenesis [6].

TB-500 also displays a range of regenerative activities, observed to promote cellular migration, blood vessel formation, and stem cell maturation [4].

Anti-Inflammatory Effеcts

Both BPC-157 and TB-500 have been shown to decrease inflammation.

In this capacity, BPC-157 has evidenced potential in the clinical management of COVID-19 and diseases associated with fibrosis and multi-organ failure. It has been found to enhance immune response and reduce oxidative stress as both a preventive and complementary treatment option. However, further research and clinical trials are necessary to determine its suitability for human use [7].

Gastrointestinal Protection

The protective effects of BPC-157 on the gastrointestinal (GI) system have been extensively studied. According to Prdrag et al. (2018), BPC-157 exhibits cell-protective properties by safeguarding the integrity of the GI mucosa [8].

It has demonstrated positive treatment outcomes for GI tract issues, periodontitis, and lesions of the liver and pancreas. The underlying mechanisms involve stimulating genes such as Egr 1, NAB2, FAK paxillin, and JAK 2 pathways [8].

Performance Enhancement

There is considerable interest within athletic and fitness communities in BPC-157 and TB-500 dual therapy for potential performance-enhancing effects. These peptides can aid in recovery, reduce downtime between training sessions, and support muscle repair and growth. This faster recovery may help athletes improve their performance rapidly by increasing training frequency and intensity [9].

Moreover, both peptides also show the potential to strengthen tissue, offering an advantage for athletes who push their physical limits. By decreasing the risk of strains and sprains, athletes can train effectively and safely [10].

Antidepressant Effects

In a study conducted by Sikiric et al. (2000), BPC-157 was investigated as a potential treatment for depressive disorders. BPC-157 exhibited similar effectiveness to antidepressants in improving stress response in various contexts [11].

Shown to regulate serotonin and dopamine levels, BPC-157 has also evidenced positive effects in addressing traumatic brain injury and spinal cord compression [8].

While these clinical findings are promising, more research is needed to fully understand the benefits and long-term effects of this peptide combination.


BPC-157 + TB-500 Side Effects

Although this peptide blend is not linked with common or severe side effects, handlers should consider these key points:

  • Limited Research: While BPC-157 +TB-500 have undergone some investigations into their properties, more studies are still needed to fully understand their long-term effects and potential side effects [12].
  • Individual Variations: Responses to BPC-157 combined with TB-500 can vary among research subjects. While some may experience no side effects, others may have mild to moderate reactions.
  • Possible Allergic Reactions: Allergic reactions are possible with any agent. If the subject has a history of allergies or sensitivities, it is advised to use BPC-157 + TB-500 with caution. Seek medical attention for severe allergic reactions [13].
  • Interactions: Since both BPC-157 and TB-500 are peptides that affect physiological processes, there is a possibility of interactions with other medications [13].
  • Concerns Regarding Injections: When injecting BPC-157 or TB-500, there is a risk of injection site reactions such as pain, redness, or swelling. To minimize these risks, it is important to follow injection techniques and sterile practices [13].

BPC-157 + TB-500 Dosage Guide

When using the combination of BPC-157 and TB-500, researchers are advised to follow dosage guidelines for effective usage.
Bearing in mind that there is no set dosing protocol for these experimental compounds, here are some general considerations per current research findings:

  • The appropriate dosage of BPC-157 + TB-500 may vary depending on factors such as desired outcome, the test subject’s body weight, and individual response.
  • BPC-157 and TB-500 are commonly given through subcutaneous or intramuscular injections. However, novel formulations have introduced oral tablets as viable administration methods.
  • It is recommended to start with a low dose of the peptide combination and gradually increase it over time in order to minimize the risk of side effects.
  • In studies on humans, the BPC-157 dosage is typically between 200 and 500 micrograms per day.
    As for TB-500 trials, the dosages range from 2 to 5 milligrams twice weekly.

These dosage recommendations are not definitive and should be adjusted based on research context and medical guidance.

Sample BPC-157 + TB-500 Dosing Protocol

Researchers using BPC-157 and TB-500 capsules may reference the below dosing protocol.

It is based on a novel oral formulation of BPC-157 and TB-500 designed for tissue repair and recovery, available through preferred research peptides vendor.

  • BPC-157 + TB-500 Dosage: Each capsule contains 250mcg of BPC-157 and 2.5mg of TB-500, along with 2mg of GHK-Cu. It is intended for once daily ingestion. The capsule should be swallowed on an empty stomach.
  • Course Duration: 4-8 weeks, or until desired outcome is achieved.
  • Notes: Our recommended vendor supplies BPC-157/TB-500 capsules in 60-day containers, which represents a 60-day supply per test subject.

Here are some additional guidelines to consider:

  • Evaluate any side effects and make necessary adjustments to the dosage or administration schedule.
  • Adherence to dosage guidelines is strongly advised.
  • Exceeding recommended limits or using these peptides for extended periods may increase the risk of adverse effects.

BPC-157 + TB-500 Capsules | The A-Z Guide

BPC-157 and TB-500 capsules have gained significant attention in regenerative medicine and athletic performance enhancement. These capsules offer an accessible way to experience the benefits of both BPC-157 and TB-500.

Benefits of BPC-157 + TB-500 Capsules

Here is a brief recap of potential benefits associated with BPC-157/TB-500 capsules:

  • Faster Healing: BPC-157 and TB-500 capsules may accelerate the healing process. BPC-157 promotes the formation of blood vessels, collagen synthesis, and cell growth. Meanwhile, TB-500 aids in cell migration and tissue remodeling. This combination can help expedite recovery from injuries and post-surgery healing [1, 4].
  • Tissue Regeneration: While BPC-157 stimulates tissue growth, TB-500 is renowned for its role in muscle repair. Together they enhance tissue regeneration, synergistically combining to restore damaged structures [4, 6].
  • Anti-Inflammatory Effects: Both BPC-157 and TB-500 exhibit anti-inflammatory properties. This can be particularly beneficial for subjects dealing with inflammatory disease or injury [7].
  • Gastrointestinal Protection: Extensive research has been conducted on the effects of BPC-157 on the GI system. It helps prevent and repair the damage to the gut lining caused by stress, injury, or certain medications. Maintaining a healthy GI tract not only enhances nutrient absorption but improves overall well-being [8].
  • Performance Enhancement: BPC-157 and TB-500 capsules have potential benefits in athletic and fitness settings. These peptides can aid in recovery, reduce downtime between training sessions, and support muscle repair and growth for enhanced performance [9, 10].

Recommended Usage

The appropriate dosage of BPC-157 and TB-500 capsules may vary depending on body weight, desired outcomes, and individual research response. Continuous use is not recommended, pending further study.

The healing and repair formula contains a daily dose of 2.5mg TB-500 with 250mcg BPC-157, to be taken orally between meals.

Precautions and Potential Interactions

Exercise caution when using BPC-157 and TB-500 capsules in subjects with a history of allergies or sensitivities. Discontinue use if severe adverse reactions occur [14].

Generally, the side effects of BPC-157 + TB-500 capsules are mild. However, some subjects may experience moderate stomach upset [15]. Handlers are advised to consult the relevant literature on both compounds to determine potential interactions [13].

Researchers are urged to choose a supplier that adheres to quality assurance methods. Below we present our go-to supplier of both BPC-157/TB-500 capsules and a host of other research chemicals.


bpc-157 tb-500 capsules


Where to Buy BPC-157 + TB-500 Capsules Online?

Qualified researchers can purchase premium BPC-157 and TB-500 capsules for their studies. However, caution is advised when selecting a source, as low-quality peptides may result in faulty research and safety hazards.

The go-to online retailer among the experts at Peptides.org is Limitless Life, known for these outstanding benefits:

  • Quality Assurance: Limitless Life verifies peptide quality via HPLC-MS analysis that confirms purity levels of 99% on all items. Their strict quality standards ensure that the products meet purity, potency, and safety requirements, giving customers peace of mind when making a purchase.
  • Peptides Made in the USA: This vendor also takes pride in offering BPC-157 + TB-500 capsules manufactured in the USA, adhering to high-quality production standards.
  • Rapid, Low-Cost Shipping: In addition, they provide free US shipping for orders totaling $350 or more, making it convenient and cost-effective for customers to receive their products quickly.
  • Customer Satisfaction: Limitless Life employs experts who possess knowledge of peptides and their applications. Their experienced staff can provide guidance and support.

Buy BPC-157 + TB-500 Capsules from our top-rated vendor...


Forms of Administration | Capsules vs. Injectables vs. Nasal Spray

When considering options for administering BPC-157 and TB-500, handlers have three choices: capsules, injectables, or nasal sprays. Here is a brief comparison of each method:

Capsules

BPC-157 and TB-500 capsules are easy to take, eliminating the need for injections or nasal administration. Capsules come pre-measured for simplified dosing. This method is ideal for researchers who prefer non-invasive and hassle-free administration.

The best capsule blend available is this popular item from Limitless Life:


Injectables

Injections offer highly effective, systemic peptide delivery. Subcutaneous or intramuscular administration of BPC-157 and TB-500 may augment their therapeutic effects. Researchers are advised to follow proper injection and dosing techniques.

Limitless Life also carries premium injectable BPC-157 and TB-500:


Nasal Spray

Nasal sprays offer a non-invasive route of administration. They deliver BPC-157 and TB-500 through the nasal mucosa, allowing for quick absorption. Ensuring the quality of the nasal spray formulation is essential for proper absorption.

Check out this nasal spray from Limitless Life, another expert-recommended brand:


BPC-157 + TB-500 Capsules | Verdict

In conclusion, BPC-157 and TB-500 capsules are non-invasive and backed by broad evidence of healing and regenerative outcomes. With pre-measured doses, easy oral administration, and no need for injections or nasal sprays, capsules offer a hassle-free experience for researchers.

While injectables or nasal sprays may provide faster absorption, capsules are ideal for those looking to eliminate potential discomfort with needles and nasal sprays. They serve as a solution for scientists looking to easily incorporate BPC-157 and TB-500 into their research.

When purchasing BPC-157 and TB-500 capsules for research, it is crucial to ensure the product's quality, purity, and safety. Choose a supplier like our top-rated vendors listed above, known for their commitment to quality assurance and satisfaction.


References

  1. Seiwerth S, Milavic M, Vukojevic J, Gojkovic S et al. Stable Gastric Pentadecapeptide BPC 157 and Wound Healing.Front Pharmacol. 2021 Jun 29;12:627533. doi: 10.3389/fphar.2021.627533. eCollection 2021.PMID: 34267654
  2. Esposito S, Deventer K, Goeman J, Van der Eycken J, Van Eenoo P. Synthesis and characterization of the N-terminal acetylated 17-23 fragment of thymosin beta 4 identified in TB-500, a product suspected to possess doping potential. Drug Test Anal. 2012 Sep;4(9):733-8. doi: 10.1002/dta.1402. Epub 2012 Sep 7. PMID: 22962027
  3. Chang CH, Tsai WC, Lin MS, Hsu YH, Pang JH. The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. J Appl Physiol (1985).(2011 Mar)
  4. Philp D, Kleinman HK (April 2010). “Animal studies with thymosin beta, a multifunctional tissue repair and regeneration peptide”. Annals of the New York Academy of Sciences. 1194 (1): 81–6.
  5. Esposito S, Deventer K, Goeman J, Van der Eycken J, Van Eenoo P. Synthesis and characterization of the N-terminal acetylated 17-23 fragment of thymosin beta 4 identified in TB-500, a product suspected to possess doping potential.Drug Test Anal. 2012 Sep;4(9):733-8. doi: 10.1002/dta.1402. Epub 2012 Sep 7.PMID: 22962027
  6. Hsieh MJ, Liu HT, Wang CN, Huang HY, Lin Y, Ko YS, Wang JS, Chang VH, Pang JS. Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulationJ Mol Med (Berl).(2017 Mar)
  7. Sarah A. Deek. BPC 157 as Potential Treatment for COVID-19. Med Hypotheses. 2022 Jan; 158: 110736.
  8. Predrag S, Sven S, Rudolf R, et al.,Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications, Curr Neuropharmacol. 2016 Nov; 14(8): 857–865.
  9. Sikiric P. The pharmacological properties of the novel peptide BPC 157 (PL-10) Inflammopharmacology.(1999)
  10. Food and Drug Administration. (2021). Peptides: What you need to know. Retrieved from https://www.fda.gov/consumers/consumer-updates/peptides-what-you-need-know
  11. P Sikiric, J Separovic, G Buljat, T Anic, D Stancic-Rokotov, et al. The antidepressant effect of an antiulcer pentadecapeptide BPC 157 in Porsolt's test and chronic unpredictable stress in rats. A comparison with antidepressants. J Physiol Paris. 2000 Mar-Apr;94(2):99-104.
  12. Klicek R, Kolenc D, Suran J, Drmic D, Brcic L, Aralica G, Sever M, Holjevac J, Radic B, Turudic T, Kokot A, Patrlj L, Rucman R, Seiwerth S, Sikiric P, Stable gastric pentadecapeptide BPC 157 heals cysteamine-colitis and colon-colon-anastomosis and counteracts cuprizone brain injuries and motor disabilityJ Physiol Pharmacol.(2013 Oct)
  13. Staresinic M, Sebecic B, Patrlj L, Jadrijevic S, Suknaic S, Perovic D, Aralica G, Zarkovic N, Borovic S, Srdjak M, Hajdarevic K, Kopljar M, Batelja L, Boban-Blagaic A, Turcic I, Anic T, Seiwerth S, Sikiric PGastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tendocytes growthJ Orthop Res.(2003 Nov)
  14. Park JM, Lee HJ, Sikiric P, Hahm KB. BPC 157 Rescued NSAID-cytotoxicity Via Stabilizing Intestinal Permeability and Enhancing Cytoprotection. Curr Pharm Des. 2020;26(25):2971-2981. doi: 10.2174/1381612826666200523180301.
  15. World Anti-Doping Agency. (2021). Prohibited List. Retrieved from https://www.wada-ama.org/en/content/what-is-prohibited/prohibited-list
  16. US Anti-Doping Agency. (2021). Prohibited Substances and Methods. Retrieved from https://www.usada.org/substances/prohibited-substances-and-methods/

Scientifically Fact Checked by:

David Warmflash, M.D.

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