Titus Thorne

Last Updated August 17, 2022

Titus Thorne

 August 17, 2022

CJC-1295 and Ipamorelin are both peptides that boost growth hormone (GH) levels, but can researchers administer them concurrently to test subjects? 

This guide will outline the main benefits, side effects, and known interactions of these two peptides with the aim of informing researchers working in this field. 

Below, researchers can gain a full understanding of the similarities and differences between CJC-1295 and Ipamorelin, and the types of effects that test subjects may experience when administered these peptides simultaneously. 

Let’s jump in.

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What is CJC-1295?

CJC-1295 is a synthetic peptide that is an analog of growth hormone-releasing hormone (GHRH) [1]. It was originally developed by ConjuChem Biotechnologies in Montreal, Canada, but is now produced by several companies around the world[2].

Because it is chemically similar to the human body’s own GHRH [3], it has a similar effect: It acts on the growth hormone (GH) pathways to upregulate GH in the blood [4].

Why does GH matter?

GH is essential for a vast number of bodily functions, especially cell and protein synthesis, cell maintenance and tissue repair [5]. GH touches everything: GH receptors are found all over the body in virtually all tissues.

Some of GH’s effects include increasing calcium retention [6], increasing muscle mass [5], promoting lipolysis (fat burning), supporting protein synthesis and stimulating the immune system [7].

While GH is plentiful in the young, it starts to decline as people age. That’s why increasing the levels of GH in the body is believed to help fight symptoms of aging.


CJC-1295 ipamorelin


Benefits of CJC-1295

The therapeutic benefits of CJC-1295 have yet to be rigorously investigated in human trials. Below is an overview of the purported benefits that CJC-1295 may offer.

The direct benefit of CJC-1295 is simply that it raises GH levels in the blood [4, 8].

That, in turn, may offer several benefits for the body, including [7]:

  • Well-developed bones: As we age, bones lose their density and can become brittle. GH has been found to improve that density and prevent bone health issues [9].
  • Muscle growth: GH has a direct impact on the body’s ability to synthesize muscle tissue after workouts. Several studies have shown that GH can increase lean muscle mass [10, 11].
  • Improved sleep: GH and sleep go together; the highest levels of GH in the body occur during stage IV sleep. The relationship goes the other way, too: CJC-1295 seems to improve the quality of sleep [12].
  • Burning fat: GH plays an important role in breaking down adipose tissue into energy [10]. Of course, this requires exercise — it’s not going to happen on its own [13].
  • Injury recovery: Growth hormone helps the body repair damaged tissue. That explains why GH has been found to help people recover faster from injuries [14].
  • Anti-aging effects: GH purportedly offers anti-aging benefits such as younger-looking skin [15]. GH can improve skin quality by repairing and replacing the collagen protein that gives skin its elasticity [16, 17].

Due to these purported benefits of CJC-1295, there is evidence to show that the bodybuilding community has taken great interest in CJC-1295.


CJC-1295 Side Effects

What about CJC-1295 side effects?

Well, again, the research in this area is clearly lacking. There are a limited number of human studies involving CJC-1295, but from this limited pool of data it appears that CJC-1295 side effects are minimal, at least in the short term [4, 7, 8].

However, some reported side effects include:

  • dizziness
  • headache
  • nausea
  • flu-like symptoms
  • hives
  • increased heart rate
  • flushing
  • hyperactivity
  • redness and tenderness at injection site
  • difficulty swallowing

These side effects appear to be uncommon and rarely severe. And side effects seem to be dose-dependent, meaning that they become more likely with larger doses. Research subjects can be started on smaller doses to reduce the chance they’ll experience side effects.


What is Ipamorelin?

Ipamorelin is another synthetic peptide made up of 5 amino acids. It’s one of a number of growth hormone-releasing peptides (GHRPs) [18].

Ipamorelin is chemically similar to one of the body’s natural peptides called “Ghrelin” so it can bind to the Ghrelin receptors that play a role in regulating GH in the body.

One of its effects is the reduction of other chemicals, namely somatostatin, that work to inhibit the release of GH. Ipamorelin helps create the conditions for increased GH release.


ipamorelin


Benefits of Ipamorelin

In common with CJC-1295 peptide, Ipamorelin appears to produce a significant increase in GH in the blood [18].

Research involving Ipamorelin has shown that it may offer the following benefits when administered to test subjects:

  • Better bone mineral density [18]
  • Faster recovery from injuries [14]
  • Greater lipolysis and fat loss [10]
  • Increases in lean muscle tissue [10, 13]
  • Anti-aging effects such as younger-looking skin [16]
  • Better sleep [12, 19]

An additional potential benefit of Ipamorelin beyond those of other GHRPs is that it does not create additional cortisol when administered to test subjects.


Ipamorelin Side Effects

Ipamorelin has been found to produce some side effects in test subjects, although, like for CJC, these are typically rare and mild. They include:

  • Headache
  • Lightheadedness
  • Pain, rash, or soreness at injection sites
  • Water retention in wrists or ankles
  • Transient fever
  • Insulin resistance
  • Neoplasm
  • Hypertension
  • Scoliosis

CJC-1295 and Ipamorelin | What Researchers MUST Know

Researchers will be aware that both CJC-1295 and Ipamorelin are peptide powerhouses in their own rights.

We’ll now go even deeper, examining key similarities and differences between the two, and exploring the effects that researchers may observe when administering CJC-1295 and Ipamorelin simultaneously to test subjects.

Similarities Between CJC-1295 and Ipamorelin

CJC-1295 and Ipamorelin have much in common.

They are both short chains of amino acids and both function as chemical signals to help the body regulate itself. They are both also synthetic, which means they’re produced in a lab.

Most importantly, both have the effect of stimulating the body to endogenously produce growth hormone. They both lead to elevated GH levels in the blood and help the body repair tissue.

Understanding the Difference Between CJC-1295 vs. Ipamorelin

To understand the difference between CJC-1295 and Ipamorelin, it’s important to understand the difference between GHRHs and GHRPs more generally. Both GHRHs, like CJC-1295 peptide, and GHRPs, like Ipamorelin, have the end result of increasing growth hormone.

So, what’s the difference?

The biology is a bit complicated, so we’re going to simplify a bit here. But essentially there are a few pieces to the GH puzzle:

  • Growth Hormone-Releasing Hormones (GHRHs): These signal somatotrophs (specialized cells) in the anterior pituitary gland to begin the process of producing additional GH. GHRHs include Sermorelin, Tesamorelin, CJC-1295 DAC, and CJC-1295 (also called Mod GRF 1-29).
  • Somatostatin: This is a GH inhibitor produced naturally in the body. It tells the somatotroph cells to downregulate the release of GH, and they inhibit GH. Their effect is typically stronger than the effect of GHRH, so if somatostatin is present, GHRHs will usually not lead to the release of GH.
  • Ghrelin: This is a substance created in the stomach and helps regulate appetite. It reduces the effect of somatostatin and encourages the release of more GHRH.
  • Growth Hormone-Releasing Peptides (GHRPs): GHRPs mimic the activity of Ghrelin. They inhibit somatostatin and create the conditions for GHRH to have its effect. These include Hexarelin, GHRP2, GHRP6, Ipamorelin and MKo677 (peptide GHRP mimetic).

So while GHRHs trigger the release of GH from the pituitary gland, the release is ultimately still controlled by the hypothalamus and by whether somatostatin is in there. The somatostatin needs to be turned down before the release of GH can take place.

GHRPs help do just that: They limit that somatostatin so that the GH can actually be released from the pituitary. So they help create the conditions for GHRHs to work.

A very simple way to think about it is that GHRHs help create more GH by the body, and GHRPs help ensure that it gets released. That’s the basic idea, although it omits a ton of detail.

The takeaway for researchers is that there are no official or published figures to indicate whether combining GHRPs together with GHRHs is more effective than administering either on its own.

CJC-1295 and Ipamorelin Together

There is strong research interest in the simultaneous application of both GHRHs and GHRPs to test subjects and many researchers are interested in the effects of administering CJC-1295 and ipamorelin together. However, there is no published researcher to indicate whether these peptides have a synergistic or adverse effect when combined. 

Instead, researchers can consult past studies to see how these peptides have been dosed [7]:

  • CJC-1295 DAC with Ipamorelin: Data from past studies shows that CJC-1295 has been dosed at 1 mcg per kg of body weight, up to a maximum of 100 mcg in test subjects. It has been administered two days out of a week during the test subject’s cycle. Ipamorelin has been dosed at 1 mcg per kg of body weight, up to a maximum of 100 mcg, every day of the test subject’s cycle.
  • Mod GRF 1-29 (CJC-1295 no DAC) with Ipamorelin. Dosing for CJC and Ipamorelin has been 1 mcg per kg of body weight, to a maximum of 100 mcg, every day of the test subject’s cycle.

Researchers interested in experimenting with CJC-1295 and Ipamorelin together may note that these peptides can be purchased as a combination in one product. Such products are sometimes referred to as “CJC-1295 Ipamorelin” or “CJC 1295/Ipamorelin.”

To avoid confusion, researchers should note that CJC-1295 and Ipamorelin are two separate peptides, but they are sometimes sold together.


CJC-1295 ipamorelin


Where to Buy CJC-1295 and Ipamorelin Online? | 2022 Guide

Researchers interested in working with CJC-1295 and Ipamorelin will note that Peptide Sciences is the best place to buy CJC-1295 and Ipamorelin online in 2022 and beyond. This vendor sells both products separately as well as several CJC-1295 Ipamorelin blends.

Our team recommends Peptide Sciences because they offer:

  • Convenient payment options including credit cards, electronic payments like Apple Pay and some cryptocurrencies like Bitcoin
  • Great customer service
  • Fair prices and high-quality product;
  • Quick and international shipping. They also waive shipping fees on US orders over $100.

Is CJC-1295 legal?

Absolutely. It’s not a controlled substance. Researchers are free to buy CJC-1295 online for their research and for use on research subjects.

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Ipamorelin and CJC-1295 | Verdict

Ipamorelin and CJC-1295 HGH peptide are two very powerful GH secretagogues. They cause the body to increase GH in the bloodstream and ultimately make that available to cells that can then grow and repair.

Research shows that test subjects administered these two peptides in conjunction have experienced significant increases in lean muscle mass and a reduction in body fat. 

But Ipamorelin and CJC-1295 work in slightly different ways. And that’s a good thing: they actually complement each other and are capable of creating better outcomes than either one alone.

Researchers looking to conduct research with Ipamorelin and CJC-1295 are strongly advised to contact Peptide Sciences for more information.


References

  1. Henninge, J., Pepaj, M., Hullstein, I., & Hemmersbach, P. (2010). Identification of CJC‐1295, a growth‐hormone‐releasing peptide, in an unknown pharmaceutical preparation. Drug Testing and Analysis, 2(11‐12), 647-650.
  2. Jetté, L., Léger, R., Thibaudeau, K., Benquet, C., Robitaille, M., Pellerin, I., … & Bridon, D. P. (2005). hGRF1-29-Albumin Bioconjugates Activate the GRF Receptor on the Anterior Pituitary in Rats: Identification of CJC-1295 as a Long Lasting GRF Analog. Endocrinology, 146(7), 3052–3058.
  3. Alba, M., Fintini, D., Sagazio, A., Lawrence, B., Castaigne, J. P., Frohman, L. A., & Salvatori, R. (2006). Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse. American Journal of Physiology-Endocrinology and Metabolism, 291(6), E1290-E1294.
  4. Teichman, S. L., Neale, A., Lawrence, B., Gagnon, C., Castaigne, J. P., & Frohman, L. A. (2006). Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults. The Journal of Clinical Endocrinology & Metabolism, 91(3), 799-805.
  5. Florini, J. R. (1987). Hormonal control of muscle growth. Muscle & Nerve: Official Journal of the American Association of Electrodiagnostic Medicine, 10(7), 577-598.
  6. Ahmad, A. M., Thomas, J., Clewes, A., Hopkins, M. T., Guzder, R., Ibrahim, H., … & Fraser, W. D. (2003). Effects of growth hormone replacement on parathyroid hormone sensitivity and bone mineral metabolism. The Journal of Clinical Endocrinology & Metabolism, 88(6), 2860-2868.
  7. Seeds, W. (2020). Peptide protocols, volume 1. Seeds scientific performance research. https://affordablebookdeals.com/products/peptide-protocols-volume-one.
  8. Ionescu, M., & Frohman, L. A. (2006). Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog. The Journal of Clinical Endocrinology & Metabolism, 91(12), 4792-4797.
  9. Landin‐Wilhelmsen, K., Nilsson, A., Bosaeus, I., & Bengtsson, B. Å. (2003). Growth hormone increases bone mineral content in postmenopausal osteoporosis: a randomized placebo‐controlled trial. Journal of Bone and Mineral Research, 18(3), 393-405.
  10. Thompson, J. L., Butterfield, G. E., Gylfadottir, U. K., Yesavage, J., Marcus, R., Hintz, R. L., … & Hoffman, A. R. (1998). Effects of human growth hormone, insulin-like growth factor I, and diet and exercise on body composition of obese postmenopausal women. The Journal of Clinical Endocrinology & Metabolism, 83(5), 1477-1484.
  11. Welle, S., Thornton, C., Statt, M., & McHenry, B. (1996). Growth hormone increases muscle mass and strength but does not rejuvenate myofibrillar protein synthesis in healthy subjects over 60 years old. The Journal of Clinical Endocrinology & Metabolism, 81(9), 3239-3243.
  12. Ghigo, E., Arvat, E., Giordano, R., Broglio, F., Gianotti, L., Maccario, M., … & Camanni, F. (2001). Biologic activities of growth hormone secretagogues in humans. Endocrine, 14(1), 87-93.
  13. Taaffe, D. R., Pruitt, L., Reim, J., Hintz, R. L., Butterfield, G., Hoffman, A. R., & Marcus, R. (1994). Effect of recombinant human growth hormone on the muscle strength response to resistance exercise in elderly men. The Journal of Clinical Endocrinology & Metabolism, 79(5), 1361-1366.
  14. Erotokritou-Mulligan, I., Holt, R. I., & Sönksen, P. H. (2011). Growth hormone doping: a review. Open Access Journal of Sports Medicine, 2, 99.
  15. Van Hout, M. C., & Hearne, E. (2016). Netnography of female use of the synthetic growth hormone CJC-1295: pulses and potions. Substance Use & Misuse, 51(1), 73-84.
  16. Ganceviciene, R., Liakou, A. I., Theodoridis, A., Makrantonaki, E., & Zouboulis, C. C. (2012). Skin anti-aging strategies. Dermato-endocrinology, 4(3), 308-319.
  17. Bartke, A. (2019). Growth hormone and aging: updated review. The World Journal of Men's Health, 37(1), 19-24.
  18. Andersen, N. B., Malmlöf, K., Johansen, P. B., Andreassen, T. T., Ørtoft, G., & Oxlund, H. (2001). The growth hormone secretagogue ipamorelin counteracts glucocorticoid-induced decrease in bone formation of adult rats. Growth Hormone & IGF Research, 11(5), 266-272.
  19. Frieboes, R. M., Murck, H., Maier, P., Schier, T., Holsboer, F., & Steiger, A. (1995). Growth hormone-releasing peptide-6 stimulates sleep, growth hormone, ACTH and cortisol release in normal man. Neuroendocrinology, 61(5), 584-589.

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