Titus Thorne

Last Updated November 17, 2021

Titus Thorne

 November 17, 2021

Curious about CJC-1295 benefits? You aren’t alone.

This powerful research peptide has caught the attention of bodybuilding and biohacking circles. It purportedly offers numerous physiological and neuroprotective benefits. But as a research chemical, it has yet to undergo clinical trials.

So, what is CJC-1295 — and is it even legal? Is it safe? And what are the main benefits subjects might derive from CJC-1295 administration?

In this guide, we’ll aim to answer those questions and more.

Buy CJC-1295 from the #1 online Peptides vendor in the world: Peptides Sciences

Disclaimer: ResearchPeptides.org contains information about products that are intended for laboratory and research use only, unless otherwise explicitly stated. This information, including any referenced scientific or clinical research, is made available for educational purposes only. ResearchPeptides.org makes every effort to ensure that any information it shares complies with national and international standards for clinical trial information and is committed to the timely disclosure of the design and results of all interventional clinical studies for innovative treatments publicly available or that may be made available. However, research is not considered conclusive. ResearchPeptides.org makes no claims that any products referenced can cure, treat or prevent any conditions, including any conditions referenced on its website or in print materials.


What Is CJC-1295?

CJC-1295 is a peptide that’s a synthetic analogue of growth hormone-releasing hormone (GHRH). In other words, it’s a modified version of the first 29 amino acids in GHRH. It was developed by, and named after, ConjuChem Technologies, a Canadian Biotech company [1]. This version developed by ConjuChem is also known as CJC-1295 DAC, or DAC:GRF (drug affinity complex:growth hormone-releasing factor), and is the one we’ll be referring to in this discussion of CJC-1295 benefits.

While the benefits of CJC-1295 have yet to be tested in human clinical trials, this peptide is believed to enhance performance. CJC-1295 bodybuilding is now a hot research topic, and the peptide is being investigated as an alternative for getting the benefits of growth hormone (GH) with fewer side effects [2].


CJC-1295


Is CJC-1295 Legal?

Although both CJC-1295 DAC and CJC-1295 no DAC are widely used by researchers, these peptides are not FDA-approved and remain restricted to researchers. Where available for sale, CJC-1295 is sold strictly for in vitro testing and laboratory experimentation.

Athletes beware: Due to its performance-enhancing potential, CJC-1295 is prohibited by the World Anti-Doping Agency (WADA) as falling under Section S2 of its Prohibited List [3], and is banned from all major drug-tested competitive sports.


What Are the Different Types of CJC-1295?

The CJC-1295 peptide was initially developed because GHRH has a very short half-life of around seven minutes. Created in the 1980s, CJC-1295 no DAC, also known as Mod GRF (1-29), had a half-life of up to 30 minutes. This was still far from ideal. But thankfully, alternatives to CJC-1295 no DAC have since been developed. We call attention to two in particular:

  • CJC-1295 DAC
  • CJC-1295 Ipamorelin

Let’s take a look at both of these CJC-1295 no DAC alternatives, and see how CJC-1295 DAC differs from CJC-1295 Ipamorelin.


What Is CJC-1295 DAC?

CJC-1295 DAC is a far improved version over CJC-1295 no DAC, and has a longer half-life of around six to eight days. DAC, which stands for Drug Affinity Complex, helps to protect the peptide after it’s injected, resulting in the much longer half-life. CJC-1295 DAC is a “bioconjugate,” meaning it’s a complex molecule that contains two smaller molecules, one of which is biologically active [4].

It’s believed that CJC-1295 DAC is more efficient than its predecessor and has a stronger effect on levels of cortisol and prolactin. However, these claims have not been verified through human studies.


What Is CJC-1295 Ipamorelin?

CJC-1295 Ipamorelin is a blend of growth hormone-releasing peptide (CJC-1295 no DAC) with growth hormone-releasing hormone (Ipamorelin). Ipamorelin is a “secretagogue,” meaning that it increases the specificity of CJC-1295. Anecdotal evidence suggests that it has a lesser effect on cortisol and prolactin levels than CPC-1295 DAC.

CJC-1295 (no DAC) and Ipamorelin are usually mixed in a 1:1 ratio with the Ipamorelin acting as a short-term trigger and CJC-1295 acting as a long-term trigger. As CJC-1295 Ipamorelin has a longer half-life than CJC-1295 DAC, it is believed to be more potent. However, this is based on anecdotal evidence and not the result of clinical studies.

Now that we’ve outlined the two key iterations over the original CJC-1295, let’s look at the potential benefits offered by this peptide.


Benefits of CJC-1295 | Top 5

Many theorized and purported benefits of CJC-1295 are based on animal studies [5] and have yet to be explored in human clinical trials. At the time of writing, with no clinical trials of CJC-1295 yet completed, most believed CJC-1295 benefits remain clinically untested. Further studies are necessary to explore how CJC-1295 behaves in the human body and with different cell groups.

But, what are the proven benefits of CJC-1295?

Longer Half-Life Than Growth Hormone

The main proven benefit of CJC-1295 is that it has a much longer half-life than GH and other GH analogues. CJC-1295 DAC has an estimated half-life of 5.8-8.1 days, according to the findings of a randomized, double-blind, placebo-controlled trial by Teichman et al in 2006 [6]. In a before-and-after comparison, test subjects had significantly elevated levels of GH up to eight days after receiving a subcutaneous injection.

Prolonged Stimulation of Growth Hormone (GH) and Insulin-like Growth Factor 1 (IGF-1)

The second proven benefit of CJC-1295 is that it offers a prolonged stimulation of the release of both GH and Insulin-Like Growth Factor 1 (IGF-1). Researchers found that CJC-1295 DAC causes a 2-10 fold increase in plasma growth hormone concentration for six days and a 1.5-4 fold increase in plasma IGF-1 concentration for 9-12 days [6].

Potential Therapeutic Uses

As IGF-1 is used to treat growth hormone insensitivity syndrome (GHIS) [7], and CJC-1295 has been shown to increase both GH and IGF-1 [6], it has been theorized that CJC-1295 may offer therapeutic benefits associated with IGF-1 therapy [8]. To date, there is no empirical data to support these claims.

Potential Performance Enhancement

While CJC-1295 hasn’t been tested in clinical trials, it’s believed to be used in bodybuilding and athletics by those seeking to improve athletic performance [9]. However, while there is convincing evidence that GH can help improve exercise capacity in people with a GH deficiency [10], there is no scientific evidence that GH therapy helps healthy individuals with normal GH levels.

The practice of administering GH or an analogue of GH to patients with a GH deficiency is known as “GH replacement.” It’s theorized to help increase oxygen delivery to muscles, leading to increased strength and improved body composition. However, there is no evidence that GH or CJC-1295 improves physical performance in healthy individuals [11].

Potential Neuroprotective Properties

As growth hormone (GH) is proven to have a significant influence on cognitive performance, anecdotal evidence suggests that GH-boosting peptides like CJC-1295 may help improve spatial learning and memory. In one animal study, mice with altered growth hormone action “showed significantly better learning parameters” than those without [12]. This has led to speculation that GH analogues like CJC-1295 may help with neuropathological and neurodegenerative conditions or offer neuroprotective properties.

As you can see, scientific data supporting CJC-1295’s effectiveness is sparse, given that it’s a research chemical not intended for human consumption. Next, we’ll dive into this peptide’s side effects.


CJC-1295

 


CJC-1295 Side Effects

According to the 2006 double-blind, placebo-controlled study by Teichman et al, subcutaneous injections of CJC-1295 DAC caused “no serious adverse reactions” [6]. The study actually compiled the findings of two separate trials. The first trial involved giving volunteers a single dose of CJC-1295 DAC , while the second trial gave volunteers two or three doses of CJC-1295 DAC per week.

The authors noted that subcutaneous administration of CJC-1295 DAC was “relatively well tolerated” when doses were higher than 30 μg/kg and lower than 60 μg/kg. They also found that CJC-1295 DAC had “cumulative effect after multiple doses.” [6].

With smaller doses (up to 30 μg/kg) of CJC-1295 DAC, some of the mild adverse effects that the volunteers experienced were:

  • Mild injection site reactions,
  • Irritation,
  • Erythema,
  • Induration,
  • Pain, and
  • Itching.

With higher doses of CJC-1295 DAC (over 30 μg/kg), the most common side effects were:

  • Headaches,
  • Diarrhea,
  • Flushing, and
  • Mild hypotension.

Although these side effects occurred in approximately 70 percent of test subjects receiving CJC-1295 DAC, they were transient and lasted no more than a few hours.

Now that we’ve gone over the safety of the CJC-1295 peptide, let’s look at where to buy some online.


Where To Buy CJC-1295 Online? | 2021 Guide

If you’re looking to buy CJC-1295 for research purposes, our preferred vendor is Peptide Sciences. They are a leading provider of USA-manufactured research peptides and offer the safest, most convenient way of buying CJC-1295 in 2021. This vendor offers all of the CJC-1295 iterations we covered in this article, including CJC-1295 DAC and the CJC-1295 Ipamorelin blend.

Some of the reasons we rate them so highly are:

High Purity CJC-1295 Peptide: PeptideSciences is partnered with WHO/GMP and ISO 9001:2008 approved manufacturers and is able to offer the highest purity products on the market.

Reasonable Prices: PeptideSciences’ partnerships let them pass their savings onto their customers and offer CJC-1295 for the best prices in the market.

Simple, Convenient Ordering: When you order from PeptideSciences, you can enjoy complete privacy and 24/7 customer support. Your shopping cart is secured using the latest SSL technology, ensuring that your order and payment information remain encrypted, protected and 100% discreet.

Bulk Discounts: You can save six percent when you buy five peptides and a whopping nine percent when you order ten. If you order over $300 worth of peptides, you’ll get 30mL of Bacteriostatic water absolutely free.

Fast and Secure Worldwide Shipping: PeptideSciences has thousands of satisfied customers around the world as they offer fast, professional shipping. Orders over $200 for USA customers ship free, and orders to the rest of the world attract a $15 flat shipping rate.

As you can see, PeptideSciences offers numerous benefits and comes highly recommended!

Buy CJC-1295 from our #1 recommended vendor...


CJC-1295

 


CJC-1295 Benefits | Verdict

If you were curious about CJC-1295 benefits and wondered what this research chemical had to offer, hopefully this guide addressed all of your questions.

While CJC-1295 remains a research chemical, peptide research on animal studies indicates that it may hold potential for further research and human trials. There is also plenty of anecdotal evidence to support its effectiveness in the bodybuilding research space.

 


References

  1. Albumin_Bioconjugates_Activate_the_GRF_Receptor_on_the_Anterior_Pituitary_in_Ra
    ts_Identification_of_CJC-1295_as_a_Long_Lasting_GRF_Analog. (2021). Retrieved 26 February 2021, from https://www.researchgate.net/publication/228484039_hGRF1-29-.
  2. Henninge J, Pepaj M, Hullstein I, Hemmersbach P. Identification of CJC-1295, a growth-hormone-releasing peptide, in an unknown pharmaceutical preparation. Drug Test Anal. 2010 Nov-Dec;2(11-12):647-50. doi: 10.1002/dta.233. Epub 2010 Dec 10. PMID: 21204297.
  3. What is Prohibited. World Anti-Doping Agency. (2021). Retrieved 26 February 2021, from https://www.wada-ama.org/en/content/what-is-prohibited/prohibited-at-all-times/peptide-hormones-growth-factors-related-substances-and-mimetics.
  4. Introduction to Bioconjugation. Chemistry LibreTexts. (2021). Retrieved 26 February 2021, from https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Supplemental_Modules_
    (Organic_Chemistry)/Reactions/Introduction_to_Bioconjugation.
  5. Lucie Jetté, Roger Léger, Karen Thibaudeau, Corinne Benquet, Martin Robitaille, Isabelle Pellerin, Véronique Paradis, Pieter van Wyk, Khan Pham, Dominique P. Bridon, Human Growth Hormone-Releasing Factor (hGRF)1–29-Albumin Bioconjugates Activate the GRF Receptor on the Anterior Pituitary in Rats: Identification of CJC-1295 as a Long-Lasting GRF Analog, Endocrinology, Volume 146, Issue 7, 1 July 2005, Pages 3052–3058, https://doi.org/10.1210/en.2004-1286
  6. Sam L. Teichman, Ann Neale, Betty Lawrence, Catherine Gagnon, Jean-Paul Castaigne, Lawrence A. Frohman, Prolonged Stimulation of Growth Hormone (GH) and Insulin-Like Growth Factor I Secretion by CJC-1295, a Long-Acting Analog of GH-Releasing Hormone, in Healthy Adults, The Journal of Clinical Endocrinology & Metabolism, Volume 91, Issue 3, 1 March 2006, Pages 799–805, https://doi.org/10.1210/jc.2005-1536
  7. Ranke MB, Wollmann HA, Savage MO. Experience with insulin-like growth factor I (IGF-I) treatment of growth hormone insensitivity syndrome (GHIS). J Pediatr Endocrinol Metab. 1999 Apr;12 Suppl 1:259-66. PMID: 10698590.
  8. Harvey S, Martinez-Moreno CG. Growth Hormone: Therapeutic Possibilities-An Overview. Int J Mol Sci. 2018 Jul 11;19(7):2015. doi: 10.3390/ijms19072015. PMID: 29997315; PMCID: PMC6073347.
  9. Siebert DM, Rao AL. The Use and Abuse of Human Growth Hormone in Sports. Sports Health. 2018 Sep/Oct;10(5):419-426. doi: 10.1177/1941738118782688. Epub 2018 Jun 22. PMID: 29932857; PMCID: PMC6116101.
  10. Widdowson WM, Healy ML, Sönksen PH, Gibney J. The physiology of growth hormone and sport. Growth Horm IGF Res. 2009 Aug;19(4):308-19. doi: 10.1016/j.ghir.2009.04.023. Epub 2009 Jun 7. PMID: 19505835.
  11. Birzniece V, Nelson AE, Ho KK. Growth hormone administration: is it safe and effective for athletic performance. Endocrinol Metab Clin North Am. 2010 Mar;39(1):11-23, vii. doi: 10.1016/j.ecl.2009.10.007. PMID: 20122446.
  12. Basu, A., McFarlane, H. G., & Kopchick, J. J. (2017). Spatial learning and memory in male mice with altered growth hormone action. Hormones and behavior, 93, 18–30. https://doi.org/10.1016/j.yhbeh.2017.04.001

 

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