Titus Thorne

Last Updated May 11, 2022

Titus Thorne

 May 11, 2022

Curious about Fragment 176-191 benefits?

You aren’t alone. This peptide offers multiple avenues for qualified researchers to explore, especially in the fields of fat weight management and cartilage regeneration.

In this guide, we will outline the top five benefits of HGH Fragment 176-191 and explain its legal status, side effects, and more.

In case you decide to buy HGH Fragment 176-191 online, we will also share our top recommendation for a peptide vendor.

Let’s get started.

Buy Fragment 176-191 from our #1 recommended vendor...

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What is Fragment 176-191?

HGH Fragment 176-191 is a synthetic peptide fragment of the C-terminus of Human Growth Hormone (hGH), also known as Tyr-hGH177-191. In other words, it is a man-made string of amino acids that contains the 177th to 191st amino acids found in hGH [1].

Fragment 176-191 is commonly referred to as AOD9604 or, more simply, as the “lipolytic fragment” of HGH. This is because the C-terminus is where the fat-reducing activities of hGH reside [1].

Fragment 176-191 has been demonstrated to promote fat loss in test subjects, and is seen by many researchers as a potential treatment for obesity. While a number of clinical trials involving Fragment 176-191 have shown that this peptide has a good safety profile, it is currently classified as a research chemical and has no approved medical use.


Fragment 176-191


Is Fragment 176-191 Legal?

In the vast majority of countries, HGH Fragment 176-191 is a research chemical that’s available exclusively to qualified researchers. At least in the United States, Fragment 176-191 is not regulated as a drug and has not undergone any part of the U.S. Food and Drug Administration’s drug review process. It thus may not be misbranded, misused, or mislabeled as a drug. Steer clear of any online vendors who label or market this research peptide as a drug. If you’re unsure whether it’s legal to import, possess, or administer Fragment 176-191 in your country, consult a local attorney.


Benefits of Fragment 176-191 | Top 5

Research has shown that HGH Fragment 176-191 could potentially offer important benefits in humans [1]. We will explore the top five below.

1. Potential treatment for obesity

Fragment 176-191’s primary benefit is that it can promote fat loss. Recall that Fragment 176-191 is the “lipolytic fragment” of Human Growth Hormone. hGH plays different roles during a person’s lifetime, and while its most obvious function is promoting growth during childhood, it also plays an important role during adulthood [2]. Besides its strong biological effect on carbohydrate and lipid metabolism [3], hGH can also:

  • Induce inhibition of lipoprotein lipase activity in adipose tissue [4];
  • Stimulate lipolysis in adipocytes, resulting in a reduction of fat cell mass [5];
  • Reduce body fat mass [6]; and
  • Influence fat distribution [7].

Research has shown that Fragment 176-191 “harbors the fat reducing activity of hGH”, and has “no negative effect on carbohydrate metabolism” or serum IGF-1 levels [1]. Fragment 176-191 is thus widely viewed as a potential treatment for obesity.

Research on mice and rats has shown that Fragment 176-191 produces a temporary reduction in blood glucose levels and a sustained increase in plasma insulin levels [8]. HGH Fragment 176-191’s ability to lower blood sugar levels suggests that it could potentially be used as a treatment for Type 2 diabetes and prediabetes.

2. Fat reduction

The second potential benefit of HGH Fragment 176-191 is its ability to increase fat burning. A 14-day study involving obese mice found that Fragment 176-191 increased thermogenesis in the rodents’ skeletal muscle and accelerated fat burning [9].

The study also found that while Fragment 176-191 induced rapid weight loss in obese mice by raising levels of beta(3)-AR RNA (ADRB3), it had no such effect in lean mice. This finding suggests that another regulatory pathway for lipolysis may exist that overrides ADRB3 function when an animal’s body weight approaches a normal level [9].

Together, the studies further indicate that HGH Fragment 176-191 may be beneficial to overweight or obese human patients, making it a potential candidate for further research [1].

3. Cartilage regeneration

HGH Fragment 176-191 may also increase the effectiveness of hyaluronic acid (HA) injections and lead to faster cartilage regeneration. In a 2015 study, white rabbits with osteoporosis (OA) experienced increased cartilage growth when injected with Fragment 176-191 and HA compared with HA injections alone. This study’s authors speculated that Fragment 176-191 “may be safer than human recombinant GH for the long-term treatment of OA” [10].

4. Lack of HGH-associated side effects

The fourth potential benefit of HGH Fragment 176-191 is that it does not appear to cause certain side effects associated with hGH treatment. While hGH has long been viewed as a potential candidate for treating obesity, it can cause side effects such as “increases in IGF-1 levels, insulin resistance, and impaired glucose tolerance.” By contrast, Fragment 176-191 has “no effect on serum IGF-1 levels” and “no negative effect on carbohydrate metabolism” [1].

A 2000 study involving obese Zucker rats concluded that Fragment 176-191 did not negatively impact insulin sensitivity [11], while a 2001 study involving obese mice found that insulin secretion was unaffected [12].

According to the results of six randomized, double-blind, placebo-controlled clinical trials performed with Fragment 176-191, this peptide does not cause increases in IGF-1 levels, insulin resistance, impaired glucose tolerance, or any negative effect on carbohydrate metabolism [1]. The adverse events (AEs) experienced by test subjects who were given Fragment 176-191 were minor and included headaches, injection site swelling, and nausea. The rate at which Fragment 176-191 caused AEs was not statistically different from the rate at which placebos caused AEs.

Unlike hGH, Fragment 176-191 may be suitable for clinical trials up to six months and could lead to breakthroughs in the area of obesity treatment.

5. Good safety profile and tolerability

The fifth benefit of HGH Fragment 176-191 is that it has displayed a good safety and tolerability profile in clinical trials. It does not appear to cause serious AEs in test subjects and has been linked to only mild, temporary side effects such as headaches, fatigue, and localized swelling [1].

At the time of writing, six clinical trials involving treatment with Fragment 176-191 have taken place, involving doses ranging from 25 µg – 400 µg/kg bodyweight (via I.V. injection) and 9 mg – 54 mg (orally). At these doses, treatment with Fragment 176-191 had no effect on:

  • Vital signs
  • Laboratory parameters
  • ECG results
  • Blood glucose levels
  • IGF-1 levels

Tests conducted on research participants taking HGH Fragment 176-191 have been indistinguishable from those conducted on those taking a placebo [1].

Given these impressive potential benefits, it’s worth exploring Fragment 176-191’s side effects.


HGH Fragment Side Effects

As noted above, HGH Fragment 176-191 has an excellent safety and tolerability profile [1]. It has been tested in six clinical trials involving around 900 test subjects and has been determined by an appropriately qualified GRAS panel of experts to be “Generally Recognized As Safe” (GRAS) under conditions of intended uses of AOD9604 in foods [1].

Here is a summary of the safety and tolerability data obtained from one of the two human clinical trials in which Fragment 176-191 was administered via I.V. injection.

In a dose-escalating study involving 15 healthy male subjects receiving three single doses of AOD9604 and placebo as single dosages, a total of twenty-nine adverse events (AEs) were reported by 12 of the subjects. The most common AEs reported during the study were:

  • Headache (6 times)
  • Fatigue (4)
  • Hypoglycemia unspecified (3)
  • Dizziness (3)
  • Nasopharyngitis (2)
  • Cough (2)
  • Lethargy (1)
  • Tonsillitis (1)
  • Abdominal pain unspecified (1)
  • Application site reaction unspecified (1)
  • Injection site bruising (1)
  • Rhinitis seasonal (1)
  • Anorexia (1)
  • Injection site pain (1)

None of the AEs were of severe intensity and there was no observable trend between the different treatment groups with respect to the incidence of certain AEs. In other words, Fragment 176-191’s safety profile was indistinguishable from the placebo.

None of the other five clinical studies found any difference in the incidence in AEs between Fragment 176-191 and a placebo.


Fragment 176-191


Where to Buy Fragment 176-191 Online? | 2021 Guide

Looking to buy HGH Fragment 176-191 online?

If so, the good news is that this peptide is readily available as a research chemical to qualified researchers.

The bad news is that the peptide industry is loosely regulated and finding high-quality peptides at fair prices can be a challenge, even for well-connected researchers.

Fortunately, we’ve done the hard work for you and tested the top peptide vendors to find an honest, reliable company that ships high-quality peptides worldwide.

Our recommended HGH Fragment 176-191 vendor is Peptide Sciences. Here are some of the things that they do exceptionally well.

  • Highest Quality Peptides: The best reason to buy from Peptide Sciences is that their peptides are all 99%+ purity and every batch is tested by an independent lab. The lab reports, including the Certificate of Analysis (COA), High-Performance Liquid Chromatography (HPLC) test, and a Mass Spectrometry (MS) test are all posted on the website. You can view them when you visit Peptide Sciences’ Fragment 176-191 page and see the exact purity and quality of Fragment 176-191 you are buying before you place an order.
  • Excellent Customer Service: Another thing that sets Peptide Sciences apart from its competition is the quality of its customer service team. Their friendly customer support specialists are always a call or email away and usually reply to messages within 24 hours.
  • Bulk Order Discounts: If you want to run a long-term clinical trial with HGH Fragment 176-191, you’ll love the discounts offered by Peptide Sciences on bulk orders. While an individual vial of Fragment 176-191 10 mg costs $65, this drops by 10% to just $59 when you place an order for more than 10 vials. This makes longer term research much more affordable.
  • Secure Ordering: Peptide Sciences’ website is highly secure so you can rest assured that your order details, personal information, and payment data will remain 100% discreet and confidential. The website is secured with the latest SSL technology.
  • Fast Worldwide Shipping: Orders over $200 for the USA ship completely free, while flat-rate worldwide shipping costs just $15. Orders over $300 include one bottle of 30mL Bacteriostatic Water absolutely free.

Peptide Sciences is the most trustworthy and professional peptide vendor we've reviewed and we highly recommend them. If you’re looking to conduct Fragment 176-191 research, Peptide Sciences is the vendor you've been looking for.

Buy Fragment 176-191 from our #1 recommended vendor...


Fragment 176-191 Benefits | Verdict

If you were curious about HGH Fragment 176-191 benefits, we hope that this guide has addressed your questions.

The primary appeal of researching HGH Fragment 176-191 is that it offers the chance to study the fat loss benefits of hGH, without exposing subjects to the harms associated with long-term hGH treatment.Clinical trials have shown that it has a good safety profile while having a profound impact on fat loss.

If you’re interested in conducting research with Fragment 176-191, check out Peptide Sciences to learn more.


References

  1. Stier, Heike et al. “Safety And Tolerability Of The Hexadecapeptide AOD9604 In Humans”. Jofem.Org, 2021, https://www.jofem.org/index.php/jofem/article/view/157.
  2. Ho KK, O'Sullivan AJ, Hoffman DM. Metabolic actions of growth hormone in man. Endocr J. 1996 Oct;43 Suppl:S57-63. doi: 10.1507/endocrj.43.suppl_s57. PMID: 9076343.
  3. Vijayakumar A, Novosyadlyy R, Wu Y, Yakar S, LeRoith D. Biological effects of growth hormone on carbohydrate and lipid metabolism. Growth Horm IGF Res. 2010;20(1):1-7.
  4. Gravhølt CH, Schmitz O, Simonsen L, Bülow J, Christiansen JS, Møller N. Effects of a physiological GH pulse on interstitial glycerol in abdominal and femoral adipose tissue. Am J Physiol. 1999 Nov;277(5):E848-54. doi: 10.1152/ajpendo.1999.277.5.E848. PMID: 10567011.
  5. Rodríguez-Arnao J, Jabbar A, Fulcher K, Besser GM, Ross RJ. Effects of growth hormone replacement on physical performance and body composition in GH deficient adults. Clin Endocrinol (Oxf). 1999 Jul;51(1):53-60. doi: 10.1046/j.1365-2265.1999.00737.x. PMID: 10468965.
  6. Takahashi S, Satozawa N. The 20-kD human growth hormone reduces body fat by increasing lipolysis and decreasing lipoprotein lipase activity. Horm Res. 2002;58(4):157-64. doi: 10.1159/000065488. PMID: 12324712.
  7. Rosenbaum M, Gertner JM, Leibel RL. Effects of systemic growth hormone (GH) administration on regional adipose tissue distribution and metabolism in GH-deficient children. J Clin Endocrinol Metab. 1989 Dec;69(6):1274-81. doi: 10.1210/jcem-69-6-1274. PMID: 2685009.
  8. Ng FM, Bornstein J. Hyperglycemic action of synthetic C-terminal fragments of human growth hormone. Am J Physiol. 1978 May;234(5):E521-6. doi: 10.1152/ajpendo.1978.234.5.E521. PMID: 645904.
  9. Heffernan M, Summers RJ, Thorburn A, Ogru E, Gianello R, Jiang WJ, Ng FM. The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice. Endocrinology. 2001 Dec;142(12):5182-9. doi: 10.1210/endo.142.12.8522. PMID: 11713213.
  10. Kwon DR, Park GY. Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model. Ann Clin Lab Sci. 2015 Summer;45(4):426-32. PMID: 26275694.
  11. Ng FM, Sun J, Sharma L, Libinaka R, Jiang WJ, Gianello R. Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone. Horm Res. 2000;53(6):274-8. doi: 10.1159/000053183. PMID: 11146367.
  12. Heffernan MA, Thorburn AW, Fam B, Summers R, Conway-Campbell B, Waters MJ, Ng FM. Increase of fat oxidation and weight loss in obese mice caused by chronic treatment with human growth hormone or a modified C-terminal fragment. Int J Obes Relat Metab Disord. 2001 Oct;25(10):1442-9. doi: 10.1038/sj.ijo.0801740. PMID: 11673763.

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