Titus Thorne

Last Updated April 19, 2022

Titus Thorne

 April 19, 2022

Looking for a Fragment 176-191 review? If so, you’ve come to just the right place.

HGH Fragment 176-191 is a synthetic peptide with great potential in the areas of cartilage regeneration and anti-obesity treatment.

In this guide, we’ll give you an overview of Fragment 176-191’s main benefits, dosage, side effects, and more.

As a bonus, we’ll also explain where to buy HGH Fragment 176-191 online and how to order it in your country, providing a step-by-step guide to the buying process.

Let’s get started.

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What is Fragment 176-191?

Fragment 176-191 (also known as “HGH Fragment 176-191”) is a synthetic peptide that corresponds to amino acids 176-191 of natural human growth hormone (HGH). Fragment 176-191 is also known as AOD9604 and is commonly referred to as the “lipolytic fragment” of HGH. Animal studies have shown that Fragment 176-191 can enhance fat burning, temporarily increase blood glucose, and produce a sustained rise in plasma insulin.

The bulk of what we know about HGH Fragment 176-191 comes from testing in vivo effects in animals, namely mice and rats [1]. While there have been several human clinical trials involving intravenous and oral administration of Fragment 176-191, this peptide is still sold exclusively as a research chemical.


Fragment 176-191


Fragment 176-191 Benefits and Effects | Top 5

HGH Fragment 176-191 has been studied for its in vivo effects in rats and mice; it may offer the following equivalent benefits in humans.

1. Lower insulin sensitivity

The main benefit of HGH Fragment 176-191 is that it appears to reduce insulin sensitivity in animals while causing a rise in blood glucose and plasma insulin levels. Intravenous insulin tolerance tests given to animal test subjects showed that the peptide has a temporary effect on blood glucose and a longer-lasting effect on plasma insulin [1].

Animal research involving six different fragments of HGH revealed that HGH’s hypoglycemic effect comes from its c-terminal end. Of the six fragments tested, Fragment 176-191 was the most effective at lowering blood sugar levels, albeit temporarily. Its secondary benefits were that it caused a sustained increase in plasma insulin levels and reduced insulin sensitivity [1].

This animal research has led to speculation that Fragment 176-191 may hold potential as a treatment for both prediabetes and Type 2 diabetes in humans.

2. Increased fat burning

The second benefit of HGH Fragment 176-191 is that it appears to increase fat burning in animals. Long-term animal studies involving obese mice revealed that this peptide has a substantial fat-burning effect [2]. These effects are believed to be attributed to an increase in the production of beta-3 adrenergic receptors (B3-AR or ADRB3) as genetically modified mice with no endogenous B3-AR (known as ‘beta(3)-AR knock-out mice) did not respond to the lipolytic effects of HGH or fragment 176-191.

As thermogenesis in skeletal muscle and fat burning in adipose tissue are two well-researched actions of ADRB3, Fragment 176-191 is commonly being referred to as a “lipolytic fragment.” Fragment 176-191 could potentially offer equivalent benefits in humans.

3. Weight loss

The third benefit of HGH Fragment 176-191 is that it appears to induce rapid weight loss in animals. The above-cited study reported that Fragment 176-191 significantly reduced body weight and body fat in obese mice when administered for 14 days [2]. The data showed that Fragment 176-191 could raise levels of beta(3)-AR RNA in obese mice to levels roughly on par with those found in lean mice. However, it produced no weight loss effects in lean mice.

These findings suggest that a secondary regulatory pathway for lipolysis may exist that overrides ADRB3 function when bodyweight approaches a normal level. Fragment 176-191 is a candidate for further research into energy homeostasis and could potentially offer equivalent weight loss benefits in humans.

4. Promotes cartilage regeneration

The fourth benefit of HGH Fragment 176-191 is that it appears to promote cartilage regeneration in animals. A 2015 study involving white rabbits found that Fragment 176-191 acetate increased the effectiveness of hyaluronic acid (HA) injections [3]. Researchers found that combined AOD9604 (Fragment 176-191) and HA injections were more effective than HA or AOD9604 injections alone and produced more substantial effects.

These findings suggest that Fragment 176-191 may offer equivalent cartilage regeneration and therapeutic benefits to human patients. It has been speculated that this peptide could potentially lead to advanced osteoarthritis therapies or even eliminate the need for surgery in certain circumstances.

5. Fewer side effects than HGH

The fifth benefit of HGH Fragment 176-191 is that it does not appear to cause common HGH-related side effects in animal test subjects, such as increasing long bone growth, impacting carbohydrate metabolism, increasing IGF-1 levels, or adversely affecting insulin sensitivity.

For example, a 2000 study involving obese Zucker rats found that unlike treatment involving intact hGH, Fragment 176-191 does not negatively impact insulin sensitivity in animals [4].

Likewise, a 2001 study found that while HGH Fragment 176-191 significantly reduced body weight gain in obese mice, it did not reduce insulin secretion, induce hyperglycemia, induce cell proliferation, or compete for, or interact with, the HGH receptor [5].

Lastly, a 2013 study into the safety and tolerability of Fragment 176-191 in humans found that the peptide had no effect on serum IGF-1 levels and no negative effect on carbohydrate metabolism [6].


Does HGH Fragment Actually Work? | Our Experience

We are repeat customers of Peptide Sciences, a US-based research peptide company that supplies us with Fragment 176-191. While we cannot disclose our opinion on the efficacy of a research peptide, nor report the results of our confidential HGH Fragment 176-191 research, we can voice our satisfaction with Peptide Sciences.

When viewing products at this vendor’s website, you will note links to documents like a Certificate of Analysis (COA), High-Performance Liquid Chromatography (HPLC), and Mass Spectrometry (MS). This documentation is sound evidence that Peptide Sciences sells high-grade Fragment 176-191 that works as it should.


HGH Fragment Dosage Guide

If you’re curious about how best to dose HGH Fragment 176-191 for your own research, this is the section for you.

Researchers should note that Fragment 176-191, when sold as a research chemical, is typically shipped in dry powder form. It must first be reconstituted with bacteriostatic water, at which point it is typically injected subcutaneously.

If you’re studying fat loss, Fragment 176-191 is typically administered at the dosage of 200-500 mcg per day. The full dose may be delivered once in the AM, or it may spread across two doses—one in the morning and another at night, in both cases on an empty stomach. Fragment 176-191 is typically administered over the course of four weeks.

Note that the six clinical trials of Fragment 176-191 to date have involved other methods of administration.

Here is a review of the doses used in each trial [6]:

In the first two trials, HGH Fragment 176-191 was administered via IV injection:

  • A Phase I safety study administered doses ranging from 25 to 400 µg/kg.
  • A Phase IIa safety study administered single doses ranging from 25, 50, and 100 µg/kg.

In the other four trials, Fragment 176-191 was administered orally at the following doses.

  • A Phase IIa safety study administered single oral doses of 9, 27, and 54 mg.
  • A Phase IIa safety study administered multiple daily doses of 9, 27, or 54 mg for 7 days.
  • A Phase IIb study administered daily doses of 1, 5, 10, 20, or 30 mg for 12 weeks.
  • A Phase IIb study administered 0.25 mg, 0.5 mg, 1 mg, or placebo for 24 weeks.

Data from these trials showed that when administered at these dosages, Fragment 176-191 did not produce side effects commonly associated with HGH treatment such as increased insulin resistance, hypertension, and edema (swelling) and led to no changes in IGF-1 levels, glucose levels, or insulin sensitivity [6].


Fragment 176-191


Where to Buy Fragment 176-191 Online? | 2021 Guide

Curious about where to buy HGH Fragment 176-191 online?

Our recommended vendor for qualified researchers is Peptide Sciences, and here’s why:

  • High Purity Fragment 176-191 Acetate: Peptide Sciences is partnered with WHO/GMP and ISO 9001:2008 approved manufacturers and offers the highest purity peptides on the market. Each batch of Fragment 176-191 comes with a complete Certificate of Analysis (COA), a High-Performance Liquid Chromatography (HPLC), and a Mass Spectrometry (MS) test to ensure its purity and quality.
  • Reasonable Prices: Peptide Sciences’ partnerships let them pass their savings onto their customers and offer Fragment 176-191 for reasonable prices. They also offer bulk discounts to researchers who want to run long-term studies.
  • Simple, Secure Ordering: Peptide Sciences’ website offers complete privacy with the latest SSL technology, ensuring that your order and payment information remain encrypted, protected, and 100% discreet at all times.
  • Responsive Customer Service: Peptide Sciences’ knowledgeable, friendly staff are on hand to offer 24/7 customer support. Should you experience any delay or issues, they will reply quickly and assist you.
  • Fast Worldwide Shipping: Peptide Sciences offers fast, discreet shipping. Orders over $200 for USA customers ship free, and orders to the rest of the world attract a $15 flat shipping rate. Orders over $300 include one bottle of 30mL bacteriostatic water free.

As you can see, Peptide Sciences offers numerous benefits for qualified researchers and is highly recommended!

Ready to order Fragment 176-191 from the top rated online vendor?


How to Order Fragment 176-191 in Your Country

To order HGH Fragment 176-191 in your country for the best prices, simply head to Peptide Sciences. Here, you need to enter the number of vials you wish to order and click on “Add to Cart.”

On the next page, click “Proceed to Checkout” and you’ll see the order form.

On this page, simply complete your:

  • Billing information
  • Shipping information
  • Shipping methods
  • Payment methods

That’s it! You’re good to go!


Stacking Fragment 176-191 with Nootropics?

As the thrust of research into HGH Fragment 176-191 has been focused on its potential anti-obesity effects, interested researchers may wish to stack this peptide with nootropics. Here are four nootropics that may also support fat loss and weight loss:

  • Caffeine: Caffeine has been scientifically proven to support weight loss. This meta-analysis of randomized controlled trials demonstrated that caffeine promotes weight loss and a reduction in BMI and body fat [7].
  • Citicoline: Research has shown that the nootropic citicoline may help control hunger when dosed at 2000mg/day [8].
  • L-Tyrosine: Research has found that L-Tyrosine can improve focus and lower stress, which may be beneficial to research subjects [9].
  • 5-HTP: 5-HTP, a natural ingredient sourced from Griffonia Simplicifolia, has been shown to aid weight loss in this clinical trial [10].

Fragment 176-191


In-Depth Fragment 176-191 Review | Verdict?

HGH Fragment 176-191 shows potential as the basis for novel treatment regimens, especially in the fields of fat loss and cartilage repair. In the latter case, further research and data can lead to advanced osteoarthritis therapies or even non-surgical treatments for osteoporosis.

Qualified researchers interested in conducting further research are well-advised to purchase from Peptide Sciences.


References

  1. Ng FM, Bornstein J. Hyperglycemic action of synthetic C-terminal fragments of human growth hormone. Am J Physiol. 1978 May;234(5):E521-6. doi: 10.1152/ajpendo.1978.234.5.E521. PMID: 645904.
  2. Heffernan M, Summers RJ, Thorburn A, Ogru E, Gianello R, Jiang WJ, Ng FM. The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice. Endocrinology. 2001 Dec;142(12):5182-9. doi: 10.1210/endo.142.12.8522. PMID: 11713213.
  3. Kwon DR, Park GY. Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model. Ann Clin Lab Sci. 2015 Summer;45(4):426-32. PMID: 26275694.
  4. Ng FM, Sun J, Sharma L, Libinaka R, Jiang WJ, Gianello R. Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone. Horm Res. 2000;53(6):274-8. doi: 10.1159/000053183. PMID: 11146367.
  5. Heffernan MA, Thorburn AW, Fam B, Summers R, Conway-Campbell B, Waters MJ, Ng FM. Increase of fat oxidation and weight loss in obese mice caused by chronic treatment with human growth hormone or a modified C-terminal fragment. Int J Obes Relat Metab Disord. 2001 Oct;25(10):1442-9. doi: 10.1038/sj.ijo.0801740. PMID: 11673763.
  6. Stier, Heike et al. “Safety And Tolerability Of The Hexadecapeptide AOD9604 In Humans”. Jofem.Org, 2021, https://www.jofem.org/index.php/jofem/article/view/157.
  7. Tabrizi R, Saneei P, Lankarani KB, Akbari M, Kolahdooz F, Esmaillzadeh A, Nadi-Ravandi S, Mazoochi M, Asemi Z. The effects of caffeine intake on weight loss: a systematic review and dose-response meta-analysis of randomized controlled trials. Crit Rev Food Sci Nutr. 2019;59(16):2688-2696. doi: 10.1080/10408398.2018.1507996. Epub 2018 Oct 18. PMID: 30335479.
  8. Killgore WD, Ross AJ, Kamiya T, Kawada Y, Renshaw PF, Yurgelun-Todd DA. Citicoline affects appetite and cortico-limbic responses to images of high-calorie foods. Int J Eat Disord. 2010;43(1):6-13. doi:10.1002/eat.20658
  9. Jongkees BJ, Hommel B, Colzato LS. People are different: tyrosine's modulating effect on cognitive control in healthy humans may depend on individual differences related to dopamine function. Front Psychol. 2014;5:1101. Published 2014 Oct 6. doi:10.3389/fpsyg.2014.01101
  10. Rondanelli, M., Klersy, C., Iadarola, P. et al. Satiety and amino-acid profile in overweight women after a new treatment using a natural plant extract sublingual spray formulation. Int J Obes 33, 1174–1182 (2009). https://doi.org/10.1038/ijo.2009.155

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