Titus Thorne

Last Updated December 3, 2021

Titus Thorne

 December 3, 2021

Interested in researching GHK-Cu for bodybuilding?

GHK-Cu can offer several positive effects that may be beneficial to bodybuilders, including increased blood flow and faster tissue repair.

You may have seen GHK-Cu marketed as a “miracle peptide” for bodybuilding that offers potent muscle-building effects.

Is there any truth to this? Or is this copper peptide a scam?

To help separate fact from fiction, we have reviewed the available literature to help qualified researchers understand more about GHK-Cu’s potential as a bodybuilding treatment.
Below, you’ll find an overview of GHK-Cu, including some of its documented benefits, how to dose it, and some potential research applications. Lastly, if you’re looking to conduct research on GHK-Cu, we’ll give you the details on our preferred peptide vendor.

Buy GHK-Cu from the #1 online Peptides vendor in the world: Peptides Sciences

Disclaimer: ResearchPeptides.org contains information about products that are intended for laboratory and research use only, unless otherwise explicitly stated. This information, including any referenced scientific or clinical research, is made available for educational purposes only. ResearchPeptides.org makes every effort to ensure that any information it shares complies with national and international standards for clinical trial information and is committed to the timely disclosure of the design and results of all interventional clinical studies for innovative treatments publicly available or that may be made available. However, research is not considered conclusive. ResearchPeptides.org makes no claims that any products referenced can cure, treat or prevent any conditions, including any conditions referenced on its website or in print materials.


What is GHK-Cu?

GHK is a peptide, which is a chain of amino acids that is not quite as long as a protein. It is naturally made in your body and consists of three amino acids: glycine, histidine, and lysine. When this peptide bonds with a molecule of copper, it becomes GHK-Cu peptide [1].

GHK-Cu is responsible for keeping DNA healthy and activating the genes that repair tissue. At the same time, it turns off the genes that are responsible for inflammation and breaking down tissue [1]. High levels of GHK-Cu have been directly linked to the rate at which wounds and injuries can heal.

GHK-Cu was first discovered by Dr. Loren Pickart and his team in 1973 [2]. They noticed that liver tissue from older adults began to behave and repair itself like young liver tissue when it was incubated in the blood of younger adults. In other words, the blood of younger people seemed to revive the liver. High levels of GHK-Cu were identified as one of the main reasons behind this observation.

This peptide is plentiful in the body during youth but declines substantially with age [3]. A relative decline in GHK-Cu production may be one of the reasons as to why your body starts to heal itself less effectively.


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Benefits of GHK-Cu

Researchers have conducted extensive research into GHK-Cu in vitro, and in both animal and human studies [3, 4, 5, 6], and have found that it offers numerous benefits.

GHK-Cu is widely available in a variety of forms including creams, skin serums, tablets, and injectable solutions and powders. It is commonly marketed as offering skin rejuvenation and anti-aging properties. Some of its potential effects include:

  • Skin repair, wrinkle reduction, and anti-aging effects [4]
  • Hair growth [1]
  • Antibacterial effects and infection reduction [5]
  • Tissue remodeling [7]
  • Repairing wounds [1]
  • Lung and gut tissue healing [1]
  • Nerve regeneration [6]

GHK-Cu may also offer psychological benefits, including anti-pain, anti-anxiety, and anti-aggression effects [3].
To date, data from cosmetic trials and wound healing studies has not revealed any link between GHK-Cu and major side effects [1].


GHK-Cu Dosage Guide | What You MUST Know

While the available research suggests that GHK-Cu peptide can have a number of cosmetic benefits, there is no clear data regarding the most effective GHK-Cu dosage. We have scanned the literature and have compiled the following dosing guidelines for informational purposes only.

Injections

GHK-Cu dosage amounts: GHK-Cu works systemically, which means you can inject it anywhere in the body, either subcutaneously (under the skin) or intramuscularly (into the muscle) and it will have an effect throughout the body—and not just where you inject it.

Data from scientific studies shows that GHK-Cu has been administered in the following doses:

  • One study found that a total treatment dose of 1.1 milligrams (mg) per kg of body weight is effective for healing [8]. That equates to 77 mg for a 70 kg person.
  • Other studies have suggested that a total treatment dose of 100-200 mg would also produce healing effects, but note that lower doses are likely effective [1, 9].

While GHK-Cu has been found to be well-tolerated [3], it has been shown to lower blood pressure [8]. This suggests that researchers should carefully screen test subjects for hypertension and other pre-existing conditions.

A lethal GHK-Cu dose has been estimated at over 330 mg/kg, roughly 23,000 mg for a 70 kg person. This makes accidental overdose extremely unlikely [8].

Although GHK-Cu appears safe at relatively high doses, we haven’t seen research recommending total doses larger than 200 mg [1]. We consider this to be the highest safe total dose unless further research yields more specific insights.

GHK-Cu dosing cycle: Anecdotal reports suggest that GHK-Cu for athletic performance can be administered based on the following guidelines [10]:

  • GHK-Cu dosing: 1-2 mg each day of the cycle, via subcutaneous or intramuscular injections.
  • Frequency: 1 per day. Or, several injections a day with partial doses.
  • Cycle duration: 10-30 days.
  • Cycle: take at least one month off; repeat based on observations.

Here we must reiterate that under no circumstances do we encourage the unsupervised self-administration of GHK-Cu or any other peptide.

Topicals

Another option is to use GHK-Cu creams and topical ointments. These can be effective for wound healing, repairing damaged skin, reducing signs of aging, and stimulating hair growth. However, there are a variety of formulas on the market, so always be sure to know how much GHK-Cu you’re getting per application.

GHK-Cu dosage amounts: Researchers typically recommend using topicals as needed. There do not seem to be any side effects linked to GHK-Cu topicals—in research the topical application of GHK-Cu has not led to any irritation or adverse effects [1]. A GHK-Cu topical is typically applied to the affected area(s) two to four times per day.
In studies, researchers usually apply GHK-Cu creams or gels once or twice a day [4, 11].

Buy GHK-Cu from our #1 recommended vendor...


GHK-Cu For Beginners

GHK-Cu is generally seen as non-harmful by the research community and should pose no challenges to researchers who are new to this peptide. Dr. Pickart has stated that “no issues have ever arisen during its use as a skin cosmetic or in human wound healing studies” [1]. Based on the research to date, all peptide researchers should confidently conduct additional studies on GHK-Cu.


GHK-Cu For Healing

Several studies have indicated that GHK-Cu can decrease the time it takes for skin tissue to repair itself. For example, GHK-Cu was found to increase the healing rate after a burn by 33% in mice [12]. The peptide also has anti-bacterial and anti-fungal properties, which is perhaps why it has been found to help prevent wound infections [13].
The peptide may be useful in subjects with compromised immune systems. For example, one study found that GHK-Cu helped people with diabetes more effectively recover from wounds. The study found that GHK-Cu resulted in a 40% improvement in ulcer closures and a 27% reduction in infections compared to a control group [5]. Similar results were found in individuals with ischemic open wounds [14].
Other studies have found that GHK-Cu can help to protect and repair lung tissue [1] and gut tissue, and even prevent the growth of cancerous tissue [9, 15].


GHK-Cu For Muscle Growth

The efficacy of GHK-Cu in increasing or somehow enhancing muscle growth has yet to be tested in human clinical trials. GHK-Cu is not typically marketed or referred to as a muscle growth peptide, and no research has linked GHK-Cu to muscle growth. Therefore, it has no known direct effect on increasing muscle mass or speeding up muscle growth.

What we do know is that some of the proven effects of GHK-Cu may be helpful in the muscle building process.

Muscle growth happens when your body repairs itself.

Muscle growth occurs through hypertrophy, a process where high levels of resistance create microscopic tears in muscle fibers, and the body repairs and replaces those muscle fibers—fusing them and adding new ones [16]. The important thing to note is that muscles do not grow during exercise; they grow during periods of recovery—when the body repairs itself.

GHK-Cu helps repair tissue.

Since GHK-Cu has some role in the body’s ability to repair itself, it may be useful in supporting muscle growth.
For example, we know that GHK-Cu is angiogenic, which means it helps to create new blood vessels, and increases blood flow [12]. Since adequate blood flow is necessary for the proper function and growth of muscle, this is one way that GHK-Cu could potentially support muscle growth.

Another is by supporting the health of DNA that directs the building of muscles. GHK-Cu has been found to repair damaged DNA and “reset” it to a healthier state [1]. Creating healthier DNA could, potentially, lead to better muscle growth.

Lastly, GHK-Cu may speed up tissue repair in general. Since the repair of muscle tissue is what leads to muscle growth, this effect could suggest an application of GHK-Cu in the fields of bodybuilding and athletic performance in general.

There is a lack of research on GHK-Cu for muscle growth.

We reiterate that the actual ability of GHK-Cu to play any role in muscle growth has yet to be tested. What we do know suggests that GHK-Cu could be useful in improving and supporting processes like hypertrophy and tissue repair. The documented effects of GHK-CU, including its role in repairing tissue, repairing DNA, and increasing blood flow, are undeniably beneficial to bodybuilders and athletes in general.

GHK-Cu’s role in muscle growth is a clear opportunity for further research.


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Where to Buy GHK-Cu Online? | 2021 Guide

Think GHK-Cu could be the right peptide for your next experiment?

Whether you want to study the effect of GHK-Cu on muscle growth, hair growth, wound healing, skin health, or any number of potential applications, you’ll want a cost-effective solution for buying research-grade GHK-Cu.

GHK-Cu is not available in stores, but you can find it online if you’re a qualified researcher. Peptide Sciences offers research-grade injectable GHK-Cu.

We love Peptide Sciences for a number of reasons:

  1. They’ve got great customer service. You actually get to talk to a human being if you have an issue with your order.
  2. You can order from anywhere in the world. Peptide Sciences is based in the US, so shipping within the US is quick, and most products arrive within a week. Shipping internationally takes longer, but it is still convenient. You might still get your product within a week and a half, depending on current circumstances.
  3. We also love that you can pay with cryptocurrencies in addition to any major credit card.

If you’re an ordinary consumer in need of a GHK-Cu cream or other topical, try Aseir Custom. Their team of scientists and skin experts create anti-aging products that feel great and achieve the results you’re looking for. They also have international shipping, convenient payments, and a decent return policy.

Buy GHK-Cu from our #1 recommended vendor...


GHK-Cu For Bodybuilding | Verdict

GHK-Cu may not be a miracle peptide for bodybuilding, but it offers several benefits that could potentially support muscle growth. Unlike many questionable supplements on the market, the effects of GHK-Cu are backed by high-quality research. The peptide has been demonstrated to increase healing speed, help improve skin quality and appearance, and cause hair growth.

As GHK-Cu has not been tested for its ability to support muscle growth, this makes it a great candidate for qualified researchers looking to conduct peptide research. The potential benefits of GHK-Cu to bodybuilders and athletes are numerous, and it may help with injury recovery, blood flow, and the DNA damage that occurs with age.

So if you’re looking for a peptide to research, buy GHK-Cu from our #1 recommended vendor.


References

  1. Pickart, L., Vasquez-Soltero, J. M., & Margolina, A. (2014). GHK and DNA: resetting the human genome to health. BioMed Research International, 151479. https://doi.org/10.1155/2014/151479
  2. Pickart, L., Thayer, L., & Thaler, M. M. (1973). A synthetic tripeptide which increases survival of normal liver cells, and stimulates growth in hepatoma cells. Biochemical and Biophysical Research Communications, 54(2), 562-566.
  3. Pickart, L., & Margolina, A. (2018). Regenerative and protective actions of the GHK-Cu peptide in the light of the new gene data. International Journal of Molecular Sciences, 19(7), 1987.
  4. Pickart, L., Vasquez-Soltero, J. M., & Margolina, A. (2015). GHK peptide as a natural modulator of multiple cellular pathways in skin regeneration. BioMed Research International, 648108. https://doi.org/10.1155/2015/648108
  5. Mulder, G. D., Patt, L. M., Sanders, L., Rosenstock, J., Altman, M. I., Hanley, M. E., & Duncan, G. W. (1994). Enhanced healing of ulcers in patients with diabetes by topical treatment with glycyl‐l‐histidyl‐l‐lysine copper. Wound Repair and Regeneration, 2(4), 259-269.
  6. Ahmed, M. R., Basha, S. H., Gopinath, D., Muthusamy, R., & Jayakumar, R. (2005). Initial upregulation of growth factors and inflammatory mediators during nerve regeneration in the presence of cell adhesive peptide‐incorporated collagen tubes. Journal of the Peripheral Nervous System, 10(1), 17-30.
  7. Pickart, L. (2008). The human tri-peptide GHK and tissue remodeling. Journal of Biomaterials Science, Polymer Edition, 19(8), 969-988.
  8. Pickart, L., Vasquez-Soltero, J. M., & Margolina, A. (2012). The human tripeptide GHK-Cu in prevention of oxidative stress and degenerative conditions of aging: implications for cognitive health. Oxidative Medicine and Cellular Longevity, 2012. Doi: 10.1155/2012/324832
  9. Pickart, L., Vasquez-Soltero, J. M., & Margolina, A. (2017). The effect of the human peptide GHK on gene expression relevant to nervous system function and cognitive decline. Brain Sciences, 7(2), 20.
  10. Ben Green Fitness (n.d.). The Little-Known Russian Wonder Compound & The Fringe Future Of Anti-Aging Medicine. https://bengreenfieldfitness.com/article/anti-aging-articles/how-to-use-peptides/
  11. Abdulghani, A. A., Sherr, A., Shirin, S., Solodkina, G., Tapia, E. M., Wolf, B., & Gottlieb, A. B. (1998). Effects of topical creams containing vitamin C, a copper-binding peptide cream and melatonin compared with tretinoin on the ultrastructure of normal skin-A pilot clinical, histologic, and ultrastructural study. Disease Management and Clinical Outcomes, 4(1), 136-141.
  12. Wang, X., Liu, B., Xu, Q., Sun, H., Shi, M., Wang, D., … & Feng, B. (2017). GHK‐Cu‐liposomes accelerate scald wound healing in mice by promoting cell proliferation and angiogenesis. Wound Repair and Regeneration, 25(2), 270-278.
  13. Kukowska, M., Kukowska-Kaszuba, M., & Dzierzbicka, K. (2015). In vitro studies of antimicrobial activity of Gly-His-Lys conjugates as potential and promising candidates for therapeutics in skin and tissue infections. Bioorganic & Medicinal Chemistry Letters, 25(3), 542-546.
  14. Canapp Jr, S. O., Farese, J. P., Schultz, G. S., Gowda, S., Ishak, A. M., Swaim, S. F., … & Martin, F. G. (2003). The effect of topical tripeptide‐copper complex on healing of ischemic open wounds. Veterinary Surgery, 32(6), 515-523.
  15. Siméon, A., Wegrowski, Y., Bontemps, Y., & Maquart, F. X. (2000). Expression of glycosaminoglycans and small proteoglycans in wounds: modulation by the tripeptide–copper complex glycyl-l-histidyl-l-lysine-Cu2+. Journal of Investigative Dermatology, 115(6), 962-968.
  16. Leonard, J. (2020, January 8). How to build muscle with exercise. Medical News Today. https://www.medicalnewstoday.com/articles/319151

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