Scientists who are curious about the research applications of liraglutide may be interested in…
How much does liraglutide cost?
While the peptide is already approved for type 2 diabetes and weight loss, studies into other potential benefits of liraglutide are ongoing.
There are several directions for further study into liraglutide that researchers can take, such as:
- Weight loss in individuals not considered overweight or obese
- Effects on insulin sensitivity and metabolism
- Anti-inflammatory and neuroprotective potential
This comprehensive guide aims to provide researchers with valuable insight into the costs associated with liraglutide research.
Read on for an overview of liraglutide, information on estimated cost based on standard dosing, and details on where to buy research-grade liraglutide online at a fair price.
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What is Liraglutide?
Liraglutide is an analog of a hormone called glucagon-like peptide-1 (GLP-1), which is naturally produced in human intestinal L-cells. While it is synthetically modified for increased stability and half-life, liraglutide shares 97% homology with the GLP-1 hormone .
By activating the GLP-1 receptors, liraglutide is known to increase insulin synthesis, reduce glucagon production, slow postprandial gastric emptying, lower overall hunger, and increase feelings of fullness after a meal .
As a result, liraglutide is recognized as an effective tool for improving glycemic control in type 2 diabetes (T2D) patients and for assisting weight loss in individuals with chronic weight management issues.
Specifically, liraglutide at up to 1.8/mg daily has been approved by the United States Food and Drug Administration (FDA) for therapy in T2D since 2010 under the brand name Victoza. In addition, liraglutide 3mg has been FDA-approved for chronic weight management in adults since 2014 under the brand name Saxenda. Both Victoza and Saxenda are registered trademarks of the Danish pharmaceutical company Novo Nordisk [3, 4].
Notably, liraglutide has also been approved for chronic weight management in adolescents aged 12-17, as well as for lowering cardiovascular disease (CVD) risk in T2D [5, 6].
Liraglutide has also shown promise in other areas of research, and scientists are actively exploring its potential in conditions like polycystic ovary syndrome (PCOS), non-alcoholic fatty liver disease (NAFLD), psoriasis, and even Alzheimer’s [7, 8, 9, 10].
The benefits of liraglutide for diabetes and chronic weight management are supported by extensive clinical data. Research into other applications is ongoing.
Read on for a summary of the key liraglutide benefits explored to date.
Liraglutide For T2D Management
A systematic review by Ostawal et al. (2016) summarized the available evidence on the clinical effectiveness of liraglutide for T2D. The authors found that liraglutide reduces glycated hemoglobin (HbA1c) by 0.9%-2.2% within six months of treatment initiation. Further, liraglutide therapy was reported to be well-tolerated, with low risk of hypoglycemia .
In the review, the researchers also noted significant weight loss following treatment, ranging from nearly nine to 19 pounds, compared to baseline. Weight loss is an important goal in T2D, as loss of excess weight improves glycemic control .
The authors concluded that liraglutide therapy improves glycemic control and is associated with significant weight loss in T2D patients, which is consistent with the clinical trial data that led to the FDA approval of liraglutide for T2D .
Liraglutide For Cardiovascular Risk in T2D
Liraglutide has been approved by the FDA for lowering the risk of major adverse cardiovascular events (MACE) in T2D since 2017 . A major study supporting this approval was the LEADER trial, which included over 9000 participants and had a median follow-up of 3.8 years .
Based on the LEADER trial data, 1.8mg/once-daily liraglutide can significantly reduce the risk of major adverse cardiovascular events, such as strokes and heart attacks. Specifically, the investigators noted a 40% lower risk of fatal myocardial infarction and a 36% lower risk of fatal stroke. MACE risk dropped by 13%, and the overall risk of death from any cause was 15% lower than baseline .
Liraglutide For Chronic Weight Management
Moon et al. (2021) conducted one of the largest meta-analyses on the appetite-suppressing and weight-loss effects of liraglutide. The researchers examined 31 randomized clinical trials involving 8060 participants.
Based on the review, once-daily liraglutide injections for at least four weeks in doses ranging from 1.8mg to 3mg significantly reduced body weight by about nine pounds, or 4.16% on average compared to baseline.
Additionally, liraglutide administration was associated with decreased body mass index (-1.55kg/m2), waist circumference (-3.11cm), blood pressure, glycated hemoglobin, and low-density lipoprotein cholesterol .
Liraglutide Side Effects
Liraglutide is generally well-tolerated according to trials examining the drug for T2D and chronic weight management. However, like any peptide medication, liraglutide comes with potential side effects.
The most common side effects reported with 3mg liraglutide are nausea, diarrhea, constipation, vomiting, headache, and increased mean resting heart rate. These tend to affect 10-40% of test subjects or patients [16, 17].
Less common side effects that occur in less than 10% of test subjects or patients include dyspepsia, abdominal pain, eructation, flatulence, dry mouth, elevated pancreatic enzymes, dizziness, hypotension, and injection site reactions such as pain, bleeding, redness, swelling, or itching.
It's important to note that rare but serious side effects have also been reported, including pancreatitis, gallbladder disease, cholestasis, and allergic reactions .
These can present with symptoms such as difficulty breathing, swelling of the face or neck, severe pain, vomiting, fever, and yellowing of the skin or eyes. If a test subject experiences any of these symptoms, discontinue liraglutide immediately and refer the subject to the relevant specialist.
Notably, animal research has suggested a potential increased risk of certain malignancies, such as thyroid, pancreatic, and breast cancer. Clinical studies are still investigating whether these effects may also occur in humans .
How Much Does Liraglutide Cost? | Comprehensive Breakdown
Now that you are already familiar with the benefits and risks of liraglutide administration, it’s time to go over the cost of liraglutide for research purposes.
The total price will depend on where and how the peptide is manufactured, as well as the quantity needed for your experiment.
We highly recommend sourcing liraglutide that is manufactured in the United States and which has undergone independent third-party laboratory testing.
Our go-to vendor, Peptide Sciences, meets both criteria and stands among the most acclaimed vendors within the research community.
Peptide Sciences offers liraglutide in batches, with each batch containing ten vials of 3mg liraglutide. One batch contains a total of 30mg of liraglutide and costs $485. Accordingly, each 3mg vial of liraglutide costs $48.50.
Researchers should also note that Peptide Sciences offers up to a 7% discount for purchasing at least six batches in one order. This reduces the liraglutide cost per vial to $45.50.
Shipping and bacteriostatic water can add to the total liraglutide cost. Yet, Peptide Sciences offers free U.S. shipping for orders above $200.
Bacteriostatic water and all other necessary research supplies are fairly priced at BacteriostaticWater.org.
Liraglutide Cost Per Dose
When creating a liraglutide dosing protocol for your research, the total dosage will dictate your total liraglutide cost. Therefore, your liraglutide dosage should be carefully estimated according to your research objective, among other factors.
For example, the research and guidelines regarding liraglutide for weight loss report a maximum daily dose of 3mg .
However, researchers are advised to start with a much lower daily dose of 0.6mg and titrate up over five weeks before reaching the maximum daily dose of 3mg. This is done to minimize the risk of liraglutide side effects .
For reference, here is a sample liraglutide dosing protocol for weight loss based on existing research and guidelines [20, 21, 22]:
- Liraglutide Dose: Initiate with a dose of 0.6mg/day during week one, then increase the dose to 1.2mg/day during week two, 1.8mg/day during week three, 2.4mg/day during week four, and 3.0mg/day during weeks five and beyond.
- Frequency: Administer liraglutide as a subcutaneous injection once daily at regular times.
- Study Duration: 20-64 weeks.
- Notes: Rotate injection sites and do not exceed the maximum daily dose of 3mg.
Based on this sample protocol, the first ten vial batch of liraglutide 3mg from Peptide Sciences would last three weeks and two days for one test subject.
Below is a full breakdown of the cost per week per test subject, based on the above protocol:
- Week 1: $67.9 (4.2mg per test subject)
- Week 2: $135.8 (8.4mg per test subject)
- Week 3: $203.7 (12.6mg per test subject)
- Week 4: $271.6 (16.8mg per test subject)
- Weeks 5 and beyond $339.5 (21mg per test subject)
The total amount of liraglutide required for the first four weeks of the dosing protocol is 42mg per test subject. This equals 14 vials or a total of $679 for the first 4 weeks.
Researchers should purchase at least two batches of liraglutide per test subject to successfully complete the first month of weight loss research.
From week five, the monthly liraglutide cost will be about $1,455 on average, again based on the above weight loss protocol and our preferred vendor’s current pricing.
Do Researchers Need a Prescription to Buy Liraglutide Online?
Qualified researchers and laboratory professionals may legally purchase liraglutide online, as it is available as reference material for research purposes through vendors like Peptide Sciences.
However, prospective buyers are advised to stay up-to-date on laws and regulations applicable to the purchase of peptides like liraglutide. These may vary depending on each country and jurisdiction.
Liraglutide may not be purchased legally for human use without a valid prescription from a physician. If you’re not a researcher but believe that liraglutide therapy may be right for you, seek the advice of a licensed healthcare provider and only use liraglutide under medical supervision.
Again, liraglutide without a prescription is available to credentialed professionals only. If that is your case, keep reading to learn about our preferred online vendor of high-purity liraglutide for investigation.
Where to Buy Liraglutide Online? | 2023 Edition
Researchers looking to conduct experiments with liraglutide are well-advised to obtain the peptide strictly from a reputable vendor that specializes in research peptides.
One of the leading vendors worldwide is Peptide Sciences, known for their high-quality, lab-tested liraglutide and other research chemicals. Here is why we trust them:
- Liraglutide made in the USA: This vendor sources their liraglutide from accredited partners in the United States, ensuring that their customers receive genuine and safe peptides. Each peptide batch is tested by a third-party laboratory using HPLC-MS analysis, providing transparent data on the contents and purity of each vial.
- Competitive pricing: Peptide Sciences offers competitive pricing and sells liraglutide in 10 vial packs, perfect for long-term study. US-based researchers can expect to receive their orders within 2-3 business days, while international orders are often delivered within 10 business days. US orders above $200 qualify for free shipping.
- Exceptional customer service: Peptide Sciences offers fantastic customer service, with knowledgeable professionals available via email or phone to address any questions or concerns. With prompt response times of just one business day, researchers can trust that they'll receive the support they need.
Overall, Peptide Sciences is an excellent choice for researchers seeking a reliable source of lab-verified liraglutide for their experiments.
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Bacteriostatic Water For Injection
Conducting effective research on liraglutide and similar peptides requires a well-equipped laboratory that includes essential tools like sterile vials, bacteriostatic water, and insulin syringes.
Unfortunately, acquiring all of these necessary supplies and ensuring their quality can be a slow and difficult process.
That is why we recommend BacteriostaticWater.org, a reputable online supplier that offers high-quality research materials and supply kits. They are an affordable option for any researcher, as they offer competitive pricing and discounts on bulk orders.
Their kits contain all necessary items for handling peptides and save researchers the hassle of sourcing products from multiple vendors.
Researchers can enjoy the convenience of a complete research kit, available in either starter or premium options, depending on their requirements.
The starter research kit contains the following items:
- Bacteriostatic Water (30mL) – 3x
- Insulin Syringes (0.5 cc/mL x 29g x ½) – 100x
- Alcohol Prep Pads – 200x
- Sterile Empty Glass Vial (10mL) – 1x
- Large Needles + Syringes Combo (3cc x 21g x 1) – 10x
The premium research kit is equipped with the following:
- Bacteriostatic Water (30mL) – 5x
- Insulin Syringes (0.5 cc/mL x 29g x ½) – 200x
- Alcohol Prep Pads – 200x
- Sterile Empty Glass Vial (10mL) – 2x
- Large Needles + Syringes Combo (3cc x 21g x 1) – 20x
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Liraglutide Costs | Verdict
Liraglutide is available online for research purposes, but cost can vary from one vendor to another.
Researchers can obtain liraglutide for $48.50/3mg when buying from our recommended vendor, Peptide Sciences.
Bulk discounts of up to 7% are available to researchers who order multiple batches at a time from this vendor.
The cost of liraglutide and options for online purchase make it highly attractive to researchers interested in investigating this peptide’s effects, potential benefits, and long-term risks.