Titus Thorne

Last Updated December 3, 2021

Titus Thorne

 December 3, 2021

Are you concerned about ipamorelin side effects?

If so, you’re in the right place.

Many peptide researchers are interested in conducting ipamorelin studies. It has the proven ability to increase GH levels and strongly influences overall body composition and levels of body fat.

But is it safe to administer?

Based on the available research, ipamorelin treatment appears to create few adverse effects. Below, we will give you the information you need to decide whether ipamorelin could be the right research peptide for your next study, and what you can expect when you administer ipamorelin to research subjects.

Buy Ipamorelin from the #1 online Peptides vendor in the world: Peptides Sciences

Disclaimer: ResearchPeptides.org contains information about products that are intended for laboratory and research use only, unless otherwise explicitly stated. This information, including any referenced scientific or clinical research, is made available for educational purposes only. ResearchPeptides.org makes every effort to ensure that any information it shares complies with national and international standards for clinical trial information and is committed to the timely disclosure of the design and results of all interventional clinical studies for innovative treatments publicly available or that may be made available. However, research is not considered conclusive. ResearchPeptides.org makes no claims that any products referenced can cure, treat or prevent any conditions, including any conditions referenced on its website or in print materials.


What is Ipamorelin?

Ipamorelin is a pentapeptide (a peptide containing five amino acids) that mimics ghrelin, a naturally occurring hormone produced by enteroendocrine cells in the gastrointestinal tract [1]. Ghrelin is responsible for several anabolic processes in the body including [2]:

  • Energy usage
  • Appetite suppression
  • Fat processing

As a ghrelin mimetic, ipamorelin significantly influences the GI system, body composition, and adiposity. It is also classified as a growth hormone (GH) secretagogue due to its ability to increase the secretion of GH and insulin growth-factor 1 (IGF-1) in the body.
What makes ipamorelin unique is that it is the world’s first selective GH secretagogue. This means that it binds to the same receptors as does endogenous ghrelin (the GHSR-1a receptors) and that it stimulates the cells in the pituitary gland to release more GH without raising ACTH or cortisol levels [3].
Ipamorelin’s secondary effect is that it reduces the amount of somatostatin, a GH-inhibiting hormone. By reducing somatostatin, ipamorelin is able to raise levels of endogenous GH and IGF-1 on par with what is possible with exogenous GH therapy [3].


Ipamorelin


Benefits of Ipamorelin

Ipamorelin is a research peptide that lacks U.S. Food and Drug Administration approval and has no recognized medical uses. However, here is a brief review of observed ipamorelin benefits based on various studies.

  • Improved gastric motility: Two studies have linked ipamorelin to improved gastric motility [4, 5]. Greenwood-Van Meerveld et al. found that ipamorelin accelerated gastric emptying in adult male rats [4]. Beck et al. found that ipamorelin did not improve measured outcomes (time to first tolerated meal and first bowel movement) any better than a placebo, but data from this study showed that ipamorelin treatment may help open laparotomy patients recover faster [5, 6, 7].
  • Increased GH-release: K Raun et al. found that ipamorelin can stimulate GH release in animals (swine and rats) to an extent comparable with GHRP-6 [3]. Other research has shown that ipamorelin can increase GH and body weight in rats [8].
  • Increased body weight: Various animal studies have linked ipamorelin to body weight gain [8, 9]. Lall et al. found that GH-deficient and non-GH-deficient mice that received twice-daily injections of ipamorelin increased their body weight by 15.3% and 16.9% respectively in just 9 weeks. Dissections revealed that ipamorelin did not increase the weight or size of the rodents’ internal organs [9].
  • Potential treatment for male hypogonadism: Deepankar et al. indicated that ipamorelin may help with weight gain in hypogonadal males [6].
  • Purported anabolic benefits: Due to ipamorelin’s ability to increase GH secretion and body weight gain in animals [9], there is a good deal of speculation as to whether this peptide can be administered for muscle growth and fat loss. While GH therapy (not ipamorelin) has been shown to increase lean body mass and decrease fat mass in recreational athletes [10], there is no evidence showing that ipamorelin offers these benefits. Based on animal studies, ipamorelin actually increases the total body fat percentage of non-GH-deficient rodents [9].
  • Purported anti-aging benefits: Anecdotal evidence shows that many anti-aging clinics tout ipamorelin as an anti-aging treatment that can reduce visible signs of aging. While there is evidence that growth hormone (GH) secretagogues like ipamorelin can increase lean body mass and decrease fat mass in seniors [11], long-term research shows that elevated GH levels increase disease risks and decrease life expectancy by accelerating the aging process [12].

Ipamorelin Side Effects | What You MUST Know

While ipamorelin appears to have a significant influence on the GI system, adiposity, and overall body composition, it also produces some direct and indirect side effects. Here’s what you must know.

First, it's important to note that data from human clinical trials involving ipamorelin is extremely limited. To date, ipamorelin’s efficacy has only been tested in one phase 2 clinical trial, which was a small, proof of concept study that involved just 114 participants [5]. While safety data from this trial is encouraging, the sample size is too small for any meaningful conclusions to be drawn.

Second, while animal studies have found that ipamorelin increases GH secretion and body weight gain in rodents without increasing liver size, as GH can, these studies were of short duration [9]. The long-term use of ipamorelin for increasing GH secretion has yet to be studied and findings are, at best, preliminary [11].

Below, we will examine the most common side effects associated with ipamorelin.

Mild ipamorelin side effects

According to Deepankar et al. adverse effects associated with ipamorelin treatment are rare and similar to those reported with sermorelin [6]. These include:

  • Redness, itching, pain, rashes, and sensitivity at the site of injection
  • Dry mouth
  • Nausea
  • Headaches
  • Lightheadedness
  • Fever (that is transient, and goes away quickly)

Some of these side effects are easily avoided or treated. For example, changing the site of injection should help reduce pain or irritation at that particular spot.

Other possible ipamorelin side effects

There is currently no data from clinical trials linking ipamorelin to major side effects in humans. However, this is more to do with how little the peptide has been researched. To date, the only human trial involving ipamorelin was just 7 days long [5], which is clearly insufficient to draw any conclusions about this peptide's long-term side effects.

While the long-term safety of ipamorelin has yet to be evaluated, we can surmise that, as a growth hormone (GH) secretagogue, long-term ipamorelin therapy may indirectly produce side effects associated with elevated GH levels. As noted by Barkte, supranormal GH levels have been associated with [12]:

  • Increased disease risks
  • Reduced life expectancy
  • Acceleration of aging

However, Deepankar et al. found that ipamorelin did not raise serum levels of GH and IGF-1 beyond “physiological norms” [6]. This suggests that it may not carry the same risks associated with exogenous GH therapy, which include joint stiffness, radiculopathy, and the risk of edema.

While ipamorelin could offer therapeutic and clinical potential, its long-term side effects have yet to be studied and this remains a clear area for further research.


Where to Buy Ipamorelin Online? | 2021 Guide

Researchers interested in buying ipamorelin online should exercise caution. Research peptides are largely unregulated across the English-speaking world, and many companies sell substandard or downright counterfeit products.

Our preferred place to buy ipamorelin online is Peptide Sciences. They are a reputable company with consistently high-quality products. In our opinion, they are the most trustworthy company currently selling ipamorelin and other research peptides. They offer:

  • Fast international shipping: As Peptide Sciences is an American company, shipping within the US takes 2 to 3 days. They also ship internationally within 7 to 10 days. Domestic shipping fees are waived on orders of over $200.
  • High quality: All of their products are 99% pure with no additives or fillers. Peptide Sciences products are made for research, so they are top grade. Not convinced? This vendor posts third-party lab reports, including a Certificate of Analysis, High Performance Liquid Chromatography, and Mass Spectrometry, for each batch of peptide that they sell.
  • Easy payment: You can use all major credit cards as well as cryptocurrencies. Peptide Sciences uses a secure payment system to ensure that your personal and financial data is kept safe from order to delivery.
  • Awesome customer service: If you have any issue with your order, you can talk to a professional who is always happy to help. But you probably won’t even need to—after dozens of orders with Peptide Sciences, we have not had a single issue!

As you can see, Peptide Sciences is the real deal when it comes to research peptides. And beyond standard ipamorelin they also sell ipamorelin peptide blends, including CJC-1295/ipamorelin, sermorelin/ipamorelin, and tesamorelin/ipamorelin. Regardless of your research objectives, Peptide Sciences has got your back.

Buy Ipamorelin from our #1 recommended vendor...


Ipamorelin


Side Effects of Ipamorelin? | Verdict

So what’s the verdict?

Having reviewed the available research, it is clear that ipamorelin is an under-researched growth hormone (GH) secretagogue that has strong clinical and therapeutic potential. It appears to be a potent stimulator of both GH and IGF-1 to an extent comparable with exogenous GH therapy, and it has a significant impact on body composition.

Ipamorelin has yet to pass phase two clinical trials, and further human studies evaluating are required before drawing any conclusions about this peptide’s side effects and long-term safety.

Ipamorelin certainly presents an interesting opportunity for further longitudinal studies and would be a strong candidate for medical research in metabolic syndrome and hypogonadism.


References

  1. Kojima M, Kangawa K. Ghrelin: structure and function. Physiol Rev. 2005 Apr;85(2):495-522. doi: 10.1152/physrev.00012.2004. PMID: 15788704.
  2. Wren AM, Seal LJ, Cohen MA, Brynes AE, Frost GS, Murphy KG, Dhillo WS, Ghatei MA, Bloom SR. Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab. 2001 Dec;86(12):5992. doi: 10.1210/jcem.86.12.8111. PMID: 11739476.
  3. Raun, K, Hansen, B., Johansen, N., Thogersen, H, Madsen, K, Ankersen, M, & Andersen, P. (1998). Ipamorelin, the first selective growth hormone secretagogue. European Journal of Endocrinology. 139 (5): 552–561.
  4. Greenwood-Van Meerveld B, Tyler K, Mohammadi E, Pietra C. Efficacy of ipamorelin, a ghrelin mimetic, on gastric dysmotility in a rodent model of postoperative ileus. J Exp Pharmacol. 2012 Oct 19;4:149-55. doi: 10.2147/JEP.S35396. PMID: 27186127; PMCID: PMC4863553.
  5. Beck DE, Sweeney WB, McCarter MD; Ipamorelin 201 Study Group. Prospective, randomized, controlled, proof-of-concept study of the Ghrelin mimetic ipamorelin for the management of postoperative ileus in bowel resection patients. Int J Colorectal Dis. 2014 Dec;29(12):1527-34. doi: 10.1007/s00384-014-2030-8. Epub 2014 Oct 21. PMID: 25331030.
  6. Sinha, Deepankar K et al. “Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males.” Translational andrology and urology vol. 9,Suppl 2 (2020): S149-S159. doi:10.21037/tau.2019.11.30
  7. Delaney CP, Marcello PW, Sonoda T, Wise P, Bauer J, Techner L. Gastrointestinal recovery after laparoscopic colectomy: results of a prospective, observational, multicenter study. Surg Endosc. 2010 Mar;24(3):653-61. doi: 10.1007/s00464-009-0652-7. Epub 2009 Aug 18. PMID: 19688390.
  8. Estrada, R. Cañete; Jiménez-Reina, L.; de la Torre, M.J.; Bernal, J. (2002). “Chronic In Vivo Ipamorelin Treatment Stimulates Body Weight Gain and Growth Hormone (GH) Release In Vitro in Young Female Rats. European Journal of Anatomy. 6(1): 37–46.
  9. Lall S, Tung LY, Ohlsson C, Jansson JO, Dickson SL. Growth hormone (GH)-independent stimulation of adiposity by GH secretagogues. Biochem Biophys Res Commun. 2001 Jan 12;280(1):132-8. doi: 10.1006/bbrc.2000.4065. PMID: 11162489.
  10. Meinhardt U, Nelson AE, Hansen JL, Birzniece V, Clifford D, Leung KC, Graham K, Ho KK. The effects of growth hormone on body composition and physical performance in recreational athletes: a randomized trial. Ann Intern Med. 2010 May 4;152(9):568-77. doi: 10.7326/0003-4819-152-9-201005040-00007. PMID: 20439575.
  11. George R. Merriam, Suzanne Barsness, David Buchner, Monica Kletke, Lawrence H. Larsen, Karen E. Moe, Robert S. Schwartz, and Michael V. Vitiello.Journal of Anti-Aging Medicine.Dec 2001.331-343.http://doi.org/10.1089/10945450152850650
  12. Bartke A. Growth Hormone and Aging: Updated Review. World J Mens Health. 2019 Jan;37(1):19-30. doi: 10.5534/wjmh.180018. Epub 2018 May 11. PMID: 29756419; PMCID: PMC6305861.

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