Titus Thorne

Last Updated March 13, 2023

Titus Thorne

 March 13, 2023

Looking for a potent PT-141 nasal spray?

Inside, researchers will learn about this sexual health peptide in nasal spray form.

When it comes to using peptide therapy to address sexual health issues, PT-141 is among the most highly sought peptides.

Also called bremelanotide, PT-141 is approved by the US Food and Drug Administration to treat low libido in premenopausal women. It has also been shown to safely and effectively address male erectile dysfunction.

While PT-141 is most commonly administered via subcutaneous injection, researchers have seen equally impressive results in subjects who have used a PT-141 nasal spray.

Researchers may thus be curious about:

  • How to best administer PT-141?
  • What are the advantages of a PT-141 nasal spray?
  • Is PT-141 nasal spray faster-acting than the injectable form?
  • Does PT-141 nasal spray need to be refrigerated?

Our research team has put together this informative guide to answer these questions and more, including our recommendation on where to buy a quality PT-141 nasal spray.

Buy PT-141 Nasal Spray from our #1 recommended vendor...

Disclaimer: Peptides.org contains information about products that are intended for laboratory and research use only, unless otherwise explicitly stated. This information, including any referenced scientific or clinical research, is made available for educational purposes only. Peptides.org makes every effort to ensure that any information it shares complies with national and international standards for clinical trial information and is committed to the timely disclosure of the design and results of all interventional clinical studies for innovative treatments publicly available or that may be made available. However, research is not considered conclusive. Peptides.org makes no claims that any products referenced can cure, treat or prevent any conditions, including any conditions referenced on its website or in print materials.

What is PT-141?

PT-141 is a synthetic peptide analog of alpha-melanocyte-stimulating hormone (alpha-MSH) that was discovered in the development of melanotan 2, which is commonly used to achieve sunless pigmentation of the skin.

Melanocortins like PT-141 and melanotan 2 regulate a variety of bodily functions, including neural activity, inflammatory response, and sexual behavior. PT-141 has strong affinity at the melanocortin receptor 4 (MC4-R), which specifically mediates sexual function and behavior in both men and women [1, 2].

PT-141 thus works differently from the erectile dysfunction treatment Viagra, which directly induces blood flow to the penis. Rather, PT-141 activates MC4-R to stimulate arousal, which can then lead to improved erectile function in men [2].

It also works differently from flibanserin, another FDA approved medication for low libido in women. Unlike flibanserin, which is a 5-HT1A receptor agonist, PT-141 does not directly impact the neurotransmitters involved in sexual response.

PT-141 Nasal Spray

What is PT-141 Used For?

PT-141 (“bremelanotide”) has been approved to treat hypoactive sexual desire disorder (HSDD) in premenopausal women in the United States, where it is available by prescription under the trade name Vyleesi. While PT-141 is currently approved for use in women only, research in subjects with erectile dysfunction indicates that PT-141 may be administered to males with similar success [2, 3, 4, 5, 6, 7].

Three early sets of research findings have demonstrated that PT-141 induces an erectile response in males with erectile dysfunction who do respond to Viagra, in males with ED who do not respond to Viagra, and in healthy males. Notably, PT-141 has shown efficacy in cases of Viagra treatment failure [5, 8, 9].

PT-141 nasal spray in particular has been shown to elevate libido and trigger an erectile response in men with ED. In a 2004 study by Diamond et al, the researchers used a PT-141 nasal spray at doses higher than 7mg to achieve statistically significant erectile results in both healthy men and men with ED, within erections achieved in about 30 minutes [9].

Benefits of PT-141

There is extensive research on PT-141 to support the FDA’s approval of the peptide as a treatment of hypoactive sexual desire disorder (HSDD) in premenopausal women.

Here is a summary of research-backed benefits of PT-141 administration.

PT-141 and Erectile dysfunction

In a 2004 study, researchers tested the efficacy of PT-141 in both healthy males and in ED patients who did not respond to Viagra, a vasodilator. Both groups achieved statistically significant erectile responses, with the healthy males reporting positive outcomes from a dose of 1mg, and the ED patients from a dose of 4mg. The authors deemed the peptide safe and well-tolerated, proposing it as an ED treatment with a “potentially broad patient base” [5].

In 2006, researchers in Iran similarly tested the peptide on ED patients who did not respond to Viagra. This time, the patients self-administered a PT-141 nasal spray at doses of 10mg each, about 45 minutes to two hours prior to intercourse. The patients reported “significantly greater intercourse satisfaction” compared to placebo [8].

PT-141 and Mood

Melanocortin peptides like PT-141 have been shown to regulate the activity of central dopamine neurons, via activation of presynaptic melanocortin 4 receptors on neurons in the medial preoptic area of the hypothalamus. This increased release of dopamine not only contributes to increased sexual desire and response, but may induce improvements in overall mood and wellbeing [7, 10].

PT-141 and Weight control

In addition to regulating sexual desire, the melanocortin 4 receptor plays a role in appetite control, with researchers theorizing that the agonistic activity of PT-141 at MC4-R induces satiety. In two clinical trials conducted on obese women, PT-141 administration contributed to reduced caloric intake and increased weight loss in the patients [11].

PT-141 and Female Libido

Prior to the regulatory approval of PT-141, researchers conducted two phase 3 clinical trials to examine the peptide’s effects on 856 premenopausal women with hypoactive sexual desire disorder. The women treated with PT-141 showed sustained improvements in their HSDD symptoms, based on indicators of female sexual function and female sexual distress [12].

PT-141 Side Effects

Multiple clinical trials have demonstrated that PT-141 is safe and well tolerated in female patients with hypoactive sexual desire disorder, as well as in males with erectile dysfunction [5, 13].

While there are no interactions reported between alcohol and PT-141, the peptide may not be safe in subjects with cardiovascular disease or uncontrolled hypertension [3, 14].

The most commonly reported PT-141 side effects are minor [3, 12]:

  • Facial flushing
  • Nausea
  • Swelling
  • General discomfort
  • Headaches

Additionally, PT-141 can induce mild serum enzyme elevations and in rare cases may cause acute liver injury [15].

There are no particular side effect concerns with administering a PT-141 nasal spray in lieu of injections.

PT-141 was well tolerated in a study where both healthy men and men with ED took doses of >7mg by nasal spray, though the researchers could not establish a maximum-tolerated dose. The researchers did not note any clinically significant changes in the vital signs or laboratory tests of the patients [8].

PT-141 Nasal Spray

PT-141 Nasal Spray | The A-Z Guide

While PT-141 is most commonly administered via subcutaneous injection, researchers may prefer the advantages of a PT-141 nasal spray.

One of the biggest benefits of using a PT-141 nasal spray is that it will produce effects rapidly, which is highly important to those testing the peptide’s effects on sexual function and performance.

Certain peptides are rapidly absorbed in the nasal cavity for the following factors [16]:

  • Large surface area
  • Porous endothelial membrane
  • High total blood flow
  • Avoidance of first-pass metabolism

Substances like PT-141 are quickly cleared from the nasal cavity after nasal administration, leading to rapid systemic absorption. The efficacy of PT-141 nasal spray is clear: intranasally administering the peptide can produce erections in erectile dysfunction patients in as little as 30 minutes [8, 9].

A PT-141 nasal spray may also be much more convenient to administer, and does not result in injection-related side effects like irritation at the injection site.

Further, many PT-141 nasal spray products are completely stable at room temperature, allowing for easy transport and storage without the concern of the peptide degrading.

Some PT-141 nasal spray formulations include oxytocin, a hormone produced by the hypothalamus that regulates feelings of sexual arousal, trust, and romantic attachment, and is linked to enhanced sexual activity [17].

Where to Buy PT-141 Nasal Spray Online | 2023 Guide

There are a number of PT-141 nasal sprays on the market, though reviewers report a range of experiences with their purchases.

To help researchers find the best PT-141 nasal spray for their needs, our team has tested products from at least a dozen peptide vendors. We looked at factors like peptide quality, deliverability, and customer service to identify our top pick.

Based on our survey, PureRawz has the best PT-141 nasal spray on the market, containing 5mg PT-141 and 5mg oxytocin per bottle.

PureRawz stands apart from other vendors for the following reasons:

  • Lab-tested products: PureRawz submits all of their compounds to rigorous third-party lab testing to ensure standards of quality and purity. Each product comes with a Certificate of Analysis for added peace of mind.
  • Convenient payments: PureRawz accepts a range of convenient and secure payments, including PayPal, Venmo, Zelle, Mesh and cryptocurrency payments. The vendor currently offers a discount on crypto orders.
  • Reliable shipping: The vendor ships all orders from its European warehouse, and uses Priority International Mail to ensure that products arrive to customers as quickly as possible. Shipping fees on all orders over $100 are waived.
  • 30-day returns: PureRawz offers a 30-day satisfaction guarantee, though all returns and exchanges are subject to its sole discretion. The customer must notify PureRawz of any issue within seven days of receipt of their product.
  • Customer service: Researchers can contact the Pure Rawz customer service team via phone, email, or the live chat button directly on their website.

Researchers looking to buy a high-quality PT-141 nasal spray for their next study are advised to check out PureRawz, a trusted name in the research chemicals industry.

Buy PT-141 Nasal Spray from our #1 recommended vendor...

Nasal Spray vs. Injectable PT-141

While we have covered the distinct benefits of a PT-141 nasal spray, the gold standard form of PT-141 administration remains subcutaneous injection.

For example, HSDD patients with a bremelanotide prescription in the United States are directed to purchase Vyleesi, which comes as a prefilled autoinjector pen that patients must self-administer into the abdomen or thigh before sexual activity [4].

However, injectable PT-141 for research purposes will likely not come in an autoinjector pen, but in the form of lyophilized powder that must be reconstituted with bacteriostatic water prior to injection. Researchers must then refrigerate any unused solution.

On the contrary, a PT-141 spray is extremely easy to administer and quite portable, as most nasal spray formulas do not even require reconstitution or refrigeration.

We also mentioned that PT-141 nasal spray may have a slightly quicker onset of effects compared to subcutaneous injections, though any difference may be negligible.

Still, many researchers would prefer a maximally pure PT-141 product that they themselves will want to reconstitute and refrigerate.

For research-grade PT-141 in injectable form, visit Peptide Sciences

Peptide Sciences is a leading vendor of research-grade peptides for injection, and only lists peptides that have been lab tested for purity levels of at least 99%.

Bacteriostatic Water for Injection

Now, it’s time to equip yourself to properly handle PT-141 and other research peptides. To follow the correct methods of injection, reconstitution, and storage, you will require a specific set of materials.

What should be in your toolkit? Alcohol prep pads, insulin syringes, sterile vials, and bacteriostatic water, to list a few.

But getting a hold of all these materials can be difficult and time-consuming for researchers.

To help you along, the experts at Peptides.org are pleased to give you our best recommendation to purchase the full range of required materials for your peptide research.


This credible online retailer delivers full supply kits that spare clients the headache of searching the web for various products from multiple sources. Take a look at the two convenient packages available from BacteriostaticWater.org, tailored to the demands of researchers like you.

Obtain all the essentials with the starter research kit, offering:

  • Bacteriostatic Water (30mL) – 3x
  • Insulin Syringes (0.5 cc/mL x 29g x ½) – 100x
  • Alcohol Prep Pads – 200x
  • Sterile Empty Glass Vial (10mL) – 1x
  • Large Needles + Syringes Combo (3cc x 21g x 1) – 10x

Fully stock up on all items with the premium research kit, containing:

  • Bacteriostatic Water (30mL) – 5x
  • Insulin Syringes (0.5 cc/mL x 29g x ½) – 200x
  • Alcohol Prep Pads – 200x
  • Sterile Empty Glass Vial (10mL) – 2x
  • Large Needles + Syringes Combo (3cc x 21g x 1) – 20x

Your ticket to improved research with deluxe supplies is just a click away!

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PT-141 Nasal Spray Review

PT-141 shows great therapeutic potential, backed by extensive clinical research highlighting its ability to safely and effectively treat sexual disorders.

The synthetic α-MSH analog targets and activates melanocortin receptor 4, a potent mediator of sexual function in both men and women. This places the peptide in a class of its own, unlike vasodilators like Viagra or serotonin modulators like flibanserin.

The peptide is available in convenient nasal spray form, having been shown to deliver effects in as little as 30 minutes.

If you’re looking for a quality PT-141 nasal spray that is infused with oxytocin, head over to trusted brand PureRawz.


  1.  Dhillon S, Keam SJ. Bremelanotide: First Approval. Drugs. 2019 Sep;79(14):1599-1606. doi: 10.1007/s40265-019-01187-w. PMID: 31429064.
  2. Wessells H, Blevins JE, Vanderah TW. Melanocortinergic control of penile erection. Peptides. 2005 Oct;26(10):1972-7. doi: 10.1016/j.peptides.2004.11.035. PMID: 15992962; PMCID: PMC4768007.
  3. Mayer D, Lynch SE. Bremelanotide: New Drug Approved for Treating Hypoactive Sexual Desire Disorder. Ann Pharmacother. 2020 Jul;54(7):684-690. doi: 10.1177/1060028019899152. Epub 2020 Jan 1. PMID: 31893927.
  4. Bremelanotide (Vyleesi) for hypoactive sexual desire disorder. Med Lett Drugs Ther. 2019 Jul 29;61(1577):114-116. PMID: 31381550.
  5. Rosen RC, Diamond LE, Earle DC, Shadiack AM, Molinoff PB. Evaluation of the safety, pharmacokinetics and pharmacodynamic effects of subcutaneously administered PT-141, a melanocortin receptor agonist, in healthy male subjects and in patients with an inadequate response to Viagra. Int J Impot Res. 2004 Apr;16(2):135-42. doi: 10.1038/sj.ijir.3901200. PMID: 14999221.
  6. Commissioner, O. of the. (n.d.). FDA approves new treatment for hypoactive sexual desire disorder in premenopausal women. U.S. Food and Drug Administration. Retrieved August 28, 2022, from https://www.fda.gov/news-events/press-announcements/fda-approves-new-treatment-hypoactive-sexual-desire-disorder-premenopausal-women
  7. Pfaus JG, Sadiq A, Spana C, Clayton AH. The neurobiology of bremelanotide for the treatment of hypoactive sexual desire disorder in premenopausal women. CNS Spectr. 2022 Jun;27(3):281-289. doi: 10.1017/S109285292100002X. Epub 2021 Jan 18. PMID: 33455598.
  8. Safarinejad MR, Hosseini SY. Salvage of sildenafil failures with bremelanotide: a randomized, double-blind, placebo controlled study. J Urol. 2008 Mar;179(3):1066-71. doi: 10.1016/j.juro.2007.10.063. Epub 2008 Jan 18. PMID: 18206919.
  9. Diamond, L. E., Earle, D. C., Rosen, R. C., Willett, M. S., & Molinoff, P. B. (2004, February 12). Double-blind, placebo-controlled evaluation of the safety, pharmacokinetic properties and pharmacodynamic effects of intranasal PT-141, a melanocortin receptor agonist, in healthy males and patients with mild-to-moderate erectile dysfunction. Nature News. Retrieved August 28, 2022, from https://www.nature.com/articles/3901139
  10. Lindblom J, Kask A, Hägg E, Härmark L, Bergström L, Wikberg J. Chronic infusion of a melanocortin receptor agonist modulates dopamine receptor binding in the rat brain. Pharmacol Res. 2002 Feb;45(2):119-24. doi: 10.1006/phrs.2001.0913. PMID: 11846623.
  11. Spana C, Jordan R, Fischkoff S. Effect of bremelanotide on body weight of obese women: Data from two phase 1 randomized controlled trials. Diabetes Obes Metab. 2022 Jun;24(6):1084-1093. doi: 10.1111/dom.14672. Epub 2022 Mar 15. PMID: 35170192; PMCID: PMC9314948.
  12. Simon JA, Kingsberg SA, Portman D, Williams LA, Krop J, Jordan R, Lucas J, Clayton AH. Long-Term Safety and Efficacy of Bremelanotide for Hypoactive Sexual Desire Disorder. Obstet Gynecol. 2019 Nov;134(5):909-917. doi: 10.1097/AOG.0000000000003514. PMID: 31599847; PMCID: PMC6819023.
  13. Althof S, Derogatis LR, Greenberg S, Clayton AH, Jordan R, Lucas J, Spana C. Responder Analyses from a Phase 2b Dose-Ranging Study of Bremelanotide. J Sex Med. 2019 Aug;16(8):1226-1235. doi: 10.1016/j.jsxm.2019.05.012. Epub 2019 Jul 2. PMID: 31277966.
  14. Walid. (2019, August 16). About Vyleesi: Approved bremelanotide injection for HSDD. Vyleesi (bremelanotide injection) 1.75mg/0.3 ml | for subcutaneous use only. Retrieved August 22, 2022, from https://www.vyleesi.com/about-vyleesi/
  15. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. Bremelanotide. 2021 Aug 20. PMID: 34436837.
  16. Türker S, Onur E, Ozer Y. Nasal route and drug delivery systems. Pharm World Sci. 2004 Jun;26(3):137-42. doi: 10.1023/b:phar.0000026823.82950.ff. PMID: 15230360.
  17. Magon N, Kalra S. The orgasmic history of oxytocin: Love, lust, and labor. Indian J Endocrinol Metab. 2011 Sep;15 Suppl 3(Suppl3):S156-61. doi: 10.4103/2230-8210.84851. PMID: 22029018; PMCID: PMC3183515.
  18. Szente V, Zelkó R. Helyspecifikus hatóanyagleadást biztosító rendszerek. III. Nazális gyógyszerformák [Site-specific drug delivery systems. III. Nasal drug delivery]. Acta Pharm Hung. 2008;78(2):87-90. Hungarian. PMID: 18807389.

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