Titus Thorne

Last Updated November 17, 2021

Titus Thorne

 November 17, 2021

Curious about Tesamorelin benefits? Then you’re in the right place.

Tesamorelin is one of several human growth hormone (HGH) secretagogues—substances that increase HGH and improve your body's ability to create and repair tissues. It's especially effective at burning through stubborn belly fat for individuals with lipodystrophy.

But what else can it do?

Find out here. In this article, you'll find a round-up of the benefits of Tesamorelin based on high-quality scientific research. You'll get a sense of how it works and what you can expect from Tesamorelin before and after.

Buy Tesamorelin from the #1 online Peptides vendor in the world: Peptides Sciences

Disclaimer: ResearchPeptides.org contains information about products that are intended for laboratory and research use only, unless otherwise explicitly stated. This information, including any referenced scientific or clinical research, is made available for educational purposes only. ResearchPeptides.org makes every effort to ensure that any information it shares complies with national and international standards for clinical trial information and is committed to the timely disclosure of the design and results of all interventional clinical studies for innovative treatments publicly available or that may be made available. However, research is not considered conclusive. ResearchPeptides.org makes no claims that any products referenced can cure, treat or prevent any conditions, including any conditions referenced on its website or in print materials.

What is Tesamorelin?

Tesamorelin is a peptide. Peptides are long sequences of amino acids that play an important role in our body's chemical signaling processes. They help keep cells healthy [1].

We know that peptides can be important to our health, and there are about 60 of them that are currently of interest to scientists looking to solve the hardest problems in health. Tesamorelin is one of the peptides that looks like it could play an especially important role in tissue growth and repair.

Tesamorelin is made up of a sequence of 44 amino acids. It is virtually identical to a hormone that your body produces naturally called growth hormone-releasing hormone (GHRH) [2].

GHRH is deeply important to how your body regulates the HGH levels in your blood.

HGH is essential to human growth and performance. It is a critical part of the process by which we build and repair tissues. That means it's involved in everything from children growing in height, to building new muscle after a workout, to the regenerating collagen in the skin, and even to recovering from injuries.

Since Tesamorelin looks almost exactly like GHRH, it can bind to the same receptors and basically have the same effect: increasing HGH levels in the blood [2]. It also increases insulin-like growth factor (IGF), another important chemical that helps regulate tissue growth [3]


Benefits of Tesamorelin

So what are the benefits of Tesamorelin?

There are many; you'll see a huge difference in your “test subjects” using Tesamorelin before and after.

But it is important to be clear that the main benefit of Tesamorelin is that it raises HGH. Several studies have, indeed, confirmed that Tesamorelin has this effect on its participants.

  • One study found that Tesamorelin successfully increased HGH and IGF [4].
  • Another confirmed these results and found that Tesamorelin significantly increased overnight HGH secretion [5].

So it's worth the reminder: Tesamorelin's main effect is up-regulating HGH. The other  Tesamorelin benefits come from that increased HGH—they're more accurately described as indirect benefits of Tesamorelin.

Tesamorelin Bodybuilding

Bodybuilders love Tesamorelin for a few reasons. While there hasn't been much research looking directly at the effects of Tesamorelin in athletics, there are definitely some reports of Tesamorelin bodybuilding online:

One Reddit user [6] said,

“Tesamorelin HGH absolutely incinerates visceral fat. My protocol was 1mg a night with 150mcg ipam, for 5 weeks. Expensive but if you want to be shredded and diced in the midsection, it’s well worth the cost. Of course diet and exercise play an important role but this accelerates the process.”

For “test subjects” that want a Tesamorelin dosage calculator for bodybuilding, try the following:

  • 1 mg of Tesamorelin, daily
  • 5 days a week
  • before bed

Peptides are very promising for bodybuilding, and more research should be done to find out what the best ways to use Tesamorelin for bodybuilding are. But until researchers do that work, the best we have to go on is research done in non-bodybuilder populations.

Tesamorelin and Lean Muscle

One reason that it's clear that Tesamorelin is great for bodybuilders even though there is no direct research on the Tesamorelin bodybuilding community is that research in other populations shows that it can help build lean muscle mass.

For example, one study looked at the effects of Tesamorelin on building skeletal muscle in the trunk: the rectus abdominis, the obliques, the psoas major, and the paraspinal muscles [7].

After 26 weeks of a Tesamorelin dosing regimen, researchers found that there was a significant increase in muscle density in all muscle groups examined, compared to a placebo [7]. They also found that there were significant increases in muscle size in several muscle groups.

These results suggest that Tesamorelin can effectively enhance skeletal muscle growth.

Tesamorelin and Fat Loss

This is actually what Tesamorelin has been approved by the FDA to do: get rid of visceral fat.

The majority of research on this has been done on patients with HIV that are taking anti-retroviral medications. These medications can cause a condition called lipodystrophy, which is basically the accumulation of fat around the midsection.

Tesamorelin has been shown in many studies that it is effective in increasing GH in these populations as well as in healthy populations and that it can be effective in reducing this stubborn belly fat [2, 8, 9, 10, 11, 12, 13].

One systematic review of the studies that look at Tesamorelin for treating lipodystrophy pooled results from over 1,511 patients. The review found that Tesamorelin reduced visceral adipose tissue (stomach fat) by 25.2 cm squared, on average [12].

This same review also found that Tesamorelin increased lean body mass by about 1.31 kg [12].

It's not just abdominal fat that Tesamorelin incinerates. It has also been found to be effective on other fat loss and body composition measures:

  • It reduces fatty deposits in the liver [11, 13]
  • It significantly reduces waist circumference [2]
  • It has been found to improve body image [2]

Patients with lipodystrophy will want to follow their doctor's guidelines on Tesamorelin dosing. Usually, the dosage is 2 mg per day.

For “test subjects” that want a Tesamorelin dosage calculator for burning fat, use the same one as for bodybuilding presented above:

  • 1 mg of Tesamorelin, daily
  • 5 days a week
  • before bed

Tesamorelin and Cognition

Tesamorelin isn't typically seen as a nootropic substance, but there is some research that suggests this peptide can have a significant impact on cognition.

For example, several studies have found that people with dementia perform significantly better on cognitive tasks when they are on a Tesamorelin dosage regimen compared to a placebo group [14, 15, 16].

In one study, older adults with mild cognitive impairments were given either Tesamorelin or a placebo for 20 weeks [15]. By the end of the study, it was found that those individuals on the Tesamorelin dosage regimen had changes in neurochemicals that were consistent with better brain functioning. In addition, these adults performed significantly better on a battery of cognitive tests.

But it doesn't seem to be just those with cognitive impairments—other research has found it can benefit healthy adults too [14, 15, 16].

Tesamorelin and Nerve Damage

Nerves are very hard to regenerate, and it's currently the case that most nerve damage is permanent.

But that looks like it could change with more research into peptides. Some research has found that Tesamorelin seems to be an effective way to repair nerve damage in some instances [17].

This is consistent with other research that shows both HGH and IGF are associated with improved nerve regeneration outcomes [18].

Tesamorelin and Cardiac Disease

Tesamorelin may also play a role in reducing the risk of developing cardiovascular disease. This is partly because it reduces fat from the midsection, which is associated with an increased risk of heart disease.

However, it also seems to reduce triglyceride levels as well as total cholesterol levels in the blood, both of which may reduce the risk of cardiovascular disease [13, 19].

Tesamorelin Side Effects

One of the Tesamorelin benefits is that it raises HGH without being HGH. Supplementing HGH directly can have very severe side effects. But because tesamorelin increases HGH indirectly using your body's own natural processes, it tends to have fewer side effects.

Still, there can be some. The most common side effects include [19]:

  • redness, itching, pain, swelling, and irritation at the site of injection
  • muscle aches
  • diarrhea
  • sweating

Despite these side effects, most research has found Tesamorelin safe and well-tolerated [2, 8, 9, 10, 11, 12, 20]

Where to Buy Tesamorelin Online? | 2021 Guide

Tesamorelin is sold as a prescription medication in many places, including the US. That means that it is possible for individuals with a prescription to get it from the pharmacy.

However, it's much, much more expensive at the pharmacy and many local pharmacies may not carry it in stock. Plus, if you need Tesamorelin for your “test subjects” and you don't have a prescription, you would be out of luck.

Instead, you can buy Tesamorelin online without a prescription. As long as you're buying it for research purposes, it's completely legal.

Just make sure you're getting it from a legitimate vendor.

We recommend Peptide Sciences. This is the best online vendor that we've found because:

  • They have high-quality products. Peptide Sciences produces its Tesamorelin right in the US and tests its purity with independent laboratory analysis. They then post the results on their site for you to view. This lets you confirm that it is of the high quality you need for your “research”.
  • Convenient, fast shipping. They ship all over the world. Shipments within the United States usually take between 2 and 3 days. To ship globally, you're only looking at about 10 days or less.
  • Convenient, secure payment options. You want to choose a legitimate vendor that won't steal or sell your payment info. Peptide Sciences has a secure payment system. They also accept all kinds of payments including the most common credit cards and cryptocurrencies like Bitcoin and Ethereum.
  • Great customer service. We've always been impressed at how accessible the customer support team is and how great they are at solving problems. They have a great guarantee that ensures that if you get the wrong product, they'll re-ship yours or give your money back.

Buy Tesamorelin from our #1 recommended vendor...


Tesamorelin Benefits | Verdict

So what are the benefits of Tesamorelin?

Tesamorelin has consistently demonstrated its promise as a substance that can help “test subjects” get the body they want. It is especially helpful at burning that stubborn fat that's keeping you back from having a visible six-pack. It also looks as if it's good at building muscle and lean body mass.

But Tesamorelin dosing isn't just for your body composition. Other benefits may include repairing damaged nerve tissue, reducing the risk of cardiovascular diseases, and even improving cognition.

Given these major Tesamorelin benefits, it's no wonder why the research community is interested in testing out its effects even further.

Peptides are the future of medicine. Get in on them today.


  1. Mine, Y., Li-Chan, E., & Jiang, B. (2010). Biologically active food proteins and peptides in health: an overview. Bioactive proteins and peptides as functional foods and nutraceuticals. Hoboken: Wiley‑Blackwell, 5-11.
  2. Dhillon, S. (2011). Tesamorelin. Drugs, 71(8), 1071-1091.
  3. McLarnon, A. (2012). Tesamorelin can improve cognitive function. Nature Reviews Endocrinology, 8(10), 568-568.
  4. Editorial, A. (2004). Pralmorelin: GHRP 2, GPA 748, Growth Hormone-Releasing Peptide 2, KP-102 D, KP-102 LN, KP-102D, KP-102LN. Drugs in R & D, 5, 236-239.
  5. Broglio, F., Boutignon, F., Benso, A., Gottero, C., Prodam, F., Arvat, E., … & Muccioli, G. (2002). EP1572: a novel peptido-mimetic GH secretagogue with potent and selective GH-releasing activity in man. Journal of Endocrinological Investigation, 25(8), RC26-RC28.
  6. Reddit (2019). Tesamorelin Dosage/cycle. https://www.reddit.com/r/Peptides/comments/dt1axv/tesamorelin_dosagecycle/ 
  7. Adrian, S., Scherzinger, A., Sanyal, A., Lake, J. E., Falutz, J., Dubé, M. P., … & Brown, T. T. (2019). The Growth Hormone Releasing Hormone analog, Tesamorelin, decreases muscle fat, and increases muscle area in adults with HIV. The Journal of Frailty & Aging, 8(3), 154-159.
  8. Zdravkovic, M., Christiansen, T., Eliot, L., Agersoe, H., Thomsen, M. S., Falch, J. F., … & Ilondo, M. M. (2001). The pharmacokinetics, pharmacodynamics, safety, and tolerability following 7 days daily oral treatment with NN703 in healthy male subjects. Growth Hormone & IGF Research, 11(1), 41-48.
  9. Svensson, J., Monson, J. P., Vetter, T., Hansen, T. K., Savine, R., Kann, P., … & Ilondo, M. M. (2003). Oral administration of the growth hormone secretagogue NN703 in adult patients with growth hormone deficiency. Clinical Endocrinology, 58(5), 572-580.
  10. Zdravkovic, M., Olsen, A. K., Christiansen, T., Schulz, R., Taub, M. E., Thomsen, M. S., … & Ilondo, M. M. (2003). A clinical study investigating the pharmacokinetic interaction between NN703 (tabimorelin), a potential inhibitor of CYP3A4 activity, and midazolam, a CYP3A4 substrate. European Journal of Clinical Pharmacology, 58(10), 683-688.
  11. Piccoli, F., Degen, L., MacLean, C., Peter, S., Baselgia, L., Larsen, F., … & Drewe, J. (2007). Pharmacokinetics and pharmacodynamic effects of an oral ghrelin agonist in healthy subjects. The Journal of Clinical Endocrinology & Metabolism, 92(5), 1814-1820.
  12. Sivakumar, T., Mechanic, O. J., Fehmie, D. A., & Paul, B. T. (2011). Growth hormone axis treatments for HIV‐associated lipodystrophy: a systematic review of placebo‐controlled trials. HIV medicine, 12(8), 453-462.
  13. Stanley, T. L., Feldpausch, M. N., Oh, J., Branch, K. L., Lee, H., Torriani, M., & Grinspoon, S. K. (2014). Effect of tesamorelin on visceral fat and liver fat in HIV-infected patients with abdominal fat accumulation: a randomized clinical trial. JAMA, 312(4), 380-389.
  14. Zdravkovic, M., Søgaard, B., Ynddal, L., Christiansen, T., Agersø, H., Thomsen, M. S., … & Ilondo, M. M. (2000). The pharmacokinetics, pharmacodynamics, safety and tolerability of a single dose of NN703, a novel orally active growth hormone secretagogue in healthy male volunteers. Growth Hormone & IGF Research, 10(4), 193-198.
  15. Friedman, S. D., Baker, L. D., Borson, S., Jensen, J. E., Barsness, S. M., Craft, S., … & Vitiello, M. V. (2013). Growth Hormone–Releasing Hormone Effects on Brain γ-Aminobutyric Acid Levels in Mild Cognitive Impairment and Healthy Aging. JAMA Neurology, 70(7), 883-890.
  16. Baker, L. D., Barsness, S. M., Borson, S., Merriam, G. R., Friedman, S. D., Craft, S., & Vitiello, M. V. (2012). Effects of growth hormone-releasing hormone on cognitive function in adults with mild cognitive impairment and healthy older adults: results of a controlled trial. Archives of Neurology, 69(11), 1420-1429.
  17. Tuffaha, S. H., Singh, P., Budihardjo, J. D., Means, K. R., Higgins, J. P., Shores, J. T., … & Brandacher, G. (2016). Therapeutic augmentation of the growth hormone axis to improve outcomes following peripheral nerve injury. Expert opinion on therapeutic targets, 20(10), 1259-1265.
  18. Bianchi, V. E., Locatelli, V., & Rizzi, L. (2017). Neurotrophic and neuroregenerative effects of GH/IGF1. International Journal of Molecular Sciences, 18(11), 2441.
  19. Falutz, J., Allas, S., Blot, K., Potvin, D., Kotler, D., Somero, M., … & Turner, R. (2007). Metabolic effects of a growth hormone–releasing factor in patients with HIV. New England Journal of Medicine, 357(23), 2359-2370.
  20. Luzi, L., Meneghini, E., Oggionni, S., Tambussi, G., Piceni-Sereni, L., & Lazzarin, A. (2005). GH treatment reduces trunkal adiposity in HIV-infected patients with lipodystrophy: a randomized placebo-controlled study. European Journal of Endocrinology, 153(6), 781-789.

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