Curious about the use of BPC-157 and treat erectile dysfunction?
This comprehensive review will provide the most important information available on the application of BPC-157 in the context of erectile dysfunction treatment.
We will explain:
- What is BPC-157
- BPC-157 and Erectile Dysfunction
- BPC-157 Benefits
- BPC-157 Safety
To add, we will offer our expert recommendation for purchasing the best BPC-157 available online.
We detail what must be known about BPC-157, including data from cutting-edge, peer-reviewed studies and how to successfully incorporate this popular peptide into research on erectile dysfunction.
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What is BPC-157?
BPC-157 (Body Protection Compound-157), also known as bepecin, is a synthetic peptide that is evidenced to have a range of therapeutic effects.
A derivative of the naturally occurring gastric protein called Body Protection Compound (BPC), BPC-157 is classed as a pentadecapeptide. BPC is found in the gastrointestinal tract and is vital to digestive function, strengthening and healing lesions in the GI lining. It is also shown to promote angiogenesis, cellular repair, and tissue growth in many organs while modulating inflammatory response [1, 2, 3].
BPC-157 is more stable than endogenous BPC and exhibits therapeutic properties without the need for a carrier agent. While the primary action of BPC is in the digestive tract, where it heals and protects the GI lining, BPC-157 is linked in clinical studies to benefits in multiple organ systems. Its systemic effects are primarily attributed to its stimulation of angiogenesis and fibroblast proliferation.
Particular benefits of BPC-157 include improved healing in many types of tissue, such as vascular, hepatic, and nervous. This indicates the peptide’s potential to address symptoms of cardiovascular and neurodegenerative diseases. It is also shown to facilitate regeneration in bone, tendon, and muscle tissues. Lastly, BPC-157 exhibits potent antioxidant properties not just in the GI tract but globally, suggesting its prospective utility in the context of inflammatory disease treatment [2, 3, 4, 5, 6].
BPC-157 was initially synthesized in the early 1990s and studied for its cytoprotective properties as an anti-ulcer agent. Although it entered phase 1 trials in consideration as a treatment of ulcerative colitis, it has not been approved by the US Food and Drug Administration (FDA) for medical use, and data on human subjects is lacking. However, wide research in animal models to date suggests that BPC-157 is safe and well-tolerated when properly administered [1–6].
It is one of the several in-demand research peptides that are prized for their healing and regenerative effects. TB-500 is also similarly under investigation for its angiogenic and reparative properties. Traditionally injected, both TB-500 and BPC-157 have seen recent advances to increase their stability and oral bioavailability, potentially augmenting their therapeutic applications and marketing appeal [7, 8].
Now…let us take a look at what, if anything, BPC-157 peptide can do in cases of erectile dysfunction.
BPC-157 and Erectile Dysfunction
Erectile dysfunction is attributable to several different causes, classified as vasculogenic, psychogenic, endocrinologic, or neurologic. Treatment is typically prescribed according to the underlying cause. However, currently available drugs fall short in some cases, prompting clinicians to search for therapeutic alternatives .
Researchers have long noted the common co-occurrence of ED and cardiovascular or metabolic diseases. Indeed, recent literature advises practitioners to consider ED as an early warning sign of these diseases. Vasculogenic ED in particular is linked with arterial and endothelial damage, often attributed to systemic inflammation.
Among vasculogenic ED patients, traditional ED treatments such as selective PDE5 inhibitors, which act on the penile musculature via the NO system, often fail to elicit long-term therapeutic outcomes in subjects with severe cardiovascular and metabolic disease. Other current treatments such as penile injections function to temporarily increase penile blood flow, a transient solution at best [10, 11, 12].
As such, researchers in the nascent field of regenerative medicine have begun to study alternative ED treatments that consider the roles of angiogenesis, vascular insufficiency, and endothelial dysfunction in the disease. In one study on rat models, cytokine therapy designed to promote angiogenesis and stimulate endothelial growth was proven to effectively treat ED. Another animal study showed that the administration of vascular growth factors led to penile neovascularization, a possible long-term solution to vasculogenic ED [13, 14].
Further novel treatments include lasting modulation through gene therapy of the NO system, which affects penile musculature to enable erectile response. This is considered a favorable alternative to orally bioavailable PDE5 inhibitors that show poor results in subjects with acute metabolic disease [10, 15, 16].
Studies on BPC-157 and Erectile Dysfunction
Despite the ready applicability of BPC-157 in therapeutic contexts such as angiogenesis, endothelial growth, and regulation of the inflammatory response, no studies to date have been specifically conducted on its use in ED patients.
However, the handful of studies available is promising. BPC-157 was shown in rat models to combat heart failure via the NO system, echoing emerging gene therapy modalities in ED treatment. Another study on diabetes-related ED in rats indicated the potential of NO modulation to successfully improve erectile response [10, 17, 18].
Furthering the scope of BPC-157’s potential benefits in ED treatment, it is ripe for synergistic combination with other traditional and emerging treatments. For example, its regenerative and angiogenic effects may aid therapies involving nerve reconstruction and penile transplants of muscle or cartilage tissues. Optimistically, its benefits may preclude the need for surgical intervention altogether. However, barring further research, this remains a speculatory point .
In short, BPC-157 shows great promise as a treatment for ED, particularly as a solution to current shortcomings in ED pharmacology regarding vascular etiologies.
There is great evidence to support the effects of BPC-157 in various contexts.
While extensive trials in human subjects are lacking, studies to date in both animal and human models are highly favorable. Here is a quick review of the most notable benefits of BPC-157:
BPC-157, like its endogenous counterpart, has potent cytoprotective properties, shown to fortify the lining of the GI tract while healing and preventing lesions. As an anti-ulcer agent, it is likely effective in the treatment of inflammatory bowel disease. It is also shown in animal models to bolster biochemical feedback mechanisms along the gut-brain axis [2, 4, 22].
The regenerative effects of BPC-157 have been widely documented in animal models, showing improved healing in bone, skin, ligaments, and muscles, among other tissue types. This is attributed to its increase in fibroblast proliferation [3, 22].
BPC-157 is further proven in animal studies to prompt vascular growth through increases in endothelial growth factor. This process contributes to injury and wound healing and may greatly benefit cardiovascular health, boosting circulation and normalizing blood pressure. Per the discussion above, this also has implications in the treatment of vasculogenic ED [11, 23, 24].
It must be noted that this can be a double-edged sword, and looking into side effects of BPC-157 is needed.
With neuroprotective properties, BPC-157 is shown in animal models to reduce damage due to central nervous system injuries and strokes. It is also evidenced to balance neurotransmitter levels, potentially addressing symptoms of Parkinson’s disease, schizophrenia, and depression [2, 6, 11].
Reduces Drug Toxicity
BPC-157 may protect against the toxic effects of certain drugs, such as neuroleptics, alcohol, NSAIDs, and insulin. Protective benefits are evidenced in the liver, GI tract, cardiovascular system, and nervous system [6, 11, 25].
Improved Inflammatory Response
Is BPC-157 Safe?
Due to a lack of clinical trials, there is a shortage of data on the safety of BPC-157 for use in humans. However, research to date suggests a positive safety profile. In humans and animals, it has shown no toxicity and good tolerability [23, 28].
However, researchers should exercise caution in the administration of BPC-157. It is occasionally known to cause transient and mild adverse effects, such as :
- Injection site irritation
To minimize the risk of adverse effects, researchers are advised to purchase peptides from legitimate suppliers and adhere to established clinical guidelines concerning proper handling.
Where to Buy BPC-157 Online? | 2024 Edition
In light of the exciting potential of BPC-157, it is an excellent addition to clinical research on effective ED treatments.
Yet, it is a must that researchers purchase lab-tested BPC-157 from a legitimate vendor.
As such, the passionate experts at Peptides.org have scoured the net to give readers our top picks for buying premium BPC-157 online:
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Here’s where they excel:
- High-Quality Peptides: All Limitless Life products are third-party lab tested for purity and potency, meaning that their BPC-157 is research-grade. Researchers will find some of the highest quality peptides from this company.
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- Fast, Dependable Shipping: Limitless Life delivers peptides to U.S. addresses within 2-3 business days and waives shipping fees on orders over $350. When our team made a test order of BPC-157, it arrived promptly without issues. They also offer affordable shipping insurance.
- International Shipping: Limitless Life also offers peptides for international researchers. With many international orders being delivered within a week. A huge benefit to the research community.
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Bacteriostatic Water and BPC-157
BPC-157 is often sold as a lyophilized powder that requires reconstitution with a sterile solvent. Scientists tend to agree that bacteriostatic water is the best solvent for this purpose.
What is Bacteriostatic Water?
Composed of sterile water and a natural preservative called benzyl alcohol, bacteriostatic water resists bacterial proliferation to combat contamination. It has an extended shelf life and efficiently dissolves lyophilized peptides while maintaining their purity [19, 20, 21].
The correct method of BPC-157 reconstitution calls for the following materials:
- Vial of bacteriostatic water
- Vial of lyophilized BPC-157
- Sterile syringe
- Alcohol wipes
- Extra sterile vials are recommended
Follow this procedure to reconstitute lyophilized BPC-157 for injection:
- Step #1: Wipe all materials with the alcohol swabs to reduce the risk of contamination.
- Step #2: Using the sterile syringe, withdraw the desired amount of bac water, typically around 1mL.
- Step #3: Slowly inject the bac water into the vial of BPC-157, allowing the powder to gradually dissolve.
- Step #4: Refrain from agitating the vial, as this may damage the contents. When the solution is fully mixed, it will appear transparent.
- Step #5: The extra solution may be safely refrigerated and accessed for up to 28 days after reconstitution.
- Step #6: For precise storage and dosage indications, refer to manufacturer labels.
BPC-157 and Erectile Dysfunction | Verdict
To conclude, BPC-157 shows promise in the treatment of erectile dysfunction as an angiogenic, anti-inflammatory, and healing agent.
It may be particularly suited to combating ED caused by underlying cardiovascular problems. While the research to date certainly indicates great potential, BPC-157 has not yet been closely studied in this context.
Researchers can seize this opportunity to conduct innovative studies into the use of BPC-157 as a novel therapy for symptoms of ED.
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