Titus Thorne

Last Updated May 11, 2022

Titus Thorne

 May 11, 2022

Looking for a reliable guide to sermorelin acetate? Many researchers are curious about this powerful research peptide and are looking for a detailed overview of its uses, potential benefits, and side effects.

This A-Z guide will give researchers a complete overview of sermorelin including what it’s used for, how it differs from “regular” sermorelin (hint: it doesn’t!), and the most common side effects it causes. In addition, we’ll provide some information and resources that will help researchers find and buy sermorelin acetate online at the best prices.

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What is Sermorelin Acetate?

Sermorelin is an analogue of human growth hormone-releasing hormone (GHRH) whereas “acetate” simply refers to the acetate salt form of regular sermorelin. It contains the first 29 amino acids of GHRH, making it the shortest synthetic peptide to have the full biological activity of GHRH [1]. Sermorelin can be administered intravenously or subcutaneously to stimulate human growth hormone (HGH) secretion from the anterior pituitary.

So what exactly is HGH and why is it important?

Human Growth Hormone (HGH) is produced naturally by the body and serves to regulate a wide variety of bodily functions. It participates in the endocrine system and acts as a chemical signal used by the body to regulate a number of processes. These include:

  • Longitudinal growth [2],
  • Sleep,
  • Reproduction,
  • Immune function,
  • Physical performance [3],
  • Bodily composition [4],
  • Mental well-being, and
  • The aging process.

Sermorelin acetate helps increase HGH production and secretion, which can enhance and improve the above processes, especially in patients with HGH deficiency. This peptide can also be used to supplement the body’s natural levels of HGH in elderly subjects as these levels decline with age [4].


Sermorelin Acetate


Is Sermorelin Acetate Different From “Regular” Sermorelin?

Sermorelin acetate and “regular” sermorelin are essentially the same thing.

The names are used interchangeably and there is no discernible difference between sermorelin acetate and sermorelin. Other names for this compound include sermorelin peptide, GHRH (1-29), Geref, and Gerel. These names all refer to the peptide that contains the first 29 amino acids of GHRH.

Researchers in the process of searching for information about sermorelin acetate online will find that the term sermorelin is more commonly used over sermorelin acetate or any of the other names.


Benefits of Sermorelin Acetate

Numerous sermorelin benefits have been reported both in scientific literature and anecdotally. Here’s a review of the main research-backed benefits offered by sermorelin.

Diagnosis of growth hormone deficiency in children

Sermorelin’s main clinical use is to diagnose and treat children with idiopathic growth hormone deficiency [1]. When administered intravenously at a dose of 1μg/kg body weight, sermorelin produces a rapid hormone response, making it more efficient at diagnosing this condition compared with other provocative tests.

Treatment of men with hypogonadism

Sermorelin is used to help manage the body composition of men with metabolic syndrome or subclinical hypogonadism (SH) [5]. It is safe and well-tolerated when used for this purpose.

Better safety profile than HGH

Sermorelin encourages the production of natural HGH in the body and has the full biological properties of GHRH, yet has a much better safety profile than other forms of HGH such as somatropin. Doctors are more likely to prescribe sermorelin as an HGH alternative because the latter has a much more concerning safety profile.

Increases HGH production and secretion

Sermorelin increases the production and release of HGH in the body. In a study on rainbow trout, sermorelin acetate was shown to be effective at stimulating the pituitary gland to naturally produce and deliver more HGH into the system [6].

Increases lean body mass and decreases fat

A study conducted on swine showed that sermorelin can enhance the body’s ability to build and repair tissue faster [7]. The results of a human study into the effects of HGH in men over 60 years old showed that the subcutaneous administration of recombinant biosynthetic HGH can increase lean body mass and decrease fat. Researchers found that “lean body mass and the average density of the lumbar vertebrae increased by 8.8 percent and 1.6 percent respectively, and adipose-tissue mass decreased by 14.4 percent” over a 12-month period [4].

Enhances athletic performance

There is no research showing that sermorelin acetate can enhance athletic performance, but strong research interest exists in this area. The idea that sermorelin can improve performance and body composition likely stems from a 2004 study funded by the World Anti-Doping Agency (WADA). This study found growth hormone (GH) supplementation had a significant influence on “body composition and increased sprint capacity when administered alone and in combination with testosterone” to recreational athletes [8]. No similar research involving sermorelin exists and further research in this area appears warranted.

Improves skin

There’s a proven link between diminished secretion of growth hormone and the thinning of the skin that occurs in old age [4]. One study found that growth hormone is able to “stimulate the collagen synthesis in human tendon and skeletal muscle”, suggesting that GH supplementation may help improve skin complexion, flexibility, and thickness [9].

The above claims suggest that sermorelin offers many benefits and makes an interesting candidate for further research.


Sermorelin Side Effects | What Researchers MUST Know

Overall, sermorelin usage has not been associated with any major side effects such as cancer or diabetes and scientific literature suggests that it is generally well-tolerated. While the recommended dosages of sermorelin have not been directly compared with those of somatropin, the majority of peer-reviewed studies have reported minimal to no side effects.

Some of the minor sermorelin side effects and adverse events that have been most commonly reported are [10,11]:

  • Nausea,
  • Vomiting,
  • Headaches,
  • Flushing or redness in the face [1],
  • Loss of color in the face or paleness,
  • Swelling, achiness, redness, or discomfort at the injection site [1],
  • Funny taste in the mouth.

Occasionally, sermorelin subjects do report some more serious side effects, although these are much less common. Reported sermorelin side effects include [10]:

  • Rash
  • Hives
  • Itching
  • Difficulty breathing/shortness of breath
  • Tightness in chest
  • Inflammation/swelling of mouth, tongue, lips, or other facial features

Researchers should note that allergic reactions are possible (although, again, uncommon). Any test subjects who experience severe side effects should seek medical attention immediately.

As higher sermorelin doses increase the risk of test subjects experiencing these side effects, most past trials have started with the lowest possible dose and then incrementally increased the dosage while monitoring the effects it has on the test subjects’ body and tolerance levels.

Adjusting the dosage of sermorelin mid-cycle can increase the chances of the subject experiencing negative side effects. It’s important to finish out one cycle before considering changing the dose and keeping the schedule and dosage consistent. This will help the test subjects’ bodies maintain consistent sermorelin and GH levels, reducing the chances of side effects.

In terms of timing, researchers should consult the relevant medical literature when administering sermorelin to test subjects. In past trials, researchers have administered sermorelin to test subjects on an empty stomach right before bed. This is believed to maximize the benefits of this peptide as nighttime is when the natural GH levels in the body are at their peak.


Sermorelin Acetate


Where to Buy Sermorelin Online? | 2022 Guide

Many researchers are curious: Is sermorelin legal to purchase online?

The answer is Yes; researchers can buy sermorelin legally online. However, since the research peptides market is a bit saturated, we have found that many online vendors are not always reliable and trustworthy.

We’ve put together a list of what researchers can look for when researching online vendors to make sure that they buy from a legitimate source. Researchers should look for:

  • Some kind of formal, autonomous gauge that speaks to the quality of the peptides on offer. Some examples of this are an independent lab analysis and independent reviews by verified users.
  • A secure payment system that offers basic safety in relation to protecting payment data and information.
  • A fair return policy that offers a free refund or reshipment in the event that a product is lost, delayed, or faulty in some way.

After doing some extensive research and testing of our own, Peptide Sciences is by far our leading choice for online peptide purchases. Peptide Sciences offers high-quality, reasonably priced products for research purposes.

Based on our own experiences using their service, Peptide Sciences has:

  • Superior customer service. We’ve been able to connect with an actual person every time we have called them, and they have always been super accommodating and helpful.
  • Secure payment methods. Peptide Sciences accepts all major credit cards, as well as Bitcoin, Ethereum, and several other forms of cryptocurrency.
  • High-quality products. They have all their lab results available on the website and are easily accessible. As far as we know, Peptide Sciences is the only online company that can substantiate the purity of their sermorelin and other peptides with a certificate of analysis and data from mass spectrometry tests.
  • Fast shipping. For those ordering from within the US, the orders typically arrive within 2 to 3 days. For international orders, researchers typically receive their order within 7 to 10 days.

Buy Sermorelin from our #1 recommended vendor...


What is Sermorelin Acetate? | Verdict

Hopefully, this guide has addressed any questions that researchers curious about sermorelin acetate may have. Sermorelin is a peptide that has been shown to offer significant benefits to test subjects including increased GH levels, more lean muscle mass, and enhanced athletic performance.

Sermorelin acetate is widely available to researchers and is considered to have a better safety profile than other types of HGH including somatropin. Overall, the consensus is that sermorelin acetate is definitely worth considering as a research peptide.

Researchers wishing to conduct further research are advised to contact Peptide Sciences before placing an order.


References

  1. Prakash A, Goa KL. Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency. BioDrugs. 1999 Aug;12(2):139-57. doi: 10.2165/00063030-199912020-00007. PMID: 18031173.
  2. Strobl JS, Thomas MJ. Human growth hormone. Pharmacol Rev. 1994 Mar;46(1):1-34. PMID: 8190748.
  3. Erotokritou-Mulligan, I., Holt, R. I., & Sönksen, P. H. (2011). Growth hormone doping: A review. Open access journal of sports medicine, 2, 99.
  4. Rudman, D., Feller, A. G., Nagraj, H. S., Gergans, G. A., Lalitha, P. Y., Goldberg, A. F., … & Mattson, D. E. (1990). Effects of human growth hormone in men over 60 years old. New England Journal of Medicine, 323(1), 1-6.
  5. Sinha DK, Balasubramanian A, Tatem AJ, Rivera-Mirabal J, Yu J, Kovac J, Pastuszak AW, Lipshultz LI. Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males. Transl Androl Urol. 2020 Mar;9(Suppl 2):S149-S159. doi: 10.21037/tau.2019.11.30. PMID: 32257855; PMCID: PMC7108996.
  6. Shepherd, B. S., Johnson, J. K., Silverstein, J. T., Parhar, I. S., Vijayan, M. M., McGuire, A., & Weber, G. M. (2007). Endocrine and orexigenic actions of growth hormone secretagogues in rainbow trout (Oncorhynchus mykiss). Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 146(3), 390-399.
  7. Bagno, L. L., Kanashiro‐Takeuchi, R. M., Suncion, V. Y., Golpanian, S., Karantalis, V., Wolf, A., … & Valdes, D. (2015). Growth hormone–releasing hormone agonists reduce myocardial infarct scar in swine with subacute ischemic cardiomyopathy. Journal of the American Heart Association, 4(4), e001464.
  8. Meinhardt U, Nelson AE, Hansen JL, Birzniece V, Clifford D, Leung KC, Graham K, Ho KK. The effects of growth hormone on body composition and physical performance in recreational athletes: a randomized trial. Ann Intern Med. 2010 May 4;152(9):568-77. doi: 10.7326/0003-4819-152-9-201005040-00007. PMID: 20439575.
  9. Doessing, S., Heinemeier, K. M., Holm, L., Mackey, A. L., Schjerling, P., Rennie, M., … & Flyvbjerg, A. (2010). Growth hormone stimulates the collagen synthesis in human tendon and skeletal muscle without affecting myofibrillar protein synthesis. The Journal of Physiology, 588(2), 341-351.
  10. Drugs.com. (2015). Sermorelin acetate. https://www.drugs.com/cdi/Sermorelin-acetate.html
  11. Mayo Clinic (n.d.). Sermorelin (Injection Route). https://www.mayoclinic.org/drugs-supplements/sermorelin-injection-route/side-effects/drg-20065923?p=1

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