Titus Thorne
Titus ThorneCurious about BPC-157 + TB-500 nasal spray?
Then you've come to the right place. See, BPC-157 and TB-500 are two peptides known to accelerate wound healing and injury recovery. But what might happen if you were to combine the two?
Researchers believe that using BPC-157 and TB-500 together can yield synergistic effects to accelerate cell migration to sites of injury, thus speeding up processes of tissue repair.
While researchers usually administer BPC-157 and TB-500 via injections, there are now nasal spray blends on the market. Using a nasal spray format could have certain advantages in terms of convenience, dosing and administration, and quicker delivery to the target site.
Due to increased interest in administering BPC-157 and TB-500 together, our research team has created this informative guide to discuss the potential benefits and drawbacks of using this peptide blend as a spray.
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What is BPC-157?
BPC-157 (Body Protection Compound 157) is a synthetic peptide derived from an endogenous protein found in human gastric juice. This protein, Body Protection Compound, is vital for normal gastrointestinal tract functioning, and its primary function is to heal and protect the GI lining.
BPC-157 is a fragment of the whole BPC protein and consists of 15 amino acids [1]. While its exact mechanism of action remains unclear, it is known to promote angiogenesis, thus enhancing oxygenation to tissues and accelerating healing processes.
It is continuously researched for a number of therapeutic applications in relation to its healing potential, which could be used to overcome soft and hard tissue injuries, GI disorders, and inflammatory diseases, just to name a few conditions [2, 3, 4, 5, 6].
There has been limited research examining the efficacy of BPC-157 in humans, and the peptide has yet to receive formal approval for any therapeutic use.
P.S: Click here to learn more about BPC-157.
What is TB-500?
TB-500 is a synthetic analog of thymosin beta-4 (TB4), a protein found in most human and animal cells. [7]. TB-500 thus exhibits similar behavior and outcomes to TB4 in clinical studies.
It plays an essential role in regenerating and healing injured tissues by upregulating actin and blocking actin polymerization, while also promoting angiogenesis and cell migration [8, 9, 10, 11].
TB-500 became prominent in the early 2000s in horse racing, with reports stating that it could build muscle, promote recovery, decrease inflammation, increase red blood cell count, and stop bleeding in the animals. Although the regulatory bodies did not confirm these performance-enhancing effects, the use of TB-500 was quickly prohibited in the sport [12, 13].
Like BPC-157, TB-500 has not been approved for human use, but is legal for purchase by qualified researchers for laboratory experimentation.
P.S: Click here to learn more about TB-500.
BPC-157 + TB-500 Benefits
Ongoing research indicates that both BPC-157 and TB-500 stimulate repair in a number of tissues. However, little is known about the precise effects of the two peptides when administered concurrently.
Here are some of the most notable findings from studies conducted to date.
Tissue Repair and Injury Healing
While BPC-157 is well-known for its ability to maintain healthy GI lining, the peptide is also known to stimulate healing in other tissues, including tendons, ligaments, muscles, and bones. It achieves these effects by promoting fibroblast proliferation, a process vital for wound healing [2, 3, 6].
TB-500 has also been shown to accelerate tissue repair and wound healing by upregulating actin, while blocking acting polymerization. Concurrent administration of the two peptides is thus believed to have more potent healing effects, with research suggesting a synergistic effect to accelerate the migration of fibroblasts and immune system cells to sites of injury [8, 9, 11].
Angiogenesis and Cardiovascular Health
Current animal studies on BPC-157 benefits show that the peptide promotes angiogenesis by upregulating vascular endothelial growth factor (VEGF). Vascular proliferation is vital to improving circulation, managing blood pressure, assisting injury recovery, and potentially reducing cardiovascular risk.
TB-500 also upregulates the expression of VEGF to induce angiogenesis, having been proposed as a potential treatment of cardiac injury. Together, BPC-157 + TB500 could have a substantial effect on promoting cardiovascular health and supporting recovery [14, 15, 16].
Digestive Health
Thanks to the strong cytoprotective properties of Body Protection Compound, BPC-157 also has the potential to aid the GI tract by stabilizing the mucosa membrane. This could be beneficial in the treatment of inflammatory bowel disease and other GI conditions. In addition, BPC-157 has been revealed in animal studies to strengthen the gut-brain axis by fortifying communication between the central nervous system and the GI tract.
Current research suggests TB-500 could promote epithelial repair and growth, and also aid in the treatment of GI conditions. When used together, BPC-157 and TB-500 could provide valuable digestive health support [4, 5, 17, 18].
Immune System Support and Anti-Inflammatory Response
Animal studies indicate that BPC-157 has potent antioxidative properties, which could reduce the inflammatory response in the brain, liver, lung, and other tissues. TB-500 has shown similar anti-inflammatory abilities in animal models. Both peptides exhibit the potential to modulate an immune response to attenuate certain conditions, as a result of which administering BPC-157 and TB-500 together may provide even stronger effects [10, 19, 20].
While these are some of the most promising BPC-157 and TB-500 benefits, research suggests other potential therapeutic applications. These include neuroprotective benefits, mitigating drug toxicity, anti-aging benefits, analgesic effects, and treatment of metabolic disease [21, 22, 23, 24].
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BPC-157 + TB-500 Side Effects
We still lack quality human studies into BPC-157 and TB-500 side effects and safety, especially when administered together. However, the research to date indicates that both peptides have favorable safety profiles.
A preclinical safety evaluation of BPC-157 published in Regulatory Toxicology and Pharmacology found this peptide to have a favorable safety profile. BPC-157 was well-tolerated and exhibited no severe toxic effects in mice, rats, rabbits, and dogs. This preclinical data provides an excellent base for human safety and efficacy trials [25].
A randomized, placebo-controlled, single and multiple dose study published in Annals of the New York Academy of Sciences evaluated the safety of TB4, a molecule that is identical to TB-500 in structure and function. The study authors found that intravenous injection of 42mg to 1260mg of TB4 was safe in healthy adults, with no dose limiting toxicities or serious adverse events reported [26].
Despite these excellent findings, researchers should note the potential for minor and transient side effects generally associated peptide administration:
- Injection site pain
- Dizziness
- Headache
- Fatigue
- Nausea
Adverse effects may be more common with the use of low-quality peptides from unverified sources. These may contain harmful contaminants, often due to a lack of proper quality testing.
Researchers should accordingly source their BPC-157 and TB-500 blend from a reputable vendor with transparent sourcing processes, third-party lab testing, and ethical marketing.
Researchers should pay attention to the latest dosing guidelines and handling practices as established by experts. Immediately discontinue peptide administration in the event of a severe adverse reaction in your test subject.
BPC-157 + TB-500 Dosage Guide
Since BPC-157 and TB-500 are not approved for human use, there are no official dosage guidelines for either peptide for any use.
However, based on the research to date, researchers will want to consider the following guidelines when when administering these peptides:
- Subcutaneous and intramuscular injections are considered more effective due to enhanced bioavailability, but using BPC-157 + TB-500 nasal spray could have certain advantages depending on the therapeutic objective and study design.
- The optimal dosing schedule will vary depending on the desired therapeutic outcome and size of the subject.
- Research suggests a TB-500 dose of 2-5mg administered twice weekly for four to eight weeks. In some cases, researchers prefer using a higher initial dose and lower maintenance doses.
- In joint, tendon, and ligament healing contexts, BPC-157 is typically administered daily at a dose of 250mcg to 500mcg.
- Most courses of both BPC-157 and TB-500 do not exceed 8 weeks of use.
Sample BPC-157 + TB-500 Nasal Spray Dosing Protocol
For reference, we include a sample dosing protocol for researchers using a nasal spray that contains 10mg of BPC-157 and TB-500 each (20mg total solution), such as the Repair Spray offered by our preferred vendor – details below.
Assuming the 50/50 blend described above, researchers may administer the nasal spray as follows:
- BPC-157 + TB-500 Dosage: 1mg administered daily. Administer at once or at different times via nasal spray, alternating nostrils. One spray contains 200mcg of peptide blend, so 5 sprays per day are needed. On a weekly basis, the subject is receiving 3.5mg of BPC-157 and 3.5mg of TB-500.
- Course Duration: 20 days
- Notes: This protocol requires one BPC-157 + TB-500 20mg total nasal spray per subject for the course duration. Researchers can adjust dosing and duration based on the desired therapeutic effects, target area, severity of condition, and other factors.
Knowledge in this area is constantly evolving, so researchers are encouraged to stay abreast of the latest research and developments regarding BPC-157 and TB-500.
BPC-157 + TB-500 Nasal Spray | The A-Z Guide
While BPC-157 and TB-500 are usually administered via injection due to high bioavailability, researchers may prefer using nasal spray for any number of reasons.
Intranasal administration may be an excellent approach for certain therapeutic effects. For example, researchers examining the impact of these two peptides on brain health and cognitive performance may prefer to use nasal spray due to quick absorption and rapid response.
Intranasal administration of peptides has been shown effective due to the following factors [27]:
- Large surface area
- Permeable endothelial membrane
- Elimination of first-pass effect
- Good circulation
Researchers who wish to administer the BPC-157 and TB-500 blend via a nasal spray are encouraged to take certain precautions to ensure delivery of maximum bioavailability:
- To optimize absorption: Wait up to one minute between sprays via the same nostril to prevent oversaturating the nasal membrane and thus losing peptide due to swallowing.
- Head position: Ensure that the subject is in a tilted head position; this prevents loss from the bottom of the nose.
- Clear any nasal congestion: Before administering the peptide via spray, clear your nasal membrane. This minimizes blockage of the nasal membrane and also optimizes absorption.
- Take care: Keep the spray pump clean and refrigerated at all times to prevent contamination and peptide degradation.
Apart from understanding the mechanics of peptide nasal absorption and following sound practices for administering peptides, researchers should perform due diligence when selecting an appropriate nasal spray product.
The research chemicals market has become saturated in recent years, with some vendors offering products of questionable quality and effectiveness and reviewers reporting a range of experiences with their peptide nasal spray purchases.
Researchers should consider several factors when buying a BPC-157 + TB-500 nasal spray, including peptide quality, third-party laboratory testing, customer service quality, and satisfaction guarantees.
Where to Buy BPC-157 + TB-500 Nasal Spray Online?
Researchers searching for BPC-157 + TB-500 nasal spray online have several options. But for the reasons we discussed above, researchers should carefully vet potential vendors for reputation, certifications, and consumer-friendly policies.
In our experience, PureRawz stands apart from other online vendors for their peptide-based nasal products. They currently offer an excellent 20mg BPC-157 + TB+500 nasal spray, aptly called Repair Spray. Here are some reasons why we endorse PureRawz:
- Lab-tested Peptides: PureRawz performs rigorous in-house lab testing and additionally collaborates with third-party labs to analyze their products for quality and purity.
- Complete transparency: PureRawz publicly displays certificates of analysis for each of their products directly on their website. In addition, they do not make unsupported medical claims and are transparent about their products.
- Reasonable prices: The vendor offers their spray products at fair prices, with their innovative Repair Spray currently retailing for just under $240. In addition, they routinely offer discounts on orders paid with cryptocurrencies.
- Reliable shipping: PureRawz provides worldwide shipping. This vendor ships from their warehouse in Europe and uses Priority International Mail to ensure all orders arrive quickly. Orders over $100 qualify for free shipping.
- Simple and secure ordering: The company’s website is secured with the latest SSL technology. The ordering process is simple and discreet and all personal information remains encrypted and protected.
- Satisfaction guarantee: PureRawz states that they offer a full refund to researchers who are not 100% satisfied with their nasal spray products. However, returns and exchanges are at the sole discretion of the vendor. If there is anything wrong with the order, the customer should contact PureRawz as soon as possible.
Do not hesitate to source your BPC-157 + TB-500 nasal spray from this top online vendor.
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Nasal Spray vs. Injectable BPC-157 + TB-500
Although researchers are increasingly testing peptides in nasal spray format, injection still remains the gold standard form of administering both BPC-157 and TB-500 for a systemic effect.
Animal studies involving parenteral injections of both BPC-157 and TB-500 have reported high bioavailability with this route of administration [4, 5, 11, 15].
A BPC-157 and TB-500 nasal spray product, by contrast, will likely not replicate the same level and consistency of bioavailability compared to subcutaneous injection. In other words, subjects will likely need a higher dose of intranasal spray to achieve comparable results to injections.
Yet a nasal spray product will typically arrive prepared in a metered spray bottle for researchers to use right away. In comparison, researchers who administer peptide injections will receive their peptides in the form of lyophilized powder, which must be reconstituted with a sterile solvent like bacteriostatic water.
Using a nasal spray eliminates the need for reconstitution, and dosing is straightforward with the metered spray format. Each product has a fixed amount of BPC-157 and TB-500, so researchers know the exact amount of each peptide in every spray.
Many BPC-157 + TB-500 nasal sprays are stable at room temperature, which makes storage more convenient. In comparison, most manufacturers recommend storing lyophilized powder at a lower temperature, away from bright light. Accordingly, BPC-157 + TB-500 nasal sprays are easier to transport without the researcher having to worry about peptide degradation.
Additionally, both the BPC-157 and TB-500 peptides are quickly cleared from the nasal cavity after administration, which leads to a quick systemic response. This type of administration does not cause irritation, pain, or tenderness, which are common side effects of injections.
A nasal spray is thus generally easier to administer than an intramuscular or subcutaneous injection. In addition, intranasal administration offers the potential advantages of a more rapid onset of action and avoidance of first-pass metabolism [28].
Whether your research will call for a BPC-157 + TB-500 nasal spray or injections will depend on the nature of trial design. If there is a need for maximum bioavailability, you will likely want to procure an injectable peptide blend.
But if there is a risk of poor subject compliance with injections and/or a need for convenient administration, then you should certainly consider a BPC-157 + TB-500 nasal spray.
BPC-157 + TB-500 Nasal Spray | Verdict
Research suggests that BPC-157 and TB-500 produce synergistic effects to enhance injury recovery and wound healing in test subjects.
Additionally, the peptides may jointly improve other processes like digestive health, immune response, and cardiovascular function.
Despite a potential sacrifice in bioavailability over injections, some researchers may wish to use a BPC-157 + TB-500 nasal spray to study the effects of concurrent administration.
Storing and administering a peptide nasal spray is easy and convenient, and there is ample evidence to support the effectiveness of intranasal administration of peptides.
Based on criteria including lab results, customer service, and shipping speed, we recommend PureRawz as the best place to source BPC-157 and TB-500 nasal spray online.