Curious about BPC-157 in the UK?
Wondering if it’s possible to buy BPC-157 online in Britain?
If so, then you’ve come to the right place.
Below, our team of researchers details everything you MUST know about BPC-157, including…
- What is BPC-157?
- Is BPC-157 Legal in the UK?
- Where to Buy BPC-157
- BPC-157 Benefits
- BPC-157 Side Effects
- BPC-157 Dosage
…and so much more!
For citizens and residents of the UK, this is your definitive guide to BPC-157. Keep on reading to find out more.
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What is BPC-157?
BPC-157 (Body Protection Compound-157), also known as bepecin, is a synthetic peptide under analysis for numerous therapeutic applications.
Classed as a gastric pentadecapeptide, BPC-157 is a derivative of Body Protection Compound (BPC), an endogenous protein found in human gastric juices. BPC is not only vital to healthy GI lining and function but has been shown to boost angiogenesis, cellular repair, inflammatory response, and growth in multiple tissue types [1, 2, 3].
BPC-157 is a stable fragment of its parent compound that does not require a carrier to achieve systemic effects. Although BPC is a gastric protein that mainly functions to heal and protect the gastrointestinal lining, its synthetic derivative is evidenced in clinical trials to benefit most organ systems when administered in small doses. Studies link these benefits to its twofold stimulation of vascular growth and fibroblast proliferation.
Documented benefits include rapid healing of lesions in a range of tissue types, including nervous, vascular, and hepatic. This suggests the potential of BPC-157 to treat cardiovascular and neurological diseases. It is also shown to promote healing and growth in bone, tendon, and muscle tissue. With powerful antioxidant effects, it reduces gastrointestinal and systemic oxidative stress, indicating its potential to treat inflammatory diseases [2, 3, 4, 5].
Research and Development
First developed in the1993 and studied as an anti-ulcer treatment due to its cytoprotective effects, BPC-157 has yet to receive EMA or MHRA approval and there have been limited trials conducted on human subjects. However, in clinical research to date, it has evidenced a highly favorable safety profile [1–7].
It is among the popular research peptides under clinical review for their potential to enhance injury recovery. Other regenerative peptides include TB-500, a synthetic angiogenic with distinct features, chemical properties, and benefits .
Is BPC-157 Legal in the UK?
BPC-157 is classed as an uncontrolled and unprescribed substance in the UK and is, therefore, legal for sale, purchase, and handling among qualified researchers for strictly educational purposes. It does not currently hold UK MHRA approval to be marketed for medical purposes, similar to the status of many research peptides within the American market according to US FDA requirements [9, 10, 11, 12].
This has unfortunately led to the rise of an unregulated and illicit peptide market, saturated with inauthentic products, false marketing claims, and potentially dangerous contaminants. Vendors who illegally offer unauthorized medical products beyond research contexts are subject to legal sanctions, and consumers risk not only low-quality peptides but grave side effects.
Peptide Market Regulations
Even within the burgeoning arena of legal peptide manufacturing, there is a marked lack of regulation regarding quality control due to the novelty of the field. This hinders the approval of peptides for clinical trials and thus market release.
Despite this, industry observers note a recent increase in both clinical trial and marketing applications for peptide products within the EU. The EMA has issued a proposal in response that calls for more stringent process control standards and impurity limits in the large-scale production of peptide therapeutics [13, 14, 15, 16].
Additional barriers to the regulatory approval of peptides include the relatively high cost of production and the strictly parenteral bioavailability of most types, which can limit their marketing appeal. These obstacles are forecast to change, however, following the trending growth of the peptide therapeutic market.
Experts foresee continued growth due to increased federal support of biotech research and development as well as interest in novel treatments for skyrocketing rates of cancer, obesity, heart disease, and inflammatory conditions. The treatment of COVID-19 is also cited as a compelling clinical target in peptide therapeutics and for BPC-157 specifically [17, 18, 19].
While the future of the peptide market certainly looks bright, the current lack of regulation continues to present a challenge to peptide approval for therapeutic use.
Choose the Right Source
Nonetheless, skilled researchers in the UK and beyond can legally acquire and safely handle research peptides including BPC-157 for educational purposes. To avert the risks of the unregulated market and assure the legality of the peptide source, adhere to these indicators of credibility in a peptide retailer [9, 20]:
- The vendor should state that the marketed peptides are for research use only, and available for purchase by qualified individuals.
- The product literature should not make direct claims or guarantees as to the medicinal benefits of peptide application.
- Third-party lab test results verifying peptide purity should be readily available to assure the quality and safety of the product.
With the rapidly growing interest in therapeutic peptides, the legal status of BPC-157 and other peptides is likely to change pending new clinical trials and access to regulatory approvals.
Specific areas of peptide research that are predicted to take off are the treatment of inflammatory and cardiovascular diseases, both noted potentials of BPC-157. Researchers are advised to keep abreast of the latest pharmaceutical breakthroughs and remain vigilant to avoid illicit retailers of sub-par peptide products [17, 18, 21].
When purchased from a reputable vendor and properly handled for investigative purposes, BPC-157 is legal for clinical researchers in the UK.
Where to Buy BPC-157 Online? | UK Edition
Given the importance of selecting the right peptide retailer, we have surveyed the market and identified the best online supplier for researchers in the UK.
The go-to peptide source for leading scientists around the world is:
Based in the United States, Peptide Sciences ships to many international destinations, including the UK!
Why is this vendor at the top of our list? Here are just a few of the reasons:
- All peptides are guaranteed to be of the highest quality with strict process standards at all phases of domestic production. In partnership with ISO 9001:2008 and WHO/GMP-approved manufacturers and in adherence with GMP standards, Peptide Sciences develops premium-grade peptides at competitive prices.
All products are of 99% purity, verified with available third-party lab screening results. Tests include the leading- standard techniques of high-performance liquid chromatography (HPLC) and mass spectrometry (MS) analysis.
- The high-grade catalog has competitive prices. A 5mg vial of BPC-157 costs just US$59.50, and price reductions are offered on bulk purchases.
- Rapid and low-cost international shipping to many select destinations is available for a low flat fee. Trackable orders are sent within just 24 hours for delivery within 7-10 business days.
- The user-friendly website features fast, easy, and secure checkout. Many payment types are accepted, and personal data is protected with state-of-the-art SSL encryption.
- Peptide Sciences is the benchmark for excellent customer service, guided by a total commitment to customer satisfaction. The helpful staff responds to emails in just 24 hours, and mistaken orders are replaced without charge. Plus, the educational website is packed with helpful articles citing the latest peer-reviewed studies.
From pricing to peptide quality, customer care, and business practices, Peptide Sciences is a superior name in global peptide sales. UK researchers can enjoy the best BPC-157 available from this highly recommended retailer.
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Although clinical studies of BPC-157 administration in human subjects are fairly limited, the research to date indicates many potential benefits of the peptide when correctly handled. These include:
Like its parent compound, BPC-157 has potent cytoprotective benefits, stabilizing the membrane of the GI tract with demonstrated efficacy as a treatment for symptoms of inflammatory bowel disease. It has been shown in animal trials to fortify the gut-brain axis, enhancing biochemical feedback between the central nervous system and the GI tract [1–7, 22, 23].
Wound healing and tissue growth
BPC-157 is evidenced in animal models to encourage the healing and regeneration of not only gastrointestinal tissues, but tendons, bone, skin, muscles, and ligaments. This is achieved primarily through the increase in fibroblast proliferation [1–6, 19, 22 ].
Angiogenesis and cardiovascular health
Studies in rat models indicate that BPC-157 upregulates endothelial growth factor to promote vascular proliferation, a process known as angiogenesis. This also aids injury recovery, increasing circulation to improve blood pressure and possibly reduce cardiovascular risk [19, 22, 23, 24].
Neuroprotection and cognitive health
BPC-157 has been shown to benefit the central nervous system. Animal studies indicate that it counters the effects of strokes and spinal cord injuries while modulating neurotransmitter levels to address symptoms of schizophrenia, depression, and Parkinson’s disease [2, 6, 22,].
In a related manner, BPC-157 has been documented in clinical trials to mitigate the side effects and toxicity of numerous drugs. These include NSAIDs, insulin, neuroleptics, and alcohol. Protective effects have been noted in GI, liver, vascular, and nervous tissues.
Studies in animal models indicate that BPC-157 counteracts oxidative stress to improve the inflammatory response in many soft tissue types, including GI, liver, lung, and brain.
While these are the most noted benefits, ongoing research suggests many further therapeutic applications of BPC-157, such as analgesic effects and anti-aging benefits through increased collagen synthesis [24, 30].
BPC-157 Side Effects
There is not yet substantial data on BPC-157 application in humans to date. However, studies indicate that BPC-157 has a favorable safety profile. In both animal and human trials, it has exhibited no toxicity when properly administered. It was proven in one study in healthy human subjects to be both safe and effective in treating inflammatory bowel disease. Indeed, as mentioned above, it is known to attenuate rather than contribute to toxic effects in many cases of drug intolerance [19, 26, 27].
Nonetheless, researchers are advised to exercise caution due to the lack of human clinical trials. Research peptides can be associated with several mild and transient side effects, such as :
- Injection site pain or irritation
- Appetite changes
- Blood pressure changes
Adverse effects tend to subside as subjects adapt to the course of treatment and are positively linked with the use of low-grade peptides from questionable sources. Such products may contain contaminants with hazardous side effects. For this reason, BPC-157 should be sourced from a reputable vendor that provides evidence of proper manufacturing practices, third-party purity testing, and legal marketing measures.
Researchers are advised to become familiar with all relevant data on the use of BPC-157 in human subjects and immediately discontinue use if serious adverse reactions occur. Use according to the dosage guidelines and best handling practices established by experts.
Read on to learn how to best handle BPC-157 for safe and successful clinical analysis, including necessary lab supplies and recommended reconstitution procedures.
Bearing in mind that BPC-157 does not hold EMA or MHRA approval for use in humans, clinicians tend to agree on several key points regarding its dosage and administration. These are as follows [3, 31, 32, 33]:
- Clinical trials have included oral and parenteral routes of administration, including subcutaneous and intramuscular injections. The latter method is considered to be the most efficient.
- The optimal dosage and timing of administration are determined by the therapeutic target. For example, in rat models, the effectiveness of BPC-157 in healing tendons was dose- and time-dependent.
- The standard dose in rat trials was around 10mcg per kg, administered in drinking water. Although dosage does not scale for human use, some clinicians roughly follow this guideline in experimental human trials, without generally exceeding a total daily dose of 1mg.
- It is recommended to begin with a low dose and cycle according to the timelines put forth by specialists.
Some studies suggest that BPC-157 is most effective as a healing agent when locally applied.
Researchers are encouraged to observe these guidelines and stay up to date on the protocols of BPC-157 administration. Now, we will explore the best practices when handling BPC-157 for injection.
Bacteriostatic Water and Injections
When issuing BPC-157 via injection, the lyophilized peptide powder must first be reconstituted with a sterile solvent. Experts recommend bacteriostatic water as the preferred solvent.
Bacteriostatic Water Basics
This solvent is made of sterile water and benzyl alcohol, an organic preservative that combats bacterial growth to decrease the risk of contamination. The bacteriostat agent gives peptide solutions an extended shelf life when properly stored. Bacteriostatic water is also considered optimal when reconstituting peptides for its effective dissolution of lyophilized compounds without compromising their purity [34, 35, 36].
To correctly reconstitute lyophilized BPC-157 before injection, the following supplies are needed:
- Vial of bacteriostatic water
- Vial of lyophilized MT-I
- Sterile syringe
- Alcohol wipes
- Extra sterile vials are recommended
Follow these steps to reconstitute BPC-157 for injection:
- Using the alcohol swabs, wide down all items to combat contamination. Don’t neglect the vial lids through which the needle will be inserted.
- Introduce the sterile syringe into the vial of bac water and withdraw the appropriate amount. This will vary with the recommended peptide dose.
- Gradually inject the solvent into the BPC-157 vial so that the powder steadily dissolves.
- Do not stir or shake the vial. Agitation can compromise the peptides. When the reconstitution is complete, the solution will appear clear.
- A stronger solvent may be necessary if the powder does not fully dissolve.
- Unused bac water solutions may be refrigerated for future application for as many as 28 days.
- Dosage and storage guidelines may vary. Refer to product guidelines and relevant literature.
BPC-157 in the UK | Overall
With mounting evidence of numerous therapeutic benefits, BPC-157 is a compelling research peptide. From improved injury recovery to cardiovascular and neurological health, this synthetic gastro peptide is of growing clinical interest. Although necessary investigation into its use in humans is pending, BPC-157 exhibits a favorable safety profile to date.
Researchers within the UK can incorporate this popular compound into their studies when it is purchased from a quality supplier. Our top-rated peptide source is available for UK-based clients to benefit from the finest BPC-157 on the web.
With superior peptides and rapid, low-cost international shipping, Peptide Sciences is your go-to source for BPC-157!