Titus Thorne

Last Updated January 15, 2023

Titus Thorne

 January 15, 2023

Curious about TB-500 in the UK?

Wondering if it’s possible to buy TB-500 online in Britain?

If so, then you’ve come to the right place.

Below, our team of researchers details everything you MUST know about TB-500, including…

  • What is TB-500?
  • Is TB-500 Legal in the UK?
  • Where to Buy TB-500
  • TB-500 Benefits
  • TB-500 Side Effects
  • TB-500 Dosage

…and so much more!

For citizens and residents of the UK, this is your definitive guide to TB-500. Keep on reading to find out more.

Buy TB-500 from our #1 recommended vendor...

Disclaimer: Peptides.org contains information about products that are intended for laboratory and research use only, unless otherwise explicitly stated. This information, including any referenced scientific or clinical research, is made available for educational purposes only. Peptides.org makes every effort to ensure that any information it shares complies with national and international standards for clinical trial information and is committed to the timely disclosure of the design and results of all interventional clinical studies for innovative treatments publicly available or that may be made available. However, research is not considered conclusive. Peptides.org makes no claims that any products referenced can cure, treat or prevent any conditions, including any conditions referenced on its website or in print materials.


What is TB-500?

TB-500 is a synthetic analog of the organic 43 amino acid peptide thymosin beta-4 (TB4) that presents a range of therapeutic benefits.

Thymosin-beta 4 is present in most human and animal cells and plays a vital role in the healing and regeneration of injured tissues. It is released by macrophages and platelets to mitigate cellular damage, inflammation, and infection while stimulating stem cell migration to promote vascular growth and tissue regeneration.

Clinical trials have uncovered numerous benefits in the application of this regenerative peptide and its synthetic analog. TB-500, like TB4, is composed of 43 amino acids and presents similar behavior in clinical studies [1, 2, 3].

Therapeutic Potential

TB-500 and TB4 are evidenced in both clinical trials and animal studies to boost angiogenesis and upregulate actin to improve injury recovery. Additional documented effects include cardiovascular and anti-aging benefits, as well as improved inflammatory response. Recent studies have shown thymosin beta-4 to be a possible treatment for numerous diseases, including ulcerative colitis, myocardial infarction, renal and liver fibrosis, corneal inflammation, and colon cancer. TB-500 retains a favorable safety profile when correctly handled in qualified settings [1, 2, 3, 4]

Research and Development

Thymosin beta-4 was first discovered in 1981 and extracted from bovine thymus tissue. It was initially analyzed for its role in the thymus-related immune response mechanism as a potential treatment for cancer, autoimmune diseases, and immunodeficiency diseases. Clinical investigations have since expanded to encompass its many physiological functions beyond immune response.

The synthetic analog TB-500 became widely used in veterinary contexts by the early 20th century, prompting a regulatory response to prohibit its use in horse racing as a performance-enhancing substance. However, it remains the subject of avid clinical research for its many documented benefits [5, 6, 7, 8, 9].


Buy TB-500 in the UK


Is TB-500 Legal in the UK?

TB-500 is currently classed as an uncontrolled and unprescribed substance in the UK, lacking MHRA approval to be marketed as a medical product. Therefore, it can be legally purchased, sold, and handled strictly for research purposes. The legal status of TB-500 and other research peptides in the UK parallels that of many peptides within the USA according to FDA mandates [10, 11, 12, 13].

Unfortunately, the unapproved status of many peptides has given rise to an unregulated market of substandard peptide products and illicit vendors. These retailers market low-quality items with fallacious medical guarantees and are subject to penalties under the law. Buyers of these goods risk not only faulty products but grave side effects due to contamination.

Peptide Regulations

The regulatory deficit concerns the licit peptide market, as well. Attributable to the newness of the field, there are few measures of quality control in place when it comes to large-scale peptide production. The lack of quality control bars many peptides from approval for clinical trials and marketing as medical products in the UK and many other countries.

Nonetheless, the EU has seen a recent upswing in the number of clinical trial and marketing approval applications of peptide products. In turn, the EMA recently put forth a sweeping proposal of higher quality control measures and standardized impurity limits for the broad manufacture of therapeutic peptides [14, 15, 16, 17].

Experts foresee the continued growth of the peptide market due to increased federal interest and spending on biotechnology and rising motivation to develop novel treatments for escalating rates of cancer as well as cardiovascular and inflammatory diseases [18, 19].

Despite current challenges in the regulatory approval and marketing of medicinal peptides, the area of peptide therapeutics is promising.

Choose the Right Source

The good news is that researchers in the UK may legally buy TB-500 and other peptides for educational and scientific purposes. To ensure the safety and legitimacy of peptide products and vendors, researchers are strongly advised to buy strictly from retailers that meet these standards of credibility [10, 20]:

  1. The peptide vendor should state that the marketed peptides are for research uses only and are eligible for purchase by qualified personnel.
  2. The vendor should not make guarantees as to the medicinal benefits of the marketed peptides.
  3. The retailer should readily display valid third-party lab results to verify the purity of the peptides, ensuring both their quality and safety for use in clinical settings.

With the growth of the peptide therapeutics market, the legal status of TB-500 is sure to shift. Researchers at present must remain cautious to evade unlawful vendors and substandard peptide products [18, 19, 21].

In short, qualified UK researchers may legally purchase and handle TB-500 from a legitimate source for educational purposes.


Where to Buy TB-500 Online? | UK Edition

To help UK researchers select a quality peptide vendor, we have combed the market to name our top recommendation for the online purchase of TB-500 and other research peptides.

The foremost peptide provider for distinguished scientists worldwide is:

Peptide Sciences

This USA-based vendor ships easily to many international destinations, such as the UK!

Here are the outstanding features of Peptide Sciences that place it at the top of our list:

  • All available peptides are manufactured according to the highest quality standards in collaboration with ISO 9001:2008 and WHO/GMP-approved partners. Purity levels of at least 99% are verified with test results from third-party labs, including mass spectrometry (MS) and high-performance liquid chromatography (HPLC) analyses.
  • Competitive prices are offered on all high-grade peptides. A 5mg vial of TB-500 is just US$85, while a 10mg vial goes for US$165. Price reductions are applied to bulk purchases.
  • Quick and affordable international shipping is available to numerous destinations for a low flat rate. Orders are trackable and dispatched within 24 hours for receipt in only 7-10 business days.
  • The accessible website provides rapid and secure checkout. Client information is secured with SSL encryption, and many payment methods are accepted.
  • Peptide Sciences is known for its peak customer service, aligned with its guiding commitment to total client satisfaction. Helpful agents respond to customer emails within 24 hours, and erroneous deliveries are re-sent without charge. Plus, the informative website features many useful articles and links to peer-reviewed studies.

Peptide Sciences stands out for its quality products, great business practices, and superior customer service. Researchers within the UK and beyond can purchase high-quality TB-500 from this world leader in peptide sales.

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TB-500 Benefits

Although more clinical trials on TB-500 administration in humans are needed, numerous studies in both animal and human subjects suggest the following therapeutic benefits [2, 3, 4, 22, 23]:

Tissue growth and injury healing

TB-500 and hymosin beta-4 have been shown in animal and human subjects to accelerate wound and injury healing, stimulating the repair and new growth of various tissue types. These include cardiac, muscle, skin, ligament, cornea, epithelial, and nerve cells.

Angiogenesis and cardiovascular health

TB-500 is shown to upregulate the expression of endothelial growth factor to induce angiogenesis, further accelerating the healing process while promoting cardiovascular health and disease recovery.

Improved inflammatory and immune response

Studies indicate the anti-inflammatory properties of thymosin beta-4 in the heart, brain, liver, kidney, and eye tissues. It has been shown to counter oxidative stress and reduce both renal and liver fibrosis. Similarly, thymosin beta-4 is evidenced to modulate the immune response to attenuate autoimmune and gastrointestinal diseases in animal models.

Anti-aging

In its healing capacity, thymosin beta-4 is shown to significantly improve collagen levels and integrity, not only reducing scarring but enhancing connective tissue structures to potentially promote a more youthful appearance. Studies into further anti-aging effects of TB-500 are ongoing.

While the above are the most prominent benefits evidenced in clinical studies, research suggests many additional therapeutic effects of TB-500. These include improved hair growth, treatment of metabolic disease, and neuroprotective benefits. Researchers are advised to stay up-to-date on the latest findings regarding this promising peptide.


TB-500 Side Effects

Despite the relative lack of data on TB-500 use in humans, studies to date indicate a positive safety profile when it is correctly administered in qualified settings. While most studies cite no adverse effects, one study on the topical administration of thymosin beta-4 in healthy human subjects evidenced these minor transient side effects [24, 25, 26, 27, 28]:

  • Fatigue
  • Headache
  • Nausea
  • Dizziness

Another study involving the intravenous injection of thymosin beta-4 in healthy adults at doses ranging from 42mg to 1260mg showed no serious adverse effects or toxicity.

Nonetheless, caution is required when handling TB-500 due to the paucity of human clinical studies. Research peptides may be linked with additional transient side effects, including [10]:

  • Injection site pain or irritation
  • Appetite changes
  • Blood pressure changes

In most cases, unwanted effects subside with adaptation to the course of therapy and are associated with low-quality peptide products. As such, TB-500 should be purchased from a trusted source with verifiable quality control measures in place and evidence of third-party purity testing. Avoid retailers with unlawful marketing practices such as direct medical guarantees. Immediately cease use if serious side effects arise, and handle peptides according to established guidelines.

Researchers are further encouraged to keep up to date on all relevant findings of TB-500 administration in humans. Emerging studies are constantly uncovering new findings in the dynamic field of therapeutic peptides.

Continue reading to learn the best practices when handling TB-500, including dosage information, required lab materials, and the recommended method of reconstitution.


Buy TB-500 in the UK


TB-500 Dosage

Because TB-500 is not under EMA or MHRA approval for human use, there are no standard dosage guidelines or safety protocols. However, clinical findings suggest the following key points regarding TB-500 administration and dosage [25, 29, 30, 31]:

  • TB-500 exhibits optimal bioavailability when subcutaneously administered via injection in animal models.
  • Target dosage and administration schedules are subject to vary based on the desired therapeutic outcome.
  • For example, one study on the healing outcomes of thymosin beta-4 in traumatic brain injuries on rat models suggested that the effects were time- and dose-dependent.
  • Studies on humans typically involve doses from 2-5 mg administered bi-weekly. Others follow a cycling schedule of a higher initial dose followed by lower maintenance doses.
  • Trials in general do not exceed 8 weeks, and indefinite use is not recommended.
  • It is advised to begin with a low dose and gradually increase it to avoid adverse effects.
  • Dosage may vary according to the weight and individual reaction of the subject.
  • Findings on appropriate doses in animal models do not convert to recommended doses in humans.
  • Research suggests that TB-500 may in some cases exhibit greater wound-healing effects when topically administered. For example, one study showed the healing potential of thymosin beta-4 on venous ulcers as a topically applied gel of 0.03%.

Sample TB-500 Dosing Protocol

Based on the data available, researchers may refer to the following TB-500 dosing protocol for injury recovery.

  • TB-500 Dosage: 2mg TB-500, administered once daily by subcutaneous injection
  • Course Duration: 15 days
  • Notes: This TB-500 protocol requires three TB-500 10mg vials per research subject per 15-day course.Researchers may continue to administer a lower maintenance dosage of 1mg daily until full or near-full recovery, depending on the subject’s recovery.

Experts advise that researchers adhere to these findings when handling TB-500, and keep up to date on emerging studies regarding the therapeutic use of peptides. Next, we will explain the best practices when safely preparing TB-500 for injection.


Bacteriostatic Water and Injections

Peptides are often sold in lyophilized powder form, requiring reconstitution using a sterile solvent before injection. Bacteriostatic water is in most cases the best solvent for peptide reconstitution and injection.

Bacteriostatic Water Facts

Bacteriostatic water is made of sterile water with benzyl alcohol, a natural preservative agent that impedes bacterial growth to combat contamination. The bacteriostat content extends the shelf life of peptide solutions with proper storage. Bacteriostatic water efficiently dissolves lyophilized peptides without reducing their purity and effectiveness [32, 33, 34].

Supplies

To reconstitute lyophilized TB-500 for injection, these supplies are required:

  • Vial of bacteriostatic water
  • Vial of lyophilized TB-500
  • Sterile syringe
  • Alcohol wipes
  • Extra sterile vials

Reconstitution

The reconstitution process is as follows:

  1. Wipe down all supplies with an alcohol swab to prevent contamination.
  2. Insert the syringe into the bacteriostatic water vial and draw out the desired amount.
  3. Slowly inject the bacteriostatic water into the vial of TB-500, allowing the powder to gradually dissolve.
  4. Avoid stirring or shaking the vial, as doing so may damage the contents. The solution will be clear when it is fully reconstituted.
  5. Extra bacteriostatic water solutions can be refrigerated and accessed for up to 28 days.
  6. Exact storage and dosage guidelines may differ. Consult product literature.

Buy Bacteriostatic Water from our #1 recommended vendor...


TB-500 in the UK | Overall

TB-500 is of wide interest due to its many evidenced benefits and markedly positive safety profile. With the proven therapeutic potential to improve healing, cardiovascular health, and inflammatory and immune responses, the prospective clinical applications of TB-500 are promising. While more studies into its use in human subjects are needed, the data at present is highly favorable.

UK researchers can safely and effectively add TB-500 to their studies when it is purchased from a trusted source. Our most recommended peptide vendor is readily available for clients within the UK to obtain the highest-grade TB-500 online.

Offering the finest peptides and international shipping with low fees, Peptide Sciences is your best source for TB-500!


References

  1. National Center for Biotechnology Information. PubChem Compound Summary for CID 16132341, Thymosin beta4. https://pubchem.ncbi.nlm.nih.gov/compound/Thymosin-beta4. Accessed July 22, 2022.
  2. Goldstein AL, Hannappel E, Sosne G, Kleinman HK. Thymosin β4: a multi-functional regenerative peptide. Basic properties and clinical applications. Expert Opin Biol Ther. 2012 Jan;12(1):37-51. doi: 10.1517/14712598.2012.634793. Epub 2011 Nov 10. PMID: 22074294.
  3. Spurney CF, Cha HJ, Sali A, Pandey GS, Pistilli E, Guerron AD, Gordish-Dressman H, Hoffman EP, Nagaraju K. Evaluation of skeletal and cardiac muscle function after chronic administration of thymosin beta-4 in the dystrophin deficient mouse. PLoS One. 2010 Jan 29;5(1):e8976. doi: 10.1371/journal.pone.0008976. PMID: 20126456; PMCID: PMC2813286.
  4. Xing Y, Ye Y, Zuo H, Li Y. Progress on the function and application of thymosin β4 [Internet]. Frontiers. Frontiers; 2021 [cited 2022Dec21]. Available from: https://doi.org/10.3389/fendo.2021.767785
  5. Crockford D. Development of thymosin beta4 for treatment of patients with ischemic heart disease. Ann N Y Acad Sci. 2007 Sep;1112:385-95. doi: 10.1196/annals.1415.051. PMID: 17947592.
  6. Ryu, K., Kang, H., & Moon, Y. (2014). The Actin-Sequestering Protein Thymosin Beta-4 Is a Novel Target of Hypoxia-Inducible Nitric Oxide and HIF-1α Regulation. PLOS ONE, 9(10), e106532. https://doi.org/10.1371/journal.pone.0106532
  7. Ho EN, Kwok WH, Lau MY, Wong AS, Wan TS, Lam KK, Schiff PJ, Stewart BD. Doping control analysis of TB-500, a synthetic version of an active region of thymosin β₄, in equine urine and plasma by liquid chromatography-mass spectrometry. J Chromatogr A. 2012 Nov 23;1265:57-69. doi: 10.1016/j.chroma.2012.09.043. Epub 2012 Sep 23. PMID: 23084823.
  8. Low TL, Hu SK, Goldstein AL (1981) Complete amino acid sequence of bovine thymosin beta 4: a thymic hormone that induces terminal deoxynucleotidyl transferase activity in thymocyte populations. Proc Natl Acad Sci U S A 78: 1162–1166.
  9. Xiong Y, Mahmood A, Chopp M. Neurorestorative treatments for traumatic brain injury [Internet]. Discovery Medicine. 2010 [cited 2022Dec22]. Available from: https://www.discoverymedicine.com/Ye-Xiong/2010/11/23/neurorestorative-treatments-for-traumatic-brain-injury/
  10. Brennan, R., Wells, J. G., & Van Hout, M. C. (2014). An unhealthy glow? A review of melanotan use and associated clinical outcomes. Performance Enhancement & Health, 3(2), 78–92. doi:10.1016/j.peh.2015.06.001
  11. Ema. Medicines for human use under evaluation – european agency [Internet]. European Medicines Agency. 2022 [cited 2022Nov28]. Available from: https://www.ema.europa.eu/en/medicines/medicines-human-use-under-evaluation
  12. Find written questions and answers – UK parliament [Internet]. [cited 2022Nov28]. Available from: https://questions-statements.parliament.uk/written-questions
  13. Notice of opportunity for hearing (Nooh) manookian, Edward 8/5/16 [Internet]. U.S. Food and Drug Administration. FDA; 2016 [cited 2022Sep23]. Available from: https://www.fda.gov/regulatory-information/electronic-reading-room/notice-opportunity-hearing-nooh-manookian-edward-8516
  14. Macdonald G. Ema proposes quality guidelines for synthetic peptides and oligonucleotides [Internet]. Regulatory Affairs Professionals Society (RAPS). [cited 2022Nov28]. Available from: https://www.raps.org/news-and-articles/news-articles/2022/9/ema-proposes-quality-guidelines-for-synthetic-pept
  15. Peptide synthesis market share, size and industry growth analysis 2021 – 2026 [Internet]. IndustryARC. [cited 2022Dec17]. Available from: https://www.industryarc.com/Research/Peptide-Synthesis-Market-Research-505605
  16. The impact of the European pharmacopeia regulations for peptides during the change of manufacturer at late phase [Internet]. Knowledge Centre. 2021 [cited 2022Dec17]. Available from: https://www.almacgroup.com/knowledge/library/the-impact-of-the-european-pharmacopeia-regulations-for-peptides-during-the-change-of-manufacturer-at-late-phase/
  17. Establishment of a guideline on the development and manufacture synthetic peptides – scientific European Medicines Agency [Internet]. European Medicines Agency. 2022 [cited 2022Dec17]. Available from: https://www.ema.europa.eu/en/establishment-guideline-development-manufacture-synthetic-peptides-scientific-guideline#current-version-section Global peptide therapeutics market size, share report, 2030 [Internet].
  18. Global Peptide Therapeutics Market Size, Share Report, 2030. [cited 2022Dec17]. Available from: https://www.grandviewresearch.com/industry-analysis/peptide-therapeutics-market
  19. Peptide drug conjugates market size & share report, 2030 [Internet]. Peptide Drug Conjugates Market Size & Share Report, 2030. [cited 2022Dec17]. Available from: https://www.grandviewresearch.com/industry-analysis/peptide-drug-conjugates-market-report
  20. Callaghan III, D. J. (2018). A glimpse into the underground market of melanotan. Dermatology Online Journal, 24(5). http://dx.doi.org/10.5070/D3245040036 Retrieved from https://escholarship.org/uc/item/2gz9f9jk
  21. Anti-inflammatory peptides market size: Global Industry Report, 2025 [Internet]. Anti-inflammatory Peptides Market Size | Global Industry Report, 2025. [cited 2022Dec17]. Available from: https://www.grandviewresearch.com/industry-analysis/anti-inflammatory-peptides-market
  22. Ehrlich HP, Hazard SW 3rd. Thymosin beta4 enhances repair by organizing connective tissue and preventing the appearance of myofibroblasts. Ann N Y Acad Sci. 2010 Apr;1194:118-24. doi: 10.1111/j.1749-6632.2010.05483.x. PMID: 20536458.
  23. Zhu J, Su LP, Ye L, Lee KO, Ma JH. Thymosin beta 4 ameliorates hyperglycemia and improves insulin resistance of KK Cg-Ay/J mouse. Diabetes Res Clin Pract. 2012 Apr;96(1):53-9. doi: 10.1016/j.diabres.2011.12.009. Epub 2012 Jan 3. PMID: 22217673.
  24. Ruff D, Crockford D, Girardi G, Zhang Y. A randomized, placebo-controlled, single and multiple dose study of intravenous thymosin beta4 in healthy volunteers. Ann N Y Acad Sci. 2010 Apr;1194:223-9. doi: 10.1111/j.1749-6632.2010.05474.x. PMID: 20536472.
  25. Guarnera G, DeRosa A, Camerini R; 8 European sites. The effect of thymosin treatment of venous ulcers. Ann N Y Acad Sci. 2010 Apr;1194:207-12. doi: 10.1111/j.1749-6632.2010.05490.x. PMID: 20536470.
  26. Zhu J, Song J, Yu L, Zheng H, Zhou B, Weng S, Fu G. Safety and efficacy of autologous thymosin β4 pre-treated endothelial progenitor cell transplantation in patients with acute ST segment elevation myocardial infarction: A pilot study. Cytotherapy. 2016 Aug;18(8):1037-1042. doi: 10.1016/j.jcyt.2016.05.006. Epub 2016 Jun 7. PMID: 27288307.
  27. Sosne G, Dunn SP, Kim C. Thymosin β4 significantly improves signs and symptoms of severe dry eye in a phase 2 randomized trial. Cornea. 2015 May;34(5):491-6. doi: 10.1097/ICO.0000000000000379. PMID: 25826322.
  28. Goldstein AL, Hannappel E, Kleinman HK. Thymosin beta4: actin-sequestering protein moonlights to repair injured tissues. Trends Mol Med. 2005 Sep;11(9):421-9. doi: 10.1016/j.molmed.2005.07.004. PMID: 16099219.
  29. Xiong, Y., Mahmood, A., Meng, Y., Zhang, Y., Zhang, Z. G., Morris, D. C., & Chopp, M. (2012). Neuroprotective and neurorestorative effects of Thymosin beta 4 treatment following experimental traumatic brain injury. Annals of the New York Academy of Sciences, 1270, 51. https://doi.org/10.1111/j.1749-6632.2012.06683.x
  30. Stark, C. K., Tarkia, M., Kentala, R., Malmberg, M., Vähäsilta, T., Savo, M., Hynninen, V., Helenius, M., Ruohonen, S., Jalkanen, J., Taimen, P., Alastalo, T., Saraste, A., Knuuti, J., Savunen, T., & Koskenvuo, J. (2016). Systemic Dosing of Thymosin Beta 4 before and after Ischemia Does Not Attenuate Global Myocardial Ischemia-Reperfusion Injury in Pigs. Frontiers in Pharmacology, 7. https://doi.org/10.3389/fphar.2016.00115
  31. Aberásturi M. How to use TB-500 [Internet]. Ben Greenfield Life – Fitness, Diet, Fat Loss and Performance Advice. 2022 [cited 2022Dec29]. Available from: https://bengreenfieldlife.com/article/supplements-articles/how-to-use-tb-500/
  32. W. B. What is Bacteriostatic Water? [Internet]. Study.com | Take Online Courses. Earn College Credit. Research Schools, Degrees & Careers. 2022 [cited 2022Aug17]. Available from: https://study.com/academy/lesson/what-is-bacteriostatic-water-definition-uses.html
  33. Bacteriostatic Water for Injection [Internet]. Drugs.com. 2021 [cited 2022Aug17]. Available from: https://www.drugs.com/pro/bacteriostatic-water-for-injection.html
  34. Jackson S. The complete guide on Bacteriostatic Water [Internet]. MedLab International. MedLab International; 2019 [cited 2022Aug17]. Available from: https://medlabgear.com/blogs/articles/guide-bacteriostatic-water

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